• The metabolism of L-fucose. (wikipedia.org)
  • A rare defect of fucose metabolism leading to a syndrome that combines neutrophil adhesion deficiency with severe neurological impairment, psychomotor retardation, and short stature. (mhmedical.com)
  • Rare leukocyte adhesion deficiency type II (LAD II) is due to an inborn error in fucose metabolism caused by mutations in the guanosine diphosphate-fucose transporter gene. (lu.se)
  • This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)
  • Cell‐free multi‐enzyme synthesis and purification of uridine diphosphate galactose. (mpg.de)
  • 2. Maxwell, E.S. and de Robichon-Szulmajster, H. Purification of uridine diphosphate galactose-4-epimerase from yeast and the identification of protein-bound diphosphopyridine nucleotide. (qmul.ac.uk)
  • In enzymology, a fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) is an enzyme that catalyzes the chemical reaction GTP + beta-L-fucose 1-phosphate ⇌ {\displaystyle \rightleftharpoons } diphosphate + GDP-L-fucose Thus, the two substrates of this enzyme are GTP and beta-L-fucose 1-phosphate, whereas its two products are diphosphate and GDP-L-fucose. (wikipedia.org)
  • The systematic name of this enzyme class is GTP:beta-L-fucose-1-phosphate guanylyltransferase. (wikipedia.org)
  • The researchers discovered that the enzyme can accept a broad range of substrates, so they attached an antibody to the enzyme's normal substrate, guanosine diphosphate fucose. (acs.org)
  • Other names in common use include GDP fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, GDP-L-fucose pyrophosphorylase, GDP-fucose pyrophosphorylase, and GTP:L-fucose-1-phosphate guanylyltransferase. (wikipedia.org)
  • Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate. (nih.gov)
  • The GDP-Fuc de novo pathway, which requires the action of GDP-mannose 4,6-dehydratase (GMD) and GDP-L-fucose synthase (FS), is conserved in the parasite genome, but the importance of fucose metabolism for the parasite is unknown. (johnshopkins.edu)
  • GDP-mannose is a nucleoside diphosphate sugar that is important in the production of fucosylated oligosaccharides. (ecmdb.ca)
  • GDP-mannose is transformed to GDP-fucose via three enzymatic reactions carried out by two proteins, GDP-mannose 4,6-dehydratase (GMD) and a second enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase. (ecmdb.ca)
  • The epimerase converts the GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. (ecmdb.ca)
  • A nucleoside diphosphate sugar formed from GDPmannose, which provides fucose for lipopolysaccharides of bacterial cell walls, and for blood group substances and other glycoproteins. (nih.gov)
  • TSTA3 gene encodes an enzyme responsible for synthesis of GDP-L-fucose as the only donor in fucosylation. (nih.gov)
  • Previous analyses showed the presence of GDP-fucose (GDP-Fuc), the precursor for all fucosylation reactions, in the blood stages of Plasmodium falciparum. (johnshopkins.edu)
  • He is well known for his discovery of guanosine-diphosphate-fucose in 1958, and his research led to the understanding of the biochemical basis of blood groups in human beings. (nih.gov)