For similar in vitro neutralization of low molecular weight heparins. (ibexpharma.com)
For the preparation of low molecular weight heparins from unfractionated heparin. (ibexpharma.com)
The products cover the entire range of oligosaccharides present in Low Molecular Weight Heparins. (galenmolecular.com)
Heparinase7
Other names in common use include heparin eliminase, and heparinase. (wikipedia.org)
A novel type of heparinase (heparin lyase, no EC number) has been purified from Bacteroides stercoris HJ-15, isolated from human intestine, which produces three kinds of heparinases. (rpi.edu)
Prepared by controlled partial depolymerisation of UF heparin by Heparinase I and separation of the derived oligosaccharides using high resolution gel filtration. (galenmolecular.com)
AAV2 containing cDNA encoding enhanced green fluorescent protein (GFP), under the control of a chicken β-actin promoter, was delivered by intravitreal injection to adult mice in conjunction with enzymes including collagenase, hyaluronan lyase, heparinase III, or chondroitin ABC lyase. (molvis.org)
The addition of heparinase III or chondroitin ABC lyase greatly enhanced transduction of the retinal ganglion cell layer and increased the depth of transduction into the outer retina. (molvis.org)
Electroretinograms survived with higher concentrations of heparinase III and chondroitin ABC lyase than were required for optimal retinal transduction. (molvis.org)
AAV2-mediated retinal transduction is improved by co-injection of heparinase III or chondroitin ABC lyase. (molvis.org)
We have examined the activities of different preparations of heparin and heparan sulfate lyases from Flavobacterium heparinum. (rpi.edu)
Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. (research.com)
Chondroitin1
The chondroitin lyases from Flavobacterium heparinum (Cytophaga heparinia) have been widely used in depolymerization of glycosaminoglycan and proteoglycan chondroitin sulphates. (rpi.edu)
Enzymes2
Heparinases, also called Heparin Lyase enzymes, are enzymes that cleave the glycosidic linkage between hexosamines and uronic acids and are known to cleave heparin and HS chains selectively, via an elimination mechanism. (neb.com)
The heparin biosynthetic enzymes mainly consist of sulfotransferases and all are integral transmembrane glycoproteins. (rpi.edu)
Hyaluronic acid was treated exhaustively with a hyaluronate lyase (hyaluronidase, EC 4.2.2.1) from Streptomyces hyalurolyticus to obtain a tetrasaccharide and a hexasaccharide product in a molar ratio of 1 to 1.2. (rpi.edu)
In his works, Jeremy E. Turnbull conducts interdisciplinary research on Glycosaminoglycan and Heparin. (research.com)
Jeremy E. Turnbull undertakes multidisciplinary studies into Heparin and Glycosaminoglycan in his work. (research.com)
Heparin, as a glycosaminoglycan, is known for its anticoagulant and antithrombotic properties for several decades. (bvsalud.org)
Eliminase1
P. Datta, L. Yan, A. Awofiranye, J.S. Dordick, and R.J. Linhardt (2020), "Heparosan Chain Characterization: Sequential Depolymerization of E. Coli K5 Heparosan by a Bacterial Eliminase Heparin Lyase III and a Bacterial Hydrolase Heparanase Bp to Prepare Defined Oligomers", Biotechnol. (rpi.edu)
Protein1
Here, we compare protein binding of a highly charged heparin (HP) hexasaccharide with four de novo designed decapeptides of varying negative net charge. (bvsalud.org)
Molecule1
The enzyme also cleaves the antithrombin III binding pentasaccharide domain in the heparin molecule. (ibexpharma.com)
Oligosaccharides1
90-110 IU/mg using the following Unit definition: One international unit (IU) is defined as the amount of enzyme that will liberate 1.0 µmole unsaturated oligosaccharides from porcine mucosal heparin per minute at 30° C and pH 7.0. (ibexpharma.com)
Citrate1
The mag and the sbeadex kits (e.g. sbeadex blood, sbeadex forensic, mag mini/maxi and mag nanogram) use magnetic beads to purify DNA from a variety of blood sample types such as EDTA heparin, citrate and buffy coats as well as swab matrices, tissue and forensic samples. (biosearchtech.com)
Thrombin1
The anticoagulant activity is mainly attributed to thrombin inhibition mediated by heparin cofactor II, with different effectiveness depending on the compound. (springer.com)
Enzyme1
The systematic name of this enzyme class is heparin lyase. (wikipedia.org)
Anticoagulant2
Heparin, an anticoagulant drug, is biosynthesized in selected animal cells. (rpi.edu)
In recent years, there have been extensive studies that heparin plays an important role in non-anticoagulant diseases, such as anti-inflammatory, anti-viral, anti-angiogenesis, anti-neoplastic, anti-metastatic effects, and so on. (bvsalud.org)
Linhardt2
A.L. Gelbach, F. Zhang, S.J. Kwon, J.T. Bates, A.P. Farmer, J.S. Dordick, C. Wang, and R.J. Linhardt (2022), "Interactions Between Heparin and SARS-CoV-2 Spike Glycoprotein RBD from Omicron and Other Variants. (rpi.edu)
P. Datta, F. Zhang, J.S. Dordick, and R.J. Linhardt (2021), "Platelet Factor 4 Polyanion Immune Complexes: Heparin Induced Thrombocytopenia and Vaccine-Induced Immune Thrombotic Thrombocytopenia," Thromb. (rpi.edu)
Oligosaccharide1
For the preparation of disaccharides of heparin and the preparation of oligosaccharide libraries. (ibexpharma.com)
Vitro2
As integral part of in vitro diagnostic tests for the neutralization of heparin (blood clotting tests, platelet tests). (ibexpharma.com)
Clinical observation and in vitro experiments indicate that heparin displays a potential multitarget effect. (bvsalud.org)
Widely1
Heparin is a life-saving drug and is widely used for anticoagulation in medical practice. (bvsalud.org)
Class1
by SAX-hplc) for further analysis of naturally-occurring heparin sequences within a specific size class or classes. (galenmolecular.com)