Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an alternative splicing factor that is mainly nuclear, although it shuttles rapidly between nuclear and cytoplasmic compartments. (pasteur.fr)
Our findings suggest that the phosphorylation of F-peptide by cell-signaling pathways regulates the rate of hnRNP A1 nuclear import. (pasteur.fr)
The protein produced from this gene, called heterogenous nuclear ribonucleoprotein K (hnRNP K), attaches (binds) to DNA or its chemical cousin RNA and to other proteins, acting as a docking station for these molecules so they can interact. (medlineplus.gov)
Heterogeneous nuclear ribonucleoprotein G (hnRNP G) demonstrates tumor suppressive effect against oral squamous cell carcinoma cells. (uclahealth.org)
Sequence analysis of five tryptic peptides revealed that their sequences matched corresponding sequences of the A2 protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. (jci.org)
Use Anti-hnRNP L Antibody, clone 4D11 (Mouse Monoclonal Antibody) validated in western blot, immunoprecipitation to detect hnRNP L also known as heterogeneous nuclear ribonucleoprotein L. (fishersci.com)
La proteína hnRNP tiene una fuerte afinidad por el ARN rico en polipirimidina y por el ADN de hebra única rico en polipirimidina. (bvsalud.org)
Existen múltiples isoformas de la proteína K hnRNP debido a ayuste alternativo y muestran características diferentes en la unión al ácido nucleico. (bvsalud.org)
[ 2 , 4 ] Protein sequencing of highly purified RA33 revealed that it is indistinguishable from heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2B1). (medscape.com)
Protein7
Heterogeneous nuclear ribonucleoprotein A3 is a protein that in humans is encoded by the HNRNPA3 gene. (wikipedia.org)
The approach was tested on polypyrimidine tract binding protein 1 and U1 small nuclear RNP. (nih.gov)
RRMs are found in a variety of RNA binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). (embl.de)
Unreported homologies in the RRM-enriched database to the metazoan SR family of splicing factors are described for an Arg-rich human nuclear protein and two yeast proteins (S. pombe mei2 and S. cerevisiae Npl3). (embl.de)
Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. (jci.org)
TDP-43 is a highly conserved, ubiquitously expressed, multifunctional nucleic acid-binding protein composed of two RNA recognition motifs (RRM), nuclear localization (NLS) and export signals (NES), and a carboxy-terminal glycine rich region. (nature.com)
Human Heat shock protein 40 (Hsp40/DnaJB1) promotes influenza A virus replication by assisting nuclear import of viral ribonucleoproteins. (cdc.gov)
HnRNPs3
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). (nih.gov)
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). (nih.gov)
We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. (lu.se)
Similar to heterogeneous2
PREDICTED: similar to heterogeneous nuclear ribonucleoprotein methy. (yeastrc.org)
Similar to Heterogeneous nuclear ribonucleoprotein K isoform a. (h-invitational.jp)
Proteins2
These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
Percipalle P*, Vartiainen, MK (2019) 'Cytoskeletal proteins in the cell nucleus: a special nuclear actin perspective. (nyu.edu)
Antigen3
One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family. (genetex.com)
To characterize RA33, the antigen was purified from HeLa cell nuclear extracts to more than 90% homogeneity by affinity chromatography on heparin-Sepharose and by chromatofocusing. (jci.org)
Mixed connective tissue disease is an uncommon, specifically defined syndrome characterized by clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. (msdmanuals.com)
HNRNPA11
Heterogeneous Ribonucleoprotein A1 (hnRNPA1) Interacts with the Nucleoprotein of the Influenza a Virus and Impedes Virus Replication. (cdc.gov)
Cytoplasm1
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. (bvsalud.org)
Localization1
Its M9 domain acts as both a nuclear localization and nuclear export signal. (antibodies-online.com)
Interacts1
Percipalle P, Fomproix N, Cavellan E, Voit R, Reimer G, Krüger T, Thyberg J, Scheer U, Grummt I, Östlund Farrants A-K (2006) 'The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1and serves a role in RNA polymerase I transcription. (nyu.edu)
Molecular2
RA33 is a nuclear autoantigen with an apparent molecular mass of 33 kD. (jci.org)
RA33 is a nuclear autoantigen with a molecular weight of approximately 33 kDa. (medscape.com)
Magnetic Resonance2
To further characterize this first example of an m(6)A-switch in a cellular RNA, we used nuclear magnetic resonance and Förster resonance energy transfer to demonstrate the effect of m(6)A on a 32-nucleotide RNA hairpin derived from the m(6)A-switch in MALAT1. (nih.gov)
The observed imino proton nuclear magnetic resonance resonances and Förster resonance energy transfer efficiencies suggest that m(6)A selectively destabilizes the portion of the hairpin stem where the U5-tract is located, increasing the solvent accessibility of the neighboring bases while maintaining the overall hairpin structure. (nih.gov)
Recognition1
Indeed, an m(6)A site in the lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was recently shown to induce a local change in structure that increases the accessibility of a U5-tract for recognition and binding by heterogeneous nuclear ribonucleoprotein C (HNRNPC). (nih.gov)
Polymerase1
Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation. (nyu.edu)
Cellular1
Ribonucleoproteins (RNPs) are key regulators of cellular function. (nih.gov)
Kinase1
Sarshad AA, Corcoran M, Al-Muzzaini B, Borgonovo-Brandter L, Von Euler A, Lamont D, Visa N, Percipalle P*. (2014) 'Glycogen synthase kinase (GSK) 3 β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells. (nyu.edu)
Chromatin1
Sarshad A, Sadeghifar F, Louvet E, Mori R, Böhm S, Vintermist A, Fomproix N, Östlund A-K, Percipalle P* (2013) 'Nuclear myosin 1 facilitates chromatin modifications required to activate rRNA gene transcription and cell cycle progression. (nyu.edu)
Functions1
Visa N, Percipalle P. (2010) 'Nuclear functions of actin. (nyu.edu)
Activity1
p53 promotes the fidelity of DNA end-joining activity by, in part, enhancing the expression of heterogeneous nuclear ribonucleoprotein G. DNA Repair. (uclahealth.org)
MRNA2
N6-methyladenosine (m6A) was first discovered in eukaryotic messenger RNA (mRNA) [ 2 , 3 ] and viral nuclear RNA [ 4 , 5 ] in the 1970s and has been identified as one of the most common and abundant RNA modifications. (biomedcentral.com)
A subset of heterogeneous-nuclear ribonucleoproteins are involved in additional functions such as nucleocytoplasmic transport (ACTIVE TRANSPORT, CELL NUCLEUS) of RNA and mRNA stability in the CYTOPLASM . (bvsalud.org)
HnRNPC1
Additionally, we have identified a novel association between Plk1 and p53 through heterogeneous ribonucleoprotein C1/C2 (hnRNPC), thus providing valuable insight into Plk1's role in cancer cell survival. (nih.gov)
Nascent1
A heterogeneous-nuclear ribonucleoprotein found associated with most nascent transcripts, most notably those of the landmark giant loops of amphibian lampbrush chromosomes. (nih.gov)
HNRNPK1
Recently, hnRNPK has been shown to interact with SINE-derived nuclear RNA localization (SIRLOIN)-containing RNAs, and orchestrate nuclear enrichment and cellular functions of long noncoding RNAs (lncRNAs). (nih.gov)
Complex1
As part of the CARMA1-BCL10-MALT1 (CBM) signalling complex, MALT1 channels upstream TCR signalling to the canonical IκB kinase (IKK)/nuclear factor-κB (NF-κB) signalling pathway. (nature.com)
Belongs1
Nucleophosmin (NPM), also known as B23, 1 NO38, and numatrin, is an abundant, highly conserved, ubiquitously expressed nucleolar phosphoprotein which belongs to the nucleoplasmin/nucleophosmin family of nuclear chaperones. (haematologica.org)
Family1
Even family members with a single genetic mutation are phenotypically heterogeneous. (medscape.com)
Export1
Cyclophilin A is required for CXCR4-mediated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration. (meharryresearch.org)
Structure1
A previous study from our laboratory showed specific alterations of nuclear structure in colon cancer. (nih.gov)