• thrombin
  • Inhibition of thrombin requires simultaneous binding of heparin to AT-III through the unique pentasaccharide sequence and binding to thrombin through a minimum of 13 additional saccharide units. (slideserve.com)
  • fragments
  • The compositions of the invention are composed of fragments of heparin consisting essentially of repeated disaccharide sequences corresponding to the regular regions of heparin and possessing a MW between 4,800 and 9,000. (google.es)
  • Heparin fragments can only bind to antithrombin - III when MW exceeds 5000 IU. (slideserve.com)
  • subcutaneously
  • It exists in two main forms: an "unfractionated" form that can be injected under the skin or through an intravenous infusion, and a "low molecular weight" form that is generally given subcutaneously (administered under the skin). (wikipedia.org)
  • liver
  • Heparin is contraindicated in those with risk of bleeding (especially in people with uncontrolled blood pressure, liver disease, and stroke), severe liver disease, or severe hypertension. (wikipedia.org)
  • blood
  • Heparin, also known as unfractionated heparin (UFH), is medication which is used as an anticoagulant (blood thinner). (wikipedia.org)
  • Common side effects include bleeding, pain at the injection site, and low blood platelets. (wikipedia.org)
  • The risk of developing blood clots can be modified by life style modifications, the discontinuation of oral contraceptives, and weight loss. (wikipedia.org)
  • This is due to the observation that not all blood clots form in the lower legs. (wikipedia.org)
  • Without prophylactic interventions, the calculated incidence of clot formation in the lower leg veins after surgery is: 22% for neurosurgery 26% for abdominal surgery 45% for 60% in orthopedic surgery 14% for gynecologic surgery As the population of the US ages, the development of blood clots is becoming more common. (wikipedia.org)
  • The benefit of treating those who are at low risk of developing blood clots may not outweigh the higher risks of significant bleeding. (wikipedia.org)
  • Heparin targets multiple factors in the blood coagulation cascade, one of them being FXa. (wikipedia.org)
  • patients
  • In addition, the specificity of CUS for distal DVT is lower than that for proximal DVT, increasing the proportion of false positive findings, making it likely that a proportion of patients diagnosed with distal DVT are treated unnecessarily, with the attendant risks of major and fatal haemorrhage. (clinicaltrials.gov)
  • To study the safety and efficacy of early administration of Low Molecular Weight Heparin to patients with traumatic brain injury. (clinicaltrials.gov)
  • The first is elevation of serum aminotransferase levels, which has been reported in as many as 80% of patients receiving heparin. (wikipedia.org)
  • The other complication is hyperkalemia, which occurs in 5 to 10% of patients receiving heparin, and is the result of heparin-induced aldosterone suppression. (wikipedia.org)
  • systemic
  • In those receiving heparin through an intravenous infusion, a complex of symptoms ("systemic reaction") may occur when the infusion is started. (wikipedia.org)