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  • Hepatic
  • Hepatocytes are arranged around a central vein in units called lobules , in close association with branches of the hepatic portal vein, hepatic artery, and bile canaliculi. (encyclopedia.com)
  • This renewable hepatic cell model is the best alternative to primary human hepatocytes for ADME/Tox studies. (corning.com)
  • Our study provides a comprehensive picture of the gene expression landscape in hepatocytes grown on different substrate stiffness, offering insights into the role of substrate stiffness in hepatic pathology. (springer.com)
  • Das N et al (2017) Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice. (springer.com)
  • The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. (wikipedia.org)
  • Hepatocytes constitute about 80% of the cell population of the liver, with the other 20% being occupied by Kupffer cells, hepatic stellate cells, endothelial cells and mesothelial cells, which are not exactly characteristic of the liver, but are present in the liver samples. (wikipedia.org)
  • vitro
  • High quality hepatocytes, with high viabilities, in vivo -like enzyme expression levels, and proper cell morphology, increase the ability to draw in vitro / in vivo correlations and make sound decisions regarding a compound's fate. (thermofisher.com)
  • In vitro model systems based on hepatocytes have been of great help to better understand the role of hepatocytes in (patho)physiological processes of the liver. (wikipedia.org)
  • Li and his researchers have developed numerous hepatocyte-based assays, including higher throughput assays for P450 inhibition, time-dependent inhibition, P450 induction, cytokine suppression of ADME gene expression, and in vitro hepatotoxicity. (wikipedia.org)
  • cells
  • Unlike immortalized cell lines, hepatocytes are primary cells that cannot be cultured indefinitely. (thermofisher.com)
  • This promising advance in the development of cell-based therapies to treat liver failure resulting from injury or disease relied on the development of scalable, reproducible methods to produce stem cell-derived hepatocytes in bioreactors, as described in an article in Stem Cells and Development , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. (medindia.net)
  • Smooth endoplasmic reticulum is abundant in hepatocytes, whereas most cells in the body have only small amounts. (wikipedia.org)
  • The hepatocyte plates are one cell thick in mammals and two cells thick in the chicken. (wikipedia.org)
  • The endothelial cells have no basement membrane and are separated from the hepatocytes by the space of Disse, which drains lymph into the portal tract lymphatics. (wikipedia.org)
  • Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. (wikipedia.org)
  • In the adult liver, most of the cells are binucleated, and most of the hepatocytes are tetraploid, which means that they have four times the amount of normal DNA. (wikipedia.org)
  • Liver cells (hepatocytes) have glucagon receptors. (wikipedia.org)
  • These cells to hepatocytes with Mallory bodies. (wikipedia.org)
  • growth factor
  • Hepatocyte growth factor as an enhancer of nmda currents and synaptic plasticity in the hippocampus. (springer.com)
  • Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. (springer.com)
  • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. (springer.com)
  • Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. (springer.com)
  • Ieraci A, Forni PE, Ponzetto C. Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. (springer.com)
  • Hepatocyte growth factor overexpression in the nervous system enhances learning and memory performance in mice. (springer.com)
  • Maina F, Klein R. Hepatocyte growth factor, a versatile signal for developing neurons. (springer.com)
  • Nakamura T, Nawa K, Ichihara A, Kaise N, Nishino T. Purification and subunit structure of hepatocyte growth factor from rat platelets. (springer.com)
  • Activation of hepatocyte growth factor by proteolytic conversion of a single chain form to a heterodimer. (springer.com)
  • Processing of hepatocyte growth factor to the heterodimeric form is required for biological activity. (springer.com)
  • Hepatocyte growth factor has been shown to interact with the protein product of the c-Met oncogene, identified as the HGF receptor (HGFR). (wikipedia.org)
  • Both overexpression of the Met/HGFR receptor protein and autocrine activation of Met/HGFR by simultaneous expression of the hepatocyte growth factor ligand have been implicated in oncogenesis. (wikipedia.org)
  • Hepatocyte growth factor interacts with the sulfated glycosaminoglycans heparan sulfate and dermatan sulfate. (wikipedia.org)
  • The interaction with heparan suflate allows hepatocyte growth factor to form a complex with c-Met that is able to transduce intracellular signals leading to cell division and cell migration. (wikipedia.org)
  • primary
  • All primary hepatocyte products are pre-screened and extensively characterized, which provides researchers with the data necessary to select lots which are well-suited to their research needs. (corning.com)
  • Primary hepatocytes are widely used to evaluate the toxic effects of drugs and xenobiotics. (bionity.com)
  • Primary hepatocytes are commonly used in cell biological and biopharmaceutical research. (wikipedia.org)
  • isolation
  • Get Alerts and Information When New Hepatocyte Isolation or Lots Are aAvailable. (corning.com)
  • HepatoLink® is the Corning immediate response system providing researchers with instant notification when new hepatocyte isolation events occur. (corning.com)
  • Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes. (thermofisher.com)
  • eosinophilic
  • Histologically, multifocal to coalescing areas of many hepatocytes contained large cytoplasmic vacuoles filled with pale eosinophilic homogeneous material and rare fine basophilic granules. (hindawi.com)
  • suspension
  • Massoud Vosough and coauthors demonstrate a large-scale, integrated manufacturing strategy for generating functional hepatocytes in a single suspension culture grown in a scalable stirred bioreactor. (medindia.net)
  • bile
  • hepatocyte (hip- at -oh-syt) n. the principal cell type in the liver: a large cell with many metabolic functions, including synthesis, storage, detoxification, and bile production. (encyclopedia.com)
  • sinusoids
  • Hepatocytes are organised into plates separated by vascular channels (sinusoids), an arrangement supported by a reticulin (collagen type III) network. (wikipedia.org)
  • The intercellular surfaces are the ones that are between two adjacent hepatocytes and they are not in contact with sinusoids or canaliculi. (wikipedia.org)