Chorionic GonadotropinThyroid-stimulaGonadotropinCommon alpha subunitThyrotropinHeterodimeric glycoprotein hormonesSpecific beta subunitPhysiologicalFree beta subunitSpecificityConfersIdenticalLuteinizing HormoneGenesGeneNoncovalentHeterodimersReceptorsAmino acidProteinsPlacentalUnique to hCGFollicle stimulatBiologically activeMRNASerumDiffersMolecularReceptorELISA KitProteinChainPlacentaNoncovalentlyPeptideStructurallyPituitary GlandPolypeptide hormoneBeta core fragmentBiologicalProgesteroneTestosteroneSteroidProlactinAnteriorGranulosaMembraneExpressionThyrostimulinFunctionalAntibodyCatalyticSecretionConsistsEnzymes
Chorionic Gonadotropin17
- The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. (wikipedia.org)
- The most commonly used assays are for the beta subunit of human chorionic gonadotropin (hCG). (medscape.com)
- This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). (prosci-inc.com)
- The 3 human pituitary glycoprotein hormones: luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyrotropin, and the placenta-derived chorionic gonadotropin, are closely related tropic hormones. (mayocliniclabs.com)
- The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. (nih.gov)
- A comparison of outcomes from in vitro fertilization cycles stimulated with either recombinant luteinizing hormone (LH) or human chorionic gonadotropin acting as an LH analogue delivered as human menopausal gonadotropins, in subjects with good or poor ovarian reserve: A retrospective analysis. (medscape.com)
- When a woman is pregnant, her placenta produces a hormone called human chorionic gonadotropin (HCG). (thehealthplace.in)
- Buy Ovidac 10000 iu online, Human chorionic gonadotropin also known as HCG which is a polypeptide hormone that is generated by the syncytiotrophoblast, a component of the fertilized egg after conception.HCG has a wide role in treating infertility in women and increases sperm count in men. (mymedistore.com)
- Ovidac 10000 iu includes an active ingredient Human chorionic gonadotropin (HCG) which is a polypeptide hormone that is generated by the syncytiotrophoblast, a component of the fertilized egg after conception. (mymedistore.com)
- Human chorionic gonadotropin is a hormone that is prescribed in the inability to conceive, enhances sperm count, and in pituitary gland condition. (mymedistore.com)
- Ovidac 10000 iu (Human chorionic gonadotropin) is a water-soluble glycoprotein obtained from the pee of expectant ladies. (mymedistore.com)
- Its structure is similar to that of the other glycoprotein hormones, follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). (aivdbiotech.com)
- Human Chorionic gonadotropin (HCG) is a hormone that supports the normal development of an egg in a woman's ovary, and stimulates the release of the egg during ovulation. (pharmabeast.is)
- Chorionic gonadotropin is a polypeptide hormone normally found in the female body during the early months of pregnancy. (secretsofbodybuilding.org)
- Although it possesses minor FSH-like (Follicle Stimulating Hormone) activity, the physiological actions of chorionic gonadotropin mainly mimic those of the gonadotropin luteinizing hormone (LH). (secretsofbodybuilding.org)
- Chorionic gonadotropin was first discovered in 1920, 767 and was identified as a pregnancy hormone approximately 8 years later. (secretsofbodybuilding.org)
- Its structure is similar to those of luteinizing hormone (LH), thyroid-stimulating hormone (TSH), and human chorionic gonadotropin (hCG). (explained.today)
Thyroid-stimula5
- A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. (harvard.edu)
- The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. (harvard.edu)
- Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. (nih.gov)
- The alpha-subunit is identical to that for luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH). (medscape.com)
- It has an alpha subunit that is 92 amino acids long and identical to that of luteininzing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH). (pharmabeast.is)
Gonadotropin8
- Our recent finding that the number of immunoreactive α-subunit cells was invariably greater than the total number of immunoreactive gonadotropin (GTH) and thyrotropin (TSH) cells in the bullfrog (Rana catesbeiana) pituitary gland raises the possibility that the α-subunit also exists in pituitary cells other than GTH and TSH cells. (elsevierpure.com)
- Luteinizing hormone (LH) is a glycoprotein gonadotropin secreted by the anterior pituitary in response to gonadotropin-releasing hormone (GnRH), which is released by the hypothalamus. (medscape.com)
- Perrett RM, McArdle CA. Molecular Mechanisms of Gonadotropin-Releasing Hormone Signaling: Integrating Cyclic Nucleotides into the Network. (medscape.com)
- The production of LH is regulated by gonadotropin-releasing hormone (GnRH) from the hypothalamus. (aivdbiotech.com)
- Human, LH is a gonadotropin and a glycoprotein having two subunits. (monobind.com)
- Follicle-stimulating hormone ( FSH ) is a gonadotropin , a glycoprotein polypeptide hormone . (explained.today)
- Low frequency gonadotropin-releasing hormone (GnRH) pulses increase FSH mRNA levels in the rat, [8] but is not directly correlated with an increase in circulating FSH. (explained.today)
- In addition, there is evidence that gonadotropin surge-attenuating factor produced by small follicles during the first half of the follicle phase also exerts a negative feedback on pulsatile luteinizing hormone (LH) secretion amplitude, thus allowing a more favorable environment for follicle growth and preventing premature luteinization. (explained.today)
Common alpha subunit2
- Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. (prosci-inc.com)
- In vertebrates, there are five glycoprotein hormones, four of which have a common alpha subunit (GPA1) bound to a specific beta subunit (GPB1, GPB2, GPB3, or GPB4), and the fifth, thyrostimulin, is formed by the dimerization of GPA2 and GPB5 subunits. (bvsalud.org)
Thyrotropin4
- Molecular cloning of the human thyrotropin-beta subunit gene. (wikipedia.org)
- hCG is a glycoprotein similar in structure to follicle-stimulating hormone (FSH), luteinizing hormone (LH), and thyrotropin. (medscape.com)
- The alpha subunit of hCG is similar to the alpha subunit of FSH, LH, and thyrotropin. (medscape.com)
- Effects of Thyrotropin on Peripheral Thyroid Hormone Metabolism and Serum Lipids. (harvard.edu)
Heterodimeric glycoprotein hormones1
- The heterodimeric glycoprotein hormones have only been identified in vertebrates and are highly conserved in organisms from primitive rayfin fish (Chondrostei) to human in both primary sequences and functional characteristics. (biovendor.com)
Specific beta subunit1
- The specific beta subunit confers the unique biologic activity. (medscape.com)
Physiological5
- Under physiological conditions, alpha- and beta-chain synthesis and secretions are tightly coupled, and only small amounts of monomeric subunits are secreted. (mayocliniclabs.com)
- Within insects, corticotropin-releasing factor/diuretic hormones (CRF/DHs) are responsible for the modulation of a range of physiological and behavioural processes such as feeding, diuresis, and reproduction. (bvsalud.org)
- Double-label immunohistochemistry displays co-localized staining of CRF-like and the glycoprotein hormone (GPA2/GPB5) subunit GPB5-like immunoreactivity in the same neurosecretory cells (NSCs) in the mesothoracic ganglionic mass (MTGM) and in their neurohemal sites in adult female R. prolixus, suggesting these peptides could work together to regulate physiological processes. (bvsalud.org)
- These hormones mediate physiological events such as development, metabolism, and reproduction, although the functional role of thyrostimulin in vertebrates has not been fully elucidated. (bvsalud.org)
- Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (edu.au)
Free beta subunit5
- The free beta subunit of hCG differs from the others in that it has a 30-amino acid tailpiece at the COOH terminus. (medscape.com)
- Intact and free beta subunit are initially the predominant forms of hCG, with the beta core fragment emerging as the predominant form in the fifth week after conception. (medscape.com)
- Additionally, intact and free beta subunit have the most day-to-day variability and are transiently undetectable even 10 days after detection of pregnancy. (medscape.com)
- [ 3 ] Optimally, tests used for early pregnancy detection should be able to recognize all forms of intact hCG, including the free beta subunit and the beta core fragment. (medscape.com)
- HCG exists in a number of biologically active iso-hormones including the intact hormone and the free beta subunit. (southtees.nhs.uk)
Specificity4
- The specificity of the antibody against the α-subunit and of that against PRL was demonstrated by preabsorption test, non-competitive binding test, and immunoblot analysis. (elsevierpure.com)
- By contrast, all the different beta-subunits are transcribed from separate genes, show less homology, and convey the receptor specificity of the dimeric hormones. (mayocliniclabs.com)
- The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. (nih.gov)
- The beta subunit is different and confers its biochemical specificity. (monobind.com)
Confers1
- FSH has a beta subunit of 111 amino acids (FSH β), which confers its specific biologic action, and is responsible for interaction with the follicle-stimulating hormone receptor . (explained.today)
Identical2
- Codina J, Stengel D, Woo SL, Birnbaumer L: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (smpdb.ca)
- The alpha subunits of the glycoproteins LH, FSH, TSH, and hCG are identical and consist of 96 amino acids , while the beta subunits vary. (explained.today)
Luteinizing Hormone9
- Human follicle stimulating hormone (hFSH): first proposal for the amino acid sequence of the alpha-subunit (hFSHa) and first demonstration of its identity with the alpha-subunit of human luteinizing hormone (hLHa). (wikipedia.org)
- The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. (prosci-inc.com)
- Luteinizing Hormone Deficiency. (medscape.com)
- IAA did not alter luteinizing hormone (LHβ) expression in vivo although exposure to 20 μM IAA decreased expression of Lhb and glycoprotein hormones, alpha subunit (Cga) mRNA in vitro. (illinois.edu)
- Alongside luteinizing hormone (LH), FSH is able to regulate the synthesis and secretion of female and male sex hormones via a negative feedback relationship, together they are able to control the growth and reproductive activities of gonadal tissues. (elisakits.co.uk)
- HCG is an analog of luteinizing hormone (LH). (mymedistore.com)
- Luteinizing hormone in addition to Follicle-stimulating hormone has a duty in advancement and also maturation of typical ovarian hair follicle and in mid-cycle LH rise launches ovulation. (mymedistore.com)
- Luteinizing hormone (LH, also known as luteinising hormone, lutropin and sometimes lutrophin) is a hormone produced by gonadotropic cells in the anterior pituitary gland. (aivdbiotech.com)
- FSH and luteinizing hormone (LH) work together in the reproductive system. (explained.today)
Genes1
- The alpha and beta-subunits have separate genes on separate chromosomes (chromosomes 6 and 19, respectively). (medscape.com)
Gene5
- Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene. (wikipedia.org)
- The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. (wikipedia.org)
- Kozasa T, Itoh H, Tsukamoto T, Kaziro Y: Isolation and characterization of the human Gs alpha gene. (smpdb.ca)
- In humans, the gene for the alpha subunit is located at cytogenetic location 6q14.3. (explained.today)
- The gene for the FSH beta subunit is located on chromosome 11p13, and is expressed in gonadotropes of the pituitary cells, controlled by GnRH , inhibited by inhibin , and enhanced by activin . (explained.today)
Noncovalent3
- Corticotroph-derived glycoprotein hormone (CGH), also referred to as thyrostimulin, is a noncovalent heterodimer of glycoprotein hormone alpha 2 (GPHA2) and glycoprotein hormone beta 5 (GPHB5). (biovendor.com)
- Each is composed of an alpha- and a beta-subunit, coupled by strong noncovalent bonds. (mayocliniclabs.com)
- After synthesis, the alpha and beta-subunits are bonded with a noncovalent bond before being released into the circulation. (medscape.com)
Heterodimers1
- Both subunits, the non-covalently bound heterodimers, are required for full biologic activity. (wakehealth.edu)
Receptors5
- Recombinant A2/B5 heterodimeric glycoproteins activates human TSH receptors, but not LH and FSH receptors, and shows high affinity to TSH receptors in a radioligand receptor assay. (biovendor.com)
- These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (nih.gov)
- Apical endosomal glycoprotein from rat, a protein probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia. (embl.de)
- subdivision Receptors under individual hormones and groups of hormones, e.g. (edu.au)
- Hormones are recognised by either cell surface receptors (modified amino acids, peptides, proteins) or cytoplasmic/nuclear receptors (steroids). (edu.au)
Amino acid5
- Primary amino acid sequence of follicle-stimulating hormone from human pituitary glands. (wikipedia.org)
- Linear amino acid sequence of the alpha subunit. (wikipedia.org)
- The alpha subunit has a similar amino acid sequence to that of LH, FSH and TSH. (southtees.nhs.uk)
- hCG is a dimer consisting of a 145 amino acid beta-subunit that is unique to hCG and a 92 amino acid alpha-subunit. (medscape.com)
- Furin (PACE, paired basic amino acid cleaving enzyme, membrane associated receptor protein) is serine endoprotease responsible for processing a variety of substrates (proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor). (eu.org)
Proteins1
- Cell surface proteins that bind gastrointestinal hormones with high affinity and trigger intracellular changes influencing the behavior of cells. (edu.au)
Placental1
- The syncytiotrophoblast covers the villous tree and has several functions, such as transport of gases, nutrients, and waste products and synthesis of peptide and steroid hormones that regulate placental, fetal, and maternal systems. (medscape.com)
Unique to hCG3
- The beta subunit is unique to hCG and is responsible for its biological activity. (thehealthplace.in)
- the alpha sub unit structure is common to other gonadotropins, for example luteinising hormone, but the beta sub unit of 145 amino acids is unique to hCG. (ibms.org)
- It has a beta subunit that is unique to hCG. (pharmabeast.is)
Follicle stimulat2
- The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. (smpdb.ca)
- Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ: Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. (smpdb.ca)
Biologically active1
- The alpha-subunit combines with four distinct beta-subunits giving rise to four biologically active hormones in human: FSH, LH, TSH, and CG. (biovendor.com)
MRNA1
- Both 10 mg/l IAA exposure in vivo and 20 μM IAA in vitro reduced follicle stimulating hormone (FSHβ)-positive cell number and Fshb mRNA expression. (illinois.edu)
Serum4
- Human FSH ELISA kit is a reliable quantitative procedure for measuring follicle stimulating hormone (FSH) in human serum samples. (elisakits.co.uk)
- Description: A sandwich ELISA kit for detection of Serine Palmitoyltransferase, Long Chain Base Subunit 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type I Alpha 2 (COL1a2) in samples from serum, plasma, tissue homogenates or other biological fluids. (2sars.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Collagen Type I Alpha 2 (COL1a2) in serum, plasma, tissue homogenates and other biological fluids. (2sars.com)
Differs2
- The beta subunit of all these hormones differs greatly and is responsible for their respective specific hormone function. (southtees.nhs.uk)
- The alpha subunit is similar in LH, FSH, TSH, and HCG, while the beta subunits differs among the hormones. (medscape.com)
Molecular1
- Mattera R, Codina J, Crozat A, Kidd V, Woo SL, Birnbaumer L: Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase. (smpdb.ca)
Receptor6
- The alpha-subunits are essential for receptor transactivation. (mayocliniclabs.com)
- As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. (smpdb.ca)
- In this study, we clone and characterize the transcripts for the glycoprotein hormone GPA2/GPB5 and its receptor (LGR1) in fifth instar Rhodnius prolixus, a hemimetabolous insect vector of Chagas disease. (bvsalud.org)
- There is a single mechanism involved in the initiation of all these biological effects, and this is the interaction of the hormone with its specific receptor. (weeksmd.com)
- The insulin receptor consists of two alpha subunits (Mr 135 000) and two beta subunits (Mr 95 000) which are linked together by disulfide bonds. (weeksmd.com)
- The transmembrane beta subunit contains tyrosine kinase activity on its cytoplasmic domain that results in rapid receptor autophosphorylation. (weeksmd.com)
ELISA Kit1
- The minimum sensitivity detection limit of follicle stimulating hormone (FSH) using current FSH ELISA kit was approximately 0.856 mIU/ml. (elisakits.co.uk)
Protein7
- This data will allow for analysis of the selected steroid hormones and related binding protein that can be used to assist in disease diagnosis, treatment, and prevention of diseases, such as Polycystic Ovary Syndrome (PCOS), androgen deficiency, certain cancers, and hormone imbalances. (cdc.gov)
- The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. (lookformedical.com)
- Harris BA: Complete cDNA sequence of a human stimulatory GTP-binding protein alpha subunit. (smpdb.ca)
- one alpha and one beta subunit make the full, functional protein. (aivdbiotech.com)
- Xenopus laevis thyroid hormone induced protein B. This protein contains 4 MAM domains. (embl.de)
- This MAb reacts with a protein of ~13kDa, identified as alpha sub-unit of HCG. (enquirebio.com)
- The protein is required for processing of precursors of alpha-factor and killer toxin. (eu.org)
Chain3
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)
- Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in samples from tissue homogenates, cell lysates or other biological fluids. (1elisakits.com)
Placenta4
- 17α-hydroxyprogesterone (17-OHP) is a steroid hormone that is primarily produced in the adrenal glands, as well as in ovaries, testes, and placenta. (cdc.gov)
- hCG is a 36.7kDa glycoprotein produced by the trophoblast tissue of the placenta in pregnancy and at a number of other sites in malignant conditions. (ibms.org)
- It is synthesized in syncytiotrophoblast cells of the placenta, and is responsible for increasing the production of progesterone, a pregnancy-sustaining hormone. (secretsofbodybuilding.org)
- The fetus also has a unique hormonal system that combines not only its own developing endocrine system, but also that of the corpus luteum, placenta and maternal hormones. (edu.au)
Noncovalently1
- These hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. (biovendor.com)
Peptide1
- The subtilisin-like proprotein convertases are expressed extensively in mammalian neural and endocrine cells and play a major role in the proteolytic processing of both neuropeptide and peptide hormone precursors. (eu.org)
Structurally2
- The immunological and biological properties of these glycoproteins is determined solely by the uniqueness of the beta subunits whilst the alpha subunits remain very similar structurally. (elisakits.co.uk)
- Meprin is composed of two structurally related subunits (alpha and beta) that form homo- or heterotetramers by the non-covalent association of two disulfide-linked dimers. (embl.de)
Pituitary Gland1
- Gestational and nongestational trophoblasts are by far the most common sources of hCG, but a small amount of the hormone may also be produced by the pituitary gland and nontrophoblastic malignancies. (medscape.com)
Polypeptide hormone1
- It is a polypeptide hormone that has a function in the normal advancement of an egg in a female's ovary and also boosts the egg released during ovulation. (mymedistore.com)
Beta core fragment2
- hCG is present in the maternal circulation as either an intact dimer, alpha or beta subunit, and degraded form, or beta core fragment. (medscape.com)
- The ″In-tact″ hormone, ″nicked″ forms of HCG, the beta-core fragment and the free beta sub-unit. (southtees.nhs.uk)
Biological2
- [4] [5] Both subunits are required for biological activity. (explained.today)
- Sex hormones from the gonads have significant effects prenatally and postnatally, specifically at puberty with a role to play in male/female biological maturity and have wide actions throughout the body. (edu.au)
Progesterone1
- Other hormones that have been used include progesterone and early pregnancy factor. (medscape.com)
Testosterone4
- It is a precursor of androgen and estrogen sex hormones, such as testosterone or estrone. (cdc.gov)
- While DHEAS itself is hormonally inactive, it can be converted to DHEA, which in turn can serve as a precursor to more active steroid hormones, such as testosterone or estradiol. (cdc.gov)
- In males, where LH had also been called interstitial cell-stimulating hormone (ICSH), it stimulates Leydig cell production of testosterone. (aivdbiotech.com)
- HCG is used by male athletes for its ability to increase endogenous testosterone production, generally during, or at the conclusion of, a steroid cycle , when natural hormone production has been interrupted. (secretsofbodybuilding.org)
Steroid1
- Androstenedione is a steroid hormone that is produced in the adrenal glands and the gonads. (cdc.gov)
Prolactin1
- The present study demonstrates that there are a considerable number of immunoreactive prolactin (PRL) cells that are also stained with antibody against the α-subunit when adjacent sections are immunocytochemically examined. (elsevierpure.com)
Anterior1
- Follicle stimulating hormone (FSH) is a glycoprotein which is secreted by basophil cells, located in the anterior pituitary. (elisakits.co.uk)
Granulosa1
- Anti-Müllerian hormone (AMH) or Müllerian-inhibiting substance, a dimeric glycoprotein secreted by granulosa cells of the preantral and small antral ovarian follicles. (cdc.gov)
Membrane2
- The hormone insulin is recognized as having actions that affect the trans-membrane transport of different substances, particularly glucose, into numerous different kinds of cells. (weeksmd.com)
- The alpha unit is predominantly located on the outer surface of the cell membrane, and the insulin binding domain is located here. (weeksmd.com)
Expression1
- Quantitative PCR (qPCR) shows that both subunit transcripts, GPA2 and GPB5, and LGR1 transcripts are present in a variety of tissues, with greatest expression of the subunits in the central nervous system (CNS) and highest LGR1 expression in the Malpighian tubules (MT). Results from temporal qPCR analyses reveal a decrease in transcript expression 24 h after feeding, followed by an increase as the days post-feeding advance. (bvsalud.org)
Thyrostimulin2
- Human thyrostimulin ranks among the glycoprotein hormone family. (biovendor.com)
- This new heterodimeric glycoprotein hormone was named as thyrostimulin based on its thyroid-stimulating activity. (biovendor.com)
Functional1
- the distinct functional characteristics of these glycoprotein hormones are determined by the unique beta subunits. (wakehealth.edu)
Antibody4
- Neither immunoreactive growth hormone nor adrenocorticotropin cells are stained with the antibody against the α-subunit. (elsevierpure.com)
- Double-immunolabeling with gold particles of different sizes for the α-subunit and PRL revealed that most of the immunolabeled PRL-secretory granules are also labeled with the α-subunit antibody. (elsevierpure.com)
- This antibody has a high affinity for CEA and shows no detectable reactivity to nonspecific cross-reacting antigen (NCA), biliary glycoprotein (BGP) and human polymorphonuclear leucocytes. (samatashkhis.com)
- Variations in HCG-alpha antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
Catalytic2
- The promoter activity of cyclin D2 was shown to be induced by FSH and the catalytic alpha subunit of PKA (PRKACA), and this activity was repressible by inducible cAMP early repressor (ICER), a cAMP response element (CRE) modulator isoform. (montclair.edu)
- In both subunits, the MAM domain is located after the catalytic domain. (embl.de)
Secretion1
- The hormone is made in the beta cells of the pancreas, and the stimulus for its secretion into the blood stream is a rise in the blood glucose concentration. (weeksmd.com)
Consists1
- HCG consists of two subunits alpha and also beta subunits. (mymedistore.com)
Enzymes1
- Free beta subunits are degraded by macrophage enzymes in the kidney to make a beta subunit core fragment, which is primarily detected in urine samples. (medscape.com)