• serine
  • 4. These enzyme activities increase markedly when R. spheroides is grown in the presence of glycine, glyoxylate, glycollate, oxalate or serine. (biochemj.org)
  • When coupled to serine hydroxymethyltransferase, the glycine cleavage system overall reaction becomes: 2 glycine + NAD+ + H2O → serine + CO2 + NH3 + NADH + H+ In humans and most vertebrates, the glycine cleavage system is part of the most prominent glycine and serine catabolism pathway. (wikipedia.org)
  • The glycine cleavage system takes glycine, which is created from an unwanted byproduct of the Calvin cycle, and converts it to serine which can reenter the cycle. (wikipedia.org)
  • Initial research using carbon labeling showed decreased levels of CO2 and serine production in the liver, pointing directly to deficiencies glycine cleavage reaction. (wikipedia.org)
  • Plants
  • In plants, animals and bacteria the glycine cleavage system catalyzes the following reversible reaction: Glycine + H4folate + NAD+ ↔ 5,10-methylene-H4folate + CO2 + NH3 + NADH + H+ In the enzymatic reaction, H-protein activates the P-protein, which catalyzes the decarboxylation of glycine and attaches the intermediate molecule to the H-protein to be shuttled to the T-protein. (wikipedia.org)
  • This reaction, and by extension the glycine cleavage system, is required for photorespiration in C3 plants. (wikipedia.org)
  • The glycine cleavage system is constantly present in the leaves of plants, but in small amounts until they are exposed to light. (wikipedia.org)
  • present
  • 6. The increase in the activity of glycine decarboxylase on illumination of R. spheroides in a medium containing glycine, and the greater increase when ATP is also present in the medium, probably accounts for the increased incorporation of the methylene carbon atom of glycine into fatty acids found previously under these conditions (Gajdos, Gajdos-Török, Gorchein, Neuberger & Tait, 1968). (biochemj.org)