CytotoxicAllelesLymphocytesHistocompatibility antigensMultiple antigensPeptideHumoralDRB1Cross-reactiveGenePeptidesCTLsTransgenicOrgan transplantAntibodiesTumorHumanProteinsAntibodyInductionMoleculesDonorEpitopeVaccinationCellularProteinTherapeuticFrequencyPatientsClassMiceCellsDonorsIncidenceDetectionSpecificKidneyPatientUniqueTypeSystemVirus
Cytotoxic5
- Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)
- Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
- Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
- cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice. (umassmed.edu)
- We previously identified papillomavirus binding factor (PBF) as an osteosarcoma antigen recognized by an autologous cytotoxic T lymphocyte clone. (bvsalud.org)
Alleles3
- A few studies have been conducted regarding the relationship between HLA alleles and the incidence of recurrent aphthous stomatitis in different human populations especially in the Iranian population (15). (ac.ir)
- Circulating T cells reactive against NY-ESO-1, MART-1, gp100 and TYRP-1, were found in 12/23 pts expressing at least one of the HLA-A1, A2, -A3 or A24 alleles with induction or augmentation of TAA reactivity in the course of treatment. (bmj.com)
- H-2-deficient mice transgenic for either A2, A24, B7, DR2, DR3, or DR4 HLA alleles were immunized with overlapping peptides of the WNV proteome, and peptide-specific T-cell activation was measured by gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) assays. (ox.ac.uk)
Lymphocytes5
- They include the involvement of HLA-DR4 genes and the infiltration of CD4 lymphocytes, eosinophils, mast cells, and a serum increase of immunoglobulin E (IgE). (medscape.com)
- Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice. (umassmed.edu)
- MRP-L28 (39S ribosomal protein L28, melanoma-associated antigen recognized by T lymphocytes) is a mitochondrial protein that belongs to the ribosomal protein L28P family. (thermofisher.cn)
- Peripheral blood lymphocytes (PBMC) and sera were collected at baseline, wk12, and wk24 to perform phenotypic and functional T cell assays, and to investigate humoral responses against a panel of tumor-associated antigens (TAAs) and soluble NKG2D ligands (sNKG2DL). (bmj.com)
- In order to determine whether or not a patient already has any specific HLA antibodies, a lab specialist will test a patient's blood (serum) against lymphocytes (white blood cells) obtained from a panel of about 100 blood donors. (hrsa.gov)
Histocompatibility antigens1
- This study aimed to determine the relationship between one of the histocompatibility antigens (HLA DRB1) and its sub-groups with the incidence of recurrent aphthous ulcers in an Iranian population (North East of Iran). (ac.ir)
Multiple antigens1
- A total of 26/33 evaluable patients treated at 1280 μg developed an immune response, directed against multiple antigens in 15 out of 33 patients. (biomedcentral.com)
Peptide6
- Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
- Vaccination with PBF-derived peptide presented by HLA-A24 (PBF peptide) elicited strong immune responses. (bvsalud.org)
- PBF TCR was successfully transduced into T cells and detected using HLA-A*24:02/PBF peptide tetramer. (bvsalud.org)
- PBF TCR-T cells generated from a healthy donor were highly expanded and recognized T2-A24 cells pulsed with PBF peptide, HLA-A24+ 293T cells transfected with PBF cDNA, and sarcoma cell lines. (bvsalud.org)
- Hybrid PBF TCR-T cells also showed reactivity against T2-A24 cells pulsed with PBF peptide and to HLA-A24+ 293T cells transfected with various lengths of PBF cDNA including the PBF peptide sequence. (bvsalud.org)
- The most restrictive step involved in antigen presentation is binding of the peptide to MHC class I. It is estimated that only 1 out of 200 peptides will bind a given MHC class I allele with sufficient strength to elicit a CTL response [ 9 ]. (biomedcentral.com)
Humoral3
- Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice. (umassmed.edu)
- 1. Introduction Sensitization to HLA antigens in organ transplant patients causes graft rejection, according to the humoral theory of transplantation [1]. (mundial-brasil2014.net)
- Although the sensitivity of naturally occurring SARS-CoV-2 variants to humoral immunity has been investigated, sensitivity to human leukocyte antigen (HLA)-restricted cellular immunity remains largely unexplored. (pasteur.fr)
DRB15
- The frequency of HLA -DRB1 *16 was 0.7% in the healthy subjects, however frequency of HLA -DRB1 *16 in patients with recurrent aphthous stomatitis (RAS) was 42.36%, and this difference was statistically significant (P=0.03). (ac.ir)
- Polymerase chain reaction was performed to amplify exons 2 and 3 of the HLA-A and HLA-B loci and exon 2 of the HLA-DRB1 locus using group-specific primer sets. (tmu.edu.tw)
- We deduced the probable HLA haplotype in association with B*40:01:35 in Taiwanese to be A*24-B*40:01:35-DRB1*11. (tmu.edu.tw)
- Since 2006, we defined and reported 194 HLA class I unique epitopes, including 56 cryptic epitopes on dissociated HLA class I heavy chains, 83 HLA class II epitopes, 60 epitopes on HLA-DRB1, 15 epitopes on HLA-DQB1, 3 epitopes on HLA-DQA1, 5 epitopes on HLA-DPB1, and 7 MICA epitopes. (mundial-brasil2014.net)
- OBJECTIVE- HLA-DRB1* 03 -DQB1* 0201 /DRB1* 04 -DQB1* 0302 ( DR3/4-DQ8 ) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. (diabetesjournals.org)
Cross-reactive2
- The RAS etiology is less described, despite the overall agreement about the role of autoimmune reaction to oral mucosa or cross-reactive antigens. (ac.ir)
- The phenomenon of cross-reactivity in HLA testing, often explained as cross-reactive groups (CREGs) of antigens with antibody, can be clearly explained now by public epitopes. (mundial-brasil2014.net)
Gene2
- This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. (wikipedia.org)
- HLAA24 (A24) is an HLA-A serotype that identifies the more common HLA-A24 gene products. (thermofisher.cn)
Peptides3
- The HLA class I histocompatibility antigen, A-24 alpha chain (HLA-A) is a α- or alpha protein sometimes glycoprotein present in blood.Antigens are peptides or recombinant or native dependent on the production method. (hla-a.com)
- Approximately 30% (137) of the WNV proteome peptides were identified as HLA-restricted T-cell ligands. (ox.ac.uk)
- In the large-scale benchmark calculation consisting of 216 known HIV epitopes covering all 12 recognized HLA supertypes, the NetCTL-1.2 method was shown to have a sensitivity among the 5% top-scoring peptides above 0.72. (biomedcentral.com)
CTLs3
- Thus, we conducted immune- and RNA-sequencing of HLA-A24-restricted CMVpp65-specific CTLs to better understand the immune reconstitution of CMV-CTLs after allo-HCT. (nature.com)
- To the best of our knowledge, this is the first report on the features of TCRβ-CDR3, diversity, and GEP of HLA-A24 CMV-CTLs according to the CMV-reactivation pattern among recipients after allo-HCT. (nature.com)
- Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)
Transgenic3
- HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells. (umassmed.edu)
- Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice. (umassmed.edu)
- TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. (umassmed.edu)
Organ transplant1
- In the case of an organ transplant, the body will recognize the HLA antigens on the transplanted organ as not being the same as its own, and form specific antibodies against those particular HLA antigens. (hrsa.gov)
Antibodies10
- Sensitization is almost ubiquitous as anti-HLA antibodies are found in almost all sera of transplant recipients. (mundial-brasil2014.net)
- It is commonly understood that antibodies bind to HLA antigens. (mundial-brasil2014.net)
- With current knowledge of epitopes, it is more accurate to describe that antibodies bind to their target epitopes on the surface of HLA molecular chains. (mundial-brasil2014.net)
- Sensitization is almost ubiquitous as it is evident in the detection of anti-HLA antibodies in the sera of recipientsin one study, almost all patients waiting for regraft of a kidney transplant have anti-HLA antibodies [2]. (mundial-brasil2014.net)
- The reactivity of anti-HLA antibodies with HLA antigens and the phenomenon of cross-reactivity has been the subject of investigation for decades. (mundial-brasil2014.net)
- however, it is more accurate to describe the reactivity of the antibody as binding to specific epitopes on the surface of HLA antigensepitopes are conformational amino acid arrangements and are the targets of antibodies. (mundial-brasil2014.net)
- For example, a patient could develop antibodies to A2 and A24. (hrsa.gov)
- HLA antigens are substances, usually a protein, found on the surface of our cells that stimulate the production of antibodies. (hrsa.gov)
- Second, because of previous medical events, some patients have already developed antibodies to specific HLA antigens. (hrsa.gov)
- Chimeric antibodies consist of an antibody's original antigen-binding variable domain with the constant domain from a different species. (absoluteantibody.com)
Tumor4
- Identification of a tumor-specific allo-HLA-restricted ?dTCR. (umassmed.edu)
- MRP-L28 potentially represents an important therapeutic reagent for HLA-A24 (A24) patients as this antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290, which targets the A24 serotype. (thermofisher.cn)
- Vaccination with messenger RNA (mRNA) encoding full-length tumor antigens is a novel option for immunotherapy. (biomedcentral.com)
- In a phase I/II trial in patients with metastatic melanoma, direct intra-dermal injection of mRNA coding for relevant tumor-associated antigens was well tolerated and influenced the frequency of vaccine-antigen directed CD4 and CD8 T cells as well as regulatory T cells (T Regs). (biomedcentral.com)
Human9
- Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice. (umassmed.edu)
- null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease. (umassmed.edu)
- Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice. (umassmed.edu)
- Major histocompatibility complex (MHC) class I and II molecules which are called human leukocyte antigens (HLA), play an important role in the immune response (16). (ac.ir)
- Objective: Human leukocyte antigen (HLA)-B*40:01:35 is a low incidence allele in the HLA-B locus. (tmu.edu.tw)
- We examined the relationships of human leukocyte antigen (HLA) and related polymorphisms to glioblastoma multiforme in adult Caucasians (non-Hispanic Whites) from the San Francisco Bay area. (aacrjournals.org)
- HLA stands for Human Leukocyte Antigen. (hrsa.gov)
- Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection, which is currently achieved by matching for human leukocyte antigen (HLA) expression, immunosuppression, and/or delivery of donor-derived cells to sanctuary sites. (ashpublications.org)
- This study focused on the identification of human leukocyte antigen (HLA)-restricted West Nile virus (WNV) T-cell ligands and characterization of their distribution in reported sequence data of WNV and other flaviviruses. (ox.ac.uk)
Proteins3
- computer simulations of proteolysis of marburg and ebola-zaire filovirus coded proteins to generate nonapeptides with motifs of known hla class i haplotypes and detection of antigenic domains in the viral glycoproteins. (liverpool.ac.uk)
- the primary amino acid sequences of the proteins coded by marburg and ebola-zaire filoviruses were studied by computer programs to search for putative proteolytic cleavages which yield nonapeptides with motifs of binding to known hla class i haplotypes. (liverpool.ac.uk)
- a few nonapeptides with motifs hla class i a24, b8, b27 and b35 were predicted in marburg virus proteins. (liverpool.ac.uk)
Antibody4
- Advances in testing assays and amino acid sequencing of HLA along with computer software contributed further to the understanding of antibody-antigen reactivity. (mundial-brasil2014.net)
- Determining specificity of the anti-HLA antibody has advanced in recent years using recombinant CHMFL-ABL-039 HLA single antigens (SA) coated on color-coded Luminex beads [3]. (mundial-brasil2014.net)
- Amino acid sequences of the HLA molecules which greatly contributed to our understanding of antibody and antigen reactivity has been introduced since 1963 [4C12]. (mundial-brasil2014.net)
- For example, if a candidate has developed a specific antibody to the HLA antigen A2, that person is said to be "sensitized" to the A2 antigen. (hrsa.gov)
Induction1
- The primary endpoint was safety and tolerability, the secondary endpoint was induction of antigen specific immune responses monitored at baseline and at weeks 5, 9 and 17. (biomedcentral.com)
Molecules1
- These molecules of cell surface play a critical role in antigen processing and T cell activity. (ac.ir)
Donor7
- The objective of this study is to report the ethnicity of B*40:01:35 and its deduced probable HLA associated haplotype in a Taiwanese unrelated bone marrow hematopoietic stem cell donor. (tmu.edu.tw)
- In addition, it can be used by stem cell transplantation donor search coordinators to determine a strategy for finding compatible donors in unrelated bone marrow donor registries when a patient has this uncommon HLA allele. (tmu.edu.tw)
- These 100 donors represent the potential HLA makeup for a donor from that area. (hrsa.gov)
- That way a potential donor with the unacceptable antigen will not even be considered for that candidate. (hrsa.gov)
- We also know the number of times A2 and A24 appear in our national donor pool. (hrsa.gov)
- Allogeneic-donor-derived cells can be genetically modified to eliminate expression of HLA-A. (ashpublications.org)
- HLA-A disruption from donor cells is a step toward generating allogeneic cells as an off-the-shelf therapeutic. (ashpublications.org)
Epitope8
- Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection. (expasy.org)
- Figure G. Epitope 5037 shared by the HLA C-locus antigens Cw4, Cw6, Cw17, Cw18 and defined by 73A+77N. (mundial-brasil2014.net)
- Figure H HLA class II DQB epitope 2007 shared by DQ4,5,6 antigens and define by 52P+55R on the beta chain of the DQ antigens. (mundial-brasil2014.net)
- Figure J. Epitope 2018 shared by the alpha chains of the DQ4, 5, 6 antigens and defined by Glutamine (Q) at position 53. (mundial-brasil2014.net)
- Figure K. Epitope 2002 shared exclusively by the beta chains of the DQ4 antigen and defined by Leucine (L) in position 56. (mundial-brasil2014.net)
- Figure L. Epitope 2010 shared by the beta chains of DQ antigens DQ4, 5, 6, 8, 9 and defined by 45G+46V. (mundial-brasil2014.net)
- Figure M. Epitope 2022 exclusive to DQB1?05:01 chain on the DQ5 antigen and defined by 125S+126Q. (mundial-brasil2014.net)
- Figure N. Epitope 2006 shared by DQB1?03:01 (DQ7), DQB1?03:02 (DQ8), DQB1?03:03 (DQ9) and defined by Proline (P) at position 55 on the beta chains of the DQ antigens. (mundial-brasil2014.net)
Vaccination1
- The follow-up vaccine CV9104 including the additional antigens prostatic acid phosphatase (PAP) and Muc1 is currently being tested in a randomized phase IIb trial to assess the clinical benefit induced by this new vaccination approach. (biomedcentral.com)
Cellular2
- Here, we demonstrate that two recently emerging mutations in the receptor-binding domain of the SARS-CoV-2 spike protein, L452R (in B.1.427/429 and B.1.617) and Y453F (in B.1.1.298), confer escape from HLA-A24-restricted cellular immunity. (pasteur.fr)
- These data suggest that HLA-restricted cellular immunity potentially affects the evolution of viral phenotypes and that a further threat of the SARS-CoV-2 pandemic is escape from cellular immunity. (pasteur.fr)
Protein1
- At this point, the antigen that provokes the inflammatory reaction is not clear, but an epidermal protein is believed to be transformed by UV exposure. (medscape.com)
Therapeutic1
- The cell-based therapeutic vaccine Sipuleucel T targeting the antigen PAP has been approved by the US Food and Drug Administration in 2010 and recently by the European Medicines Agency for the treatment of asymptomatic - minimally symptomatic metastatic CRPC based on a median prolongation in overall survival by 4.1 months compared to placebo controls [ 4 ]. (biomedcentral.com)
Frequency1
- Type 1 diabetes is characterized by the destruction of the insulin-secreting β-cells of the islets of Langerhans, by the production of little or no insulin, and, in most cases, by immune-mediated pathogenetic mechanisms highlighted by the presence of islet cell autoantibodies and by an altered frequency of immune-regulating genes in the HLA region. (diabetesjournals.org)
Patients2
- Such patients probably have the same disease process as patients with type 1 diabetes in that they have similar HLA genetic susceptibility as well as autoantibodies to islet antigens, low insulin secretion, and a higher rate of progression to insulin dependency. (diabetesjournals.org)
- Eighteen HLA- A*2402-positive colorectal cancer patients who had failed to standard therapy were enrolled in this study. (biomedcentral.com)
Class2
- However, the relationship between HLA-class I (HLA-A, -B and -C) and HLA-class II (DR, -DQ - DP) with oral disorder has not yet been investigated extensively (16). (ac.ir)
- the computer analyses predicted that numerous nonapeptides with motifs to bind hla class i a68 and a2 haplotypes were detected. (liverpool.ac.uk)
Mice1
- Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. (umassmed.edu)
Cells1
- Because these cells are resistant to their demise after UV exposure, they might handle and deliver UV-modified cutaneous antigens to T cells in larger amounts or in a more persistent way. (medscape.com)
Donors2
- Entering unacceptable antigens for candidates increases the efficiency of organ allocation by screening off incompatible donors. (hrsa.gov)
- To determine the CPRA value, the computer system will use an established formula and HLA frequencies derived from the HLA types found in more than 12,000 donors. (hrsa.gov)
Incidence1
- Conclusion: Information on the deduced probable HLA haplotype in association with the low incidence B*40:01:35 allele that we report here is of value for HLA testing laboratories for reference purposes. (tmu.edu.tw)
Detection3
- development of the immunoenzyme test-system for detection of ebola virus antigen]. (liverpool.ac.uk)
- an enzyme immunoassay system has been developed for the detection of ebola virus antigen. (liverpool.ac.uk)
- it permits a highly accurate and sensitive rapid detection of the antigen. (liverpool.ac.uk)
Specific2
- HLA polymorphism can directly affect the bonding capacity of antigens and thus affect antigen-specific T-cell response (17). (ac.ir)
- Thus, both the occurrence and the prognosis of glioblastoma multiforme could be associated with specific but different HLA genotypes. (aacrjournals.org)
Kidney1
- If the patient were transplanted with a kidney that had A2 and/or A24, it could be rejected hyperacutely. (hrsa.gov)
Patient2
Unique1
- Each person's HLA make-up is unique. (hrsa.gov)
Type1
- A24 is a split antigen that is also recognized by the A9 broad antigen type and the similar A23 types. (thermofisher.cn)
System1
Virus1
- the biochemical and hemostatic parameters were compared in guinea pigs after inoculation of ebola virus strains lethal and nonlethal for them and of inactivated antigen of this virus. (liverpool.ac.uk)