• mast
  • Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. (pharmacycode.com)
  • high doses
  • I've also found that supplementing with C's cofactors can raise my histamine by competing with C. High doses of these nutrients, or long-term use of not-so-high doses, will eventually bring on that spacy, can't-do-crap feeling. (adnuther.com)
  • As I've explained elsewhere, most nutrients that interact with each other are cofactors at low doses - they work to increase the efficiency of each other - but at high doses they become antagonists and start competing for absorption. (adnuther.com)
  • allergic
  • Antihistamines that target the histamine H1-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing) as well as for insomnia. (wikipedia.org)
  • Brain
  • A histaminergic agent (or drug) is a chemical which functions to directly modulate the histamine system in the body or brain. (wikipedia.org)
  • Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. (wikipedia.org)
  • occurrence
  • Histamine is essential for occurrence, development and deterioration of schizophrenia that has become a focus in the treatment of mental disorder diseases and antipsychotic agents are following come out as medical development. (alliedacademies.org)
  • Agents
  • Several cases of torsade de pointes recently have been reported in patients administered the nonsedating histamine H 1 -receptor antagonists astemizole 6 7 8 9 10 and terfenadine, 11 prompting warnings for potentially serious adverse cardiovascular events with these agents. (ahajournals.org)
  • release
  • It has fewer hypotensive effects than morphine and is safer in patients with hyperactive airway disease because of minimal or no associated histamine release. (medscape.com)
  • body
  • Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. (wikipedia.org)
  • actions
  • Abstract We compared the cardiac electrophysiological actions of two types of H 1 -receptor antagonists-the piperidines, astemizole and terfenadine, and the nonpiperidines, chlorpheniramine and pyrilamine-in vitro in guinea pig ventricular myocytes and in vivo in chloralose-anesthetized dogs. (ahajournals.org)
  • studies
  • Data from phase 1 studies with two H 4 R antagonists, UR-63325 and PF-3893787 [( R )- N 4-(cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine], have been reported at scientific meetings and are summarized in a review by Salcedo et al. (aspetjournals.org)
  • Effects
  • 13 14 15 16 Therefore, we designed this study to assess the effects of the piperidine-containing H 1 -receptor antagonists astemizole and terfenadine on APD and various ionic currents in guinea pig isolated ventricular myocytes. (ahajournals.org)
  • The effects were compared with those of two standard, non-piperidine-containing H 1 -receptor antagonists, chlorpheniramine and pyrilamine. (ahajournals.org)
  • available
  • As the result of a consensus meeting in Munich in December 1988, a panel of eminent specialists arrived at common recommendations as to the usefulness of the available histamine assays for the most common experimental biomedical conditions. (springer.com)
  • addition
  • In addition, dose-dependent inhibition of histamine-induced eosinophil shape change was detected, suggesting that the H 4 R was inhibited in vivo. (aspetjournals.org)