• harmala
  • It was assumed to be a newly discovered chemical at the time, however, it was soon realized that Telepathine was already more widely known as "harmine" from its previous discovery in Peganum harmala (Syrian Rue). (wikipedia.org)
  • MAOIs
  • Harmine has not been the subject of much clinical research in the treatment of depression, which could be due in part to its restricted legal status in many countries, as well as the existence of synthetic MAOIs with fewer side effects. (wikipedia.org)
  • serotonin
  • The difficulty distinguishing between L-tryptophan and free tryptamine as the precursor of harmine biosynthesis originates from the presence of the serotonin biosynthetic pathway, which closely resembles that of harmine, yet necessitates the availability of free tryptamine as its precursor. (wikipedia.org)
  • found
  • With the radioisotope carbon-11 harmine is used in positron emission tomography neuroimaging to examine its binding to MAO-A. Harmine found in root secretions of Oxalis tuberosa has been found to have insecticidal properties. (wikipedia.org)
  • Harmine has been found to increase EAAT2 glutamate pump expression in central nervous system, therefore reducing glutamate toxicity. (wikipedia.org)
  • various
  • Harmine: evaluation of its antileishmanial properties in various vesicular delivery systems: S. Lala, et al. (adipogen.com)
  • study
  • In this study, harmine was applied to human breast cancer MCF-7 cells. (peerj.com)
  • In a press release to Science Daily, senior study author Andrew Stewart said "the harmine drug class can make human beta cells proliferate at levels that may be relevant for diabetes treatment. (zamnesia.com)
  • Objectives: The aim of the study is to investigate whether harmine affects BoHV-1 infection and the virus induced inflammation related signaling MAPK pathways. (lettersindrugdesigndiscovery.com)
  • cells
  • Research published by Nature Medicine shows that harmine has the ability to regenerate and grow beta cells as well as improve glycaemic control. (zamnesia.com)
  • structure
  • As such, it is unclear if the decarboxylation of L-tryptophan, or the incorporation of pyruvate into the basic tryptamine structure is the first step of harmine biosynthesis. (wikipedia.org)
  • treatment
  • Could Harmine Be A Key In Diabetes Treatment? (zamnesia.com)
  • Researchers are still pleased with the results and it would seem that the medical community are looking forward to finding out more about how harmine could be used as a potential treatment for diabetes. (zamnesia.com)