AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
GlycolysisGlucosePhosphofructokinase-1Lactic AcidLactatesPhosphofructokinasesFructosediphosphatesHexokinaseOxidative PhosphorylationPyruvate KinasePhosphofructokinase-2Energy MetabolismAdenosine TriphosphatePentose Phosphate PathwayPyruvic AcidGlycogenCitric Acid CycleDeoxyglucoseIodoacetatesGlyceraldehyde-3-Phosphate DehydrogenasesAerobiosisPyruvatesPhosphofructokinase-1, Muscle TypeGlucose-6-PhosphateGluconeogenesisIodoacetic AcidOxygen ConsumptionMitochondriaHexosephosphatesFructose-Bisphosphate AldolasePhosphocreatineDichloroacetic AcidGlucose-6-Phosphate IsomeraseHexosediphosphatesPhosphofructokinase-1, Type CFructosephosphatesPhosphoglycerate MutaseCarbohydrate MetabolismGlucokinaseGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)L-Lactate DehydrogenaseDihydroxyacetoneGlucosephosphatesAdenine NucleotidesAnaerobiosisMetabolic Networks and PathwaysCell RespirationTriosesGlucose Transporter Type 1Oxidation-ReductionNADMagnetic Resonance SpectroscopyCitratesHypoxia-Inducible Factor 1, alpha SubunitModels, BiologicalKineticsIsethionic AcidGlutaminePyruvaldehydeHydrogen-Ion ConcentrationCell HypoxiaOxygenAdenosine MonophosphateGlyceraldehyde 3-PhosphateCarbon IsotopesAntimetabolitesLiverCell Line, TumorCyanidesLiver GlycogenMetabolomeAminooxyacetic AcidInsulinCarbonUncoupling AgentsEnzymesMonocarboxylic Acid TransportersMyocardiumOligomycinsSodium CyanideAdenosine DiphosphateTriose-Phosphate IsomeraseCarcinoma, Ehrlich Tumoralpha-ChlorohydrinGlycerolDihydroxyacetone PhosphateMetabolomicsRotenoneMusclesChloroacetatesAntimycin APhosphopyruvate HydrataseGlycogen Storage Disease Type VIIFructose-BisphosphataseAnoxiaFructoseNeoplasmsLactoylglutathione LyasePhosphatesPhosphoenolpyruvate
PathwaysNADHLactateHexokinaseCitric AcidStep in glycolysisProducts of glycolysisIntroduction to GlycolysisMetabolismEnzymeCytoplasmFructose 1,6-bisphosphateMoleculeSteps in understandOxygenMoleculesGluconeogenesisInhibitionMitochondriaProduct of glycolysisFermentationPhosphorylationPyruvate kinaseReactionsLiving organismsProducesAerobic or anaerobicEmbden-Meyerhof-ParnasEnzymes involvedKrebs CyclePentoseBreakdownSubstrateProcess in which glucoseIntracellularDefectsEntry of glucoseBiochemistryTumorPyruvicCytosolGlucose is convertedCellsOXPHOSCellular RespirationRegulatesAncient metabolic pathwayCarbonConverts glucose
Pathways13
  • Glycolysis also refers to other pathways, such as the Entner-Doudoroff pathway and various heterofermentative and homofermentative pathways. (wikipedia.org)
  • Current insight revealed aerobic glycolysis supports various biosynthetic pathways and, consequently, the metabolic requirements for proliferation. (sigmaaldrich.com)
  • Glycolysis serves two main intracellular functions: generating ATP and generating intermediate metabolites to feed into other pathways. (jove.com)
  • Simplified schematic of the EMP (left) and ED (right) pathways of glycolysis. (frontiersin.org)
  • Objectives To begin to think about enzymes as regulated catalysts To understand the different ways enzymes can be regulated To learn the key, regulated steps in glycolysis, the mediators of regulation, and how it is connected to other pathways So today we will talk first about general features of metabolic/enzyme regulation and then the specifics as they relate to glycolysis. (powershow.com)
  • In this study, we demonstrated that IMQ can enhance aerobic glycolysis by up-regulating HIF-1α expression at the transcriptional and translational levels via ROS mediated STAT3- and Akt-dependent pathways, independent of TLR7/8 signaling. (oncotarget.com)
  • The Glucose-6-phosphate can then be used as a substrate for different pathways, namely glycolysis and the pentose phosphate way, and (depending on the organism) also be converted into glycogen and starch for further storage. (stackexchange.com)
  • This article provides a clear understanding of the byproducts, limitations, and significance of glycolysis products, such as pyruvate, NADH, and ATP, in cellular respiration, giving tips on how to identify these products and how they are used in other metabolic pathways. (vetrina-eventi.com)
  • Glycolysis is a central pathway for glucose catabolism because it connects glucose with other metabolic pathways. (stemcelldaily.com)
  • Unlike in anaerobic glycolysis, the end product of Aerobic glycolysis (pyruvate) is used to initiate other pathways in mitochondria. (circat.cat)
  • The Krebs Cycle and Glycolysis are two metabolic pathways that serve different purposes in the body. (differencess.com)
  • The difference between the two pathways is that glycolysis generates less ATP than the Krebs cycle. (differencess.com)
  • The more active of the 2 pathways, anaerobic glycolysis provides most of the high-energy phosphate bonds required for lens metabolism. (aao.org)
NADH10
  • These further aerobic reactions use pyruvate, and NADH + H+ from glycolysis. (wikipedia.org)
  • The sixth step in glycolysis oxidizes the sugar (glyceraldehyde-3-phosphate), extracting high-energy electrons , which are picked up by the electron carrier NAD + , producing NADH. (cloudaccess.net)
  • The second half of glycolysis involves phosphorylation without ATP investment (step 6) and produces two NADH and four ATP molecules per glucose. (cloudaccess.net)
  • This article explores how many NADH molecules are produced by glycolysis, and the importance of NADH in energy production and metabolism in the body. (vetrina-eventi.com)
  • It also delves into how NADH is used in fueling the body, and provides a step-by-step guide on glycolysis and its energy output. (vetrina-eventi.com)
  • Anaerobic glycolysis is the main pathway responsible for supplying the cell with both ATP and nicotinamide adenine dinucleotide (reduced) (NADH), a cofactor for methaemoglobin reductase, the enzyme that catalyses the reduction of methaemoglobin to functional haemoglobin (see … Download PDF for free. (zestrestaurant.co.za)
  • During the latter stages of this process NADH (generated during glycolysis) is converted back to NAD by losing a hydrogen. (zestrestaurant.co.za)
  • Fermentation allows glycolysis to continue by regenerating NAD+ (the oxidized form of NADH) from NADH. (stemcelldaily.com)
  • The glycolysis equation summarizes the process of breaking down glucose into two molecules of pyruvate, along with the production of ATP and NADH. (stemcelldaily.com)
  • During glycolysis, which means breakdown of glucose, glucose is separated into two ATP and two NADH molecules, which are used later in the process of aerobic respiration. (livestrong.com)
Lactate11
  • Glycolysis was evaluated by relative glucose consumption, lactate generation, ATP levels, and hexokinase II (HK2), while glucose transporter 1 (GLUT1) protein expression levels. (ajol.info)
  • Glycolysis refers to the process by which glucose is decomposed into pyruvate in the cytoplasm and produces large amounts of lactate[ 6 ]. (ijpsonline.com)
  • Regardless of whether anaerobic or aerobic, glycolysis produces acid if lactate is the end product of the pathway. (mo-mag.cz)
  • Lactate Threshold - Lactate threshold represents the point at which the athlete's body requires a greater contribution from the glycolysis energy system (anaerobic system) and a smaller contribution from the oxidative phosphorylation energy system (aerobic system). (bigskymultisportcoaching.com)
  • Aerobic glycolysis produces pyruvate at the end of glycolysis while anaerobic glycolysis produces lactate. (circat.cat)
  • Unlike the aerobic glycolysis, anaerobic glycolysis produces lactate, which reduces the pH and inactivates the enzymes. (circat.cat)
  • Anaerobic glycolysis is the transformation of glucose to lactate when limited amounts of oxygen (O2) are available. (circat.cat)
  • Pyruvate is reduced to lactate during anaerobic glycolysis whereas, during aerobic glycolysis, pyruvate is oxidation to acetyl coenzyme A (acetyl- CoA). (circat.cat)
  • Ultimate end product of anaerobic glycolysis is lactate, which may be harmful to the cell itself, whereas that of aerobic glycolysis is water and carbon dioxide, which are not harmful to cells. (circat.cat)
  • Glycolysis does not use oxygen, instead, it uses lactate as a by-product of glucose metabolism. (differencess.com)
  • In anaerobic glycolysis, substrate-linked phosphorylation of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) occurs at 2 steps along the pathway from glucose metabolism to lactate. (aao.org)
Hexokinase5
  • The combined results indicate that glycolysis is regulated by the compartmental expression of hexokinase 2, pyruvate kinase M1, and pyruvate kinase M2 in photoreceptors, whereas the inner retinal neurons exhibit a lower capacity for glycolysis and aerobic glycolysis. (molvis.org)
  • Western blot was carried out to detect the expression levels of autophagic-related proteins (Unc-51 like autophagy activating kinase 1, beclin 1, autophagy related 5, microtubule-associated protein 1A/1B-light chain 3, ubiquitin-binding protein p62), glycolysis-related proteins (hexokinase 2, phosphofructokinase, pyruvate kinase M2) and activated protein kinase signalling pathway proteins. (ijpsonline.com)
  • The first step in glycolysis is catalyzed by hexokinase, an enzyme with broad specificity that catalyzes the phosphorylation of six-carbon sugars. (cloudaccess.net)
  • Metabolism Problem SetProblem 12: HexokinaseIn the first step of glycolysis, the enzyme hexokinase uses ATP to transfer a phosphate to glucose to form glucose-6-phosphate. (jonnevandermeijden.nl)
  • In high-glucose conditions, hexokinase becomes inhibited by products of glycolysis, and aldose reductase becomes relatively increased, converting more glucose to sorbitol. (aao.org)
Citric Acid1
Step in glycolysis4
  • The fourth step in glycolysis employs an enzyme, aldolase, to cleave fructose-1,6-bisphosphate into two three-carbon isomers: dihydroxyacetonephosphate and glyceraldehyde-3-phosphate. (cloudaccess.net)
  • The first step in glycolysis is the breaking down of glucose into two smaller molecules called glycogen and glucose-6-phosphate. (differencess.com)
  • The next step in glycolysis is the conversion of glucose-6-phosphate into fructose-6-phosphate. (differencess.com)
  • [ 3 ] PFK catalyzes the irreversible transfer of phosphate from ATP to fructose-6-phosphate and converts it to fructose-1,6-bisphosphate during the third step in glycolysis. (medscape.com)
Products of glycolysis3
Introduction to Glycolysis1
  • Introduction to Glycolysis - definition Glycolysis or EMP pathway was discovered by Gustav Embden, Otto Meyerhof and J. Parnas in 1930. (zestrestaurant.co.za)
Metabolism10
  • Glucose is the major substrate for ATP synthesis through glycolysis and oxidative phosphorylation (OXPHOS), whereas intermediary metabolism through the tricarboxylic acid (TCA) cycle utilizes non-glucose-derived monocarboxylates, amino acids, and alpha ketoacids to support mitochondrial ATP and GTP synthesis. (molvis.org)
  • Glycolysis is the first step of metabolism and the biochemical pathway by which glucose is converted into pyruvate. (usmle-rx.com)
  • If there is no glucose there is no need for glycolysis: I deduce from this truism that - at some early stage in the evolution of metabolism - a pathway resembling gluconeogenesis must have arisen before glycolysis. (stackexchange.com)
  • Mechanical regulation of cell metabolism (glycolysis)! (altmetric.com)
  • Anaerobic glycolysis exclusively uses glucose (and glycogen) as a fuel in the absence of oxygen, or more specifically when ATP is needed at rates that exceed those provided by aerobic metabolism. (zestrestaurant.co.za)
  • It can occur aerobically or … Glycolysis is the first step in the breakdown of glucose to extract energy for cellular metabolism. (zestrestaurant.co.za)
  • Rather, it is an important energy "shuttle" whose production is triggered by a variety of metabolites even before the onset of anaerobic metabolism as part of an adaptive response to a hypermetabolic state and, in particular, during sepsis.2 Here, we review hyperlactatemia and lactic acidosis in Glycolysis is the first step in the breakdown of glucose to extract energy for cellular metabolism. (zestrestaurant.co.za)
  • Complete aerobic metabolism of glucose produces water andComplete aerobic metabolism of glucose produces water and The Reactions of Glycolysis Fermentation: The Anaerobic Fate of Pyruvate Control of Metabolic Flux Metabolism of Hexoses Other Than Glucose. (zestrestaurant.co.za)
  • Nearly all living organisms carry out glycolysis as part of their metabolism. (zestrestaurant.co.za)
  • Lens metabolism maintains a clear lens and derives most of its energy from anaerobic glycolysis. (aao.org)
Enzyme4
  • Describe the roles of insulin and glucagon in the regulation of glycolysis and the enzyme targets. (usmle-rx.com)
  • Aldolase is an enzyme that plays a crucial role in glycolysis, a metabolic pathway that breaks down glucose into pyruvate. (labtestpk.com)
  • Since the level of Fru-P 2 did not change much upon oxygenation, this suggests that in aerobic glycolysis there is control of at least one enzyme in the lower part of the Embden-Meyerhof-Parnas pathway, below Fru-P 2 , which gives the 13 C level more time to equilibrate between C 1 and C 6 of Fru-P 2 . (umn.edu)
  • PFK is the key regulatory enzyme for glycolysis. (medscape.com)
Cytoplasm8
  • 0000001853 00000 n 0000037081 00000 n 0000027082 00000 n Glycolysis Glycolysis takes place in the cytoplasm of the cell and is common to both aerobic and anaerobic respirations. (zestrestaurant.co.za)
  • Glycolysis occurs in the Cytoplasm of cells. (mo-mag.cz)
  • Glycolysis is a unique pathway that occurs in the cytoplasm or cytosol of all cells. (mo-mag.cz)
  • Glycolysis occurs in the cytoplasm of the cell and is present in all living organisms. (mo-mag.cz)
  • Glycolysis occurs in the cytoplasm. (mo-mag.cz)
  • The entire glycolysis process occurs in the cytoplasm of eukaryotic cells (cells with nuclei and membranes). (jonnevandermeijden.nl)
  • Glycolysis occurs in the cytosol of cells, which is the fluid part of the cytoplasm. (stemcelldaily.com)
  • Anaerobic glycolysis takes place in the cytoplasm when a cell lacks oxygenated environment or lacks mitochondria. (circat.cat)
Fructose 1,6-bisphosphate1
  • They also shed light on the role of one compound as a glycolysis intermediate: fructose 1,6-bisphosphate. (wikipedia.org)
Molecule10
  • Eukaryotic aerobic respiration produces approximately 34 additional molecules of ATP for each glucose molecule, however most of these are produced by a mechanism vastly different from the substrate-level phosphorylation in glycolysis. (wikipedia.org)
  • The reason for the phosphorylation lies further downstream in glycolysis: The isomerization by the glucose phosphate isomerase and the subsequent second phosphorylation into Fructose-1,6-biphosphate make the conversion and dedication of the molecule into the glycolysis irreversible. (stackexchange.com)
  • The first part of the glycolysis pathway traps the glucose molecule in the cell and uses energy to modify it so that the six-carbon sugar molecule can be split evenly into the two three-carbon molecules. (cloudaccess.net)
  • Anaerobic glycolysis is a metabolic process in which glucose, a sugar molecule, is broken down without the use of oxygen.Like aerobic glycolysis, which metabolizes glucose in the presence of oxygen, it produces energy for the cells. (zestrestaurant.co.za)
  • Anaerobic glycolysis yields two ATP molecules for each glucose molecule metabolized…oxidation of glucose in the mitochondrion would yield an additional 34 ATP molecules. (mo-mag.cz)
  • Glycolysis is an anaerobic pathway consisting of ten steps in which one molecule of glucose is reduced to form two molecules of pyruvate at the end. (jonnevandermeijden.nl)
  • As the name suggests, glycolysis involves the splitting of a six-carbon glucose molecule into two three-carbon molecules called pyruvate. (stemcelldaily.com)
  • Anaerobic glycolysis produces 2ATPs per glucose molecule while aerobic glycolysis produces 36 to 38 ATPs per glucose molecule. (circat.cat)
  • When compared to anaerobic glycolysis, this pathway is much more efficient and produces more ATP per glucose molecule. (circat.cat)
  • In fact, glycolysis can only produce 2 ATP molecules per molecule of glucose while the Krebs cycle can produce up to 8 ATP molecules per molecule. (differencess.com)
Steps in understand1
  • The first steps in understanding glycolysis began in the nineteenth century with the wine industry. (wikipedia.org)
Oxygen12
  • Indeed, the reactions that make up glycolysis and its parallel pathway, the pentose phosphate pathway, can occur in the oxygen-free conditions of the Archean oceans, also in the absence of enzymes, catalyzed by metal ions, meaning this is a plausible prebiotic pathway for abiogenesis. (wikipedia.org)
  • The goal of this study was to explore the regulatory mechanism of trehalose on the autophagy death of SHSY5Y cells induced by oxygen and sugar deprivation from the aspect of glycolysis. (ijpsonline.com)
  • Explain 2,3-bisphosphoglycerate and its relevance to glycolysis and the binding of oxygen to hemoglobin. (usmle-rx.com)
  • In the absence of oxygen, the cells make small amounts of ATP as glycolysis is followed by fermentation . (byjus.com)
  • Glycolysis does not require oxygen and can occur under aerobic and anaerobic conditions. (mo-mag.cz)
  • Anaerobic glycolysis is thought to have been the primary means of energy production in earlier organisms before oxygen was at high concentration in the atmosphere and thus would represent a more ancient form of energy production in cells. (mo-mag.cz)
  • Cellular respiration in the absence of molecular oxygen is (a) photorespiration (b) glycolysis (c) EMP pathway (d) HMS pathway Answer: (b) glycolysis 2. (mo-mag.cz)
  • The pyruvate end product of glycolysis can be used in either anaerobic respiration if no oxygen is available or in aerobic respiration via the TCA cycle which yields much more usable energy for the cell. (jonnevandermeijden.nl)
  • In the presence of oxygen, pyruvate is oxidized and acetyl CoA is formed, which feeds into the citrate acid cycle and the complete oxidation … In the catabolism of carbohydrates, understand the general chemical reactions of glycolysis and the krebs cycle. (jonnevandermeijden.nl)
  • Depending on the availability of oxygen and the type of organism, pyruvate can undergo different fates after glycolysis. (stemcelldaily.com)
  • Conditions in humans that greatly increase anaerobic glycolysis because of a shortage of oxygen, for example, failure of the respiratory system or the blood circulatory system, often cause the production of more acid than can be handled by the buffering systems of the body. (circat.cat)
  • Aerobic glycolysis occurs in oxygen rich environments, whereas anaerobic glycolysis occurs in oxygen lack environments. (circat.cat)
Molecules5
  • The first half of glycolysis uses two ATP molecules in the phosphorylation of glucose, which is then split into two three-carbon molecules. (cloudaccess.net)
  • So far, glycolysis has cost the cell two ATP molecules and produced two small, three-carbon sugar molecules. (cloudaccess.net)
  • The answer is glycolysis, a series of biochemical reactions that break down glucose into smaller molecules, releasing energy in the process. (stemcelldaily.com)
  • Glycolysis is the process of breaking down glucose molecules into energy-rich molecules called ATP. (differencess.com)
  • Glycolysis is the process by which glucose is converted into energy through the breakdown of glucose molecules. (differencess.com)
Gluconeogenesis1
Inhibition2
  • pH response of the incubation buffers was compared to starting pH's and an Area Under Curve (AUC)aggregate analysis of glycolysis inhibition was used for treatment comparisons. (umich.edu)
  • Studies on the biochemical basis of distal axonopathies - I. Inhibition of glycolysis by neurotoxic hexacarbon compounds. (cdc.gov)
Mitochondria1
  • Glycolysis is the first step of ATP formation that takes place in the cytosol outside of the mitochondria, using glucose as the energy source. (circat.cat)
Product of glycolysis5
Fermentation1
  • Insight into the component steps of glycolysis were provided by the non-cellular fermentation experiments of Eduard Buchner during the 1890s. (wikipedia.org)
Phosphorylation1
Pyruvate kinase2
  • Identify the diseases associated with defects in glycolysis, particularly pyruvate kinase defect. (usmle-rx.com)
  • The first step of glycolysis results in the formation of: Glycolysis is stimulated During exercise ATP is being used and generates high amounts of AMP which stimulate Phosphofructokinase and pyruvate kinase to generate ATP through glycolysis. (jonnevandermeijden.nl)
Reactions3
Living organisms1
  • Glycolysis is an ancient metabolic pathway that evolved long ago and is found in almost all living organisms. (stemcelldaily.com)
Produces3
Aerobic or anaerobic1
  • Several misconceptions contained in this question… Firstly, glycolysis is neither aerobic or anaerobic! (mo-mag.cz)
Embden-Meyerhof-Parnas1
  • The most common type of glycolysis is the Embden-Meyerhof-Parnas (EMP) pathway, which was discovered by Gustav Embden, Otto Meyerhof, and Jakub Karol Parnas. (wikipedia.org)
Enzymes involved3
  • In this article, we will explore the details of each step of glycolysis, the enzymes involved, the regulation mechanisms, and the clinical implications of glycolysis defects. (stemcelldaily.com)
  • This reaction is 70-100 times slower than that of other enzymes involved in lens glycolysis and is, therefore, rate-limited. (aao.org)
  • Here, we report that three consecutive triose- phosphate -processing enzymes involved in cytosolic glycolysis , triose- phosphate - isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPC), and phosphoglycerate kinase (PGK), designated TGP, negatively regulate autophagy . (bvsalud.org)
Krebs Cycle6
  • Glycolysis is followed by the Krebs cycle during aerobic respiration. (byjus.com)
  • Glycolysis Vs Krebs Cycle: What's The Difference? (differencess.com)
  • If you're like most people, you probably don't really understand the glycolysis and krebs cycle differences. (differencess.com)
  • The glycolysis step of the Krebs cycle is responsible for generating energy for your body's cells. (differencess.com)
  • What are the differences between Glycolysis and the Krebs Cycle? (differencess.com)
  • The glycolysis pathway occurs in the mitochondrial matrix and is responsible for producing energy from glucose using the Krebs cycle. (differencess.com)
Pentose2
Breakdown2
  • The word glycolysis originates from the Latin glyco (sugar) and lysis (breakdown). (jove.com)
  • Take a look at the ten enzymes that make possible the ten steps in the breakdown of sugar the process is called glycolysis. (sharemylesson.com)
Substrate1
Process in which glucose1
  • Glycolysis is the process in which glucose is broken down to produce energy. (byjus.com)
Intracellular3
  • Apical Na+/H+ antiporter and glycolysis-dependent H+-ATPase regulate intracellular pH in the rabbit S3 proximal tubule. (jci.org)
  • S3 tubules also possess a plasma membrane H+-ATPase that can regulate pHi, has a requirement for intracellular chloride, and utilizes ATP derived primarily from glycolysis. (jci.org)
  • This article explores the intracellular location of glycolysis, discussing where glycolysis occurs within cells, the organelles involved, and how this knowledge can be applied to support innovative research and medical treatments. (vetrina-eventi.com)
Defects1
  • Defects in glycolysis (rare) may cause syndromes similar to GSDs. (msdmanuals.com)
Entry of glucose2
  • The glycolysis process starts with the entry of glucose into the mitochondrion, where it is converted to pyruvate. (differencess.com)
  • In addition, the excess carbohydrate worsens the energy crisis in Tarui disease because the metabolic block in PFK deficiency occurs below the entry of glucose into glycolysis and therefore, it cannot be used by the muscle for energy production. (medscape.com)
Biochemistry1
  • Ugurbil, K , den Hollander, JA & Shulman, RG 1986, ' 31 P and 13 C NMR Studies of Intermediates of Aerobic and Anaerobic Glycolysis in Saccharomyces cerevisiae ', Biochemistry , vol. 25, no. 1, pp. 212-219. (umn.edu)
Tumor2
  • Tumor cells rely on aerobic glycolysis to maintain unconstrained cell growth and proliferation. (oncotarget.com)
  • Thus, we hypothesize that the IMQ-induced up-regulation of HIF-1α and aerobic glycolysis is a protective response to the metabolic stress generated by IMQ treatment, and thus, co-treatment with inhibitors of HIF-1α and/or glycolysis may be a useful therapeutic strategy to enhance the anti-tumor effects of IMQ in clinical settings. (oncotarget.com)
Pyruvic2
Cytosol1
  • Glycolysis is the metabolic pathway that converts glucose (C6H12O6) into pyruvate, and in most organisms, occurs in the liquid part of cells, the cytosol. (wikipedia.org)
Glucose is converted1
Cells14
  • Cells performing aerobic respiration synthesize much more ATP, but not as part of glycolysis. (wikipedia.org)
  • Otto Heinrich Warburg demonstrated in 1924 that cancer cells show an increased dependence on glycolysis to meet their energy needs, regardless of whether they were well-oxygenated or not. (sigmaaldrich.com)
  • Glycolysis is an important metabolic pathway that generates energy in various cells of the blood vessel wall. (wjgnet.com)
  • Interestingly, activated DCs and T-effector cells, such as T-helper 1 (Th1) and T-helper 17 (Th17), utilize glycolysis for their energy needs while Tregs rely on fatty acid oxidation for their energy needs. (aiche.org)
  • In the present work, we found that 5-ALA, a natural precursor of heme, can hinder cell glycolysis, which is the main path of energy production for most cancer cells. (mdpi.com)
  • Based on the antibody intensities and the COX and LDH activity, Müller glial cells (MGCs) had the lowest capacity for glycolysis, aerobic glycolysis, and OXPHOS. (molvis.org)
  • NOX4 affects breast cancer glycolysis through ROS-induced activation of the YAP pathway, further promoting the proliferation and migration of breast cancer cells. (jcancer.org)
  • Downregulation of KLF8 inhibits proliferation and glycolysis, and also promotes apoptosis in AML cells via AKT/mTOR pathway. (ajol.info)
  • In the early stage of ischemia and hypoxia, cells will increase the energy supply to the ischemic area, especially the functional area of the ischemic penumbra, by regulating glycolysis. (ijpsonline.com)
  • The genetic silencing of HIF-1α not only repressed IMQ-induced aerobic glycolysis but also sensitized cells to IMQ-induced apoptosis due to faster ATP and Mcl-1 depletion. (oncotarget.com)
  • Typically, anaerobic glycolysis occurs in muscle cells during vigorous physical activity. (mo-mag.cz)
  • Since the pH range in which cells can function is quite narrow (pH 7.0-7.6), uncontrolled glycolysis can lead to cell death. (circat.cat)
  • How does Glycolysis result in the production of energy for our cells? (differencess.com)
  • In both in vitro and in vivo settings, steering pyruvate use toward glycolysis or OXPHOS differentially skews the hematopoietic output of HE cells toward either an erythroid fate with primitive phenotype, or a definitive lymphoid fate, respectively. (lu.se)
OXPHOS2
  • The pattern and intensity of the antibodies and of the COX and LDH activity showed the high capacity of photoreceptors for aerobic glycolysis and OXPHOS. (molvis.org)
  • In both in vitro and in vivo settings, steering pyruvate use toward glycolysis or OXPHOS. (lu.se)
Cellular Respiration2
  • Glycolysis is the primary step of cellular respiration, which occurs in all organisms. (byjus.com)
  • Glycolysis helps to provide the glucose needed for cellular respiration, but it is not the primary source of energy for the body. (differencess.com)
Regulates3
  • Zhang Z, Luan Q, Hao W, Cui Y, Li Y, Li X. NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway. (jcancer.org)
  • Li, X. NOX4-derived ROS Regulates Aerobic Glycolysis of Breast Cancer through YAP Pathway. (jcancer.org)
  • Cytoskeletal architecture regulates glycolysis - from @gdanuser1 & co. https://t.co/3800CYabOI 2. (altmetric.com)
Ancient metabolic pathway1
  • The wide occurrence of glycolysis in other species indicates that it is an ancient metabolic pathway. (wikipedia.org)
Carbon1
  • We attempted to identify carbon metabolic genes that modulate autophagy using VIGS screening of 45 glycolysis - and Calvin-Benson cycle -related genes in Arabidopsis ( Arabidopsis thaliana ). (bvsalud.org)
Converts glucose1