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  • cells
  • Two possibilities are that (1) the HLA-DR is shed by neighboring immunocompetent cells, or (2) that the keratinocytes are synthesizing the antigen themselves. (semanticscholar.org)
  • survival
  • Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival). (wikipedia.org)
  • Good matching of these antigens between host and donor are most critical for achieving graft survival. (wikipedia.org)
  • detect
  • The recommended ELISA Kit will likely detect the antigen better in the approved sample types than the available alternatives. (antibodies-online.com)
  • The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives. (antibodies-online.com)
  • leukocyte
  • Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping sets of peptides due to sharing specific residues at the anchor positions-the B and F pockets-of the peptide-binding region (PBR). (springer.com)
  • Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. (wikipedia.org)
  • however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. (wikipedia.org)
  • HLA-A36 (A36) is a human leukocyte antigen serotype within HLA-A serotype group. (wikipedia.org)
  • differentiation
  • Analysis of the H pylori-specific DC transcriptome revealed that large parts of the bacteria-induced transcriptional changes depended on Myd88 signaling, comprising numerous genes involved in crucial steps of immune regulation, such as DC maturation/differentiation, antigen uptake/presentation, and effector cell recruitment/activation. (tum.de)
  • Based on original studies on the roles of T cell receptor triggering, sustained signalling and costimulation in T cell activation (12-14), Lanzavecchia also proposed a progressive model of T cell differentiation to explain the generation of central and effector memory T cells within a single clone of antigen-primed T cells (15). (wikipedia.org)
  • APCs
  • BACKGROUND& AIMS: Recognition of infection leads to induction of adaptive immunity through activation of antigen-presenting cells (APCs). (tum.de)
  • amino acid
  • To test our previous hypothesis that the segment between amino acid position 63 to 73 of the H-2D d antigen forms a major allo-antigenic site, mutations were introduced into the H-2L d gene in a sequential fashion, which replaced the codons for amino acid position 63, 65, 66, 70 and 73 of the H-2L d antigen with those of the H-2D d antigen. (springer.com)
  • The amino acid substitutions at position 63, 65, and 66 led to the acquisition of multiple serological H-2D d specificities which were expressed in the mutant H-2L d antigen. (springer.com)
  • 1985. Polymorphism of murine major histocompatibility class I antigens: Assignment of putative allodeterminants to distinct positions of the amino acid sequence within the first external domain of the antigen. (springer.com)
  • A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. (githubusercontent.com)
  • locus
  • Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 (6p21.3) and also denotes the genetic locus which contains this gene. (wikipedia.org)
  • adaptive
  • Furthermore, Helicobacter-specific IgG2c/IgG1 ratios were reduced in Myd88(-/-) animals, suggesting the involvement of the Myd88-dependent pathway in the instruction of adaptive immunity toward a T helper cell type 1 phenotype. (tum.de)
  • binds
  • An antigen binds the highly variable immunoreceptor products (B-cell receptor or T-cell receptor) once these have been generated. (wikipedia.org)
  • polymorphic
  • New polymorphic microsatellite markers in the human MHC class III region. (semanticscholar.org)
  • Less commonly, SAgs attach to the polymorphic MHC class II β-chain in an interaction mediated by a zinc ion coordination complex between three SAg residues and a highly conserved region of the HLA-DR β chain. (wikipedia.org)
  • epitopes
  • Gain and loss of serological and CTL epitopes specific for the H-2D d and H-2L d antigens were examined. (springer.com)
  • Further, some H-2L d specific alto CTL clones lost reactivity to the mutant molecules, demonstrating the presence of CTL epitopes in this region of the H-2L d antigen. (springer.com)
  • cytokines
  • DCs from wild-type, IL-1R(-/-), and IL-18(-/-) mice responded to H pylori with secretion of proinflammatory cytokines and up-regulation of major histocompatibility complex II and costimulatory molecules. (tum.de)
  • bind
  • This occurs because a cognate antigen activates a T cell not because of its structure per se, but because its affinity allows it to bind the TCR for a lengthy enough time period, and the SAg mimics this temporal bonding. (wikipedia.org)
  • secretion
  • Their functions include phagocytosis and pinocytosis , presentation of antigens to T and B lymphocytes, and secretion of a variety of products, including enzymes, several complement components and coagulation factors, some prostaglandins and leukotrienes, and several regulatory molecules. (thefreedictionary.com)
  • chains
  • Proteases cleave the invariant chains in multiple locations, leaving behind the class-II-associated invariant chain peptide (CLIP) in the binding pocket. (antibodies-online.com)