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  • cells
  • Two possibilities are that (1) the HLA-DR is shed by neighboring immunocompetent cells, or (2) that the keratinocytes are synthesizing the antigen themselves. (semanticscholar.org)
  • normal
  • The ability of normal mice to mount an SV40 T antigen-specific cytolytic T lymphocytes response when immunized in vivo with splenocytes from the SV40 T antigen transgenic 427-line mice and restimulated in vitro with SV40-transformed fibroblasts, or when immunized with SV40 and restimulated with 427-line splenocytes, was analyzed. (jax.org)
  • allogeneic stem cell trans
  • The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
  • Some of these antigens are ubiquitiouly expressed in nucleated male cells, and the presence of these antigens has been associated with a greater risk of developing GVHD allogeneic stem cell transplantation for a HLA matched gene when there's a male recipient and female donor. (wikipedia.org)
  • receptors
  • Minor histocompatibility antigen (also known as MiHA) are receptors on the cellular surface of donated organs that are known to give an immunological response in some organ transplants. (wikipedia.org)
  • Bjorkman continued her postdoctoral research at Stanford University in the laboratory of Mark Davis, studying the T-cell receptors that recognize antigens presented in the binding groove of MHC proteins. (wikipedia.org)
  • nonself
  • Alloimmunity (sometimes called isoimmunity) is an immune response to nonself antigens from members of the same species, which are called alloantigens or isoantigens. (wikipedia.org)
  • found
  • For example, HLA-B27 antigen is found in many people (but not all) with ankylosing spondylitis and Reiter syndrome . (indiatoday.in)
  • APCs
  • BACKGROUND& AIMS: Recognition of infection leads to induction of adaptive immunity through activation of antigen-presenting cells (APCs). (tum.de)
  • immune
  • Analysis of the H pylori-specific DC transcriptome revealed that large parts of the bacteria-induced transcriptional changes depended on Myd88 signaling, comprising numerous genes involved in crucial steps of immune regulation, such as DC maturation/differentiation, antigen uptake/presentation, and effector cell recruitment/activation. (tum.de)
  • In a normal immune response, a type of white blood cell known as T cells are instructed by another kind of immune cell called an antigen-presenting cell (APC) to expand their numbers and stay alive. (eurekalert.org)
  • As biochemist at Goethe University's Biocenter in Frankfurt, Robert TampĂ© gained an international reputation for his contribution to the mechanistic understanding of antigen processing and to solving the question of how viruses avoid detection by the immune system. (cef-mc.de)
  • however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. (wikipedia.org)
  • Baruj Benacerraf (October 29, 1920 - August 2, 2011) was a Venezuelan-American immunologist, who shared the 1980 Nobel Prize in Physiology or Medicine for the "discovery of the major histocompatibility complex genes which encode cell surface protein molecules important for the immune system's distinction between self and non-self. (wikipedia.org)
  • He noticed that if antigens (something that causes a reaction with the immune system) were injected into animals with a similar heredity, two groups emerged: responders and non-responders. (wikipedia.org)
  • He then conducted further study and found that the dominant autosomal genes, termed the immune response genes, determined the response to certain antigens. (wikipedia.org)
  • The histocompatibility complex is a complex part of DNA that controls the immune response. (wikipedia.org)
  • protein
  • Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. (wikipedia.org)
  • These are subunit vaccines, consisting of specific protein antigens (such as tetanus or diphtheria toxoid) or recombinant protein components (such as the hepatitis B surface antigen). (wikipedia.org)
  • populations
  • Besides the guidelines above, the HLA-NET network made a contributions in the following areas The most fine grained map of HLA distribution in the pan-European region is a result of cooperation with the AHPD - Analysis of HLA Populations Data - component of the International Histocompatibility Workshops. (wikipedia.org)
  • vaccines
  • Denise Faustman, Type 1 diabetes William Frankland, popularisation of the UK pollen count, and prediction of increased penicillin allergy Ian Frazer, development of a cervical cancer vaccine Samuel O. Freedman, discovered Carcinoembryonic antigen Jules T. Freund (1890-1960) Sankar Ghosh John Grange Waldemar Haffkine (1860-1930), first microbiologist who developed and used vaccines against cholera and bubonic plague. (wikipedia.org)
  • surface
  • In subsequent studies, he showed that antigens can be effectively targeted to surface molecules other than membrane immunoglobulins (2, 3), a finding that has contributed to current strategies of antigen targeting to improve vaccination. (wikipedia.org)
  • specific
  • An alto CTL epitope of the H-2D d antigen was also localized to this stretch of amino acid sequence, as one of several H-2D d specific CTL clones reacted with the mutant molecule in which amino acids were replaced at position 63 to 70. (springer.com)
  • structure
  • This occurs because a cognate antigen activates a T cell not because of its structure per se, but because its affinity allows it to bind the TCR for a lengthy enough time period, and the SAg mimics this temporal bonding. (wikipedia.org)