Hla dq antigens. Medical search. Frequent questions

At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 . (medlineplus.gov)
A matrix approach to human class II histocompatibility antigens: reactions of four monoclonal antibodies with the products of nine haplotypes. (bdbiosciences.com)
Association of various HLA haplotypes with SARS-CoV-2 infection and the course of COVID-19 could improve assessment of viral severity in the population. (antibodies-online.com)
This family study allowed the establishment of the precise composition of the 200 HLA haplotypes, which cannot be obtained from unrelated individuals. (wayne.edu)
Five HLA-B,HLA-DR haplotypes showed significant delta values (observed vs. expected frequencies) after correcting for the number of comparisons. (wayne.edu)
Ten of the 17 HLADR, HLA-DQ haplotypes had significant postcorrection delta values. (wayne.edu)
The relative increase in CII-reactivity in RA patients as compared with healthy control individuals, and the association of a higher response with RA-associated HLA haplotypes, suggest the existence of a potentially pathogenic cellular reactivity against CII in RA. (biomedcentral.com)
Associations of particular dog leucocyte antigen (DLA) class II haplotypes with DM have been identified, but investigations to date have only considered all breeds pooled together. (biomedcentral.com)
In this case-control study, we used next-generation sequencing to determine HLA-DQA1 and ~DQB1 genotypes and haplotypes associated with CeD in Indian patients. (bvsalud.org)
Amplicons were fragmented and sequenced on the Illumina platform, and alleles and haplotypes were assigned by matching against the HLA-international ImMunoGeneTics (IMGT) database. (bvsalud.org)
Among the haplotypes, HLA-DQA1*05:01 ~ HLA-DQB1*02:01 (OR 8.56, 95% CI 5.67-13.19) showed a strong risk association with symptomatic CeD. (bvsalud.org)

Serotyping is capable of identifying most aspects of DQ isoform structure and function, however sequence specific PCR is now the preferred method of determining HLA-DQA1 and HLA-DQB1 alleles, as serotyping cannot resolve, often, the critical contribution of the DQ α-chain. (wikipedia.org)
Researchers have identified hundreds of different versions (alleles) of the HLA-DQB1 gene, each of which is given a particular number (such as HLA-DQB1*06:02 ). (medlineplus.gov)
Methods: Thirty-seven patients with histomorphologic findings of inflammatory AAA at operation were genotyped for the polymorphism of the HLA-DR B1 and HLA-DQ B1 alleles and compared to ethnically matched, healthy control subjects (n = 90). (usuhs.edu)
Results: Distribution of HLA-DR B1 alleles was nonrandom in patients with inflammatory AAAs versus control subjects. (usuhs.edu)
HLA-DR B1 alleles overrepresented in patients with inflammatory AAA express a glutamine substitution at position 70, whereas alleles disfavored in the patient cohort express a negatively charged aspartic acid. (usuhs.edu)
Distribution of HLA-DQ B1 alleles were indistinguishable in patients and control subjects. (usuhs.edu)
Alleles defined by DNA sequencing are named to identify the gene, followed by an asterisk, numbers representing the allele group (often corresponding to the serologic antigen encoded by that allele), a colon, and numbers representing the specific allele (eg, A*02:01, DRB1*01:03, DQA1*01:02). (msdmanuals.com)
We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)
13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)

This region encoded the subunits for DP,-Q and -R which are the major MHC class II antigens in humans. (wikipedia.org)
In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6. (msdmanuals.com)
In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. (edu.au)

While the DQ3 molecules are structurally similar in beta chain, the DQ molecules differ markedly in function, even when present with the same DQ alpha subunit. (wikipedia.org)
This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. (novusbio.com)
The L243 monoclonal antibody reacts with the HLA-DR antigen, a member of MHC class II molecules. (biolegend.com)
for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
Celiac disease (CD), with a 1% world-wide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, that codify for histocompatibility molecules HLA DQ-2/DQ-8. (uandes.cl)
7 T cells only recognize antigens as complexes with MHC molecules. (wholisticmatters.com)
Because every nucleated cell expresses class I MHC molecules, all infected cells can act as antigen-presenting cells for CD8 T cells (CD8 binds to the nonpolymorphic part of the class I heavy chain). (msdmanuals.com)
Some class I MHC genes encode nonclassical MHC molecules, such as HLA-G (which may play a role in protecting the fetus from the maternal immune response) and HLA-E (which presents peptides to certain receptors on natural killer [NK] cells). (msdmanuals.com)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)
Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)
Variable region constitutes the antibody binding region of the molecule to the different antigens as it consists of about 110 amino acids that vary widely among the different antibody molecules. (medscape.com)

The α and β chains are encoded by two loci, HLA-DQA1 and HLA-DQB1, that are adjacent to each other on chromosome band 6p21.3. (wikipedia.org)
The DQ loci are in close genetic linkage to HLA-DR, and less closely linked to HLA-DP, HLA-A, HLA-B and HLA-C. Different isoforms of DQ can bind to and present different antigens to T-cells. (wikipedia.org)
HLA class II antigens (DR, DQ loci) and peripheral arthritis in ankylosing spondylitis. (bmj.com)
Many observations point to a major role for classical HLA loci in determining susceptibility to viral infections 1 . (antibodies-online.com)
The heavy chain of the class I molecule is encoded by genes at HLA-A, HLA-B, and HLA-C loci. (msdmanuals.com)
Individual serologically defined antigens encoded by the class I and II gene loci in the HLA system are given standard designations (eg, HLA-A1, -B5, -C1, -DR1). (msdmanuals.com)
METHODS: HLA-DQA1 and ~DQB1 loci were amplified, using long-range polymerase chain reaction (PCR), from DNA of 259 patients with symptomatic CeD (160 typical and 99 atypical), 45 asymptomatic CeD, 96 potential CeD, and 300 healthy adults. (bvsalud.org)

These children, who carry specific human leukocyte antigen (HLA)-DQ genotypes conferring increased susceptibility to type 1 diabetes, were observed from birth for the appearance of diabetes-associated antibodies and viral infections. (cdc.gov)
One strong indicator for antigenic involvement in RA is the fact that certain major histocompatibility complex (MHC) class II genotypes [human leucocyte antigen (HLA)-DR4 and HLA-DR1] predispose for the development of the disease [ 1 ]. (biomedcentral.com)
To study cellular immune reactivity to CII in patients with RA and in healthy control individuals and to correlate this reactivity to HLA class II genotypes and to the presence of antibodies to CII in serum. (biomedcentral.com)
BACKGROUND AND AIM: Human Leukocyte Antigen DQ (HLA-DQ) genotypes play a permissive role in the genesis of celiac disease (CeD). (bvsalud.org)
RESULTS: HLA-DQA1*05:01 (odds ratio [OR] 8.39, 95% confidence interval [CI] 5.64-12.47) and HLA-DQB1*02:01 (OR 8.59, 95% CI 5.75-12.83) were the genotypes that showed a risk association with symptomatic CeD. (bvsalud.org)
Genotypes consistent with expression of HLA DQ2 and/or 8 were noted in 128 (80%) typical, 73 atypical (74%), 27 (60%) asymptomatic, and 52 (54%) potential CeD participants. (bvsalud.org)

The DQ α subunit is encoded by the HLA-DQA1 gene and the DQ β subunit is encoded by the HLA-DQB1 gene. (wikipedia.org)
The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DQB1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1 . (medlineplus.gov)
The other haplotype, known as DQ8, is composed of the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 bound to the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 . (medlineplus.gov)
A version of the HLA-DQB1 gene called HLA-DQB1*06:02 increases the risk of developing the sleep disorder narcolepsy, particularly in people who also have cataplexy. (medlineplus.gov)
It is unclear how HLA-DQB1*06:02 causes this elevated risk. (medlineplus.gov)
Most people who have narcolepsy with cataplexy have the HLA-DQB1*06:02 variation, and many also have specific versions of other, closely related HLA genes (including HLA-DQA1 ). (medlineplus.gov)
DQB1*0301 the DQ7 gene, is detailed on HLA-DQ7 DQB1*0302 the DQ8 gene, is detailed on HLA-DQ8 DQB1*0303 the DQ9 gene, is detailed on HLA-DQ9 DQB1*0304 is similar in structure and function to DQB1*0301 generally considered to be HLA-DQ7 DQB1*0305 is similar in structure and function to DQB1*0302 generally considered to be HLA-DQ8 Goyert SM, Silver J (1983). (wikipedia.org)
Narcolepsy cataplexy syndrome, characterised by excessive daytime sleepiness and cataplexy, is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02. (plos.org)
It is strongly associated with a genetic marker, human leukocyte antigen (HLA) DQB1*06:02, indicating an autoimmune-mediated process [9] , [10] . (plos.org)
The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological variant(s) remains unknown. (lincoln.ac.uk)
After recalculating the response to CII taking this hyporesponsiveness into account the CII response was higher in RA patients, and was associated with human leucocyte antigen (HLA)-DRB1*0401 and HLA-DQA1*0301-DQB1*0302 (HLA-DQ8). (biomedcentral.com)
When comparing symptomatic CeD with subclinical forms (asymptomatic and potential) CeD, HLA-DQA1*05:01 ~ HLA-DQB1*02:01 (OR 2.34, 95% CI 1.61-3.43) was significantly associated with risk of symptomatic disease. (bvsalud.org)
CONCLUSION: HLA-DQA1*05:01 ~ HLA-DQB1*02:01 (haplotype DQ2.5) showed a very strong risk association with symptomatic CeD in Indian patients. (bvsalud.org)

The strategy of the present work has accordingly been to reinvestigate T-cell reactivity to CII in RA patients, to relate it to the response to commonly used recall antigens and to analyze IFN-γ responses as an alternative to proliferative responses. (biomedcentral.com)
Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. (edu.au)

His postdoctoral training was performed on minor H antigens in organ- and stem-cell transplantation in the laboratory of Prof. Dr. Els Goulmy, Leiden, The Netherlands. (umcutrecht.nl)
His current scientific interest focusses on the role of indirect recognition of mismatched HLA in transplantation and on post-transplant immunomonitoring via Next Generation Sequencing of T- and B-cell receptors and immunoglobulins. (umcutrecht.nl)
The field of the subject invention is the use of major histocompatibility complex antigen lacking cells and organs which may serve as universal donors in cellular and organ therapies including transplantation and to produce chimeric non-human mammals. (justia.com)
Mild Acute Graft-Versus-Host Disease Improves Outcomes After HLA-Haploidentical-Related Donor Transplantation Using Posttransplant Cyclophosphamide and Cord Blood Transplantation. (kyoto-u.ac.jp)

Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Ramos cell lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
Engleman EG, Warnke R, Fox RI, Dilley J, Benike CJ, Levy R. Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. (bdbiosciences.com)
The TU169 monoclonal antibody specifically binds to the human Major Histocompatibility Complex (MHC) Class II HLA-DQ1 and DQ2 antigens and weakly to HLA-DQ3. (bdbiosciences.com)
This antibody does not cross-react with HLA-DR2 and HLA-DR7. (bdbiosciences.com)
Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. (cdc.gov)

As such, successful incorporation of CD4 epitopes into cancer vaccine construction and generation of durable antigen-specific CD4 immunity remains a challenge. (bmj.com)
Additionally, these results represent a novel strategy to rapidly and reproducibly identify class II-promiscuous immunogenic CD4 epitopes from any tumor antigen for cancer immunotherapy using a DC1-Th1 platform. (bmj.com)
Epitopes are a component of the antigen that are recognized by the immune system and determine whether the cellular or the humoral arm of the immune system shall be activated against that particular antigen. (medscape.com)

[ 11 ] Some studies have also shown an association between microscopic colitis and human leukocyte antigen (HLA)-DQ, as noted in celiac disease. (medscape.com)

We measured anti-endomysium antibodies (EMA) by immunofluorescence on monkey esophagus, antihuman-tissue transglutaminase autoantibodies (anti-tTG Abs) by radioimmunoprecipitation, and HLA-DQ2/DQ8 heterodimers by polymerase chain reaction using specific primers. (nih.gov)
EMA, anti-tTG Abs, and HLA-DQ2/DQ8 heterodimers were present in all patients. (nih.gov)
HLA-DQ antigens exits as heterodimers comprised of polymorphic transmembrane HLA-DQ alpha and beta glycoproteins. (bdbiosciences.com)

Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)

Familial clustering and other similarities between inflammatory AAAs and giant cell arteritis (GCA), which possesses a genetic risk determinant mapped to the HLA-DR molecule, suggest a role of genetic risk factors in inflammatory AAAs. (usuhs.edu)
Conclusion: These data indicate that a genetic risk determinant can be mapped to the HLA-DR B1 locus in patients with inflammatory AAAs. (usuhs.edu)
These findings demonstrate for the first time that type 1 diabetes-associated genetic variants that restore immune tolerance to islet antigens also result in functional changes in the gut immune system and resultant changes in the microbiota. (biomedcentral.com)
Genetic response to an environmental pathogenic agent: HLA-DQ and onchocerciasis in northwestern Ecuador. (cdc.gov)

and DQ3 at the DQ locus. (wayne.edu)
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. (edu.au)

In the human population DQ is highly variable, the β subunit more so than the alpha chain. (wikipedia.org)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Differential expression of HLA class II antigens in fetal human spleen: relationship of HLA-DP, DQ, and DR to immunoglobulin expression. (bdbiosciences.com)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)
Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)
To investigate the association between Mooren's ulcer and human leucocyte antigen (HLA) type DR17(3) in patients from the Tamil Nadu State of South India. (bmj.com)
Figure B. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse anti Human HLA DP DQ DR ( MCA477AMO ). (bio-rad-antibodies.com)
Analysis by sequential immunoprecipitations of the specificities of the monoclonal antibodies TU22,34,35,36,37,39,43,58 and YD1/63.HLK directed against human HLA class II antigens. (anticorps-enligne.fr)

HLA-DQ (DQ) is encoded on the HLA region of chromosome 6p21.3, in what was classically known as the "D" antigen region. (wikipedia.org)
Both polypeptide chains are encoded by genes in the HLA-DP, -DQ, or -DR region of chromosome 6. (msdmanuals.com)

But DQ is also involved in recognizing common self-antigens and presenting those antigens to the immune system in order to develop tolerance from a very young age. (wikipedia.org)
The immune system surveys antigens for foreign pathogens when presented by MHC receptors (like HLA DQ). (wikipedia.org)
The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
The distinction between antigen and pathogen is subtle, but key to understanding the dynamic interplay between the innate and acquired immune system. (wholisticmatters.com)
The body's immune system can react adaptively against the antigen via 2 pathways: cellular or humoral. (medscape.com)

The MHC Class II antigens are found on antigen presenting cells (APC) (macrophages, dendritic cells, and B-lymphocytes). (wikipedia.org)
HLA-DQ is expressed primarily on B cells, monocytes, macrophages, dendritic cells and activated T lymphocytes. (bdbiosciences.com)

As part of the system for the self-versus-foreign recognition, the surface membrane protein major histocompatibility complex (MHC) antigens serve an important role. (justia.com)
We describe new information on the frequency and association of class II antigens (HLA-DR and HLA-DQ) of the major histocompatibility complex (MHC) in Mexicans. (wayne.edu)

Class I HLAs present peptides from inside the cell whereas class II HLAs present antigens from outside of the cell to T-lymphocytes. (antibodies-online.com)
A recent study shows that individuals with the allele HLA-B*46:01 have the fewest predicted binding peptides for SARS-CoV-2, suggesting they may be particularly vulnerable to COVID-19, as they were previously shown to be for SARS. (antibodies-online.com)
Using the extracellular domain (ECD) of HER3 as a candidate "oncodriver" tumor antigen, we sought to identify immunogenic HER3 peptides that demonstrate Class II promiscuity and generate anti-HER3 CD4 immunity for inclusion in vaccine development. (bmj.com)
Four immunogenic peptides - HER3(51-75), HER3(402-417), HER3(417-432), HER3(451-465) - were reproducibly identified and promiscuous across HLA-DR, DP, and DQ subtypes. (bmj.com)
DC1 pulsed with an overlapping tumor antigen-derived peptide library can identify promiscuous class II peptides for CD4 T cell vaccine development. (bmj.com)
In this study, immunogenic HER3 CD4 peptides effectively overcome immune tolerance to self-tumor antigens. (bmj.com)

Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)

Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. (cdc.gov)

sub.2 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. (justia.com)
Analysis of functionally relevant amino acid polymorphisms encoded by the HLA-DR B1 gene showed relevance at amino acid position 70. (usuhs.edu)

DQ functions in recognizing and presenting foreign antigens (proteins derived from potential pathogens). (wikipedia.org)
When tolerance to self proteins is lost, DQ may become involved in autoimmune disease. (wikipedia.org)
Others result in changes in regions that are removed when the proteins is processed to the cell surface, still others result in change in the non-functional regions of the protein, and some changes result in a change of function of the DQ isoform that is produced. (wikipedia.org)
As a result, these antibodies can discriminate different classes of DQ based on the recognition similar DQβ proteins known as serotypes. (wikipedia.org)
The increased intestinal permeability was accompanied by augmented expression of genes marking immune cell infiltration and encoding key proteins for immune cell adhesion, antigen presentation, and cytokine signaling in the orbital tissue. (frontiersin.org)
An antigen is a component of a pathogen, such as cell a surface marker comprised of proteins and complex carbohydrates, that is identified by macrophages of the innate immune response as "foreign" to the body. (wholisticmatters.com)
It is important to recognize that MHC class I and MHC class II proteins are specialized to present different types of antigens, thereby eliciting different responses. (wholisticmatters.com)
MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)

2 These observations point towards a potential influence of different HLA composition - the haplotype - in the present SARS-CoV-2 pandemic. (antibodies-online.com)

Alternatively, macrophages and other megalocytes consume cells by apoptotic signaling and present self-antigens. (wikipedia.org)

Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. (novusbio.com)

DQ is made up of two different subunits to form an αβ-heterodimer. (wikipedia.org)
Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. (medlineplus.gov)
Clone L243 binds a conformational epitope on HLA-DRa which depends on the correct folding of the aß heterodimer. (biolegend.com)

The purpose of this study was to explore whether patients with inflammatory AAAs express disease-relevant genes associated with the HLA-DR region on the short arm of chromosome 6. (usuhs.edu)

HLA-DR and HLA-DQ genotyping was performed utilizing a polymerase chain reaction-based technique with sequence-specific oligonucleotide probe hybridization. (biomedcentral.com)

Serological studies of DQ recognized that antibodies to DQ bind primarily to the β-chain. (wikipedia.org)

Th1 responses, measured by IFN-γ ELISA, were considered antigen-specific if IFN-γ production was at least twice that of irrelevant control. (bmj.com)

It does not cross react with HLA-DP and HLA-DQ. (novusbio.com)

A few TCR variants that recognize these DQ/antigen complexes are on CD4 positive (CD4+) T-cells. (wikipedia.org)

Two autoimmune diseases in which HLA-DQ is involved are coeliac disease and type 1 diabetes. (wikipedia.org)

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. (justia.com)

DQ is one of several antigens involved in rejection of organ transplants. (wikipedia.org)

These T-cells, called T-helper cells, can promote the amplification of B-cells which, in turn recognize a different portion of the same antigen. (wikipedia.org)
Antibodies raised against DQ tend to recognize these functional regions, in most cases the β-subunit. (wikipedia.org)

These data demonstrate an association between HLA-DR17(3) and Mooren's ulcer in South Indian patients, supporting autoimmune theories about the pathogenesis of the disorder. (bmj.com)

HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. (cdc.gov)

When B cells become activated by helper T cells, they differentiate into plasma cells which can rapidly form and circulate in the blood stream with antibodies that can bind to the antigens originally engaged by the macrophage. (wholisticmatters.com)
The antibodies then specifically bind to only those particular antigens. (medscape.com)

To analyze whether HLA may be a determinant of the risk of developing cervical cancer precursor lesions, the association between HLA and cervical neoplasia among HPV16-seropositive and -negative subjects was determined in a population-based cohort in the Västerbotten county of Northern Sweden. (nih.gov)
Unravelling an HLA-DR association in childhood acute lymphoblastic leukemia. (bdbiosciences.com)
The study includes HLA-B typing and its association with the HLA-DR antigens determined in 50 families, which included 100 individuals. (wayne.edu)
This association suggests a critical contribution of antigen binding in the pathogenesis of this disease. (usuhs.edu)

HLA class I antigens HLA-A, -C and -E are recognized by CD8+ T cells to mediate cell killing. (hohoweiya.xyz)

HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. (wikipedia.org)
As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft-versus-host disease when lymphoid tissues are transplanted between people. (wikipedia.org)
Normally, these APC 'present' class II receptor/antigens to a great many T-cells, each with unique T-cell receptor (TCR) variants. (wikipedia.org)
HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
Anti-HLA-DR is intended for in vitro diagnostic use in the identification of cells expressing the HLA-DR antigen, using a BD FACS™ brand flow cytometer. (bdbiosciences.com)
Then defined as an antigen presenting cell, the macrophage interacts with circulating helper T cells of the acquired immune response to engage further immunoprotection through interleukin signaling, forming cytotoxic T and B cells. (wholisticmatters.com)
A key mechanism of immune evasion deployed by tumour cells is to reduce neoantigen presentation through down-regulation of the antigen presentation machinery. (portlandpress.com)
The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)

A collection of genes encoding the dog leucocyte antigens (DLA) play a critical role in regulating immune responses and previous studies have implicated a role for these genes in canine DM. (biomedcentral.com)

The lymphoid system is predicated upon recognition of the presence of such MHC antigens as self. (justia.com)

Anatomy5

Organisms1

Diseases1

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes10

Information Science2

Health Care1

Haplotypes12

Alleles10

Humans4

Molecules12

Loci7

Genotypes6

DQB116

Reactivity2

Transplantation4

Antibody7

Epitopes3

Celiac disease1

Heterodimers3

Histocompatibility antigens1

Genetic4

Locus2

Human9

Region of chromosome2

Immune system5

Dendritic cells2

Major histoco2

Peptides6

Pathways1

Allele1

Gene2

Proteins8

Haplotype1

Macrophages1

Tumor1

Heterodimer3

Chromosome1

Genotyping was performed1

Serological1

ELISA1

Cross react1

Complexes1

Type 1 diabet1

Genes associated1

Rejection1

Recognize2

Autoimmune1

DRB11

Bind2

Association4

Mediate1

Cells8

Responses1

Recognition1