Hepatocyte nuclear factor 3 beta. Medical search. Frequent questions

FOXA2 belongs to a subfamily of the Forkhead box (FOX) transcription factors, the other members being FOXA1 and FOXA3. (wikipedia.org)
These transcription factors contain a forkhead domain (also known as the winged-helix domain) flanked by sequences necessary for nuclear localization Their N- and C-termini are also conserved and serve as transactivation domains. (wikipedia.org)
FOXA transcription factors have "pioneering" property, i.e. they can directly bind to condensed chromatin. (wikipedia.org)
This feature has been observed both in vitro and in vivo, where FOXA transcription factors can bind nucleosome-bound target DNA sequences. (wikipedia.org)
In this way, FOXA2 promotes local chromatin opening, permits the recruitment of alternative histones and facilitates the subsequent binding of other transcription factors. (wikipedia.org)
Dysregulation of FOXA transcription factors have been linked to several types of human cancers, including acute myeloid leukemia and cancer of the esophagus, lung, thyroid, pancreas, breast and prostate. (wikipedia.org)
We further provide evidence to support the hypothesis that transcription factors (TFs) required to drive induction, differentiation, and maintenance of midbrain dopaminergic neural progenitor cells which give rise to terminally differentiated SNpc neurons are uniquely involved in both developmental patterning and metabolism, a dual function unlike other TFs that program neurons in other brain regions. (frontiersin.org)
MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. (ox.ac.uk)
Transcription factors FOXA1 and FOXA2 (FOXA1/2) are key determinants of mDA neuronal identity during development, but their roles in adult mDA neurons are unknown. (ox.ac.uk)
The HNF-1β protein is one of a large group of transcription factors called homeodomain proteins. (medlineplus.gov)
Hepatocyte nuclear factors are a family of evolutionarily conserved transcription factors that are preferentially expressed in HEPATOCYTES. (umassmed.edu)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
Essential FA, mainly polyunsaturated fatty acids (PUFA), may modulate gene expression in diverse biological processes thought regulating transcription factors (TF), including peroxisome proliferator receptors (PPAR) , liver X receptors (LXR) , and sterol regulatory element-binding proteins ( SREBP ) 3 . (nature.com)
Transcription factors (TFs) drive gene expression programs that shape specific phenotypes [ 3 ], and are frequently dysregulated in cancer [ 4 ]. (aging-us.com)

Diabetes in subjects with hepatocyte nuclear factor (HNF)-1α gene mutations (maturity-onset diabetes of the young [MODY]-3) is characterized by impaired insulin secretion. (diabetesjournals.org)
Mutations in the hepatocyte nuclear factor (HNF)-1α gene cause the most common form of maturity-onset diabetes of the young (MODY), type 3 ( 1 ). (diabetesjournals.org)
Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
Conclusions: Since maximum number of variations exists in exon 5 of the said gene, hence one can initially go for exon5 followed by other exons, while screening for pathogenic MODY 3 mutations in the responsible gene by PCR-SSCP method. (scirp.org)
ObjectiveThe aim of this study was to document the association between pancreatic agenesis or hypoplasia and multicystic renal dysplasia related to transcription factor 2 (TCF2) or hepatocyte nuclear factor 1 beta mutations. (cyp17-signal.com)

This subfamily of mammalian FOX proteins was first identified because of their ability to bind DNA in rat liver nuclear extracts. (wikipedia.org)
The proteins were therefore originally named hepatocyte nuclear factor 3 alpha, beta and gamma. (wikipedia.org)
One of the principal differences between HTH motifs in these different proteins arises from the stereo-chemical requirement for glycine in the turn which is needed to avoid steric interference of the beta-carbon with the main chain: for cro and repressor proteins the glycine appears to be mandatory, while for many of the homeotic and other DNA-binding proteins the requirement is relaxed. (embl.de)
To circumvent the hepatic functional redundancy of the Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) promoter functioned to increase hepatocyte expression of the Foxa2 cDNA. (duke.edu)

One example is that ectopic expression of FOXA2 together with HNF4A drives transdifferentiation of fibroblasts to hepatocyte-like cells. (wikipedia.org)
During the progression of colitis, genetic alterations associated with mucosal permeability [ e.g. those in extracellular matrix protein 1 ( ECM1 ), cadherin 1 ( CDH1 ), and hepatocyte nuclear factor 4 alpha ( HNF4A )] have been observed and considered to confer the risk of severe UC ( 11 , 12 ). (iiarjournals.org)

Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays an important role during development, in mature tissues and, when dysregulated or mutated, also in cancer. (wikipedia.org)
The pioneering property is conferred by the factors' highly conserved DNA-binding domain, which is structurally similar to the linker histones H1 and H5 This feature enables FOXA2 to access closed chromatin and displace linker histones. (wikipedia.org)
Thus, FOXA2 have important roles in cell type specification by promoting chromatin accessibility for the binding of lineage- or tissue-specific factors The FOXA factors also facilitate the maintenance of cell identity by bookmarking cell type-specific genes so that these genes can be rapidly reactivated after cytokinesis. (wikipedia.org)
Consistent with its role as a pioneering transcription factor, FOXA2 is expressed in early development and essential for the development and homeostasis of various cell types and tissues. (wikipedia.org)
Conditional knockout studies show that Foxa2 is important for the formation of pancreatic islets and maturation of alpha and beta cells, thereby being essential for glucose homeostasis. (wikipedia.org)
The Forkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulate liver-specific gene expression. (duke.edu)
In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle. (duke.edu)

Although there are often found on insulin-like growth factor-1 binding protein excretion or indirectly. (lorenzopetrantoni.com)
Members of the C/EBP transcription factor family stimulate expression of the human and rat surfactant protein A (SP-A) genes. (ucsf.edu)
Transforming growth factor-beta(1) regulation of surfactant protein B gene expression is mediated by protein kinase-dependent intracellular translocation of thyroid transcription factor-1 and hepatocyte nuclear factor 3. (ucsf.edu)
The HNF1B gene provides instructions for making a protein called hepatocyte nuclear factor-1 beta (HNF-1β). (medlineplus.gov)
Based on this role, the protein is called a transcription factor. (medlineplus.gov)
The HNF-1β protein is important for development and function of the kidneys and beta cells in the pancreas. (medlineplus.gov)
The GLUT2 facilitated glucose transporter isoform is a membrane protein present in the pancreatic .beta. (justia.com)
cell lines, these transcripts are translated into immunodetectable cytoplasmic and nuclear protein. (justia.com)

SNHG1 directly interact with the histone methyltransferase enhancer of the zeste homolog 2 (EZH2) and modulate the histone methylation of promoter of Kruppel-like factor 2 (KLF2) and altered the progress osteogenic differentiation of PDLSCs. (biomedcentral.com)
Long noncoding RNA NEAT1 (nuclear-enriched abundant transcript 1) inhibited hepatocyte proliferation in fulminant hepatic failure via strengthened recruitment of EZH2 to the LATS2 (large tumor-suppressor kinase 2) promoter region [ 18 ]. (biomedcentral.com)
A fragment of the murine GLUT2 promoter has been cloned and shown to be glucose-responsive when transfected into differentiated insulin-producing cells or into hepatocytes (35,36,52). (justia.com)
Important cis-regulatory sequences were identified within this promoter region including a functionally responsive PDX-1 element, a cyclic AMP responsive element, and three cis elements termed GTI, GTII and GTIII (3,36,53). (justia.com)
This rat insulin promoter element 3 (RIPE3) is an important enhancer sequence sufficient to confer .beta. (justia.com)

A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. (reference.md)
Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
A shortage of this transcription factor disrupts the activity of genes that direct the development and function of certain tissues and organs. (medlineplus.gov)
We show that TG liver developed a substantial transient steatosis, which reached a maximum at postnatal day 5 and is associated with increased expression of hepatic genes involved in fatty acid and triglyceride synthesis, lipid beta-oxidation, and amino acid biosynthesis. (duke.edu)
Similarly, lncRNA H19 also was reported to promote osteogenic differentiation of rat ectomesenchymal stem cells through enhancing the expressions of osteogenic markers, beta-catenin, and target genes of Wnt/beta-catenin signaling pathway partly through sponging miR-22 and miR-141 [ 12 ]. (biomedcentral.com)
The present invention is based on successful expression cloning of a transcription factor that binds to the GTII element of the GLUT2 and insulin genes from a differentiated insulin-secreting cDNA library. (justia.com)

In the presence of Recombinant Mouse Klotho beta (Catalog # 2619-KB ), Recombinant Human FGF-21 (Catalog # 2539-FG ) stimulates proliferation in the BaF3 mouse pro-B cell line transfected with human FGF-RIIIc in a dose-dependent manner (orange line). (bio-techne.com)

HiPSC differentiate into cell derivatives from the 3 embryonic layers: Neuronal marker beta III tubulin (TUJ1), Smooth Muscle Actin (SMA) and Hepatocyte Nuclear Factor 3 Beta (HNF3b). (cellapplications.com)

Neonatal diabetes mellitus (NDM) and maturity-onset diabetes of the young (MODY) account for a major proportion of monogenic diabetes, while syndromic diabetes constitutes a smaller proportion [ 3 , 4 ]. (pfmjournal.org)
Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). (cdc.gov)

Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes J Immunol. (usc.edu)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)
TNF-a Induced by Hepatitis C Virus via TLR7 and TLR8 in Hepatocytes Supports Interferon Signaling via an Autocrine Mechanism PLoS Pathog. (usc.edu)
Hepatitis B virus alters the antioxidant system in transgenic mice and sensitizes hepatocytes to Fas signaling PLoS One. (usc.edu)

Our HiPSC are generated with the RNA-based Sendai virus to deliver reprogramming factors to donor skin fibroblasts. (cellapplications.com)

Krüppel-like factor 15 activates hepatitis B virus gene expression and replication Hepatology. (usc.edu)

Sustained expression of Hnf6 also results in downregulation of the β-cell-specific transcription factor MafA and a decrease in total pancreatic insulin. (diabetesjournals.org)
These observations are critical since several experimental models of diabetes have shown that GLUT2 expression is dramatically reduced specifically in the pancreatic .beta. (justia.com)
The presence of GTI, II and III are both sufficient and necessary to confer pancreatic-specific expression to a reporter gene in vitro or in vivo, using a transgenic mice approach (3,51). (justia.com)
This factor is abundantly expressed in the pancreatic islets and in the brain and has been named IB-1 for Islet-Brain 1. (justia.com)

Glibenclamide uptake into hepatocytes was dramatically decreased in vivo and in vitro. (diabetesjournals.org)
OAT1 and 3 are predominantly renal anion-exchanging antiporters responsible for the uptake of substrates from the blood into renal proximal tubular cells. (solvobiotech.com)
OAT1 and 3, in conjunction with other uptake (e.g. (solvobiotech.com)

integrin subunit beta 3 [Source:HGNC Sym. (gsea-msigdb.org)

The postnatal TG mice displayed significant reduction in serum glucose levels and in hepatocyte glycogen storage without increased serum levels of ketone bodies and free fatty acid suggesting that they are not undergoing a starvation response. (duke.edu)
The acetyl-CoA is recombined into 4-carbon ketone bodies (acetoacetate and beta-hydroxybutyrate), released, and transported to peripheral tissues for TCA processing and energy generation (11, 12). (bio-techne.com)

Human INT1 has been found to be very similar to mouse INT1, thus most revealing the highly conserved nature of this pathway across species [3]. (chemdiv.com)

Challenges faced when implementing precision medicine in diabetes are disease heterogeneity, various genetic influences, difficulties of accurate diagnosis, limitations of current treatment, and social, environmental, and psychological factors [ 6 ]. (pfmjournal.org)
Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. (degruyter.com)
Insulin replacement in type 1 diabetes should ideally mimic beta-cell function to provide basal and prandial requirements (physiologic replacement or basal-bolus dosing). (msdmanuals.com)

OAT1 and 3 are among the several important drug transporters in kidney proximal tubules that maintain systemic levels of endogenous substrates (e.g. uric acid), and facilitate the active renal secretion of drugs into the urine. (solvobiotech.com)

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria. (lookformedical.com)

The Onecut homeodomain transcription factor hepatic nuclear factor 6 (Hnf6) is necessary for proper development of islet β-cells. (diabetesjournals.org)

With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC. (iiarjournals.org)
Fibroblast growth factor 21 (FGF-21) is a member of the FGF gene family, which currently contains 22 human members. (bio-techne.com)

Scholars@Duke publication: Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. (duke.edu)

Our study is focused on HNF1-alpha related to MODY 3, which is the most common one. (scirp.org)

Its phenotype is changing from single lesions to multiple lesions owing to the reduction in estrogen exposure and increasing incidence of obesity and metabolic syndrome as driving factors in the formation of hepatic adenoma. (medscape.com)

Mice lacking the Hnf-1α gene ( 3 , 4 ) also have a dramatic reduction in insulin secretory response to glucose. (diabetesjournals.org)

Fluorine-18L-3,4-hydroxyphenylalanine positron emission tomography ( 18 F-DOPA-PET) is considered the gold standard for preoperative differentiation of focal from diffuse disease and localization of the focal lesion. (medscape.com)
Mouse studies suggest that Rgs8 is likely to control aspects of islet progenitor cell activation, differentiation and beta-cell expansion in embryos and metabolically stressed adults. (guidetopharmacology.org)

Description: A sandwich ELISA kit for detection of Beta-1,3-Galactosyltransferase 2 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (operatiebrp.nl)
Description: A competitive ELISA for quantitative measurement of Mouse Î² 1,3 galactosyltransferase 2(B3GALT2) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (operatiebrp.nl)
Description: Quantitativesandwich ELISA kit for measuring Rat Glypican-3 (GPC3) in samples from serum, plasma, tissue homogenates. (lotuskringpoeldijk.nl)
Description: A sandwich quantitative ELISA assay kit for detection of Rat Glypican 3 (GPC3) in samples from serum, plasma, tissue homogenates or other biological fluids. (lotuskringpoeldijk.nl)
Description: A sandwich ELISA kit for detection of Glypican 3 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lotuskringpoeldijk.nl)
Description: A sandwich quantitative ELISA assay kit for detection of Human Fas Apoptotic Inhibitory Molecule 3 (FAIM3) in samples from tissue homogenates, cell lysates or other biological fluids. (1elisakits.com)

hepatocyte nuclear factor 4 alpha [Sourc. (gsea-msigdb.org)

Hypoxia stimulates hypoxia inducible factor (HIF)-dependent expression of CXCL12 and KITL promoting mobilization from the bone marrow and recruitment to primary tumor and metastatic sites of CXCR4 + CD11b + bone marrow-derived cells and KITbCD11b + cells assisting vasculogenesis and metastasis respectively (Kuonen et al. (biomedcentral.com)

That mutation impacts the insulin-producing beta cells, which in turn impacts insulin production and glucose regulation. (healthline.com)
Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. (uchicago.edu)
Hepatocyte nuclear factor-4-α is associated with 5 mutation . (guidetopharmacology.org)

SOX2 & DAPI nuclear co-localization yields purple (Left). (cellapplications.com)

coagulation factor X [Source:HGNC Symbol. (gsea-msigdb.org)
coagulation factor XII [Source:HGNC Symb. (gsea-msigdb.org)
coagulation factor V [Source:HGNC Symbol. (gsea-msigdb.org)
coagulation factor VIII [Source:HGNC Sym. (gsea-msigdb.org)
coagulation factor IX [Source:HGNC Symbo. (gsea-msigdb.org)

For the refinement of RCC therapeutic strategies, a better realization of the RCC-underlying molecular mechanisms will be mandatory [ 3 ]. (hindawi.com)

HiPSC-derived Neural Stem Cells (L) and Neurons (R) . i-HNSC stained w/ Nestin (neural stem cell marker, green), SOX 2 (stem cell marker, red) & DAPI (nuclear stain, blue). (cellapplications.com)
In the focal form, the histologically abnormal beta cells are limited to one or more focal areas, whereas in the diffuse form, the beta-cell abnormality is distributed throughout the pancreas. (medscape.com)
OAT1 and 3 have 12 predicted transmembrane domains and are primarily expressed in the basolateral (blood-side) membrane of proximal tubule cells in the kidney, with highest levels in the middle segment, and are considered as kidney-specific transporters in humans [1, 2]. (solvobiotech.com)
OAT1 and 3 are multispecific exchangers or antiporters that transport predominantly anionic substrates against a concentration gradient from the blood into proximal tubule cells for subsequent elimination into the urine. (solvobiotech.com)
Beta cells produce and release (secrete) the hormone insulin. (medlineplus.gov)
Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
insulin-secreting cells, the basolateral membrane of intestinal and kidney absorptive cells, in hepatocytes and in a subset of neurons (21,31,44). (justia.com)

All three subfamily members impact some aspect of metabolism, all three are induced by a nuclear receptor heterodimer that includes RXR, and all three utilize Klotho family members for signal transduction (7, 8, 9). (bio-techne.com)

The hepatocyte nuclear factor-1-beta and display the evidence of abnormal platelet of available. (lorenzopetrantoni.com)

Renal cell carcinoma (RCC) accounts for approximately 3% of human malignancies, and its incidence appears to be increasing globally [ 1 ]. (hindawi.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fas Apoptotic Inhibitory Molecule 3 (FAIM3) in Tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
In human .beta. (justia.com)
UDS activity in the rat liver of the human carcinogens benzidine and 4-aminobiphenyl, and the rodent carcinogens 3,3'-dichlorobenzidine and direct black 38. (cdc.gov)
These guidelines update previous CDC recommendations for treating and preventing active tuberculosis (TB) among adults and children coinfected with human immunodeficiency virus (HIV) (1-3). (cdc.gov)

Liver carcinogenesis is a multistep, long process associated with multiple risk factors, e.g. viral hepatitis, alcohol abuse, metabolic disorders, and obesity [ 2 ]. (aging-us.com)

platelet factor 4 [Source:HGNC Symbol;Ac. (gsea-msigdb.org)

An increased proportion of omega (n)-6:n-3 PUFA, which is observed typically in Western diets, leads to a wide range of pathologies, such as cardiovascular, inflammatory, autoimmune, and diabetic diseases. (nature.com)

LncRNA is a non-coding RNA molecule longer than 200 nucleotides [ 3 ] . (jcancer.org)

Case 3 had multicystic renal dysplasia, oligohydramnios and hypoplasia of the tail of the pancreas. (cyp17-signal.com)

stage 3, the formation of stable fibrin polymers. (gsea-msigdb.org)

ChemDiv proposes the new library of beta-catenin inhibitors/modulators. (chemdiv.com)

A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
EZH2 (enhancer of the zeste homolog 2) which was characterized as a histone methylase was also found to interact with lncRNAs and then impact the transcription of downstream factors [ 17 ]. (biomedcentral.com)

The classical clinical inhibitor of OAT1/3 is the uricosuric drug probenecid (which is also a substrate). (solvobiotech.com)
World journal of clinical cases 2022 3 10 (6): 1909-1913. (cdc.gov)

The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. (scialert.net)
T2DM is a complex trait where common genetic variants having modest individual effects act together and interact with environmental factors to modulate the risk of the disease. (scialert.net)

90(3): e13762, 2023 09. (bvsalud.org)

Vertebrate catenins contain a large number of Arm-domains including 3 subfamilies: β-tencains, p120 and plakophilins 1 and 3. (chemdiv.com)

3 evaluation of the level of ovarian function is eliminated. (lorenzopetrantoni.com)
In the pancreas, these changes prevent normal beta cell function. (medlineplus.gov)

Anatomy23

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HNF4A2

Foxa27

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