• binds
  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells ( APC ) and presents them on the cell surface for recognition by the CD4 T-cells. (rcsb.org)
  • 1992
  • 1992. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. (wikipedia.org)
  • immune
  • AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. (wikipedia.org)
  • Increased abundance of DR 'antigen' on the cell surface is often in response to stimulation, and, therefore, DR is also a marker for immune stimulation. (wikipedia.org)
  • They process antigen material and present it on the surface to other cells of the immune system. (wikipedia.org)
  • pathway
  • Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. (rcsb.org)
  • and for this reason this antigen presentation pathway is usually referred to as exogenous. (nih.gov)
  • a trimer) to prevent it from binding cellular peptides or peptides from the endogenous pathway (such as those that would be loaded onto class I MHC). (wikipedia.org)
  • Binding to Ii might also prevent binding of peptides from the endogenous pathway to the groove of MHC class II. (wikipedia.org)
  • lysosomal
  • The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. (rcsb.org)
  • As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. (rcsb.org)
  • subunit
  • HLA-DR is an αβ heterodimer, cell surface receptor, each subunit of which contains two extracellular domains, a membrane-spanning domain and a cytoplasmic tail. (wikipedia.org)
  • HLA-DRA encodes the alpha subunit of HLA-DR. Unlike the alpha chains of other Human MHC class II molecules, the alpha subunit is practically invariable. (wikipedia.org)
  • proteins
  • Of the eleven proteins that are encoded for by the genome, two are nonstructural, while the remaining nine are structural. (wikipedia.org)
  • CD74
  • In addition to APC s, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APC s, which is an unusual trait of the GI tract. (rcsb.org)
  • cells
  • MHC class II is also expressed on group 3 innate lymphoid cells. (wikipedia.org)
  • Leukemic transformation can occur in any of these two cells, but transformation of myeloid dendritic cell is less common and it leads to a form of leukemia known as acute myeloid dendritic cell leukemia. (wikipedia.org)
  • Responder cells proliferated without previous exposure to Stimulator MHC antigens. (wikipedia.org)
  • Stimulator cell populations that also contain T-cells (Two way mixed lymphocyte reaction) will replicate in the presence of the Responder cells, therefore for a One way mixed lymphocyte reaction, stimulator cells are prevented from replicating by irradiation or treatment with mitomycin C, a DNA crosslinker to prevent cell replication. (wikipedia.org)
  • β2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells). (wikipedia.org)
  • In the absence of MHC class I, CD8 T cells cannot develop. (wikipedia.org)
  • cell
  • The stable class II MHC is then presented on the cell surface. (wikipedia.org)
  • Altogether, this complex contributes to maintain MHC-II loaded vesicles within the Immature Dendritic Cell, impeding its translocation to the cell membrane. (wikipedia.org)
  • HLA (human leukocyte antigens) were originally defined as cell surface antigens that mediate graft-versus-host disease. (wikipedia.org)
  • This response became quantifiable when incorporating radioactivity, [3H] thymidine or 5-bromo-2'-deoxyuridine (BrdU), into the mixed cell suspension. (wikipedia.org)