• cell
  • Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. (nih.gov)
  • We demonstrate that the cell surface heparan sulfate proteoglycan syndecan-2 plays a critical role in spine development.Deletion of the COOH-terminal EFYA motif of syndecan-2, the binding site for PDZ domain proteins, abrogates the spine-promoting activity of syndecan-2.Our results indicate that syndecan-2 plays a direct role in the development of postsynaptic specialization through its interactions with PDZ domain proteins. (nih.gov)
  • We demonstrate that the cell surface heparan sulfate proteoglycan syndecan-2 plays a critical role in spine development. (nih.gov)
  • Double staining for heparan sulfate and either MAP2, a dendritic marker (Fig. 3, A-E), or NCAM (Fig. 3, F-H) further demonstrated a punctate distribution of cell surface heparan sulfate along the dendrites of hippocampal neurons. (nih.gov)
  • cells
  • A glycosaminoglycoside (GAG) composition predominantly of tetrasacchardie units derived from heparin/heparan sulfate has enchanced activity in preventing the proliferation of smooth muscle cells. (google.com)
  • This staining was not seen in the case of immunolabeling of live cells (Fig. 2 D), suggesting that some heparan sulfates are associated with intracellular compartments. (nih.gov)
  • responsible
  • 1998). These observations further support our finding that syndecan-2 is one of the HSPGs responsible for the spine-specific accumulation of heparan sulfate on mature hippocampal neurons in vitro, though a contribution by unknown HSPGs has not been ruled out. (nih.gov)