InfectionKSHVVirusesInfectionsHepatitis C virLatentInfectKaposi'sCytomegalovirusDiseaseHijacksSalivaLyticGenomeMember of the herpesPathogensImmunityVirusAsymptomaticImmunologyReactivationGenomicNeuronsInfectious MononucleosisBiologyReceptorImmuneClosely2018GuidelinesProteinCellsEncephalitisLaboratoryAntigen
Infection21
- HHV-4, also known as Epstein-Barr virus (EBV), causes the primary infection infectious mononucleosis , and it is implicated in various diseases, such as African Burkitt lymphoma , other immunoproliferative disorders, and nasopharyngeal carcinoma. (medscape.com)
- Upon infection many viruses, including Herpesviruses, target T cell function via specific interactions with TCR and HLA-I molecules. (frontiersin.org)
- Seventeen additional cases of B virus infection in humans were described through 1973 (2)* and four cases, including the first known case of person-to-person transmission of the virus, occurred in Pensacola, Florida, in 1987 (5). (cdc.gov)
- This extreme degree of morbidity and mortality has given the impression that B virus infection in humans nearly always results in severe or fatal disease. (cdc.gov)
- The purpose of the working group was to supplement existing methods with specific guidelines intended to minimize transmission of B virus infection from macaque monkeys to humans. (cdc.gov)
- As with herpes simplex virus I infection in humans, primary infection with B virus in macaques may result in gingivostomatitis with characteristic buccal mucosal lesions, but it probably occurs frequently without such signs. (cdc.gov)
- Except for one instance of person-to-person transmission, however, all cases of B virus infection in humans have occurred in persons exposed to monkeys or monkey tissues. (cdc.gov)
- Identifying human herpesvirus 8 infection: performance characteristics of serological assays. (cdc.gov)
- Latent class analysis of human herpesvirus 8 assay performance and infection prevalence in sub-Saharan Africa and Malta. (cdc.gov)
- 14.9% (95% CI: 12.4-17.4%) for human herpes virus 8 infection. (nature.com)
- Atypical patterns of human cytomegalovirus infection and spread in U373 glioblastoma cells. (uc.edu)
- After initial infection, all herpesviruses remain latent within specific host cells and may subsequently. (merckmanuals.com)
- A perfect example of this would be chickenpox, caused by the human herpesvirus 3 - after infection, "the body responds and the virus goes into latency. (thehindu.com)
- Dr. Jung leads the Department of Cancer Biology, the Infection Biology Program, and the newly-established Global Center for Pathogen & Human Health Research, which is focused on understanding of viral pathogens and the human immune responses toward preparing and protecting future public health threats. (ccf.org)
- Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). (medscape.com)
- Previous results indicate that the HHV-8 viral transactivator ORF50 interacts synergistically with Tat protein in the transactivation of human immunodeficiency virus (HIV) long terminal repeat (LTR), leading to increased cell susceptibility to HIV infection. (ashpublications.org)
- Human herpesvirus 8 (HHV-8) infection is associated with the development of primary effusion lymphoma, Kaposi's sarcoma, and multicentric Castleman's disease. (biomedcentral.com)
- We recently described that the herpes simplex virus type 1 (HSV-1), a neurotropic virus inducing chronic infection and neuron latency, and rabies virus (RABV), a neuronotropic virus triggering acute neuron infection, up-regulate HLA-G expression in human neurons (NT2-N). Surface expression was only detected after RABV infection. (pasteur.fr)
- Congenital infection with human herpesvirus 6 variante B associated with neonatal seizures and for neurological outcome. (bvsalud.org)
- Infection with human papillomavirus increases the probability of developing carcinoma of the cervix, which is the second leading cause of cancer- related mortality in females worldwide, killing some 240 000 women per year.1 Making a correct diagnosis of a sexually transmitted infection is essential for the provision of appropriate and effective treatment. (who.int)
- Infection is very common in birds destined for human consumption. (cdc.gov)
KSHV7
- In order to better treat this disease, it is essential to understand the functioning of Kaposi's sarcoma-associated herpesvirus (KSHV), which causes it. (pasteur.fr)
- Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma-associated herpesvirus (KSHV), is a γ-2 herpesvirus originally identified in Kaposi sarcoma (KS) lesions. (ashpublications.org)
- and by analogy to other saliva borne herpesviruses, KSHV in saliva is a likely source for transmission. (prn.org)
- In the setting of HIV disease, Epstein-Barr Virus (EBV) and Kaposi's Sarcoma-associated Herpesvirus (KSHV/HHV-8) may transform B cells into lymphomas. (prn.org)
- The seroprevalence of human herpesvirus-8 (HHV-8)-also known as Kaposi sarcoma-associated herpesvirus (KSHV)-varies worldwide and is estimated to be 1% to 5% in the general U.S. population 1,2 compared with 10% to 20% in certain Mediterranean countries and 30% to 80% in parts of sub-Saharan Africa. (hiv.gov)
- Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma (KS)-associated herpesvirus (KSHV), is a gamma human herpesvirus most closely related to Epstein-Barr virus. (hiv.gov)
- Kaposi's sarcoma-associated herpesvirus (KSHV), which was originally detected in Kaposi's sarcoma, also has been found in primary effusion lymphomas (PELs) and some cases of multi-centric Castleman's disease. (tau.ac.il)
Viruses19
- Herpesvirus family members are icosahedral DNA viruses. (medscape.com)
- These closely related viruses are two of the nine known herpesviruses that have humans as their primary host. (wikipedia.org)
- This genus consisted of 23 viruses among 4 groups. (wikipedia.org)
- Order Herpesvirales contains three families, the Herpesviridae, which contains the long-recognized herpesviruses of mammals, birds, and reptiles, plus two new families - the family Alloherpesviridae which incorporates herpes viruses of bony fish and frogs, and the family Malacoherpesviridae which contains viruses of molluscs. (wikipedia.org)
- During maturation of HHV-6 virions, human cell membranes are used to form viral lipid envelopes (as is characteristic of all enveloped viruses). (wikipedia.org)
- Herpesvirus simiae (B virus) is a member of the herpes group of viruses that is enzootic in rhesus (Macaca mulatta), cynomolgus (M. fascicularis) and other Asiatic monkeys of the genus Macaca. (cdc.gov)
- It is one of the most common human viruses. (cdc.gov)
- Examples are Herpes simplex viruses type 1 and 2, varicella-zoster virus, HIV, Epstein-Barr virus (human herpesvirus 4), and cytomegalovirus. (thehindu.com)
- Human Herpesvirus Six (HHV-6) is one of the eight known viruses that are members of the human herpesvirus family. (wikidoc.org)
- Herpesviruses are enveloped viruses that are prevalent in the human population and are responsible for diverse pathologies, including cold sores, birth defects and cancers. (rcsb.org)
- Thus, neurotropic viruses that escape the host immune response totally (RABV) or partially (HSV-1) regulate HLA-G expression on human neuronal cells differentially. (pasteur.fr)
- HSV is part of a group of 8 viruses in the Herpes virus family that can cause human disease. (adam.com)
- The human herpes viruses (HHV) take part of a virus family - Herpesviridae- and these viruses have human as only host. (bvsalud.org)
- This paper is a review about the human herpes viruses types, their treatments and emphasizes their oral manifestations. (bvsalud.org)
- These include the retroviruses avian leucosis/sarcoma viruses (ALSV) and reticuloendothesiosis viruses (REV), and the herpesvirus Marek's disease virus (MDV). (cdc.gov)
- These viruses have been shown to be capable of infecting human cells in vitro, and causing them to become cancerous. (cdc.gov)
- Human exposure to these viruses occur occupationally (workers in poultry slaughtering/processing plants and poultry farms, egg candlers, veterinarians, cooks, laboratory workers, etc. (cdc.gov)
- However, in spite of the scientific evidence accumulated thus far, definitive proof that can confirm beyond any doubt that these viruses cause cancer in humans is currently lacking. (cdc.gov)
- Two critical pieces of evidence are needed to incriminate these viruses as causing cancer in humans: 1) laboratory demonstration of ALSV integrated within the human genome, and 2) epidemiologic evidence of excess cancer occurrence in human exposed to these viruses. (cdc.gov)
Infections13
- Members of the human herpesvirus (HHV) and human papillomavirus (HPV) families cause the most common primary viral infections of the oral cavity. (medscape.com)
- Nonetheless, many other viral infections can affect the oral cavity in humans, either as localized or systemic infections. (medscape.com)
- Herpesviruses establish latent permanent infections in their hosts, although clinical signs of disease may not be detected. (medscape.com)
- Their fundamental role in anti-viral responses has been unveiled in patients with NK cell deficiencies suffering from severe Herpesvirus infections. (frontiersin.org)
- This lifelong challenge has contributed to the development of numerous evasion mechanisms by Herpesviruses, many of which devoted to elude NK cell surveillance from viral reactivations rather than primary infections. (frontiersin.org)
- There is growing evidence that host cells try to control Herpesvirus infections by activating the autophagic machinery. (mdpi.com)
- Famciclovir is a human antiviral agent used in the treatment of Feline Herpes (FHV-1) infections. (medi-vet.com)
- We conducted a meta-analysis among PLWHA in China to describe the prevalence of major cancer risk factors including tobacco smoking, alcohol consumption, overweight and obesity, and cancer-related viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV), Epstein-Barr virus (EBV) and human herpes virus 8 (HHV8). (nature.com)
- Overview of Herpesvirus Infections Eight types of herpesviruses infect humans ( see Table: Herpesviruses That Infect Humans). (merckmanuals.com)
- They are known to cause typical latent infections in humans, Sheleg and Vasilevsky add. (thehindu.com)
- Panel on Sexually Transmitted Infections including those due to Human Immunodeficiency Virus, was posted on the WHO web site in February 2006 for a discussion and submission of comments by Member States. (who.int)
- infections that proceed acute encephalopathy nationally after influenza virus and human herpesvirus-6. (who.int)
- 1997 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immuno- deficiency virus. (cdc.gov)
Hepatitis C vir1
- Recently, the association between Behçet nization after history taking and clinical ex- disease and hepatitis C virus (HCV) [ 4-6 ] amination. (who.int)
Latent1
- Antibody reactivity to latent and lytic antigens to human herpesvirus-8 in longitudinally followed homosexual men. (cdc.gov)
Infect3
- HHV-6A and HHV-6B infect almost all of the human populations that have been tested. (wikipedia.org)
- A study in which the Structural Virology team at the Institut Pasteur participated investigates the way this herpesvirus manages to infect human cells. (pasteur.fr)
- Infect Agents Cancer 4 (Suppl 2), P36 (2009). (biomedcentral.com)
Kaposi's3
- How does the Kaposi's sarcoma herpesvirus enter the cell? (pasteur.fr)
- The Kaposi's sarcoma herpesvirus causes skin cancers, especially in immunocompromised people. (pasteur.fr)
- Aspects of the vasculopathy in some of the rhinoceroses resembled proliferative vascular lesions in immunosuppressed humans associated with several Bartonella species (the cause of bacillary angiomatosis) 1 , and human herpesvirus 8 (implicated in Kaposi's lesions) 2 . (vin.com)
Cytomegalovirus3
- Rescue of Pentamer-Null Strains of Human Cytomegalovirus in Epithelial Cells by Use of Histone Deacetylase Inhibitors Reveals an Additional Postentry Function for the Pentamer Complex. (uc.edu)
- Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
- Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium. (uc.edu)
Disease7
- The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
- The virus can live dormant in humans for a lifetime, and most infected people do not know they are disease carriers. (sciencedaily.com)
- At 19 to 27 months after infusion, 4 patients treated in remission from locally advanced disease remain disease free. (nih.gov)
- Before planning construction for the new BSL-4 facility, Patterson and her team made many trips to labs at the Centers for Disease Control and Prevention, or CDC. (asbmb.org)
- Behçet disease and HCV [ 12 ], other studies saemia and HBV vaccination as well as hae- dispute it [ 4-6 ]. (who.int)
- Periodontal disease and detection of human herpesviruses in saliva and gingival crevicular fluid of chronic kidney disease patients. (bvs.br)
- The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
Hijacks2
- Scientists have identified a component of the herpesvirus that "hijacks" machinery inside human cells, allowing the virus to rapidly and successfully invade the nervous system upon initial exposure. (sciencedaily.com)
- Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. (ccf.org)
Saliva1
Lytic1
- [ 5 ] The "oncoweed" hypothesis states that biologic plants in the environment account for the lytic reactivation of human herpesvirus 8. (medscape.com)
Genome4
- This cross-sectional study evaluated the presence of the Human Herpes Virus-8 genome in 138 formalin-fixed and paraffin-embedded (FFPE) breast cancer tissues, using real-time PCR. (org.ir)
- A key process in the herpesvirus life cycle involves the recruitment of an ATP-driven terminase to a unique portal vertex to recognize, package and cleave concatemeric dsDNA, ultimately giving rise to a pressurized, genome-containing virion 4,5 . (rcsb.org)
- Although this process has been studied in dsDNA phages 6-9 -with which herpesviruses bear some similarities-a lack of high-resolution in situ structures of genome-packaging machinery has prevented the elucidation of how these multi-step reactions, which require close coordination among multiple actors, occur in an integrated environment. (rcsb.org)
- This work showcases how to resolve symmetry-mismatched elements in a large eukaryotic virus and provides insights into the mechanisms of herpesvirus genome packaging. (rcsb.org)
Member of the herpes1
- Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the herpes virus family. (cdc.gov)
Pathogens2
- However, it is well-known that Herpesviruses are smart pathogens and several, such as HSV-1, HCMV and HHV-8, are known to have developed numerous defense strategies for evading the host's immune response. (mdpi.com)
- BSL-4 labs also use biosafety cabinets and multiple redundant safety measures to protect both the users and the outside environment from the pathogens within. (asbmb.org)
Immunity1
- 3) therapeutic/vaccine development and stabilization, and (4) inflammation and immunity (host-pathogen standoff, programmed cell death, immune atlas of pregnancy and inflammation). (ccf.org)
Virus12
- Electron microscopy revealed a novel virus that they named Human B-Lymphotrophic Virus (HBLV). (wikipedia.org)
- However, the constant stimulus provided by virus-host interplay has also favored NK-cell adaptation to Herpesviruses. (frontiersin.org)
- This page lists the EVAg products having been related to the "Human herpesvirus 4" virus name. (european-virus-archive.com)
- The report of a case of encephalitis caused by B virus in a monkey handler in 1932 indicated that B virus can be highly pathogenic for humans (1). (cdc.gov)
- Researchers link the Human Herpes Virus 6A to the development of multiple sclerosis. (neurosciencenews.com)
- A recent study offers new modellings of one of the virus' a surface proteins, and its receptor, on human cells. (pasteur.fr)
- The article shows how the virus interacts with a receptor on human cells, the EphA2 receptor, via a surface protein complex made of glycoproteins H and L (gH/gL). (pasteur.fr)
- The breakthrough came in 1994, when the Kaposi sarcoma-associated herpes virus (human herpesvirus type 8 [HHV-8]) was identified using representational difference analysis. (medscape.com)
- Infectious mononucleosis is caused by Epstein-Barr virus (EBV, human herpesvirus type 4) and is characterized by fatigue, fever, pharyngitis, and lymphadenopathy. (merckmanuals.com)
- Early in her career, Patterson worked at Boston's Children's Hospital affiliated with Harvard Medical School , where she studied respiratory syncytial virus , or RSV, and later witnessed the outbreak of human immunodeficiency virus , or HIV. (asbmb.org)
- Culture de myotubes murins infectés par le virus de la rage fixe, observée en immunoflorescence indirecte. (pasteur.fr)
- Humanized mice have been used to study human immunodeficiency virus type 1 (HIV-1) transmission, pathogenesis, and treatment. (bvsalud.org)
Asymptomatic1
- Is there an indication for serologic testing for human herpesvirus 8 (HHV-8) in asymptomatic HIV-infected children (compared with not testing) to guide clinical management? (hiv.gov)
Immunology1
- Led by Gregory Smith, associate professor in immunology and microbiology at Northwestern University Feinberg School of Medicine, researchers found that viral protein 1-2, or VP1/2, allows the herpesvirus to interact with cellular motors, known as dynein. (sciencedaily.com)
Reactivation1
- Herpesviruses however, generate a complicated balance with the host immune system through their latency cycle moving between immune control and viral reactivation. (frontiersin.org)
Genomic2
- The major mechanisms of recognition and effector responses employed by NK cells against Herpesviruses, related to their genomic organization will be addressed, including those allowing NK cells to generate memory-like responses. (frontiersin.org)
- Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6. (cdc.gov)
Neurons1
- Until now, scientists knew that herpesviruses travel quickly to reach neurons located deep inside the body, but the mechanism by which they advance remained a mystery. (sciencedaily.com)
Infectious Mononucleosis1
- The HHV-4 is directly linked to Infectious Mononucleosis, Burkitt Lymphoma and Nasopharyngeal Carcinoma. (bvsalud.org)
Biology1
- The outbreak was unprecedented in scale, providing an opportunity for an in-depth analysis of infected humans and observations of previously unknown aspects of EBOV biology. (asm.org)
Receptor2
- El receptor 2 del complemento humano (CR2) sirve como receptor tanto para el C3dg como para la glicoproteína gp350/220 del HERPESVIRUS 4 HUMANO, y se une al anticuerpo monoclonal OKB7, el que bloquea la unión de ambos ligandos al receptor. (bvsalud.org)
- Human complement receptor 2 (CR2) serves as a receptor for both C3dg and the gp350/220 glycoprotein of HERPESVIRUS 4, HUMAN, and binds the monoclonal antibody OKB7, which blocks binding of both ligands to the receptor. (bvsalud.org)
Immune2
- There is also some concern that loss of immune control of both herpesviruses might further increase the risk of these malignancies in AIDS. (prn.org)
- The ability of pediatric thymus tissue implanted either in the leg (Leg PedThy) or under the renal capsule (Renal PedThy) with allogeneic CD34+ hematopoietic cells (HSCs) in NSG mice was evaluated for reconstitution of human immune cells and for rectal transmission of HIV-1. (bvsalud.org)
Closely1
- HHV-8 has been linked closely with all 4 types of Kaposi sarcoma, ie, classic (traditional), endemic (African), epidemic (AIDS related), and iatrogenic (related to immunosuppression). (medscape.com)
20181
- 6th Workshop on Biostatistics and Bioinformatics (workshop) Georgia State University, May 4-6, 2018. (cdc.gov)
Guidelines1
- In formulating these guidelines, the working group recognizes that other methods of caring for nonhuman primates and preventing transmission of pathogenic agents from animal to human and from human to animal have been described (6,7). (cdc.gov)
Protein1
- Yet the herpesvirus uses one protein, no others required, to transport its genetic information over long distances without stopping. (sciencedaily.com)
Cells3
- The team studied the herpesvirus in animals, and also in human and animal cells in culture under high-resolution microscopy. (sciencedaily.com)
- Even now, laboratories are working on how to use herpesviruses to deliver genes into the nervous system and kill cancer cells. (sciencedaily.com)
- Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers. (uc.edu)
Encephalitis1
- RV1 is administered at 2 and 4 months and encephalitis/encephalopathy. (who.int)
Laboratory2
- Jean Patterson is an emeritus professor at the Texas Biomedical Research Institute , or Texas Biomed she was the initial director and for a time, chair, of the institute's biosafety laboratory level 4 , or BSL-4, Task Force. (asbmb.org)
- Jean Patterson stands next to positive pressure suits in the BSL-4 laboratory at Texas Biomed. (asbmb.org)
Antigen1
- Human Leukocyte Antigen (HLA)-G and E are nonclassical human MHC class I molecules. (pasteur.fr)