• Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses. (wikipedia.org)
  • Signs and symptoms of VHFs include (by definition) fever and bleeding: Flushing of the face and chest, small red or purple spots (petechiae), bleeding, swelling caused by edema, low blood pressure (hypotension), and circulatory shock. (wikipedia.org)
  • Viral hemorrhagic fevers (VHFs) are a group of diseases that are caused by several distinct families of viruses. (cdc.gov)
  • Viral hemorrhagic fevers (VHFs) are a group of febrile illnesses caused by RNA viruses from several viral families. (medscape.com)
  • Acute kidney injury with oliguria is a prominent feature of hemorrhagic fever with renal syndrome (HFRS) seen in Hantavirus infection and may be seen in other VHFs as intravascular volume depletion becomes more pronounced. (medscape.com)
  • Viral haemorrhagic fevers (VHFs) are severe viral infections capable of causing vital death associated with multi-organ failure resulting in high mortality rates. (omicsonline.org)
  • Ebola and Marburg virus), Crimean-Congo hemorrhagic fever (CCHF), and the South American hemorrhagic fevers caused by arenaviruses, but only in a small minority of patients with dengue or Rift Valley fever. (wikipedia.org)
  • DIC is thought to cause bleeding in Rift Valley, Marburg, and Ebola fevers. (wikipedia.org)
  • Hepatic involvement varies with the infecting organism and is at times seen with Ebola, Marburg, RVF, Crimean-Congo hemorrhagic fever (CCHF), and yellow fever. (medscape.com)
  • Although a number of other febrile viral infections may produce hemorrhage, only the agents of Lassa, Marburg, Ebola, and Crimean-Congo hemorrhagic fevers are known to have caused significant outbreaks of disease with person-to-person transmission. (cdc.gov)
  • Important examples are Crimean-Congo Haemorrhagic Fever(CCHF), Ebola and Marburg Haemorrhgic Fevers, Lassa Fever, Rift Valley Fever(RVF), Dengue Haemorrhagic fever (DHF), Yellow Fever and Smallpox. (gov.hk)
  • Important agents are Lassa fever virus ( Arenavirus ), Ebola virus, Marburg virus ( Filoviradae ) and Crimean-Congo haemorrhagic fever virus. (nsw.gov.au)
  • These include the Ebola and Marburg, Lassa fever, and yellow fever viruses. (medlineplus.gov)
  • They discuss four of the most serious and deadly viral hemorrhagic fevers: Ebola, Marburg, Lassa, and Crimean-Congo Hemorrhagic fevers. (netecweb.org)
  • While cases in the U.S. are rare, recent outbreaks of Marburg in Ghana, Crimean-Congo Hemorrhagic Fever in Iraq, Lassa Fever in Nigeria, and Ebola in the Democratic Republic of Congo mean that health care workers need to know how to identify and treat these viral illnesses. (netecweb.org)
  • The former family Bunyaviridae includes the causative agents of Hantavirus hemorrhagic fever with renal syndrome (HV-HFRS) (Hantaviridae), the Crimean-Congo hemorrhagic fever (CCHF) virus from the genus Orthonairovirus (Nairoviridae), Garissa virus and Ilesha virus from the genus Orthobunyavirus (Peribunyaviridae), and the Rift Valley fever (RVF) virus from the genus Phlebovirus (Phenuiviridae). (wikipedia.org)
  • Viruses in the order Bunyavirales include the Arenaviridae family viruses, Crimean-Congo hemorrhagic fever (CCHF) virus (family Nairoviridae ), hantaviruses (family Hantaviridae ), and Rift Valley fever (RVF) virus (family Phenuiviridae ). (cdc.gov)
  • This knowledge sheds light on the potential of these mAbs to be effective against a broad range of CCHF viral strains. (sciencedaily.com)
  • Management and control of viral haemorrhagic fevers / Advisory Committee on Dangerous Pathogens. (who.int)
  • Learn more about specific viral hemorrhagic fevers - their signs and symptoms, how they are spread, and how to prevent them. (cdc.gov)
  • The family Arenaviridae include the viruses responsible for Lassa fever (Lassa virus), Lujo virus, Argentine (Junin virus), Bolivian (Machupo virus), Brazilian (Sabiá virus), Chapare hemorrhagic fever (Chapare virus), Venezuelan (Guanarito virus) and Whitewater Arroyo virus hemorrhagic fevers. (wikipedia.org)
  • Lassa fever was first recognized in 1969 in northern Nigeria (3) when two of three nurses infected in a rural hospital died. (cdc.gov)
  • This can occur due eating food contaminated by animal faeces/urine (or eating infected animals), or contact of damaged skin with animal faeces/urine or breathing in dust contaminated with infected animal or urine faeces, for example, Lassa fever, Ebola. (fitfortravel.nhs.uk)
  • Lassa fever virus is carried by rodents and transmitted by excreta, either aerosol or by direct contact. (gov.hk)
  • For example, Lassa fever is limited to rural areas of West Africa where rats and mice carry the virus. (medlineplus.gov)
  • The first imported case of Lassa fever in more than 20 years occurred in New Jersey in 2004. (medscape.com)
  • [ 9 ] Lassa fever imported to the US was again reported in 2010. (medscape.com)
  • In West Africa, Lassa fever is spread to humans when infected rodents are captured for consumption, as well as by person-to-person exposures. (medscape.com)
  • While we were doing our work on Lassa fever in 2014, we were faced with the largest Ebola outbreak in West Africa. (nih.gov)
  • We have established sequencing facilities in Nigeria, Sierra-Leone, Senegal and Liberia that have been used to respond to many outbreaks of diseases such as Lassa fever, monkeypox and yellow fever. (nih.gov)
  • Symptoms of Lassa fever and South American arenavirus hemorrhagic fevers usually start about 5 to 16 days after people are exposed to the virus. (merckmanuals.com)
  • About 80% of cases of Lassa fever are mild and are often not diagnosed. (merckmanuals.com)
  • About 20 to 30% of people with Lassa fever lose their hearing. (merckmanuals.com)
  • Obvious bleeding is less common in Lassa fever. (merckmanuals.com)
  • The diagnosis of Lassa fever or a South American hemorrhagic fever is confirmed by blood tests to identify the virus or antibodies to the virus. (merckmanuals.com)
  • The results demonstrate that Lassa fever is endemic in Liberia. (who.int)
  • Consistent with the occurrence of active Lassa fever cases, the prevalent Lassa virus activity seems to be in Lofa County and neighbouring Guinea. (who.int)
  • Statistically, medical personnel exposed to Lassa fever patients are not at a higher risk for Lassa virus infection than the general population. (who.int)
  • With the exception of Argentinian Haemorrhagic Fever and Yellow Fever, no vaccine exist's that can protect against these diseases. (gov.hk)
  • The yellow fever vaccine is usually considered safe and effective. (specialtycareclinics.com)
  • Current lead vaccine candidates include a multivalent vaccine for S. aureus infections as well as trivalent vaccine and antibody therapeutic for filovirus hemorrhagic fever. (vhfimmunotherapy.org)
  • The currently available yellow fever vaccine confers near lifelong immunity in 95% of patients. (medscape.com)
  • In a retrospective analysis of patients with yellow fever vaccine-associated viscerotropic disease accompanied by shock, 75% of those treated with stress-dose steroids survived, compared with 29% of those not treated with stress-dose steroids. (medscape.com)
  • Previously, we showed complete protection using one dose of a viral replicon particle (VRP) vaccine administered 28 days before CCHFV challenge. (utmb.edu)
  • Viral hemorrhagic fevers (VHF) are a group of diseases that affect multiple organ systems in the body and may be accompanied by hemorrhage, or bleeding. (cdc.gov)
  • Viral hemorrhagic fever (VHF) diseases are caused by 3 families ( Arenaviridae , Filoviridae , Flaviviridae ) and 1 order ( Bunyavirales ) of enveloped RNA viruses. (cdc.gov)
  • Epidemic Intelligence Service (EIS) Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases (ext. 1344). (cdc.gov)
  • Chief, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Joseph B. McCormick, M.D. (ext. 3308). (cdc.gov)
  • Senior Medical Officer, Special Pathogens Branch, Division of Viral Diseases, Center for Infectious Diseases: Susan P. Fisher-Hoch, M.D. (ext. 3308). (cdc.gov)
  • Director, Division of Viral Diseases, Center for Infectious Diseases (ext. 3574). (cdc.gov)
  • Viral haemorrhagic fevers include a spectrum of relatively mild to severe life-threatening diseases characterized by sudden onset of muscle and joint pain, fever, bleeding and shock from loss of blood. (who.int)
  • This book should appeal to that audience, and also to a wider audience of persons interested in the public health ramifications of these serious viral diseases in their geographic niches as well as their potential to cause disease in industrialized nations, either when imported by returning travelers or deliberately released in an act of terrorism. (cdc.gov)
  • In unstable countries of North Africa with fragile health services complicated with armed conflicts and population displacement, such infections could be easily confused with other local parasitic and viral diseases. (omicsonline.org)
  • Viral hemorrhagic fevers are infectious diseases that could cause severe, life-threatening diseases. (specialtycareclinics.com)
  • Viral hemorrhagic fevers are rare diseases in the United States but more prevalent in Africa. (marshallcountyhealthdepartment.com)
  • In the wake of a concerning development, authorities in Longochuk County, Upper Nile State, reported a series of fatalities on 15 May 2023, believed to be linked to a suspected viral hemorrhagic fever outbreak in the secluded villages of Dajo and Pacime. (who.int)
  • Family Rhabdoviridae (order Mononegavirales): In September 2012 scientists writing in the journal PLOS Pathogens reported the isolation of a member of the Rhabdoviridae responsible for two fatal and two non-fatal cases of hemorrhagic fever in the Bas-Congo district of the Democratic Republic of Congo. (wikipedia.org)
  • One example is the discussion of Whitewater Arroyo virus and its probable (but contentious) role in 3 fatal cases of hemorrhagic fever from 1999 to 2000. (cdc.gov)
  • In vitro studies reveal these cytokines lead to shock and increased vascular permeability, the basic pathophysiologic processes most often seen in viral hemorrhagic fever infection. (medscape.com)
  • Lack of timely laboratory diagnosis, late detection, inadequate infection control practices at health care facilities, and weak vector control programmes could also prolong outbreaks of haemorrhagic fevers. (who.int)
  • Viral hemorrhagic fever has been associated with high mortality rate which brought serious concern for public health worldwide and prompted a sense of urgency to halt this infection. (omicsonline.org)
  • Ebola virus haemorrhagic fever : proceedings of an International Colloquium on Ebola Virus Infection and Other Haemorrhagic Fevers held in Antwerp, Belgium, 6-8 December 1977 / editor, S. R. Pattyn. (who.int)
  • Dengue fever, or breakbone fever, results from a viral infection carried by Aedes mosquitoes. (medicalnewstoday.com)
  • Do your best to avoid these insects, particularly when traveling in areas where there are outbreaks of viral hemorrhagic fevers. (specialtycareclinics.com)
  • Introduction: There have been 3 outbreaks of viral hemorrhagic fever (VHF) in Uganda in the last 2 years. (johnshopkins.edu)
  • Five families of RNA viruses have been recognised as being able to cause hemorrhagic fevers. (wikipedia.org)
  • These virus types cause hemorrhagic fever or profuse bleeding inside and outside the body. (healthline.com)
  • Its presentation can range from asymptomatic illness to acute-onset viral hepatitis and hemorrhagic fever. (medscape.com)
  • Revised case definitions were implemented for the following conditions: plague, legionellosis, acute hepatitis C, spotted fever rickettsiosis, and pertussis. (cdc.gov)
  • Nowadays, in Africa many viruses are known to cause haemorrhagic fevers including Ebola, Magdeburg and yellow fever . (omicsonline.org)
  • Yellow fever is a mosquito-borne disease that is endemic to tropical South America and Sub-Saharan Africa (see the image below). (medscape.com)
  • Trends in the underlying drivers of EVD risk suggest a 1.75 to 3.2-fold increase in the endemic rate of animal-human viral spill-overs in Africa by 2070, given current modes of healthcare intervention. (nature.com)
  • A research team has discovered important details about how therapeutically relevant human monoclonal antibodies can protect against Crimean Congo Hemorrhagic Fever virus. (sciencedaily.com)
  • Valley fever, dengue haemorrhagic fever, Crimean-Congo haemorrhagic fever and Ebola haemorrhagic fever. (who.int)
  • Crimean-Congo hemorrhagic fever virus (CCHFV) causes mild to severe and fatal disease in humans. (utmb.edu)
  • The role of the PD-1/PD-L1 axis during viral infections is further complicated by evidence that PD-L1 also mediates inflammatory effects in the acute phase of an immune response. (frontiersin.org)
  • Patient with Ebola hemorrhagic fever during 1976 outbreak in Zaire demonstrating palatal petechiae and hemorrhage. (medscape.com)
  • This illness is characterized by fever and, in the most severe cases, shock and hemorrhage (1). (cdc.gov)
  • Hemorrhagic Fevers Overview Hemorrhagic fevers are serious viral infections characterized by bleeding (hemorrhage). (merckmanuals.com)
  • are viral infections that cause bleeding (hemorrhage) and organ malfunction. (merckmanuals.com)
  • Dengue Fever and Yellow Fever are usually described separately while smallpox had already been eradicated. (gov.hk)
  • The "VHF syndrome" (capillary leak, bleeding diathesis, and circulatory compromise leading to shock) appears in a majority of people with filoviral hemorrhagic fevers (e.g. (wikipedia.org)
  • These highly infectious viruses lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding, edema, and hypotension. (medscape.com)
  • The term "Viral Haemorrhagic Fever" (VHF) is often used to describe a severe syndrome often accompanied by haemorrhage (bleeding). (gov.hk)
  • The World Health Organization (WHO) dispatched a multidisciplinary team comprising clinicians, nurses, and public health experts to investigate the suspected viral hemorrhagic fever (VHF) outbreak and augment surveillance measures in Longochuk County. (who.int)
  • The role of the laboratory in outbreak investigation of viral haemorrhagic fever in Nigeria, 2014. (afenetnigeria.net)
  • Tissue from the upper or lower respiratory tract, sputum samples, and samples obtained by nasopharyngeal washing, bronchoalveolar lavage, and biopsy may be submitted for viral culture. (medscape.com)
  • Because there are no effective treatments for some of these viral infections, there is concern about their use in bioterrorism . (medlineplus.gov)
  • Overview of Viral Infections A virus is a tiny living organism. (msdmanuals.com)
  • As many of the hosts that carry haemorrhagic fever viruses are rodents, disease prevention efforts focus on their control. (gov.hk)
  • Detection and identification of viral pathogens. (utmb.edu)
  • However, the detection of viral pathogens does not always indicate active disease. (medscape.com)
  • Viral cultures are still the criterion standard for most viral pathogens, but they take a long time to complete. (medscape.com)
  • Exhaustion and suppression of antiviral immune responses can result in viral immune evasion. (frontiersin.org)
  • The viruses that cause viral hemorrhagic fevers reside in a variety of animal and insect hosts. (specialtycareclinics.com)
  • For several viral hemorrhagic fevers, person-to-person transmission may occur through direct contact with infected patients, their blood, or their secretions and excretions. (medscape.com)
  • They are spread in a variety of ways and can cause a severe viral illness accompanied by bleeding. (fitfortravel.nhs.uk)
  • VHF is a general term indicating a severe viral illness with fever and associated with internal/external bleeding (hence the name haemorrhagic fever). (fitfortravel.nhs.uk)
  • Mosquitoes and tick control are important to prevent spread of haemorrhagic fever viruses transmitted through insect vectors. (gov.hk)
  • Infectious agents that are arthropod-borne (usually mosquitoes) cause many viral hemorrhagic fevers. (medscape.com)
  • A person is at risk of dengue fever if they live or travel in an area where dengue occurs and mosquitoes that can carry it live. (medicalnewstoday.com)
  • The pathogen that caused the cocoliztli epidemics in Mexico of 1545 and 1576 is still unknown, and the 1545 epidemic may have been bacterial rather than viral. (wikipedia.org)
  • The primary defect in patients with viral hemorrhagic fever (VHF) is that of increased vascular permeability. (medscape.com)
  • Hemorrhagic fever viruses are highly contagious by touching bodily fluids of infected patients and then touching your mouth or eyes. (marshallcountyhealthdepartment.com)
  • Because of the difficulty in distinguishing between the various etiologic agents, both viral and bacterial, causing pneumonia, the workup for symptomatic patients with an infiltrate on chest radiograph should include laboratory studies. (medscape.com)
  • This document contains the laboratory case definition for viral haemorrhagic fever. (health.gov.au)
  • Administration of interferon-α (or possibly IVIG) would be a reasonable postexposure prophylactic treatment in an unvaccinated laboratory or hospital worker exposed to yellow fever or blood of an acutely ill (potentially viremic) patient with yellow fever if administered within 24 hours. (medscape.com)
  • Hemorrhagic complications are multifactorial and are related to hepatic damage, consumptive coagulopathy, and primary marrow injury to megakaryocytes. (medscape.com)
  • The term viral hemorrhagic fever (VHF) refers to the illness associated with a number of geographically restricted viruses. (cdc.gov)
  • Viral hemorrhagic fevers are associated with high rates of illness and death. (columbia.edu)