• Modeling suggests that access to these titratable residues is blocked by a ladder of hydrophobic residues, and ATP-driven conformational changes open and close this hydrophobic seal to permit metal binding and release. (nih.gov)
  • The conservation of this arrangement of titratable and hydrophobic residues among ABC transporters of transition metals suggests a common mechanism. (nih.gov)
  • The influence of molecular characteristics on the mutual interaction between peptides and nonionic surfactants has been investigated by studying the effects of surfactants on amphiphilic, random copolymers of alpha-L-amino acids containing lysine residues as the hydrophilic parts. (lu.se)
  • The hydrophobic residues were either phenylalanine or tyrosine. (lu.se)
  • The model has only two types of residues, hydrophobic and hydrophilic. (lu.se)
  • Docking studies with these compounds against cyclooxygenase-2 receptor(PDB 1D: 1PXX) indicated that they exhibit specific interactions with key residues located in the site of the COX2 structure, which corroborates the hypothesis that these molecules are potential ligands of COX2. (ias.ac.in)
  • In solution, compstatin forms a β-turn at residues Gln-5-Gly-8 with the disulfide bridge Cys-2-Cys-12, residues Ile-1-Val-4 and Thr-13 forming a hydrophobic cluster (PCT Pub. (justia.com)
  • Versatile chromatography systems are available to separate compounds by hydrophobic, hydrophilic or ionic interactions, also by special affinity chromatography or size exclusion. (uni-tuebingen.de)
  • It was found that predominantly hydrophobic interactions together with ionic/hydrophilic interactions between 12-2-12 Gemini surfactant and the saccharides maltodextrin and lactose play a role. (degruyter.com)
  • A systematic study of the effects of hydrophilic ionic liquids concentration and nature (alkyl chain length and type of anion) on the activity of Candida antarctica lipase B is here reported. (ua.pt)
  • This behavior is partially due to the ionic liquid impact on the thermodynamic water activity, but direct interactions between the hydrophilic ionic liquid and the enzyme are also disclosed. (ua.pt)
  • However, a certain degree of peptide hydrophobicity is necessary to obtain an interaction with nonionic surfactant. (lu.se)
  • It achieved unprecedented mass loading of hydrophilic enzyme and hydrophobic/conductive metal nanoparticles and greatly increased electron transfer efficiency and current density. (phys.org)
  • Amphiphilic assembled multilayers composed of glucose oxidases in aqueous media and hydrophobic/conductive nanoparticles in nonpolar media were deposited onto cotton fiber/textile to form the anode, which has notably increased electron transfer efficiency and immobilization stability. (phys.org)
  • To mitigate the high fouling propensities of hydrophobic MD membranes while retaining their high salt rejection efficiencies, superhydrophobic poly-vinylidene fluoride (PVDF) nanofibre membranes embedded with silanized silica nanoparticles (f-SiO(2)NPs) were synthesised and coated with a hydrophilic active layer containing silver nanoparticles and carboxylated multi-walled carbon nanotubes (AgNPs/f-MWCNTs). (ugent.be)
  • Therefore, the peptide-surfactant complex is best described in terms of a necklace model, with the peptide interacting primarily with the palisade region of the micelles via its hydrophobic side chains. (lu.se)
  • 2 Proteins are incorporated into these micelles via hydrophobic interactions. (sigmaaldrich.com)
  • 1 These integral membrane proteins (IMPs) ( Figure 2 ) are not soluble in aqueous solutions as they aggregate to protect their hydrophobic domains, but are soluble in detergent solutions as micelles formed by detergents are analogous to the bilayers of the biological membranes. (sigmaaldrich.com)
  • Hydrophobic regions of membrane proteins, normally embedded in the membrane lipid bilayer, are now surrounded by a layer of detergent molecules and the hydrophilic regions are exposed to the aqueous medium. (sigmaaldrich.com)
  • Complete removal of detergent could result in aggregation due to the clustering of hydrophobic regions and, hence, may cause precipitation of membrane proteins. (sigmaaldrich.com)
  • Superhydrophobic PVDF nanofibre membranes coated with an organic fouling resistant hydrophilic active layer for direct-contact membrane distillation," COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS , vol. 575, pp. 363-372, 2019. (ugent.be)
  • This article discusses a Sartobind phenyl membrane adsorber that has been developed for the manufacturing-scale production of biomolecules based on hydrophobic interaction chromatography (HIC) principles. (biopharminternational.com)
  • In addition to positively charged membranes, hydrophobic interaction membrane chromatography (HIC) has been described for the purification of a humanized MAb. (biopharminternational.com)
  • The hydrophobic membrane adsorber is based on hydrophilic regenerated stabilized cellulose with hydrophobic phenyl groups covalently attached to the base matrix. (biopharminternational.com)
  • Solute carriers (SLCs) are membrane transport proteins tasked with mediating passage of hydrophilic molecules across lipid bilayers. (duke.edu)
  • We construct 3M™ LifeASSURE™ PSN Series filter capsules with high efficiency, naturally hydrophilic, Nylon 6,6 membrane. (3m.com)
  • Another benefit our Nylon 6,6 membrane offers is a reduction for potential microbubble formation by not de-wetting in outgassing fluids unlike hydrophobic membranes such as polypropylene, UPE, and PTFE. (3m.com)
  • Biological membranes consist of phospholipids that contain two hydrophobic groups connected to a polar head. (sigmaaldrich.com)
  • This result justifies the observed correlations as dichloromethane extractives, being hydrophobic, compete with phenanthrene adsorption, whereas phenolic groups, as well as negatively charged groups, enhance the hydrophilic character of the sorbent surface, thus hindering the adsorption of phenanthrene. (nih.gov)
  • The non-specific adsorption of blood proteins on nanorobot surfaces could lead to clinical difficulties such as thrombosis and unwanted protein-mediated recognition interactions such as cell-nanorobot and nanorobot-nanorobot adhesion (aggregation). (nanomedicine.com)
  • Various hydrophilic adsorbed coatings have been attached to artificial surfaces to make them more protein-resistant, in effect "passivating" them against protein adsorption and greatly reducing or preventing cell adhesion to biomedical implants [ 754 ]. (nanomedicine.com)
  • f-SiO2 NPs-modified PVDF nanofibres showed the highest flux decline (82% after 60 h) associated with BSA adsorption induced by favourable hydrophobic-hydrophobic interactions. (ugent.be)
  • This molecular architecture allows phospholipids to assemble as lipid bilayers in which the hydrophobic chains face each other while the polar head groups face outward to the aqueous milieu ( Figure 1 ). (sigmaaldrich.com)
  • Hydrophilic konjac glucomannan (KGM)/hydrophobic ethyl cellulose (EC) film was prepared in the ethanol/water environment. (bvsalud.org)
  • Two approaches were integrated to reach this objective: (1) statistical multivariate analysis to obtain correlations between the sorption capacity, measured as K(oc), and the sorbent properties (i.e. polarity, acidic functional groups, %dichloromethane extractives, %ethanol and water extractives, %suberin, %lignin and %holocellulose) and (2) modeling calculations to obtain information on interaction at the molecular level. (nih.gov)
  • A. Ben-Naim, "The Rise and Fall of the Hydrophobic Effect in Protein Folding and Protein-Protein Association, and Molecular Recognition," Open Journal of Biophysics , Vol. 1 No. 1, 2011, pp. 1-7. (scirp.org)
  • A. Ben-Naim, "Molecular Theory of Water and Aqueous Solutions," Part II: Hydrophilic Effects in Protein Folding, Self-Assembly and Molecular Recognition," World Scientific, Singapore, 2011. (scirp.org)
  • The film-forming solution and film properties were both characterized to analyze the molecular interaction changes. (bvsalud.org)
  • The changing trend of mechanical properties and the FTIR results suggested that both ethanol content and ethanol evaporation impacted the molecular interaction during the film formation. (bvsalud.org)
  • Here, we use Raman spectroscopy combined with multivariate curve resolution (Raman-MCR), partial molar volume, and fluorescence spectroscopic methods to detect and quantify changes in hydration extent and structure due to hydrophobic aggregation and hydrophobic cavity structure. (purdue.edu)
  • This hydration-shell spectrum therefore contains evidence of hydrophobic aggregation by changes in the solute vibrational features as well as information on the extent and structure of water perturbed in the hydration shell of the solute. (purdue.edu)
  • Consequently, it will usually be desirable to suppress non-specific adhesive interactions involving individual physically-unlinked nanorobots, in order to permit unfettered nanorobot mobility and freedom of action within the human body and avoid particle aggregation. (nanomedicine.com)
  • Phenylalanine and leucine are both hydrophobic, however phenylalanine is large, aromatic and strand-preferring, while leucine is medium in size and prefers to be in a helix. (wikipedia.org)
  • This inorganic phosphate ion increases the toxin stability by neutralizing the positively charged basic amino acids of the monomers, creating possibilities for more Van Der Waals interactions. (wikipedia.org)
  • Separation mechanism based on hydrophobic (van der Waals) and polar interactions. (mn-net.com)
  • The aggregates are hydrophobic and hydrophilic dimers, joined by intermolecular interaction. (wikipedia.org)
  • Open questions remain regarding the degree of water restructuring in hydrophobic cavities, the extent of hydration in self-assembled aggregates, and the influence of water restructuring on hydrophobic interactions. (purdue.edu)
  • Water mediated hydrophilic and hydrophobic interactions are important for biological systems, atmospheric, geological, and environmental chemistry, and pharmaceuticals formulation development. (purdue.edu)
  • Cations with longer alkyl chains decrease the enzyme activity by obstruction of its non-polar active site, while direct interactions established between the enzyme and the anions, dominated by dispersion forces and hydrogen-bonding, contribute also for the loss of activity observed. (ua.pt)
  • Based on high-purity NUCLEODUR silica gel, a polar group was embedded in a hydrophobic C18. (mn-net.com)
  • On montmorillonite, an ion exchange reaction of Lys side groups against alkali ions as well as interactions between alkali cations and polar groups in the peptide are explained. (aps.org)
  • 2002). Mutational studies showed that the polar 3-turn and the hydrophobic cluster are essential for the inhibitory activity of compstatin (Furlong et al. (justia.com)
  • The attractive supramolecular interactions (hydrogen bonding, interactions, and hydrophobic effects) drive the monomers to assemble, while opposed by repulsive electrostatic interactions that resist polymerisation. (europa.eu)
  • In related experiments, we are examining hydrophobic and hydrophilic interactions between water and various other materials using thermal desorption and surface spectroscopic techniques to probe interphase transport and phase separation. (pnnl.gov)
  • By including sequence independent local interactions, which qualitatively reproduce local properties of functional proteins, the dominance of a native state for many sequences is observed. (lu.se)
  • You can use the SurPASS 3 surface zeta potential analyzer to study the interaction of proteins in solution with the implant material. (anton-paar.com)
  • In addition, several proteins that are not previously linked with blood-biomaterial interaction are presented and discussed. (ibecbarcelona.eu)
  • Proteins are held in the lipid bilayer by hydrophobic interactions between the lipid tails and hydrophobic protein domains. (sigmaaldrich.com)
  • Since both of these amino acids are also hydrophobic this mutation is thought to have little interference with the folding and stability of the protein. (wikipedia.org)
  • The interactions also offered simple and straightforward answers to the problems of protein folding, and protein-protein association. (scirp.org)
  • Nevertheless, three striking differences were detected in the ATP-binding pocket, which influences protein-ligand interactions. (uni-marburg.de)
  • In comparison with already published PKA and Pim1 binders, we could detect either known but also new structural scaffolds for the interactions with the protein. (uni-marburg.de)
  • Our results suggest that a screening approach using protein crystallography is particularly useful to identify universal fragments for the conserved hydrophilic recognition sites found in target families such as SH2 domains, phosphatases, kinases, proteases, and esterases. (rcsb.org)
  • The approach, which can induce favorable interfacial interactions between electrocatalysts and significantly improve the electron transfer kinetics of electrodes, generated hybrid biofuel cells with high power output and good operational stability. (phys.org)
  • The method induced favorable interfacial interactions between electrocatalysts and improved electron transfer kinetics of electrodes. (phys.org)
  • In contrast, we were unable to identify electron density for hydrophobic fragments, confirming that hydrophobic interactions are important for inhibitor affinity but of minor importance for ligand recognition. (rcsb.org)
  • The study of the different hydrophobic/hydrophilic interactions in the Gemini surfactant-sacharide-water mixtures are very helpful to understand the structural behaviour of Gemini surfactants in the view of their biological significance. (degruyter.com)
  • His study includes, inter alia, evaluating different (co)polymer systems on their solution behavior as well as the different hydrophilic-hydrophobic interactions and, investigating their potential use as carriers for active ingredients and as surfactants for emulsions. (ugent.be)
  • The modeling study showed that the lignin-phenanthrene interaction is mostly hydrophobic in nature being largely determined by the π-stacking interaction between the aromatic groups of the interacting partners. (nih.gov)
  • When researching biocompatible coatings for implant materials, one crucial parameter is the interaction of the implant with its biological environment. (anton-paar.com)
  • Water-mediated collagen and mineral nanoparticle interactions guide functional deformation of human tooth dentin. (mpg.de)
  • It is a hydrophobic phase with pronounced hydrophilic properties. (mn-net.com)
  • Typical studies on biomaterials include measuring hardness and structural properties, characterization of surface charge, surface interaction, hydrophobic/hydrophilic properties, and many more. (anton-paar.com)
  • Taking advantage of hydrophobic interactions and self-recognition properties of the BTA units, the 'free' BTAs are captured into the interior of the SCPN in water as evidenced by fluorescence studies. (stanford.edu)
  • While the f-SiO2 NPs-modified PVDF nanofibres exclusively allow the transport of water vapour, the AgNPs/f-MWCNTs active provides hydrophilic and biocidal (i.e., biofouling control) properties. (ugent.be)
  • Moreover, MSC supporting material selection is fundamental to allow for an active interaction with cells. (nature.com)
  • The analysis of the docking results, which takes into account the hydrophilic and hydrophobic interactions betweenthe ligands and the target, identified N-(4-bromophenyl)-4,5-bis(4 hydroxyphenyl)thiophene-2-carboxamide (6k) having high binding free energy of −11.67 kcal/mole (comparable with standard diclofenac sodium) and the best docking score, indicating effective binding of the compound 6k at the active site. (ias.ac.in)
  • In particular, Raman-MCR is used to observe the presence and extent of water penetration into micelle interiors, and partial molar volume results from density measurements of deep-cavity cavitands demonstrate experimental observation of a hydrophobic cavity dewetting transition. (purdue.edu)
  • The effects of temperature and concentration/strength of the solutions on the interaction behaviour were analysed by conductivity studies over a wide temperature (293.15-313.15) K and concentration range of the saccharides as well as of the surfactant. (degruyter.com)
  • The void created was immediately filled by Kauzmann's idea of hydrophobic ( HφO ) effect which reigned supreme in biochemical literature for over 50 years (1960-2010). (scirp.org)
  • Cracks in the HB-inventory argument on one hand, and doubts about the adequacy of Kauzmann's model for the HφO effect, have led to a comeback of the HBs, along with a host of new hydrophilic ( HφI ) effects. (scirp.org)
  • Brooks, D. E. Barrier Capacity Of Hydrophilic Polymer Brushes To Prevent Hydrophobic Interactions: Effect Of Graft Density And Hydrophilicity . (ubc.ca)
  • In order to study the immune escape of Omicron in more detail, we comprehensively and systematically studied the interaction between the antibodies reported in PDB and current Omicron strains. (nature.com)
  • In the present study, the interaction behaviour of 12-2-12 Gemini surfactant in aqueous saccharide solutions (lactose and maltodextrin solutions) is investigated using density, sound velocity and viscosity measurements. (degruyter.com)
  • 2003). Both main-chain and side-chain atoms of compstatin are thought to be involved in interaction with C3 (Sahu et al. (justia.com)
  • They found that when the size of the hydrophilic dendron becomes too large, it limits 1D growth, producing objects that are restricted in size and globular in shape. (europa.eu)
  • Such interactions could not only result in injury to the patient but also inactivation of the nanorobots with a subsequent failure of the nanomedical mission. (nanomedicine.com)
  • indicating essential involvement of specific interactions. (lu.se)
  • The peptide-surfactant interactions were studied by means of circular dichroism spectroscopy and binding isotherms, as well as by 1D and 2D NMR. (lu.se)
  • The interaction yields an increased amount of alpha-helix conformation in the peptide. (lu.se)
  • Researchers created a small library of charge-neutral dendritic peptide amphiphiles with a branched nonaphenylalanine-based core that was conjugated to hydrophilic dendrons of variable steric demand. (europa.eu)
  • In absence of local interactions, native structure formation does not occur for the temperatures considered. (lu.se)
  • Like other members of the lipocalin family, BLG these specific interactions have been shown to be critical for has a -barrel fold with a large internal cavity that binds dimer stability (Kobayashi et al. (lu.se)
  • This allows the filter to be used with no need to pre-wet with IPA and flush, which reduces chemical interaction and eliminates a potential source of contamination and reduces chemical usage. (3m.com)
  • Newer strategies recognize the close biologic interactions between the skeletal cells and the immune cells. (medscape.com)
  • This method exploits the ability of detergents to bind to hydrophobic resins. (sigmaaldrich.com)
  • Brooks, D. E. Surface Modification Of Polyvinyl Chloride Sheets Via Growth Of Hydrophilic Polymer Brushes . (ubc.ca)