• PLP is a cofactor for glutamic acid decarboxylase, the enzyme that produces GABA, such that PLP deficiency results in insufficient GABA. (medscape.com)
  • They were disappointed to find that the 65-kd protein was GAD, an enzyme largely found in the central nervous system (CNS), and, unfortunately, the pathophysiologic link between diabetes and glutamic acid decarboxylase remains unclear. (medscape.com)
  • 7524) oxaloacetate decarboxylase alpha subunit CP001857 CDS Arcpr_0006 complement(7556. (go.jp)
  • Glycine-tRNA ligase, alpha subunit [Interproscan]. (ntu.edu.sg)
  • Exploration of the supramolecular interactions involving tris-dipicolinate lanthanide complexes in protein crystals by a combined biostructural, computational and NMR study. (ibs.fr)
  • Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex. (ibs.fr)
  • The ubiquitinated protein is then degraded by the 26S proteasome, a protein complex that degrade proteins by proteolysis. (greek.doctor)
  • The enzyme is a component of several MULTIENZYME COMPLEXES . (nih.gov)
  • Furthermore, in AD brains, mitochondrially associated APP formed stable ∼480 kDa complexes with the translocase of the outer mitochondrial membrane 40 (TOM40) import channel and a super complex of ∼620 kDa with both mitochondrial TOM40 and the translocase of the inner mitochondrial membrane 23 (TIM23) import channel TIM23 in an "N in mitochondria -C out cytoplasm " orientation. (jneurosci.org)
  • As an example of one of the complex transformations on this pathway, the figure below shows the structure of the pyrimidine synthase catalyzing the complex rearrangement of aminoimidazole ribotide (left) to the thiamin pyrimidine (right). (tamu.edu)
  • It was thus be possible to carry out functional analysis, in particular of the proteins involved in photorespiration and the subunits of the glycine-decarboxylase complex. (wikipedia.org)
  • The conclusions reveal that will body's genes enjoy a strong along with preferential position within forming the actual functionally useful, metabolically costly contacts in between connectome hubs.Glycine decarboxylase (GLDC) is often a important chemical associated with glycine bosom method in which turns glycine directly into one-carbon products. (8-bromo-camp.com)
  • Here we report that mechanistic focus on involving rapamycin complex A single (mTORC1) indication stops GLDC acetylation at amino acid lysine (K) 514 through causing transcribing from the deacetylase sirtuin Several (SIRT3). (8-bromo-camp.com)
  • Last but not least, we discover which GLDC K514 acetylation inhibits glycine catabolism, pyrimidines combination and glioma tumorigenesis. (8-bromo-camp.com)
  • Ornithine decarboxylase for example has a half-life of only 11 minutes. (greek.doctor)
  • Interestingly, taurine has been reported to interact with neurotransmitter receptors involved in sleep regulation, including GABA-A, GABA-B, and glycine. (life-enhancement.com)
  • The authors thus note, "[b]y far the strongest evidence speaks in favor of glycine receptors being the major and most specific target of endogenous taurine. (life-enhancement.com)
  • Glycine radical, Pyruvate formate lyase-like [Interproscan]. (ntu.edu.sg)
  • Orotidine 5'-phosphate decarboxylase / HUMPS family [Interproscan]. (ntu.edu.sg)
  • Cucumber malate decarboxylase, CsNADP-ME2, functions in the balance of carbon and amino acid metabolism in fruit. (mpg.de)
  • Beyond photorespiration: the significance of glycine and serine in leaf metabolism. (mpg.de)
  • Characterization of a pre-export enzyme-chaperone complex on the twin-arginine transport pathway. (ibs.fr)
  • Amino acids like alanine and glycine increase the half-life, while amino acids like arginine and lysine decrease it. (greek.doctor)
  • Gene copies of the glycine decarboxylase in the C 2 -species Salsola divaricata . (lmu.de)
  • In our study, ictal fever-VGKC-complex antibody and pilomotor seizure-GABAAR antibody associations were documented for the first time. (ox.ac.uk)
  • The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
  • The Begley Group is interested in the mechanistic chemistry and enzymology of complex organic transformations, particularly those found on the vitamin biosynthetic pathways. (tamu.edu)
  • The biosyntheses of the thiamin pyrimidine and thiazole are complex and are different from any of the characterized chemical or biochemical routes to these heterocycles. (tamu.edu)
  • Cartoon diagram of human COMT in complex with 3,5-dinitrocatechol (dark blue) and S -adenosyl methionine (yellow). (en-academic.com)
  • The complex interplay between cancer cells and the TIME influences the outcome of immunotherapy and other anticancer therapy (Fig. 1 ). (biomedcentral.com)
  • Finally, CcpA controls a complex and extended regulatory network through the modulation of a large set of regulators. (studyres.com)