• mRNA
  • Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract. (wikipedia.org)
  • selenenic acid
  • This selenenic acid derivative of the peroxidase then reacts with a thiol-containing cofactor (GSH) to generate the key intermediate selenenyl sulfide (E-SeSG). (wikipedia.org)
  • activity
  • DESIGN: Using in-vitro cell models, experiments were performed that included glutathione peroxidase (GPX) activity, Amplex UltraRed, CM-H(2)DCFDA, Annexin V, 8-oxoguanine, phospho-H2A.X, quantitative real-time PCR and western blot assays. (biomedsearch.com)
  • Glutathione peroxidase activity was found to be much lower in patients with relapsing-remitting multiple sclerosis. (wikipedia.org)
  • The cyanogenic glycosides in some white clover (Trifolium repens) varieties may influence the Se requirement, presumably because of cyanide from the aglycone released by glucosidase activity in the rumen and inactivation of glutathione peroxidases by the effect of absorbed cyanide on the glutathione moiety. (wikipedia.org)
  • Their activity is attributed to their mimicry of glutathione peroxidase activity. (wikipedia.org)
  • Sequence
  • Glutathione peroxidase 1 is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (Ala) repeats in this sequence. (wikipedia.org)