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  • soluble epoxide h
  • 14, 61-71) we selected candidate amino acid residues for the putative catalytic triad of the rat soluble epoxide hydrolase. (uzh.ch)
  • In case of impaired catalytic activity of a given mutant, the structural integrity of the recombinant enzyme protein was assessed either by its ability to covalently bind the substrate trans-stilbene oxide or by affinity purification on benzyl thio-Sepharose, using the soluble epoxide hydrolase-specific competitive inhibitor 4-fluorochalcone oxide to release the bound enzyme from the affinity matrix. (uzh.ch)
  • Microsomal epoxide hydrolase (epoxide hydrolase 1, EH1, or mEH), soluble epoxide hydrolase (sEH, epoxide hydrolase 2, EH2, or cytoplasmic epoxide hydrolase), and the more recently discovered but not as yet well defined functionally, epoxide hydrolase 3 (EH3) and epoxide hydrolase 4 (EH4) are structurally closely related isozymes. (wikipedia.org)
  • Vernolic acid (leukotoxins) and Coronaric acids (isoleukotoxins) to their corresponding diols which are highly toxic in animal models and possibly humans (see Vernolic acid#toxicity, Coronaric acid#toxicity, and soluble epoxide hydrolase). (wikipedia.org)
  • amino
  • The predicted amino acid residues were exchanged by site-directed mutagenesis of the epoxide hydrolase cDNA, followed by the expression of the respective mutant enzymes in Escherichia coli. (uzh.ch)
  • The gene for EH4, EPHX4, is projected to encode an epoxide hydrolase closely related in amino acid sequence and structure to mEH, sEH, and EH3. (wikipedia.org)

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  • enzymology
  • In enzymology, a phosphonoacetaldehyde hydrolase (EC 3.11.1.1) is an enzyme that catalyzes the chemical reaction phosphonoacetaldehyde + H2O ⇌ {\displaystyle \rightleftharpoons } acetaldehyde + phosphate Thus, the two substrates of this enzyme are phosphonoacetaldehyde and H2O, whereas its two products are acetaldehyde and phosphate. (wikipedia.org)
  • In enzymology, a phloretin hydrolase (EC 3.7.1.4) is an enzyme that catalyzes the chemical reaction phloretin + H2O ⇌ {\displaystyle \rightleftharpoons } phloretate + phloroglucinol Thus, the two substrates of this enzyme are phloretin and H2O, whereas its two products are phloretate and phloroglucinol. (wikipedia.org)
  • (wikipedia.org)
  • In enzymology, an allophanate hydrolase (EC 3.5.1.54) is an enzyme that catalyzes the chemical reaction allophanate + 3 H2O + H+ ⇌ {\displaystyle \rightleftharpoons } 2 HCO3− + 2 NH4+ Thus, the two substrates of this enzyme are allophanate (urea-1-carboxylate or N-carbamoylcarbamate) and H2O, whereas its two products are HCO3− and NH4+. (wikipedia.org)
  • In enzymology, a hydroxyisourate hydrolase (EC 3.5.2.17) is an enzyme that catalyzes the chemical reaction 5-hydroxyisourate + H2O ⇌ {\displaystyle \rightleftharpoons } 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate Thus, the two substrates of this enzyme are 5-hydroxyisourate and H2O, whereas its product is 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate. (wikipedia.org)
  • In enzymology, a chlorogenate hydrolase (EC 3.1.1.42) is an enzyme that catalyzes the chemical reaction chlorogenate + H2O ⇌ {\displaystyle \rightleftharpoons } caffeate + quinate Thus, the two substrates of this enzyme are chlorogenate and H2O, whereas its two products are caffeate and quinate. (wikipedia.org)
  • PMID
  • A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ PMID: 7624375 , PMID: 8535779 ]. (ebi.ac.uk)
  • One of these families is known as the cellulase family K or as the glycosyl hydrolases family 45 [ PMID: 8352747 ]. (ebi.ac.uk)
  • and are inactivated by bleomycin hydrolase, which hydrolyses the carboxyamide bond of the beta-aminoalanine moiety [ PMID: 4122312 ]. (ebi.ac.uk)
  • Bleomycin hydrolase acts mainly as an aminopeptidase on short peptides, but the rat orthologue has been shown to cleave amyloid beta-peptides, acting as an endopeptidase or a carboxypeptidase, as well as an aminopeptidase [ PMID: 16472072 ]. (ebi.ac.uk)
  • Bleomycin hydrolase is intracellular and exists naturally as a homohexamer, with all the active site in the central cavity of the barrel [ PMID: 7638617 ]. (ebi.ac.uk)
  • This domain is also found in lysophospholipases such as cytosolic phospholipase A2 (which has additional structural features) [ PMID: 10319815 ], and in patatin proteins, which are plant glycoproteins that act as non-specific lipid acyl hydrolases [ PMID: 12779324 ]. (ebi.ac.uk)
  • Fatty-acid amide hydrolase 1 (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signalling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide [ PMID: 15952893 ]. (ebi.ac.uk)
  • binds
  • 1) A hydrolase which binds other hydrolase molecules of its type may have gotten eliminated thru natural selection if it did not impart any evolutionary advantage to the organism. (biology-online.org)