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  • Disorders
  • The Emory Clinic Movement Disorders Center is a Huntington's Disease Society of America (HDSA) Center of Excellence. (emoryhealthcare.org)
  • The Journal of Huntington's Disease is a quarterly peer-reviewed scientific journal in neuroscience that covers all aspects of Huntington's disease and related disorders. (wikipedia.org)
  • The field of neurogenetics emerged from advances made in molecular biology, genetics and a desire to understand the link between genes, behavior, the brain, and neurological disorders and diseases. (wikipedia.org)
  • While the genetic basis of simple diseases and disorders has been accurately pinpointed, the genetics behind more complex, neurological disorders is still a source of ongoing research. (wikipedia.org)
  • Central nervous system diseases, also known as central nervous system disorders, are a group of neurological disorders that affect the structure or function of the brain or spinal cord, which collectively form the central nervous system (CNS). (wikipedia.org)
  • Hyperkinesia is a state of excessive restlessness which is featured in a large variety of disorders that affect the ability to control motor movement, such as Huntington's disease. (wikipedia.org)
  • genes
  • Some of these genes are also targets for SP1 and/or REST, which may suggest a pathological mechanism of action for this neurodegenerative disease. (qiagen.com)
  • The Human Huntington's Disease RT 2 Profiler PCR Array profiles the expression of 84 key genes directly or potentially involved in Huntington's disease (HD). (qiagen.com)
  • What we have observed in our study is that the mutated fragment acting as a conveyor-the so-called messenger RNA-is key in the pathogenesis," says Dr. Eulàlia Martí, lead author of the research project, together with Xavier Estivill, and acting group leader of the Genes and Disease laboratory at the Centre for Genomic Regulation. (innovations-report.com)
  • Each of the parents have two genes for the disease, a good copy and a faulty copy. (smore.com)
  • Since it is passed down through the genes of your parents that makes it difficult for someone to prevent them selves from getting the disease. (smore.com)
  • movements
  • As the disease advances, uncoordinated, jerky body movements become more apparent. (wikipedia.org)
  • In evaluating the individual with a suspected form of hyperkinesia, the physician will record a thorough medical history including a clear description of the movements in question, medications prescribed in the past and present, family history of similar diseases, medical history including past infections, and any past exposure to toxic chemicals. (wikipedia.org)
  • Several prominent forms of hyperkinetic movements include: The term ataxia refers to a group of progressive neurological diseases that alter coordination and balance. (wikipedia.org)
  • behavioral
  • Menalled L, El-Khodor BF, Patry M et al (2009) Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models. (springer.com)
  • Laforet GA, Sapp E, Chase K et al (2001) Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. (springer.com)
  • clinical
  • The Emory HD team has also been part of the Huntington Study Group since its inception 25 years ago and actively participates in ongoing clinical research trials focusing on Huntington's disease. (emoryhealthcare.org)
  • Initiated by Professor William H. Durham in 2000, HOPES is a team of faculty members and undergraduate students at Stanford that surveys the rapidly growing scientific and clinical literature on Huntington's disease. (wikipedia.org)
  • occur
  • This lateral hypothalamic abnormality would be expected to affect the function of most of the pituitary axes (as shown in other neurodegenerative diseases where neuroendocrine alterations occur ), potentially modifying the basal levels of GH, TSH, ACTH, LH, FSH, and prolactin, at least at late in the course of HD. (plos.org)
  • Research
  • Our mission is propelled by active research into the underlying mechanisms of Huntington's disease in the laboratory to develop novel therapies to improve the care of our patients. (emoryhealthcare.org)
  • Despite all the research on this tragic disease, there is no cure and very few medications to alleviate symptoms. (wisc.edu)
  • The research just published by a group of scientists from the Centre for Genomic Regulation (CRG) led by Eulàlia Martí, in cooperation with researchers from the University of Barcelona (UB) and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), has brought to light new information on the molecular mechanisms that cause Huntington's disease, and defines new pathways to therapy discovery. (innovations-report.com)
  • The research on this disease being done by most groups around the world seeking new therapeutic strategies focuses on trying to prevent expression of the mutated protein. (innovations-report.com)
  • The research we have just published points to RNA's clear role in Huntington's disease. (innovations-report.com)
  • For example, research must explore whether it will be possible to revert the effects of Huntington's disease in patients, just as researchers have demonstrated in mouse models. (innovations-report.com)
  • I have not known any one who has had Huntington's disease, but from the research that i have done it shows that many people do inherit the disease. (smore.com)
  • The charity was instrumental in the 2010 launch of an All-Party Parliamentary Group for Huntington's disease in the UK Parliament, chaired by Lord Walton of Detchant, and 2010 research revealing that the prevalence of HD is much higher than previously thought. (wikipedia.org)
  • HOPES website "Sources of Research Information" Huntington's Disease Society of America, 2008 Miller, Marsha. (wikipedia.org)
  • He also started conducting research in neurodegeneration in fruit flies in an attempt to discover ways to suppress neurological diseases in humans. (wikipedia.org)
  • mechanisms
  • These models are used to further enhance our understanding of the mechanisms underlying the disease, as well as investigating and identifying therapeutic targets for this disorder. (springer.com)
  • Here we review the transgenic, knock-in mice commonly used to model HD, as well those that have been generated to study specific disease mechanisms. (springer.com)
  • The work of scientists at the CRG has helped explore the molecular mechanisms that cause the disease. (innovations-report.com)
  • protein
  • The direct consequence of this excess of repetitions is the synthesis of a mutated protein-different from what would be obtained without the additional CAG repetitions-which has been considered the main cause of the disease for the past 20 years. (innovations-report.com)
  • syndrome
  • Examples of this type of disorder are Albinism, Medium-chain acyl-CoA dehydrogenase deficiency, cystic fibrosis, sickle-cell disease, Tay-Sachs disease, Niemann-Pick disease, spinal muscular atrophy, and Roberts syndrome. (wikipedia.org)
  • lengths
  • The lengths of CAG repeat in normal and disease alleles are plotted separately as a percentage of each class for a collection of 307 patients with HD, based on genotyping of postmortem brain specimens. (els.net)