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  • fructose
  • TIGAR acts as a direct regulator of fructose-2,6-bisphosphate levels and hexokinase 2 activity, and this can lead indirectly to many changes within the cell in a chain of biochemical events. (wikipedia.org)
  • TIGAR is a fructose bisphosphatase which activates p53, in results of inhibiting the expression of glucose transporter and also regulating the expression of hexokinase and phosphoglycerate mutase. (wikipedia.org)
  • metabolism
  • Hexokinase IV is present in the liver, pancreas, hypothalamus, small intestine, and perhaps certain other neuroendocrine cells, and plays an important regulatory role in carbohydrate metabolism. (wikipedia.org)
  • hexoses
  • The intracellular reactions mediated by hexokinases can be typified as: Hexose-CH2OH + MgATP2− → Hexose-CH2O-PO2− 3 + MgADP− + H+ where hexose-CH2OH represents any of several hexoses (like glucose) that contain an accessible -CH2OH moiety. (wikipedia.org)
  • Species
  • Genes that encode hexokinase have been discovered in every domain of life, and exist among a variety of species that range from bacteria, yeast, and plants to humans and other vertebrates. (wikipedia.org)