Loading...
  • patients
  • This is an open-label (all people know the identity of the intervention), multi-center (study conducted at multiple sites), uncontrolled (all the patients receiving darunavir) clinical and observational study (study in which the investigators/physicians observe the patients and measure their outcomes) to evaluate the safety and effectiveness of darunavir for the treatment human immunodeficiency virus-type 1 (HIV-1) infection among adult Filipino patients. (clinicaltrials.gov)
  • To evaluate, in HIV-infected patients whose baseline CD4 count is 300 to 750 cells/mm3, whether an antiretroviral treatment regimen based upon clinical evaluation and CD4 counts plus HIV RNA viral load is more effective than a treatment regimen based upon clinical evaluation and CD4 counts without the use of HIV RNA viral load information. (clinicaltrials.gov)
  • It is hypothesized that among HIV-infected patients whose baseline CD4 count is in the range of 300 to 750 cells/mm3, those patients who incorporate initial and periodic viral RNA measurements in their therapeutic decisions will have higher CD4 counts after 48 weeks than patients whose therapeutic decisions do not incorporate initial and periodic viral RNA measurements. (clinicaltrials.gov)
  • Abstract
  • article{ff4f8a23-6ca4-4f67-9971-6842888c6b56, abstract = {Human immunodeficiency virus type-2 (HIV-2) infected individuals develop immunodeficiency with a considerable delay and transmit the virus at a lower rate as compared to HIV-1 infected. (lu.se)
  • human immun
  • The etiological agent of acquired immunodeficiency syndrome (AIDS) is the retrovirus referred to as human immunodeficiency virus (HIV) (Montagnier et al. (google.es)
  • The discovery of medicinal agents capable of specifically inhibiting human immunodeficiency virus (HIV) is urgently needed due to its globally widespread infection. (ingentaconnect.com)
  • Human immunodeficiency virus type-2 (HIV-2) infected individuals develop immunodeficiency with a considerable delay and transmit the virus at a lower rate as compared to HIV-1 infected. (lu.se)
  • magnitude
  • Using the area-under-curve (AUC)-based readout, multivariate statistical analysis confirmed that type of HIV infection was independently associated with the magnitude of the C' effect. (lu.se)
  • study
  • In the present study we have further examined the function of the humoral immune response and studied the potentiating effect of complement (C') on antiviral activity of plasma from singly HIV-1 or HIV-2 infected, as well as HIV-1/HIV-2. (lu.se)
  • Aids
  • Despite the drop in new infections, black women are still at a high risk for HIV, the virus that causes Aids. (medhelp.org)
  • Luo and Perelson's research was supported by the National Institute of Health through a grant to the Duke Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID). (lanl.gov)
  • Blick G et al (2007) The probable source of both the primary multidrug-resistant (MDR) HIV-1 strain found in a patient with rapid progression to AIDS and a second recombinant MDR strain found in a chronically HIV-1-infected patient. (springer.com)
  • Washington, June 11 (ANI): An international team of researchers claim to have identified the 'hijacking mechanism' of human immunodeficiency virus type 1 (HIV-1)- a finding that could lead to novel treatments for the AIDS. (thaindian.com)
  • An international team of scientists, led by researchers at the University of Alabama at Birmingham (UAB), has discovered a crucial missing link in the search for the origin of HIV-1, the virus responsible for human AIDS. (rxpgnews.com)
  • HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. (wikipedia.org)
  • Management of HIV/AIDS Discovery and development of HIV-protease inhibitors The MEROPS online database for peptidases and their inhibitors: A02.001 Proteopedia HIV-1_protease - the HIV-1 protease structure in interactive 3D HIV-1 Protease at the US National Library of Medicine Medical Subject Headings (MeSH) Davies DR (1990). (wikipedia.org)
  • He served as an investigator of the DBT-IAVI Programme jointly organized by the Department of Biotechnology]] and International AIDS Vaccine Initiative for the development of HIV vaccines. (wikipedia.org)
  • study of SIVcpz in wild living chimpanzees suggests that infected chimpanzees experience an AIDS-like illness similar to HIV-1 infected humans. (wikipedia.org)
  • The simian (monkey-hosted) immunodeficiency viruses are a species of retrovirus in the Primate group of genus Lentivirus along with the human viruses HIV-1 and HIV-2 that cause AIDS, and a few other viruses that infect other primates. (wikipedia.org)
  • The discovery of SIV was made shortly after HIV-1 had been isolated as the cause of AIDS and led to the discovery of HIV-2 strains in West Africa. (wikipedia.org)
  • HIV-2 is common in West Africa, but is much rarer in the United States than HIV-1, which is more virulent and progresses more quickly to the fully fledged AIDS disease. (wikipedia.org)
  • As of 2016, about 675,000 people have died of HIV/AIDS in the USA since the beginning of the HIV epidemic. (wikipedia.org)
  • The overall death rate among persons diagnosed with HIV/AIDS in New York City decreased by 62% from 2001 to 2012. (wikipedia.org)
  • The second prong of the American approach to containment has been to maintain strict entry controls to the country for people with HIV or AIDS. (wikipedia.org)
  • simian virus
  • According to UAB post-doctoral researcher Brandon Keele, Ph.D., lead author of the report, this allowed for unprecedented genetic comparisons to be done between HIV-1 and its closest simian virus counterpart. (rxpgnews.com)
  • this allowed for unprecedented genetic comparisons to be done between HIV-1 and its closest simian virus counterpart. (rxpgnews.com)
  • PMID
  • Nucleic Acids Research Database issue Volume 42 Issue D1 1 January 2014 PubMed PMID 24214957. (wikipedia.org)
  • proteins
  • On episode #232 of the science show This Week in Virology , Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates. (virology.ws)
  • Assembly of this Rev-RRE complex is followed by the recruitment of a human protein complex containing the proteins exportin-1 (XPO1/CRM1) and Ran-GTP. (wikipedia.org)
  • This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. (wikipedia.org)
  • Afterwards, PDI can be regenerated to its oxidized form in the endoplasmic reticulum by transferring electrons to reoxidizing proteins such ER Oxidoreductin 1 (Ero 1), VKOR (vitamin K epoxide reductase), glutathione peroxidase (Gpx7/8), and PrxIV (peroxiredoxin IV). (wikipedia.org)
  • This is regulated by three ER membrane proteins, Protein Kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring kinase 1 (IRE1), and activating transcription factor 6 (ATF6). (wikipedia.org)
  • molecule
  • Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle. (springer.com)
  • CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. (wikipedia.org)
  • lymphocytes
  • On episode #278 of the science show This Week in Virology , Vincent, Dickson, Alan, and Kathy discuss disruption of the ccr5 gene in lymphocytes of patients infected with HIV-1. (virology.ws)
  • integrase
  • On episode #314 of the science show This Week in Virology , Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells. (virology.ws)
  • retroviruses
  • However, due to the high mutation rates of retroviruses, and considering that changes to a few amino acids within HIV protease can render it much less visible to an inhibitor, the active site of this enzyme can change rapidly when under the selective pressure of replication-inhibiting drugs. (wikipedia.org)
  • latency
  • HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. (springer.com)
  • Cell-associated (CA) HIV RNA has received much attention in recent years as a surrogate measure of the efficiency of HIV latency reversion and because it may provide an estimate of the viral reservoir size. (biomedcentral.com)
  • protein
  • HIV protease's protein structure has been investigated using X-ray crystallography. (wikipedia.org)
  • According to the mechanism for HIV protease protein cleavage proposed by Mariusz Jaskolski and colleagues, water acts as a nucleophile, which acts in simultaneous conjunction with a well-placed aspartic acid to hydrolyze the scissile peptide bond. (wikipedia.org)
  • He is known for his researches in the fields of protein structure and protein folding and his contributions in developing vaccines and drugs for treating a type of fatal influenza and HIV-1. (wikipedia.org)
  • One of these small, 2kb messages encodes the HIV-1 Rev protein which is imported into the nucleus via its nuclear localization sequence. (wikipedia.org)
  • CD1D is the human gene that encodes the protein CD1d, a member of the CD1 (cluster of differentiation 1) family of glycoproteins expressed on the surface of various human antigen-presenting cells. (wikipedia.org)
  • Influenza
  • The discovery of bNAbs has led to an important area of research, namely, discovery of a vaccine, not only limited to HIV, but also other rapidly mutating viruses like Influenza, etc. (wikipedia.org)
  • Holding the position of a professor of Molecular Biophysics Unit, he heads The Varadarajan Laboratory of IISc which has research interests in the design of HIV-1 and influenza immunogens. (wikipedia.org)
  • individuals
  • Castor D et al (2012) Transmitted drug resistance and phylogenetic relationships among acute and early HIV-1-infected individuals in New York City. (springer.com)
  • The risk of being infected with human immunodeficiency virus type 1 (HIV-1) is substantially enhanced in individuals with other sexually transmitted diseases. (virology.ws)
  • nucleic
  • In 2002, Gen-Probe received approval of its Biologics License Application (BLA) for the first FDA-approved nucleic acid test for HIV-1 and HCV in donated human blood. (bio-medicine.org)
  • CXCR4
  • These cells express the HIV-1 receptors CD4 and CCR5, but not CXCR4, and can therefore be infected with CCR5-tropic* but not CXCR4-tropic HIV-1. (virology.ws)
  • CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells. (wikipedia.org)
  • HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. (wikipedia.org)
  • It is unclear as to whether the emergence of CXCR4-using HIV is a consequence or a cause of immunodeficiency. (wikipedia.org)
  • Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikipedia.org)
  • In a small human clinical trial to evaluate the safety and efficacy of fucoidan ingestion (brown seaweed extract), 3g daily of 75% w/w oral fucoidan for 12 days increased the proportion of CD34+CXCR4+ from 45 to 90% and the serum SDF-1 levels, which could be useful in CD34+ cells homing/mobilization via SDF-1/CXCR4 axis. (wikipedia.org)
  • Citation
  • citation needed] Some HIV-positive travellers took to sending anti-HIV medication through the post to friends or contacts in advocacy groups in advance. (wikipedia.org)
  • citation needed] This process was condemned as intrusive and invasive by a number of advocacy groups, on the grounds that any time the passport was later used for travel elsewhere or for identification purposes, the holder's HIV status would become known. (wikipedia.org)
  • infect
  • Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIV's ability to replicate and infect additional cells, making HIV protease inhibition the subject of considerable pharmaceutical research. (wikipedia.org)
  • vaccine
  • Scientists have created a computational model that could change the way that researchers look at possibilities for an HIV-1 vaccine. (lanl.gov)
  • viruses
  • An HIV-1 infected person can make as many as 10,000,000,000 virus particles each day, so 10 10 /10 4 = one million viruses will be produced each day with resistance to one drug. (virology.ws)
  • Discovery
  • This discovery is extremely exciting because now that researchers understand a little more about how the cell's transport machinery is hijacked by HIV-1, they have hopes that they can now begin to devise strategies to block the process, he added. (thaindian.com)
  • The following table shows the characteristics of various HIV-1 bNAbs Recent years have seen an increase in HIV-1 bNAb discovery. (wikipedia.org)
  • Online databases like bNAber and LANL constantly report and update the discovery of new HIV bNAbs. (wikipedia.org)
  • Molecular
  • Additionally, HIV protease has two molecular "flaps" which move a distance of up to 7 Å when the enzyme becomes associated with a substrate. (wikipedia.org)
  • HIV-1 protease molecular dynamics of a wild-type and of the V82F/I84V mutant: possible contributions to drug resistance and a potential new target site for drugs" (PDF). (wikipedia.org)
  • test
  • Does anyone know of an HIV-1 DNA test panel that can be used to establish sensitivity/specificity of a set of pcr reagents. (bio.net)
  • I saw on a previous thread that thai testing procedures are quite up-to-date and that recently thailand was praised for its hiv stratagy generally, so I am assuming that the test was third or fourth gen. (medhelp.org)
  • I also read however that there is minimal incidence of hiv 2 in thailand and therefore it is not mandatory to test for it, thats what had me worried. (medhelp.org)