• efficacy
  • Following those studies, scientists at the Institute conducted a series of animal experiments, including a pharmacokinetics experiment, pharmacodynamics experiments, and two separate efficacy experiments with two different guanabenz administration protocols. (prweb.com)
  • The Institute's researchers observed a statistically significant acceleration of onset of paresis and shortened lifespan of mice treated with guanabenz in both efficacy experiments when compared to vehicle treated controls. (prweb.com)
  • findings
  • These findings are important to ALS drug discovery and development researchers because they are in direct contrast to previous published results indicating that guanabenz is efficacious in SOD1 mice. (prweb.com)
  • Our findings suggest that guanabenz can be repurposed into an effective anti-parasitic with a unique ability to reduce tissue cysts in the brain. (blogspot.com)
  • mice
  • Several published research reports have suggested a neuroprotective effect by guanabenz in SOD1 mice resulting in slower disease progression and an improvement in survival. (prweb.com)
  • In these studies from the Institute, treatment of SOD1 mice with guanabenz actually accelerated disease progression. (prweb.com)
  • In addition to protecting mice from lethal doses of Toxoplasma, guanabenz has a remarkable ability to reduce the number of brain cysts in chronically infected mice. (blogspot.com)