• gluconeogenesis
  • Inhibitors of G6PT1 are the most studied as this subunit catalyzes the rate limiting step in glucose production through gluconeogenesis or glycogenolysis, and without its function these two processes could not occur. (wikipedia.org)
  • G6PT1
  • G6PT1 transports Glucose-6-Phosphate from the cytosol into the lumen of the endoplasmic reticulum, where it is hydrolyzed by the catalytic subunit of G6Pase. (wikipedia.org)
  • Studies monitoring blood glucose levels in rabbits revealed that the activity of G6Pase, and therefore G6PT1, is increased in specimens with diabetes. (wikipedia.org)
  • This strong correlation with diabetes type 2 makes the G6Pase complex, and G6PT1 in particular, an appealing drug target for control of blood glucose levels as its inhibition would directly prevent the release of free glucose into the bloodstream. (wikipedia.org)
  • glycolysis
  • View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose , the pathway glycolysis and in Carbohydrate degradation . (uniprot.org)
  • The addition of the 2nd phosphoryl group to produce fructose-1,6-bisphosphate is an irreversible step, and so is used to irreversibly target the glucose 6-phosphate breakdown to provide energy for ATP production via glycolysis. (wikipedia.org)
  • urine
  • Within 6 to 24 hours, urine may become noticeably dark and can appear red, brown or even black. (rarediseases.org)
  • tissue
  • Tissue (10-100 mg) or cells (1-5 x 10 6 ) can be homogenized in 2-3 volumes of ice cold PBS or other buffer (pH 6.5-8). (sigmaaldrich.com)
  • mechanism
  • This is a very efficient storage mechanism for glucose since it costs the body only 1 ATP to store the 1 glucose molecule and virtually no energy to remove it from storage. (wikipedia.org)
  • cell
  • This is a compound that is very common in cells as the vast majority of glucose entering a cell will become phosphorylated in this way. (wikipedia.org)
  • Because of its prominent position in cellular chemistry, glucose 6-phosphate has many possible fates within the cell. (wikipedia.org)
  • Beutler E, Mitchell M. New rapid for the estimation of red cell galactose-1-phosphate uridyl transferase activity. (wikipedia.org)