• efficacy
  • Following those studies, scientists at the Institute conducted a series of animal experiments, including a pharmacokinetics experiment, pharmacodynamics experiments, and two separate efficacy experiments with two different guanabenz administration protocols. (prweb.com)
  • The Institute's researchers observed a statistically significant acceleration of onset of paresis and shortened lifespan of mice treated with guanabenz in both efficacy experiments when compared to vehicle treated controls. (prweb.com)
  • findings
  • These findings are important to ALS drug discovery and development researchers because they are in direct contrast to previous published results indicating that guanabenz is efficacious in SOD1 mice. (prweb.com)
  • Our findings suggest that guanabenz can be repurposed into an effective anti-parasitic with a unique ability to reduce tissue cysts in the brain. (blogspot.com)
  • treatment
  • Scientists from the ALS Therapy Development Institute announced today the publication of the paper, "Guanabenz treatment accelerates disease in a mutant SOD1 mouse model of ALS," in the peer-reviewed journal PLOS ONE . (prweb.com)
  • Treatment with guanabenz in this assay has been shown by the ALS Therapy Development Institute and other research groups to be protective. (prweb.com)