AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed Groups
Heart-Lung TransplantationLung TransplantationBronchiolitis ObliteransLungLiver TransplantationTransplantation, HomologousPrimary Graft DysfunctionHeartGraft RejectionHeart TransplantationKidney TransplantationLung DiseasesBone Marrow TransplantationHematopoietic Stem Cell TransplantationGraft SurvivalTissue DonorsTransplantation, AutologousHeart RateMedlinePlusPulmonary EmbolismAngiographyAngiography, Digital SubtractionVentilation-Perfusion RatioTechnetium Tc 99m Aggregated AlbuminPulmonary ArterySodium Pertechnetate Tc 99m
Recipients2022Advanced Lung DiseaseJournal of Heart and Lung TransplantationTransplantsInterstitial Lung DiOutcomesCysticOrgan and tissue transplantationRejectionDiseaseDetection of allograft dysfunctionSolid organ transplantationDysfunctionInfectionMortalityDonation and TransplantationGraftLiverKidney TransplantationSurgicalOrgansBilateralDiseasesTissueChronicAcuteISHLTSurgeryTherapeuticTissuesCongenitalDisordersHttpsModalitiesTherapies2017PathologyRecipientDonorsDonor heart1988SurvivalProgrammeExtracorporealSingle-lungProcedures
Recipients21
  • Outcomes after heart and lung transplants have improved, and many recipients survive long enough to develop secondary renal failure, yet remain healthy enough to undergo kidney transplantation. (johnshopkins.edu)
  • Furthermore, renal transplantation reduced the risk of death compared with dialysis by 43% for KAH and 54% for KAL recipients. (johnshopkins.edu)
  • From the total sample, 37% of liver recipients and 20% of lung had cognitive disorders compared to only 9% of heart recipients. (hippokratia.gr)
  • With greater experience and analysis of significant numbers of cases, lung transplant recipients are living longer, and follow-up regimens are becoming streamlined. (medscape.com)
  • Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
  • Many lung transplant physicians advocate surveillance bronchoscopy with transbronchial lung biopsy and bronchoalveolar lavage (TBB/BAL) to monitor lung recipients despite limited evidence this strategy improves outcomes. (nih.gov)
  • This report compares rates of infection (INF), acute rejection (AR), bronchiolitis obliterans syndrome (BOS) and survival in lung allograft recipients managed with surveillance TBB/BAL (SB) versus those with clinically indicated TBB/BAL (CIB). (nih.gov)
  • With no obvious advantage identified, surveillance bronchoscopy may pose a risk to stable lung transplant recipients. (nih.gov)
  • We prospectively measured anti-HLA IgE antibodies in a cohort of kidney (n=60), liver , heart and lung (n=15 each) transplant recipients before and within one-year after transplantation , employing a single- antigen bead assay for HLA class I and class II antigens . (bvsalud.org)
  • Pre-existing anti-HLA IgE antibodies were detected in 10% of renal recipients (including 3.3% IgE -DSA) and in 4.4% of non-renal solid organ transplant recipients ( heart , liver and lung cohort). (bvsalud.org)
  • These data demonstrate that anti-HLA IgE antibodies occur at low frequency in kidney , liver , heart and lung transplant recipients . (bvsalud.org)
  • Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. (nature.com)
  • The airways of CF are susceptible to colonization by respiratory pathogens ( 3 ), a condition that is improved in lung transplant recipients. (cdc.gov)
  • Nevertheless, I. limosus infection has been reported twice in lung transplant recipients ( 4 , 5 ). (cdc.gov)
  • Today, a main focus of the transplant community is the long-term outcomes of lung and heart allograft recipients. (terasaki.org)
  • Infection rates among lung transplant recipients appear to be higher than those encountered in other solid organ transplant populations, likely related to the unique exposure of the lung allograft to the external environment and to the greater magnitude of immunosuppression employed 1 , 2 . (ersjournals.com)
  • To investigate possible changes following lung transplantation, the structure and in vitro ciliary beat frequency (CBF) of airway epithelium from the cytology brushings of 9 heart-lung (HLT) and 5 single-lung (SLT) transplant recipients were examined. (soton.ac.uk)
  • Unfavorable Outcome of Heart Transplantation in Recipients With Type D Personality. (bvsalud.org)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
20221
  • A 45-year-old woman in France who had received a lung transplant in 2016 for end-stage cystic fibrosis (CF) sought care for rhinorrhea on March 1, 2022. (cdc.gov)
Advanced Lung Disease4
  • A Society that Includes Basic Science, the Failing Heart and Advanced Lung Disease. (ishlt.org)
  • 1 Program for Advanced Lung Disease and Lung Transplantation, Pulmonary and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA. (nih.gov)
  • He performs health services and outcomes research focused on understanding and improving the lives and care of patients with advanced lung disease and is actively involved in clinical trials to improve outcomes in interstitial lung disease. (stanford.edu)
  • While offering a vital therapeutic option for patients with advanced lung disease, LTx remains fraught with complications that threaten both the quality and duration of the recipient's life. (ersjournals.com)
Journal of Heart and Lung Transplantation3
Transplants4
  • Lung transplants can come from a living donor or from someone who has recently died. (msdmanuals.com)
  • We used national data reported to United Network for Organ Sharing (UNOS) to evaluate outcomes of 568 kidney after heart (KAH) and 210 kidney after lung (KAL) transplants performed between 1995 and 2008. (johnshopkins.edu)
  • Lung transplants are used for people who are likely to die from lung disease within 1 to 2 years. (medlineplus.gov)
  • Given that sicker/riskier patients are now receiving more heart and lung transplants, future studies need to take place to better understand these patients so that they can have the same survival as patients entering transplant with less severe illnesses. (terasaki.org)
Interstitial Lung Di1
  • Joshua Mooney, MD, MS, is a board certified pulmonologist and critical care physician who specializes in the care of interstitial lung disease and lung transplant patients. (stanford.edu)
Outcomes3
  • Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
  • Prediction of Outcomes After Heart Transplantation in Pediatric Patients Using National Registry Data: Evaluation of Machine Learning Approaches. (cdc.gov)
  • Temporal shift and predictive performance of machine learning for heart transplant outcomes. (cdc.gov)
Cystic1
  • Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
Organ and tissue transplantation1
  • 4 World Health Assembly - Resolution WHA63.22 on Human organ and tissue transplantation, May 2010. (who.int)
Rejection14
  • BACKGROUND: Lung function is altered by infection and rejection in patients who undergo heart-lung transplantation. (bmj.com)
  • Infection and rejection were accompanied by airflow obstruction, a rise in the slopes of the alveolar plateaus for nitrogen, hexafluoride sulphur and helium (SN2, SSF6, and SHe), and a decrease in the difference between SSF6 and SHe (delta S), total lung capacity (TLC), and lung transfer factor (TLCO). (bmj.com)
  • CONCLUSIONS: Indices of ventilation distribution, FEF25-75, and TLC have the best optimal sensitivity for the diagnosis of infection and rejection after heart-lung transplantation. (bmj.com)
  • Complications of lung transplantation include rejection of the transplanted lung and infection. (medlineplus.gov)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Although aimed at protecting the host from infection, in the context of transplantation, this injury leads to allograft rejection. (medscape.com)
  • Antibody mediated rejection (ABMR) is a major factor limiting outcome after organ transplantation . (bvsalud.org)
  • 11 , 12 Compelling evidences have also showed that the gut microbiome could modulate alloimmunity and rejection, directly implicating the gut microbiome as a therapeutic target in organ transplantation. (nature.com)
  • This article will review the major medical complications, excluding allograft rejection, which may be encountered in the lung transplant recipient. (ersjournals.com)
  • In addition toallograft rejection (a topic covered elsewhere in this series), a multitude of medical complications mark the post-transplantation course. (ersjournals.com)
  • This includes regular sampling (biopsies) of the transplanted heart tissue to check for rejection. (healthlinkbc.ca)
  • Rejection of the donor heart. (healthlinkbc.ca)
  • To check for rejection, surgeons will regularly test a sample (biopsy) of the heart tissue. (healthlinkbc.ca)
  • Donor-Derived DNA Predicts Lung Transplant Rejection Before any clinical signs of graft failure are evident in patients who undergo lung transplant, experimental research suggests that donor-derived cell-free DNA could help predict a poor outcome. (medscape.com)
Disease15
  • The cut surface shows the characteristic findings of the disease for which lung transplantation was indicated. (medscape.com)
  • ISHLT is the world's largest multidisciplinary organization dedicated to improving the care of patients with advanced heart or lung disease through transplantation, mechanical circulatory support and innovative therapies. (asaecenter.org)
  • Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
  • At the Johns Hopkins Heart and Vascular Institute, cardiac specialists swiftly translate laboratory discoveries into new treatments, with the ultimate goal of saving more lives from heart disease, the leading cause of death in the United States. (hopkinsmedicine.org)
  • Call 310-825-9011 to learn more about adult congenital heart disease treatment. (uclahealth.org)
  • The Ahmanson/UCLA Adult Congenital Heart Disease Center is the first and one of the largest facilities of its kind in the United States. (uclahealth.org)
  • The center is a tertiary care national and international resource that provides services to the growing number of patients with congenital heart disease who reach adulthood. (uclahealth.org)
  • We are pleased to announce the creation of the Adolescent/Young Adult Transitional Care Program, for Congenital Heart Disease . (uclahealth.org)
  • The program is the combined efforts of the Division of Pediatric Cardiology and the Ahmanson/UCLA Adult Congenital Heart Disease Center. (uclahealth.org)
  • The program provides comprehensive treatment of adolescents with congenital heart disease, ages 15 to 20. (uclahealth.org)
  • Patients who are new to the Ahmanson/UCLA Adult Congenital Heart Disease Center should ideally have their doctor's mail or fax in cardiac related medical records prior to scheduling an appointment. (uclahealth.org)
  • A heart transplant may be considered when a person has severe heart disease and is likely to benefit most from a donor heart. (healthlinkbc.ca)
  • The person has end-stage heart failure, ischemic heart disease, cardiomyopathy, or congenital heart disease. (healthlinkbc.ca)
  • Stress Testing Stressing the heart (by exercise or by use of stimulant drugs to make the heart beat faster and more forcibly) can help identify coronary artery disease. (merckmanuals.com)
  • Pulmonary Rehabilitation Pulmonary rehabilitation is the use of supervised exercise, education, support, and behavioral intervention to improve how people with chronic lung disease function in daily life and to enhance. (merckmanuals.com)
Detection of allograft dysfunction2
  • Role of pulmonary function in the detection of allograft dysfunction after heart-lung transplantation. (bmj.com)
  • The sensitivity, specificity, and positive/negative predictive values (PPV and NPV) of lung function for the detection of allograft dysfunction in these patients were measured. (bmj.com)
Solid organ transplantation2
  • 1 Nevertheless, the overall survival after a lung transplant is still inferior compared to other solid-organ transplantation modalities. (nature.com)
  • 12 These results supported that potential gut microbiome-targeted interventions could influence the survival of patients received solid organ transplantation. (nature.com)
Dysfunction2
  • 4 These diseases are not only the major causes of death but are also associated with chronic lung allograft dysfunction (CLAD). (nature.com)
  • We report a case of I. limosus bacteremia in a patient in France who received a lung transplant and experienced chronic graft dysfunction and SARS-CoV-2 infection. (cdc.gov)
Infection2
  • Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
  • Infection is an ever-present threat to the well-being of the lung transplant recipient and is a leading cause of both early and late mortality. (ersjournals.com)
Mortality1
  • The study will compare the time to a composite endpoint of relative decline in lung function [10% relative decline in forced vital capacity (FVC), first respiratory hospitalization, lung transplantation, or all-cause mortality] The secondary objectives will be to examine the effect of NAC on the components of the primary composite endpoint, the rates of clinical events, change in physiology, change in health status, and change in respiratory symptoms. (stanford.edu)
Donation and Transplantation4
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
  • Organ and tissue donation and transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ or tissue. (who.int)
  • 3 Global Observatory on Donation and Transplantation 2016. (who.int)
  • 5 United Nations General Assembly - Resolution A/RES/71/322 on Strengthening and promoting effective measures and international cooperation on organ donation and transplantation to prevent and combat trafficking in persons for the purpose of organ removal and trafficking in human organs, September 2017. (who.int)
Graft3
  • Indeed, the lung graft microbiome is affected by donor and recipient factors ( 6 ), but early posttransplant infections mainly involve the bacteria of the recipient rather than those of the donor ( 7 ). (cdc.gov)
  • CT12 Chapter 5: Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
  • Factors Affecting Graft Survival Within 1-year Post-Transplantation in Heart and Lung Transplant: An Analysis of the OPTN/UNOS Registry. (terasaki.org)
Liver4
  • The total number of patients included in the study was 48, 27 of them referred from the Cardiothoracic Centre of Northern Greece (heart n=22, lung n=5) and 21 from the Transplant Unit of Aristotelian University of Thessaloniki, Hippokratio G.P. Hospital (liver n=21). (hippokratia.gr)
  • anti-HLA IgE in kidney, liver, lung and heart transplantation. (bvsalud.org)
  • Prospective assessment of pre-existing and de novo anti-HLA IgE in kidney, liver, lung and heart transplantation. (bvsalud.org)
  • For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)
Kidney Transplantation1
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Surgical4
  • Lung transplantation is the surgical removal of a healthy lung or part of a lung from a living person and then its transfer into someone whose lungs no longer function. (msdmanuals.com)
  • Surgical advances, in conjunction with more effective immunosuppressive strategies, have propelled the field of lung transplantation forward and have made intermediate-term survival an achievable goal. (ersjournals.com)
  • Surgical options are limited to heart transplantation. (medscape.com)
  • Advanced surgical techniques such as heart and lung transplantations are also developed at the centre. (lu.se)
Organs6
  • Overview of Transplantation Transplantation is the removal of living, functioning cells, tissues, or organs from the body and then their transfer back into the same body or into a different body. (msdmanuals.com)
  • The test assesses the person's overall function but, if the person's exercise capacity is reduced, does not tell which of the individual organs and systems (that is, the heart, lungs, muscles and bones, or other organs and systems) is the limiting factor. (merckmanuals.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
Bilateral1
  • Double lung transplant (sometimes called bilateral lung transplant) - In this operation a patient receives two lungs. (gosh.nhs.uk)
Diseases1
Tissue2
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • There is no information about reproductive tissue transplantation as a method of treating infertility in the African Region. (who.int)
Chronic1
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
Acute3
  • I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. (ucsf.edu)
  • The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models. (ucsf.edu)
  • New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. (ucsf.edu)
ISHLT1
Surgery2
  • To prevent the body from rejecting the donor heart, your surgeon will give you powerful drugs (immunosuppressants) right after surgery. (healthlinkbc.ca)
  • This is because some of the nerves that control your heart were cut during your surgery. (healthlinkbc.ca)
Therapeutic1
  • Conservative management with medications and/or lung and cardiac transplantation are therapeutic approaches that can offer quality-of-life improvement. (medscape.com)
Tissues2
  • CPT 33933 describes the standard backbench preparation of a cadaver donor heart/lung allograft before transplantation, including the dissection of the allograft from surrounding soft tissues to prepare the aorta, superior vena cava, inferior vena cava, and trachea for implantation. (codingahead.com)
  • Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
Congenital2
Disorders3
  • done to diagnose heart disorders. (merckmanuals.com)
  • Medical History and Physical Examination for Lung Disorders A doctor first asks the person about symptoms. (merckmanuals.com)
  • to monitor response to treatments and pulmonary rehabilitation, and to predict the risk of disability or death in people with heart and lung disorders. (merckmanuals.com)
Https3
  • https://en.wikipedia.org/wiki/Organ_transplantation. (who.int)
  • https://ec.europa.eu/health/sites/health/files/policies/docs/ev_20191017_co04_en.pdf. (who.int)
  • https://apps.who.int/gb/ebwha/pdf_files/WHA63/A63_24-en.pdf. (who.int)
Modalities1
Therapies1
  • The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
20171
Pathology1
  • The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)
Recipient5
  • This screening is done to be sure that the organ is healthy enough for transplantation and the recipient does not have any medical conditions that would prohibit transplantation. (msdmanuals.com)
  • CPT 33927 describes the implantation of a total replacement heart system (artificial heart) with recipient cardiectomy. (codingahead.com)
  • CPT 33935 describes a heart-lung transplant with recipient cardiectomy-pneumonectomy. (codingahead.com)
  • CPT 33945 describes a heart transplant, with or without recipient cardiectomy. (codingahead.com)
  • The transplantation of a "foreign" organ, despite meticulous matching for donor-recipient compatibility, leads to a complex adaptive and innate immune system-mediated injury. (medscape.com)
Donors1
  • Donors must be under 65 years old, have never smoked, and not have a lung disorder. (msdmanuals.com)
Donor heart4
  • A heart transplant is a procedure in which a surgeon removes a diseased heart and replaces it with a donor heart. (healthlinkbc.ca)
  • The surgeon connects the donor heart to the major blood vessels and hooks the heart up to wires that temporarily control the heartbeat. (healthlinkbc.ca)
  • If your body rejects the heart, you will receive other drugs (such as immunosuppressants or steroids) to suppress your immune system so that it does not reject the donor heart. (healthlinkbc.ca)
  • Clogging of the arteries (atherosclerosis) that may develop in the donor heart. (healthlinkbc.ca)
19882
  • In 1988, a surgeon sewed a new heart into a cowboy. (ctsurgerypatients.org)
  • The Cardiothoracic Transplant Unit at GOSH has been established since 1988 when the first heart transplant at GOSH was performed. (gosh.nhs.uk)
Survival5
  • There are of course associated risks with transplantation, and while the early survival rates after the transplant are good, there can be no guarantees that any particular transplant will be a success. (gosh.nhs.uk)
  • Since 2003, survival in children after lung or heart-lung transplant has significantly improved at GOSH, giving a survival of over 70 per cent at five years, and an estimated survival of more than 50 per cent by seven years. (gosh.nhs.uk)
  • Two recent series from North American centres with extensive experience in transplantation of CF patients have documented 1-yr survival rates of 50% versus 83% and 67% versus 96% among CF patients with and without B. cepacia , respectively 7 , 8 . (ersjournals.com)
  • The doctor strongly expects that a heart transplant will increase survival and improve the person's quality of life. (healthlinkbc.ca)
  • Survival Trend Seen With LVAD in Advanced Heart Failure Some patients with advanced heart failure not on the transplantation wait list might benefit from an LVAD, but robust evidence is lacking on the optimal management of patients in this 'grey zone. (medscape.com)
Programme1
  • During the early years of the lung and heart-lung transplant programme at GOSH (1998) approximately half of the children who received a transplant survived less than four years following transplantation. (gosh.nhs.uk)
Extracorporeal1
  • In heart transplant, there is an increase in the number of heart retransplant patients and an increase in patients on extracorporeal membrane oxygenation. (terasaki.org)
Single-lung1
  • Single Lung Transplant - In this operation a patient receives one lung (left or right), although this is rarely carried out in children. (gosh.nhs.uk)
Procedures2