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  • GSTs
  • Domain 1 of the cytosolic GSTs contains a highly conserved isoleucine residue in α-helix 3, located below the active site at position 71 in human class Alpha glutathione transferase A1-1 (hGST A1-1), that is involved in maintaining the packing within the hydrophobic core of domain 1. (wits.ac.za)
  • metabolites
  • Effect of N-acetylcysteine on the spinal-cord glutathione system and nitric-oxide metabolites in rats with neuropathic pain . (nih.gov)
  • Glutathione S-transferase uses GSH to clean up various metabolites, xenobiotics, and electrophiles to mercapturates for excretion. (wikipedia.org)
  • xenobiotics
  • Glutathione interacts with foreign chemicals (primarily, it is a scavenger of harmful xenobiotics that have been oxidized) compounds to neutralize and break them down, then eliminate them from the body. (immunehealthscience.com)
  • conjugation
  • Conjugation to heavy metals (conjugation - joining with and transforming by becoming part of) Glutathione joins with heavy metals to neutralize them and eliminate them from the body. (immunehealthscience.com)
  • The primary role of GSTs is to catalyse the conjugation of glutathione (GSH) with the electrophilic centers of a wide variety of molecules. (wikipedia.org)