• toxicity
  • Paine A (1990).The maintenance of cytochrome P$%) in rat hepatocyte cultures: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P450 system.Chem-biol Interact. (springer.com)
  • Skett P. (1994) Problems in using isolated and cultured hepatocytes for xenobiotic metabolism-based toxicity testing - solutions? (springer.com)
  • In addition, these freshly differentiated hepatocytes are functionally stable for a longer timeframe compared to cryopreserved primary hepatocytes, enabling prolonged experiments such as long-term toxicity assays or viral infection studies. (clontech.com)
  • He is a pioneer in the isolation, cryopreservation, and culturing of human hepatocytes and their application in the evaluation of drug metabolism, drug-drug interactions, and drug toxicity. (wikipedia.org)
  • Metabolism
  • Rooda S.J.E., van Loon M.A.C., Visser T.J. (1986) Metabolism of rT 3 by Isolated Rat Hepatocytes. (springer.com)
  • In order to establish the relative contributions of the various pathways leading to activated and detoxicated products, we examined AN metabolism in isolated Fischer 344 rat hepatocytes as a model. (aacrjournals.org)
  • Hepatocytes have the ability to metabolize, detoxify, and inactivate exogenous compounds such as drugs, (drug metabolism), and insecticides, and endogenous compounds such as steroids. (wikipedia.org)
  • In addition, pharmaceutical industry has heavily relied on the use of hepatocytes in suspension or culture to explore mechanisms of drug metabolism and even predict in vivo drug metabolism. (wikipedia.org)
  • isolation
  • Get Alerts and Information When New Hepatocyte Isolation or Lots Are aAvailable. (corning.com)
  • HepatoLink® is the Corning immediate response system providing researchers with instant notification when new hepatocyte isolation events occur. (corning.com)
  • viability
  • To maximize post-thaw viability and recovery of Corning cyropreserved hepatocytes, a cryohepatocyte recovery kit was developed (Cat. (corning.com)
  • Albumin
  • The hepatocyte is a cell in the body that manufactures serum albumin, fibrinogen, and the prothrombin group of clotting factors (except for Factors 3 and 4). (wikipedia.org)
  • protein
  • 2-Cyanoethylene oxide accumulated in the hepatocyte incubations but did not appear to contribute extensively to alkylation of GSH or protein. (aacrjournals.org)
  • The ability of nonprotein thiols to modulate rates of protein synthesis was investigated in isolated rat hepatocytes. (springer.com)
  • Hepatocyte growth factor has been shown to interact with the protein product of the c-Met oncogene, identified as the HGF receptor (HGFR). (wikipedia.org)
  • Both overexpression of the Met/HGFR receptor protein and autocrine activation of Met/HGFR by simultaneous expression of the hepatocyte growth factor ligand have been implicated in oncogenesis. (wikipedia.org)
  • exhibit
  • However, current hepatocyte differentiation protocols exhibit varying differentiation efficiencies across diverse iPS cell lines derived from multiple donor sources (2). (clontech.com)