• Antibody
  • Differential sensitivity of human B cell subsets to activation signals delivered by anti-u antibody and proliferative signals delivered by a monoclonal B cell growth factor. (springer.com)
  • The contribution of the shared IL - 10 promoter haplotype accounted for 27% of the genetic influence on anti-HBs antibody response. (wiley.com)

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  • receptors
  • This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity). (uniprot.org)
  • Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. (dymocks.com.au)
  • Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. (dymocks.com.au)
  • The transcriptional factors are activated by the primary messengers, in most cases, due to their function as nuclear receptors for these messengers. (wikipedia.org)
  • Activated TGF-β complexes with other factors to form a serine/threonine kinase complex that binds to TGF-β receptors, which is composed of both type 1 and type 2 receptor subunits. (wikipedia.org)
  • genes
  • One of the important factors in this process is the set of signal molecules which inform cells of where they are in a developing body and give them instructions as to which genes they should activate. (sunyorange.edu)
  • The gene is flanked by the genes for granulocyte-macrophage colony-stimulating factor and Colony stimulating factor 1 receptor (also termed macrophage-colony stimulating factor receptor), all three of which may be lost together by a single deletional mutation thereby causing development of the 5q-syndrome. (wikipedia.org)
  • Human chromosome 5 deletions that remove three adjacent genes, those for granulocyte-macrophage colony-stimulating factor, PDGFRB, and Colony stimulating factor 1 receptor, cause the Chromosome 5q deletion syndrome (5q- syndrome). (wikipedia.org)
  • Human chromosome translocations between the PDGFRB gene and at least any one of 30 genes on other chromosomes lead to myeloid and/or lymphoid neoplasms that are many ways similar to the neoplasm caused by the fusion of the PDGFRA (i.e. platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see FIP1L1-PDGFRA fusion gene. (wikipedia.org)
  • Ovarian
  • Growth factors synthesized by ovarian somatic cells directly affect oocyte growth and function. (wikipedia.org)
  • The functions of BMP15 include: Promotion of growth and maturation of ovarian follicles, starting from the primary gonadotrophin-independent phases of folliculogenesis. (wikipedia.org)
  • tumor
  • FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (wikipedia.org)
  • tissue
  • GDF8 is now officially known as myostatin and controls the growth of muscle tissue. (wikipedia.org)
  • For example, the tissue factor pathway in the coagulation cascade of secondary hemostasis is the primary pathway leading to fibrin formation, and thus, the initiation of blood coagulation. (wikipedia.org)
  • mice
  • Mice harboring a single activated allele of pdgfrb show a number of postnatal phenotypes including reduced differentiation of aortic vascular smooth muscle cells and brain pericytes. (wikipedia.org)
  • inhibition
  • In contrast, overexpression or knockdown of YY1 does not affect growth inhibition induced by TGF-beta or BMP. (diva-portal.org)
  • The activation and inhibition of these particular factors clearly is maintaining the immortal quality inherent in cancer cells and specifically in the resistant cell types. (wikipedia.org)
  • Cells
  • I. Effect of anti-immunoglobulin and enhancing soluble factor on differentiation and proliferation of B cells. (springer.com)
  • T cell derived B cell growth factors can innduce stimulation of both resting and activated B cells. (springer.com)
  • MK has been identified as one of the factors that "transfers" this chemoresistance from the resistant cells to the WT cells. (wikipedia.org)
  • Following co-culture experiments and the determination that MK was one of the factors that was conferring chemo-resistance to the wild, non-resistant cell type, the gene for MK was transfected into WT cells to determine if MK was overexpressed in the WT cells themselves, would the cells become resistant to chemotherapy independent of resistant cell influence. (wikipedia.org)
  • Stat-3, however, which is another survival pathway factor, does not appear to have any change in activation between the wild type cells and the MK-transfected WT cells, as was initially believed from a previous study. (wikipedia.org)