A haplotype epidemiologic association with PA involves the expression of both class I and class II human leukocyte antigen (HLA) alleles, including HLA-B13, HLA-B17, HLA-B27, HLA-B38, HLA-B39, HLA-Cw6, HLA-DR4, and HLA-DR7. (medscape.com)
Risk is increased in patients with human leukocyte antigen B27 (HLA-B27) or some other specific alleles (HLA-Cw6, HLA-B38, HLA-B39, HLA-DR) in family members. (msdmanuals.com)
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. (bvsalud.org)
RESULTS: Relative to r-axSpA, patients with axPsA had a lower prevalence of HLA-B27, HLA-C01, and HLA-C02 alleles and a higher prevalence of HLA-B13, HLA-B38, HLA-B57, HLA-C06, and HLA-C12 alleles. (bvsalud.org)
Psoriatic arthritis3
A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma. (wikipedia.org)
[2] Genes associated with psoriatic arthritis include those in the HLA region, which are involved in antigen presentation and immune recognition, and non-HLA genes involved in immune activation and inflammation, including intracellular signaling, cytokine expression, and signaling, and T cell effector function. (nih.gov)
Genetic associations in psoriatic arthritis include HLA-B*08:01, HLA-B*27:05, HLA-B*38:01, HLA-B*39:01, HLA-B*44:02HLA-B*57:01, and HLA-C*06:02 . (nih.gov)
To investigate the relationship between patients diagnosed with nodal generalized osteoarthritis (NGOA) and tissue antigens HLA-A and HLA-B in the Western Black Sea Region of Turkey. (nih.gov)
Allele4
The serotype identifies the B*38 allele products of the HLA-B gene-locus. (wikipedia.org)
Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele Marsh, S. G. (wikipedia.org)
The relationship between positive family history and HLA-B(*)44 allele was also statistically significant. (nih.gov)
Members of this subtype contain alpha chains that are encoded by the HLA-B *38 allele family. (nih.gov)
Frequency1
In the control group, the frequency of HLA-A(*)29 was 11.7% and it was statistically significant. (nih.gov)
Prevalence1
Prevalence of allo-immunization anti-HLA and anti-integrin alphaIIbbeta3 in Glanzmann Thromboasthenia patients. (scielo.br)
Sacroiliitis2
[6] HLA-B*08:01 is also associated with peripheral arthritis, joint damage, asymmetric sacroiliitis, and ankylosis. (nih.gov)
HLA-B*27:05 is associated with axial involvement with symmetric sacroiliitis, enthesitis, and dactylitis. (nih.gov)
Involvement2
B27 is associated with more spinal involvement, while B38 and B39 are associated with peripheral arthritis. (medscape.com)
Axial involvement may be present, especially in male patients with positive HLA-B27, and usually manifests as asymmetric involvement of the sacroiliac joints. (msdmanuals.com)
Human3
PMID- 3894221 TI - Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages. (nih.gov)
AB - A panel of monoclonal antibodies to monomorphic determinants of the MHC class II subregion locus products: DP, DR and DQ, was used to investigate the expression of these antigens on early lymphocytes and macrophages from human fetal liver (13 20 weeks), placenta (16 weeks and term) and cord blood, in relation to the class II phenotype of cells from adult tonsil and peripheral blood. (nih.gov)
Alloimmunization against human platelet antigen (HPA) or human leucocyte antigen (HLA) epitopes is also common 4 4 Santoro C, Rago A, Biondo F, Conti L, Pulcinelli F, Laurenti L, et al. (scielo.br)
Genes1
HLA-B38 and HLA-B39 genes are associated with polyarthritis. (nih.gov)
Genetic1
CONCLUSION: The differences in HLA genetic associations, serum cytokines, and enrichment scores support the concept that axPsA and r-axSpA may be distinct disorders. (bvsalud.org)
Class3
Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes. (bvsalud.org)
Fetal liver sections and cell suspensions showed differential expression of class II antigens. (nih.gov)
These data suggest that class II antigens are expressed in the sequence DP, DR, DQ on developing lymphocytes. (nih.gov)
Sequence1
HLA-A and HLA-B were typed by PCR using sequence specific primer. (nih.gov)
Expression1
a pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (pVAC-Seq) that integrates tumor mutation and expression data (DNA- and RNA-Seq) ( original article ). (sixthresearcher.com)
Patients3
In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients. (wikipedia.org)
The frequencies of HLA-A(*)02 and HLA-B(*)38 were 58.7% and 15.2%, respectively, in patients with NGOA, and there was a statistically significant relationship between the disease and HLA-A(*)02 and HLA-B(*)38. (nih.gov)
[6] (See Table 1) The subset of patients with symmetric polyarthritis is associated with HLA-DR4 (this gene is associated with RA). (nih.gov)
Specific2
A specific HLA-B surface antigen subtype. (nih.gov)
In non-rejector combinations, liver allografts possess remarkable properties of tolerance induction and antigen-specific immunosuppression, leading to a state of donor-specific unresponsiveness in which grafts of other organs are also accepted. (nih.gov)
Positive1
If a positive result was obtained, a confirmatory step using the Monoclonal Antibody Immobilization of Platelet Antigens (MAIPA) and Luminex bead-based platelet assay (PAKLx) was executed. (scielo.br)
Study1
To our knowledge this is the first study to demonstrate the epidemiologic association between HLA-A(*)02 and HLA-B(*)38 with NGOA in our population. (nih.gov)
Present1
HLA-B27 is present in 60% of individuals with the disease, as compared with 8% of the general population. (medscape.com)
Type1
B38 is a split antigen of the broad antigen B16, and is a sister type of B39. (wikipedia.org)