• However, even when these hormonal stains are negative, positive staining for SF1 alone is sufficient to diagnose gonadotroph adenoma. (cap.org)
  • Ganirelix Acetate acts by competitively blocking the GnRH receptors on the pituitary gonadotroph and subsequent transduction pathway. (nih.gov)
  • Endothelin-3 immunoreactivity in gonadotrophs of the human anterior pituitary. (yale.edu)
  • GnRH travels via the portal vasculature to the anterior pituitary stimulating the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the gonadotroph. (jneurosci.org)
  • SF1 drives gonadotroph adenomas while Pit-1 drives GH, PRL, and TSH adenomas. (cap.org)
  • Adenomas driven by the transcription factor SF1, which are exclusively of the gonadotroph type, are a common subtype encountered by the surgical pathologist. (cap.org)
  • Traditionally, gonadotroph adenomas have been defined by positive immunostaining for LH and/or FSH, with or without alpha-subunit (α-SU) staining. (cap.org)
  • The majority of previously classified "null cell" adenomas - negative for all hormonal markers - are now recognized as SF1 - driven and therefore would be classified as gonadotroph adenomas. (cap.org)
  • PD-L1 RNA and protein expression were significantly increased in functioning (growth hormone and prolactin-expressing) pituitary adenomas compared to non-functioning (null cell and silent gonadotroph) adenomas. (wustl.edu)
  • By electron microscopy five types of secretory cells (somatotrophs, mammotrophs, thyrotrophs, gonadotrophs, and corticotrophs) plus endothelial and follicular cells can be identified and are morphologically well preserved up to 20 h after dissociation. (rupress.org)
  • Specialized hypothalamic neurons secrete pulses of gonadotropin-releasing hormone (GnRH) into the portal blood vessels, which acts on the gonadotrophs to cause a pulsatile release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which act on ovarian follicle cells to control folliculogenesis. (glowm.com)
  • We analyzed neuroendocrine disrupting effects of neonatal exposure of female rats to PEG-b-PLA NPs and diethylstilbestrol (DES) on the function of adenohypophyseal gonadotrophs of infantile or adult rats by examining in vitro luteinizing hormone releasing hormone (LHRH)-induced luteinizing hormone (LH) release. (nel.edu)
  • Local regulation of gonadotroph function by pituitary gonadotropin releasing hormone. (unicatt.it)
  • A new look to the andropause: Altered function of the gonadotrophs. (bvsalud.org)
  • TZDs have been demonstrated to induce G0-G1 cell-cycle arrest and apoptosis in human, rat somatolactotroph, murine corticotroph and gonadotroph pituitary tumor cells. (nel.edu)
  • TGFBR3L showed membranous immunolabeling and was found to be gonadotroph cell lineage-specific, verified by co-expression with SF1 and FSH/LH staining in both tumour and non-neoplastic anterior pituitary tissues. (nih.gov)
  • TGFBR3L immunoreactivity was observed in gonadotroph tumours only and demonstrated intra-tumour heterogeneity with a perivascular location. (nih.gov)
  • Melatonin inhibits gonadotropin-releasing hormone-induced release of luteinizing hormone (LH) from the neonatal rat gonadotrophs. (nih.gov)
  • In a subgroup of previously characterised gonadotroph tumours, correlation with expression of FSH/LH, E-cadherin, oestrogen (ER) and somatostatin receptors (SSTR) was explored. (nih.gov)