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  • Donepezil
  • To that aim, 14 month old C57/Bl6 mice were administered per oesophagy during nine consecutive days with Donepezil (at 0.1 and 0.3 mg/kg) and S 38093 (at 0.1, 0.3, and 1.0 mg/kg), a H3 histaminergic antagonist developed by Servier, alone or in combination and tested for memory in a contextual memory task that modelized the age-induced memory dysfunction. (frontiersin.org)
  • allergic
  • Histamine produces increased vascular permeability, causing fluid to escape from capillaries into tissues, which leads to the classic symptoms of an allergic reaction - a runny nose and watery eyes. (wikipedia.org)
  • pharmacological
  • Results demonstrate that the selective antagonist of H 4 R, JNJ, systemically and chronically administered after ischemia, reduces the ischemic brain damage, improves the neurological deficit and decreases blood pro-inflammatory cytokines, suggesting that H 4 R is a valuable pharmacological target after focal brain ischemia. (frontiersin.org)
  • Brain
  • Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. (wikipedia.org)
  • deficits
  • In addition to deficits in ACh, histamine neurotransmission is also reportedly diminished in elderly or in AD ( Fernández-Novoa and Cacabelos, 2001 ). (frontiersin.org)
  • release
  • It has fewer hypotensive effects than morphine and is safer in patients with hyperactive airway disease because of minimal or no associated histamine release. (medscape.com)
  • Dopamine antagonist that stimulates acetylcholine release in the myenteric plexus. (medscape.com)
  • increase
  • Histamine 2 (H2)-receptor antagonists should be administered preoperatively to prevent increase in gastric secretion during the procedure. (medscape.com)
  • Extracellular levels of histamine increase in the ischemic area after focal cerebral ischemia induced by occlusion of the middle cerebral artery (MCAo). (frontiersin.org)
  • Malmlöf K, Golozoubova V, Peschke B, Wulff BS, Refsgaard HH, Johansen PB, Cremers T, Rimvall K. Increase of neuronal histamine in obese rats is associated with decreases in body weight and plasma triglycerides. (wikipedia.org)
  • effects
  • 13 14 15 16 Therefore, we designed this study to assess the effects of the piperidine-containing H 1 -receptor antagonists astemizole and terfenadine on APD and various ionic currents in guinea pig isolated ventricular myocytes. (ahajournals.org)
  • The effects were compared with those of two standard, non-piperidine-containing H 1 -receptor antagonists, chlorpheniramine and pyrilamine. (ahajournals.org)
  • Agents
  • Several cases of torsade de pointes recently have been reported in patients administered the nonsedating histamine H 1 -receptor antagonists astemizole 6 7 8 9 10 and terfenadine, 11 prompting warnings for potentially serious adverse cardiovascular events with these agents. (ahajournals.org)
  • actions
  • Abstract We compared the cardiac electrophysiological actions of two types of H 1 -receptor antagonists-the piperidines, astemizole and terfenadine, and the nonpiperidines, chlorpheniramine and pyrilamine-in vitro in guinea pig ventricular myocytes and in vivo in chloralose-anesthetized dogs. (ahajournals.org)
  • studies
  • Data from phase 1 studies with two H 4 R antagonists, UR-63325 and PF-3893787 [( R )- N 4-(cyclopropylmethyl)-6-(3-(methylamino)pyrrolidin-1-yl)pyrimidine-2,4-diamine], have been reported at scientific meetings and are summarized in a review by Salcedo et al. (aspetjournals.org)