• Objectives: In the present study, we studied the effects of systemically administered Epo on lipid peroxidation levels and antioxidant enzyme ( superoxide dismutase and glutathione peroxidase) activities following hypoxic-ischemic brain injury in neonatal rats. (deu.edu.tr)
  • The whole medium and posterior intestine was collected after 30 or 60 experimental days and the activity of catalase, superoxide dismutase and glutathione peroxidase was determined as one international unit per milligram of protein, and the oxygen radical absorbance capacity as µM of equivalent Trolox per milligram of protein. (lajar.cl)
  • citation needed] In one study, the activity of glutathione peroxidase along with other antioxidant enzymes such as superoxide dismutase and catalase was not associated with coronary heart disease risk in women. (wikipedia.org)
  • Glutathione level and activity of studied glutathione enzymes were determined in the supernatants. (nih.gov)
  • Glutathione Peroxidase (GPx) family of enzymes plays important roles in the protection of organisms from oxidative damage. (projectng.com)
  • Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). (hindawi.com)
  • Glutathione peroxidases are key antioxidant enzymes, catalysing the decomposition of potentially toxic lipid peroxides. (elsevierpure.com)
  • The aim of this study was to determine the effect of acute intoxication with chlorfenvinphos on the liver reduced glutathione (GSH) level and the activities of two enzymes involved in glutathione metabolism, as well as the activity of catalase (CAT), glucose-6-phosphate dehydrogenase (G6PDH) and the level of liver hydrogen peroxide. (pjoes.com)
  • Selenium is a component of the antioxidant enzymes glutathione peroxidase and thioredoxin reductase (which indirectly reduce certain oxidized molecules in animals and some plants). (cdc.gov)
  • In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)
  • Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. (wikipedia.org)
  • Mice genetically engineered to lack glutathione peroxidase 1 (Gpx1−/− mice) are grossly phenotypically normal and have normal lifespans, indicating this enzyme is not critical for life. (wikipedia.org)
  • The role of the glutathione peroxidase/reductase (GSH-Px/GSSG-Rd) enzyme system in protection from paracetamol toxicity was investigated in isolated mouse hepatocytes in primary culture. (nih.gov)
  • An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. (umassmed.edu)
  • The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration. (umassmed.edu)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glutathione Peroxidase 1 (GPX1) in serum, plasma and other biological fluids. (jsce-ip.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Glutathione Peroxidase 1 (GPX1) in samples from Serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (jsce-ip.com)
  • Glutathione Peroxidase is a critical antioxidant enzyme produced by our body. (immunotec.com)
  • RÉSUMÉ L'objectif de la présente étude était d'évaluer l'efficacité d'un programme d'exercice sur tapis roulant électronique sur le malondialdéhyde, en tant que marqueur de la peroxydation lipidique et sur une enzyme antioxydante, le glutathion peroxydase, chez des adolescents atteints du Syndrome de Down. (who.int)
  • Selenium (Se) is a part of the enzyme glutathione peroxidase, which metabolizes hydroperoxides formed from polyunsaturated fatty acids. (msdmanuals.com)
  • Glutathione peroxidase 1 (GPx1) is the most abundant version, found in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. (wikipedia.org)
  • So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans. (wikipedia.org)
  • We found that expression of glutathione peroxidase-1 (Gpx1) is silenced in the non-TNBC cells but significantly maintained in the TNBC cell lines. (ewha.ac.kr)
  • Gpx1 and Gpx2 gene transcripts were not elevated in association with increased activity of the soluble glutathione peroxidase activity. (elsevierpure.com)
  • Recent studies indicate that glutathione peroxidase 1 (GPx1) mutation decreases GPx activity in myocardial cells and increases the risk of KD. (geneticsmr.com)
  • Based on this, several procedures for measuring glutathione peroxidase activity were developed using various hydroperoxides as substrates for reduction, e.g. cumene hydroperoxide, tert-butyl hydroperoxide and hydrogen peroxide. (wikipedia.org)
  • Diagnosis of selenium deficiency is made clinically or sometimes by measuring glutathione peroxidase activity or plasma selenium , but neither of these tests is readily available. (msdmanuals.com)
  • The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water. (wikipedia.org)
  • The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. (nih.gov)
  • Is the protein surrounding the active site critical for hydrogen peroxide reduction by selenoprotein glutathione peroxidase? (umassmed.edu)
  • GPx converts reduced glutathione (GSH) to oxidized glutathione (GSSG) while reducing lipid hydroperoxides to their corresponding alcohols or free hydrogen peroxide to water. (projectng.com)
  • Each test tube was heated at different temperatures ranging from -30°C to 50°C, after which Glutathione and Hydrogen Peroxide substrates were introduced to each test tube.Results showed that measurements were higher in test tubes were heating temperature were either exactly at or close to the acclimation temperature of the African Flathead Catfish. (projectng.com)
  • The liver glutathione peroxidase (GPx) and reductase (GR) activities as well as GSH and hydrogen peroxide levels were determined using Bioxytech Assay kits. (pjoes.com)
  • 2011 ). On the other side, plants have developed some enzymatic systems including superoxide dismutases (SOD), catalases (CAT), ascorbate peroxidases (APX), peroxiredoxins and non-enzymatic mechanisms to protect against oxidative damage caused by these ROS (Agrawal et al. (springeropen.com)
  • Also, the interactive effects of group and time on total antioxidant capacity and glutathione peroxidase were also significant (P=0.001). (ac.ir)
  • The main reaction that glutathione peroxidase catalyzes is: 2GSH + H2O2 → GS-SG + 2H2O where GSH represents reduced monomeric glutathione, and GS-SG represents glutathione disulfide. (wikipedia.org)
  • A simplified representation is shown below: RSeH + H2O2 → RSeOH + H2O RSeOH + GSH → GS-SeR + H2O GS-SeR + GSH → GS-SG + RSeH Glutathione reductase then reduces the oxidized glutathione to complete the cycle: GS-SG + NADPH + H+ → 2 GSH + NADP+. (wikipedia.org)
  • therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. (nih.gov)
  • Glutathione peroxidase activity was measured as an indicator of H2O2 scavenging. (cdc.gov)
  • Overall, BSO administration was effective in decreasing total glutathione levels and increasing H2O2 levels in old and young rats exposed to SSCs. (cdc.gov)
  • GPxs are members of a multiple-isozyme family that catalyze the reduction of H 2 O 2 or organic hydroperoxides to generate water or corresponding alcohols using reduced glutathione (GSH) as an electron donor [ 11 ]. (biomedcentral.com)
  • article{Barbosa2014, abstract = {The aim of this study was to investigate the potential modulators of erythrocyte glutathione peroxidase (GPx) activity in young and apparently healthy individuals. (dissem.in)
  • The changes in reduced glutathione (GSH), activity of glutathione transferase (GST) and glutathione peroxidase (GSPx) after administration of exogenous melatonin (N-acetyl-5-methoxy-tryptamine) at a dose 20 mg/kg b.w. were investigated for five and ten days in the liver and kidney of male and female mice. (nih.gov)
  • Glutathione peroxidase activity in selenium-deficient rat liver. (scienceopen.com)
  • Glutathione peroxidase was extracted and purified from the liver of the fish using the purification method of Eze et al (2010).The extracted and purified GPX was then divided into 23 test tubes and labeled. (projectng.com)
  • Malondialdehyde (MDA) concentration and glutathione peroxidase (GPx) activity represent the lipid peroxidation and spermicidal antioxidant, respectively. (ijbs.com)
  • Consequences of genetic variations in the glutathione peroxidase 1 selenoprotein. (uic.edu)
  • We investigated effects of age and glutathione synthesis inhibition on the oxidative stress status of tibialis anterior muscles from young and old Fisher 344 x Brown Norway male rats after chronic administration of stretch-shortening contractions. (cdc.gov)
  • Oral supplementation of l-buthionine-(S,R)-sulfoximine (BSO) inhibited glutathione synthesis. (cdc.gov)
  • No. Glutathione peroxidase (GPx) is a protein and will be removed by deproteination. (nwlifescience.com)
  • This is the first report that a particular isotype of the glutathione peroxidase family is regulated by TCDD at both mRNA and protein levels. (molcells.org)
  • The glutathione peroxidase gene has positive function to damage induced by ROS. (springeropen.com)
  • To understand the mechanism of tolerance to deferent stresses in tea plant, a new glutathione peroxidase gene of tea plant was cloned and its expression pattern was analyzed under abiotic and biotic stresses. (springeropen.com)
  • Glutathione peroxidase 3 gene polymorphisms and the risk of sudden sensorineural hearing loss. (cdc.gov)
  • Association of Glutathione s-transferase M1 and T1 gene polymorphisms with the susceptibility to acquired sensorineural hearing loss: a systematic review and meta-analysis. (cdc.gov)
  • After continuous inhalation for 3 days, the swimming time, blood glucose, blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and malondialdehyde (MDA) in blood were determined. (hindawi.com)
  • Description: A sandwich ELISA kit for detection of Glutathione Peroxidase 1 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (jsce-ip.com)
  • CusabioFish Glutathione Peroxidase (GSH-PX) ELISA kit is Available at Gentaur Genprice with the fastest delivery.Online Order Payment. (joplink.net)
  • As the integrity of the cellular and subcellular membranes depends heavily on glutathione peroxidase, its antioxidative protective system itself depends heavily on the presence of selenium. (wikipedia.org)
  • May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (joplink.net)
  • also known as PHGPx) is a monomeric, 21 kDa member of the glutathione peroxidase family of proteins. (rndsystems.com)
  • Because glutathione peroxidase (GPx) is limiting, the decrease in absorbance at 340 nm is directly proportional to the glutthione (GPx) concentration. (nwlifescience.com)
  • Glutathione may be useful for monitoring melatonin's protective role on cell damage. (nih.gov)
  • Can Glutathione Peroxidase (GPX) be detected in cell culture supernatant? (nwlifescience.com)
  • Glutathione peroxidase (GPx) activity is detectable in the supernatant from homogenates of cultured cells but is likely not present in sufficient quantities in the cell culture medium to be detectable. (nwlifescience.com)
  • Measurement of levels of antioxidant capacity and glutathione peroxidase measurements were conducted by the Antioxidant capacity and GPX assay kit (ZellBio, German). (ac.ir)
  • A kinetic, rate based assay kit for quantification of glutathione peroxidase (GPx) in a variety of samples including blood products, tissues and cultured cells. (nwlifescience.com)
  • One of the regulated genes was that for plasma glutathione peroxidase (pGPx). (molcells.org)
  • This study was conducted to investigate the possible effects of temperature in vivo on Glutathione peroxidase (GPX) oxidative activity in fish tissues.An adult fully grown cat fish, (the African flathead catfish , Clariasgariepinus ) about 0.7m in length and 0.15 in width, weighing 15Kg was obtained from the school pond. (projectng.com)
  • It has been shown that low levels of glutathione peroxidase as measured in the serum may be a contributing factor to vitiligo. (wikipedia.org)
  • Glutathione Peroxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Une recherche documentaire a été effectuée dans PubMed de 1980 à 2021 en utilisant diverses combinaisons de termes MeSH comme tabac, diabète, hypertension, dyslipidémie, trouble dépressif majeur, trouble bipolaire, schizophrénie. (bvsalud.org)
  • Lower plasma glutathione peroxide levels were also observed in patients with type 2 diabetes with macroalbuminuria and this was correlated to the stage of diabetic nephropathy. (wikipedia.org)
  • For this purpose, the present study was conducted to evaluate the effect of 10 weeks supplementation of sesamin and aerobic exercise on plasma levels of total antioxidant capacity and glutathione peroxidase in athletic men. (ac.ir)
  • Glutathione measurements confirmed the effectiveness of BSO treatment. (cdc.gov)
  • Mice with knockouts for GPX3 (GPX3−/−) or GPX2 (GPX2−/−) also develop normally However, glutathione peroxidase 4 knockout mice die during early embryonic development. (wikipedia.org)
  • Some evidence, though, indicates reduced levels of glutathione peroxidase 4 can increase life expectancy in mice. (wikipedia.org)