• In addition, Geerdink's thesis describes the synthesis of a putative sex pheromone of a parasitic wasp ( Trichogramma turkestanic ) and our efforts towards the synthesis of another glycolipid from Mycobacterium tuberculosis (DAT2) and a sulfo-glycopeptidolipid from Mycobacterium avium (S-GPL). (rug.nl)
  • This thesis presents a short protecting group free route to trehalose amide glycolipids, thus allowing for the synthesis of the straight chain glycolipid amides 1a-e in four steps and in excellent (53-61%) overall yields (Figure 1). (vuw.ac.nz)
  • Here we report a new solid-phase (glyco)lipid synthesis (SPLS), which gives traceless glycolipids using an acetal linker. (elsevierpure.com)
  • During the synthesis, we incidentally found some of the artificial glycolipids act as good organogelators, the property of which is greatly dependent on the modular saccharide structure. (elsevierpure.com)
  • The enzymes of the antigen 85 complex (Ag85A, B, and C) possess mycolyltransferase activity and catalyze the synthesis of the most abundant glycolipid of the mycobacterial cell wall, the cord factor. (helmholtz-hzi.de)
  • Caveolae, plasmalemmal invaginations in which several other glycolipid-anchored proteins are concentrated, are not seen in neuroblastoma cells analyzed by thin-section or deep-etch electron microscopy. (rupress.org)
  • According to the glycolipid-lectin (GL-Lect) hypothesis, the construction of tubular endocytic pits is driven in a glycosphingolipid-dependent manner by sugar-binding proteins of the galectin family. (institut-curie.org)
  • This enzyme plays a role in the breakdown of complexes of sugar molecules (oligosaccharides) attached to certain proteins (glycoproteins) and fats (glycolipids). (medlineplus.gov)
  • Glycosphingolipids (GSLs) are a subclass of glycolipids that are found in cell membranes of various organisms ranging from bacteria to humans. (springer.com)
  • Antibodies to the major phenolic glycolipid purified from Mycobacterium leprae have been demonstrated previously in sera of leprosy but not tuberculosis patients using an ELISA. (unboundmedicine.com)
  • TY - JOUR T1 - Analysis of the major antigenic determinants of the characteristic phenolic glycolipid from Mycobacterium leprae. (unboundmedicine.com)
  • Here, we provide evidence for the involvement of the specific trisaccharide unit of the phenolic glycolipid-1 (PGL-1) of Mycobacterium leprae in determining the bacterial predilection to the peripheral nerve. (ed.ac.uk)
  • The mycolyltransferase 85A, a putative drug target of Mycobacterium tuberculosis: development of a novel assay and quantification of glycolipid-status of the mycobacterial cell wall. (helmholtz-hzi.de)
  • Antigens which are not present in an individual's blood will cause antibodies to be produced, which will bind to the foreign glycolipids. (wikipedia.org)
  • To assess the frequency of glycolipid complex antibodies in a Western European cohort of patients GBS we used a newly developed combinatorial glycoarray methodology to screen against large range of antigens (11 gangliosides, 8 other single glycolipids and 162 heterodimeric glycolipid complexes). (ox.ac.uk)
  • Natural killer T cells ( NKT cells ) recognize glycolipid antigens presented by CD1d. (bvsalud.org)
  • Retinol-binding protein 4 (RBP4) is closely associated with a variety of abnormal glycolipid metabolism diseases such as insulin resistance, obesity, diabetes mellitus, and metabolic syndrome. (nih.gov)
  • In Fabry disease, a glycolipid, which is a product of fat metabolism, accumulates in tissues. (msdmanuals.com)
  • The Glycolipid Cream Cleanser effectively cleanses the skin and removes makeup such as foundation, eyeliner, and mascara. (theordinary.com)
  • Glycolipids are lipids with a carbohydrate attached by a glycosidic (covalent) bond. (wikipedia.org)
  • The saccharide of the glycolipid will bind to a specific complementary carbohydrate or to a lectin (carbohydrate-binding protein), of a neighboring cell. (wikipedia.org)
  • Matreya's monoclonal and polyclonal anti-ganglioside antibodies are directed against the carbohydrate chains of ganglioside and globoside glycolipids. (matreya.com)
  • VC 2006 Wiley-Liss, Inc. a glycolipid antigen with globo-series carbohydrate core structures (Kannagi et al. (lu.se)
  • N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. (ox.ac.uk)
  • We have investigated the effects of deoxynojirimycin and its alkylated derivatives on the biosynthesis of glycolipids in HL-60 cells. (ox.ac.uk)
  • A lack of enzyme activity results in an incomplete breakdown of glycolipids and glycoproteins. (medlineplus.gov)
  • Brain cells are particularly sensitive to the buildup of glycolipids and glycoproteins, which can result in cell death. (medlineplus.gov)
  • Accumulation of glycolipids and glycoproteins also occurs in other organs such as the liver, spleen, skin, heart, pancreas, and kidneys, contributing to the additional symptoms of fucosidosis. (medlineplus.gov)
  • The human genome contains at least 35 genes that encode Golgi sulfotransferases that function in the secretory pathway, where they are involved in decorating glycosaminoglycans, glycolipids, and glycoproteins with sulfate groups. (lu.se)
  • Ac2SGL, one of the glycolipids in the cell enveloppe of M. tuberculosis , stimulates the production of antibodies and is considered as a candidate for a tuberculosis vaccine. (rug.nl)
  • Antibodies to heteromeric glycolipid complexes in Guillain-Barré syndrome. (ox.ac.uk)
  • This study demonstrates that while antibodies against single gangliosides are often found in cases with axonal-type electrophysiology, antibodies against glycolipid complexes predominate in cases with demyelinating electrophysiology, providing a more robust serum biomarker than has ever been previously available for such cases. (ox.ac.uk)
  • We also examined sera for anti-glycolipid antibodies, a biomarker of GBS, and C jejeunispecific antibodies, a biomarker of C jejeuni exposure. (cdc.gov)
  • Anti-glycolipid IgG antibodies were more common among male poultry workers as compared to male referents (p = 0.07). (cdc.gov)
  • We hypothesised that antibody specificities reliant on the cis interactions of neighbouring membrane glycolipids could explain this discrepancy, and would not have been detected by traditional serological assays using highly purified preparations of single gangliosides. (ox.ac.uk)
  • This report is the first example of trehalose amide glycolipids acting as Mincle agonists, and further studies into the potential of the amides as vaccine adjuvants will be undertaken in due course. (vuw.ac.nz)
  • Meanwhile, TDM and related glycolipids act as vaccine adjuvants when delivered in dimethyldioctadecyl bromide (DDA) liposome formulations. (bioglyco.com)
  • Using altered glycolipid ligands, we discovered that the Vb repertoire of iNKT cells impacts recognition and Ag avidity, and that stimulation with suboptimal avidity Ag results in preferential expansion of high-affinity iNKT cells. (ox.ac.uk)
  • Trehalose glycolipids, consisting of α,α'-trehalose esterified at the 6- and 6'- positions with lipids, exhibit adjuvant activity by binding and activating Macrophage inducible C-type lectin (Mincle). (vuw.ac.nz)
  • However, the adjuvant activity of trehalose glycolipids could potentially be improved by substituting the ester linkages for more physiologically stable amide bonds. (vuw.ac.nz)
  • A second generation of trehalose amide glycolipids, the lipidated brartemicin amide analogues 2a-c, were subsequently synthesised (Figure 1). (vuw.ac.nz)
  • As a promising vaccine adjuvant, trehalose glycolipid (TGL) has been extensively studied in recent years. (bioglyco.com)
  • We provide high-quality trehalose monoester glycolipids adjuvant and trehalose diester glycolipid adjuvant to our customers. (bioglyco.com)
  • CD BioGlyco provides custom trehalose glycolipid adjuvant development services, including trehalose monoester glycolipids and trehalose diester glycolipids. (bioglyco.com)
  • We are committed to providing our customers with the highest level of trehalose glycolipid-based adjuvants to accelerate your vaccine development. (bioglyco.com)
  • The effects of trehalose glycolipid presentation on cytokine production by GM-CSF macrophages. (bioglyco.com)
  • Glycolipid Biosurfactant: A non-stripping surfactant that cleanses and supports the microbiome. (sephora.com)
  • This class of compounds is therefore called natural glycolipids, and Dacryopinax spathularia produces these in quite sufficient amounts. (huachengbio.com)
  • In this study, quantitative and array-based affinity evaluation of gp120 and gp160 was performed by surface plasmon resonance (SPR) and the SPR imaging technique using a substrate immobilized with glycolipid-like compounds (Gb3, GM3, and Lac). (elsevierpure.com)
  • Glycolipid surfactants are biocompatible and biodegradable compounds characterized by potential applications in various sectors including pharmaceuticals, cosmetics, agriculture, and food production. (researchgate.net)
  • The glycolipid is assembled in the Golgi apparatus and embedded in the surface of a vesicle which is then transported to the cell membrane. (wikipedia.org)
  • The vesicle merges with the cell membrane so that the glycolipid can be presented on the cell's outside surface. (wikipedia.org)
  • AbstractGlycoproteins and glycolipids at the plasma membrane contribute to a range of functions from growth factor signaling to cell adhesion and migration. (institut-curie.org)
  • Glycolipids dominate in PL. Among the unsaponifiable substances were found biologically active components such as hydrocarbons, carotenoids, aliphatic alcohols, sterols and triterpenols. (who.int)
  • The four main human blood types (A, B, AB, O) are determined by the oligosaccharide attached to a specific glycolipid on the surface of red blood cells, which acts as an antigen. (wikipedia.org)
  • The main function of glycolipids in the body is to serve as recognition sites for cell-cell interactions. (wikipedia.org)
  • Glycolipids are also responsible for other responses, notably the recognition of host cells by viruses. (wikipedia.org)
  • Blood types are an example of how glycolipids on cell membranes mediate cell interactions with the surrounding environment. (wikipedia.org)
  • Amide glycolipids 1a-e were demonstrated to be Mincle agonists with comparable activity to their ester counterparts, as determined using a green fluorescent protein (GFP) reporter cell line assay. (vuw.ac.nz)
  • A glycolipid-anchored prion protein is endocytosed via clathrin-coated pits. (rupress.org)
  • The cellular prion protein (PrPc) is a glycolipid-anchored, cell surface protein of unknown function, a posttranslationally modified isoform of which PrPSc is involved in the pathogenesis of Creutzfeldt-Jakob disease, scrapie, and other spongiform encephalopathies. (rupress.org)
  • They can also remove glycans from glycolipids to turn them back into unmodified lipids. (wikipedia.org)
  • The cell wall of pathogenic mycobacteria is abundant with complex glycolipids whose roles in disease pathogenesis are mostly unknown. (ed.ac.uk)
  • Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. (bvsalud.org)
  • The accumulation of glycolipid causes noncancerous (benign) skin growths (angiokeratomas) to form on the lower part of the trunk. (msdmanuals.com)
  • This study categorizes the global Glycolipids breakdown data by. (emailwire.com)
  • The enzyme needed to breakdown the glycolipid, called alpha-galactosidase A, does not work correctly. (msdmanuals.com)
  • Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. (mcw.edu)
  • This formulation uses a plant-derived glycolipid cleansing agent that cleanses the skin while respecting the skin barrier to maintain hydration. (theordinary.com)
  • Polyglyceryl-6 Dicaprate: Assists in the makeup removal alongside the glycolipids. (sephora.com)
  • Selectins, a class of lectins found on the surface of leukocytes and endothelial cells bind to the carbohydrates attached to glycolipids to initiate the immune response. (wikipedia.org)
  • An example of how glycolipids function within the body is the interaction between leukocytes and endothelial cells during inflammation. (wikipedia.org)
  • Here we show that NKT cells recognized diacylglycerol -containing glycolipids from Streptococcus pneumoniae , the leading cause of community -acquired pneumonia , and group B Streptococcus , which causes neonatal sepsis and meningitis . (bvsalud.org)
  • The glycolipid response was dependent on vaccenic acid , which is present in low concentrations in mammalian cells . (bvsalud.org)
  • Va14Ja18 natural T (iNKT) cells rapidly elicit a robust effector response to different glycolipid Ags, with distinct functional outcomes. (ox.ac.uk)
  • This study examines the potential surface display of this glycolipid by chlamydiae-infected cells and the ability of the GLXA they secrete to associate with the plasma membranes of uninfected cells, a prerequisite for exerting influence on them. (umass.edu)
  • A small, but significant cross-reaction was observed with the glycolipids from M. bovis and M. kansasii, which contain the phenolphthiocerol dimycocerosate part of the molecule but have different sugars, and also with a semi-synthetic 'attenuation indicator lipid' which shares the phenolphthiocerol but has no sugars. (unboundmedicine.com)
  • The cross-reactivity observed with the M. bovis and M. kansasii glycolipids was not inhibited by the synthetic disaccharide. (unboundmedicine.com)
  • Glycolipids: Glycolipids are biosurfactants, a category of ingredients that work to cleanse the skin by lifting surface level impurities. (sephora.com)
  • The essential feature of a glycolipid is the presence of a monosaccharide or oligosaccharide bound to a lipid moiety. (wikipedia.org)
  • Glycolipids are found on the surface of all eukaryotic cell membranes, where they extend from the phospholipid bilayer into the extracellular environment. (wikipedia.org)
  • The major antigenic determinants on this molecule were investigated using antisera raised in rabbits to the purified glycolipid and with a pool of sera from human lepromatous leprosy patients. (unboundmedicine.com)
  • Enzymes called glycosyltransferases link the saccharide to the lipid molecule, and also play a role in assembling the correct oligosaccharide so that the right receptor can be activated on the cell which responds to the presence of the glycolipid on the surface of the cell. (wikipedia.org)
  • Cell surface display of the chlamydial glycolipid exoantigen (GLXA) demonstrated by antibody-dependent complement-mediated cytotoxicity. (umass.edu)
  • Natural glycolipids help control microorganisms in soft drinks-College-Hunan Huacheng Biotech, Inc. (huachengbio.com)
  • These natural glycolipids offer consumer-friendly marketing options while reliably protecting beverages from spoilage. (huachengbio.com)
  • The natural glycolipids that the fungus contains are nature's way for the fungus to keep its food free of spoilage. (huachengbio.com)
  • The natural glycolipids of the Dacryopinax spathularia exclusively are available from LANXESS under the brand name Nagardo, derived from "natural guardian. (huachengbio.com)
  • Therefore, Nagardo natural glycolipids can be applied in a wide range of beverages. (huachengbio.com)
  • Autoimmune ataxic neuropathies (sensory ganglionopathies): are glycolipids the responsible autoantigens? (nih.gov)
  • Fabry disease occurs when the body lacks enzymes needed to break down a glycolipid. (msdmanuals.com)
  • EMAILWIRE.COM, September 21, 2018 ) This report researches the worldwide Glycolipids market size (value, capacity, production and consumption) in key regions like North America, Europe, Asia Pacific (China, Japan) and other regions. (emailwire.com)