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  • pharmacologic
  • RESULTS: Glucocorticoids, administered in the critical care setting for planned extubation, markedly reducing the risk of reintubation and remain a rudimentary pharmacologic adjunct in laryngeal manifestations of common autoimmune and inflammatory disorders. (biomedsearch.com)
  • acute
  • This summary of a Cochrane review presents what we know from research about the effect of glucocorticoid injections (into affected joints) in people with acute gout. (cochrane.org)
  • There is presently no evidence from randomised trials to support the use of intra-articular glucocorticoid treatment in acute gout. (cochrane.org)
  • Although intra-articular glucocorticoids are a commonly used intervention in the treatment of acute gout, there is little evidence to support their safety and efficacy in this setting. (cochrane.org)
  • To evaluate the safety and efficacy of intra-articular glucocorticoids in the treatment of acute gout. (cochrane.org)
  • No trials were identified that evaluated the efficacy and safety of intra-articular glucocorticoids for acute gout. (cochrane.org)
  • Wechalekar MD, Vinik O, Schlesinger N, Buchbinder R. Intra-articular glucocorticoids for acute gout. (cochrane.org)
  • 2001) presented a 10-year-old male patient, with no prior psychiatric history, who showed significant declines in academic performance that began during a 5-week course of glucocorticoid treatment for acute asthma flare. (wikipedia.org)
  • Topical
  • See 'General principles of dermatologic therapy and topical corticosteroid use', section on 'Side effects' and 'Major side effects of inhaled glucocorticoids', section on 'Contact hypersensitivity' . (uptodate.com)
  • topical glucocorticoids may be tried. (wikipedia.org)
  • Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. (wikipedia.org)
  • secretion
  • In accordance, glucocorticoids are known to affect cognition, stress-adaptive behavior, and neuroendocrine output (e.g., suppression of oxytocin and vasopressin secretion) within minutes. (wikipedia.org)
  • In GRA, the hypersecretion of aldosterone and the accompanying hypertension are remedied when ACTH secretion is suppressed by administering glucocorticoids. (wikipedia.org)
  • Medication
  • Dementia-like symptoms have been found in some individuals who have been exposed to glucocorticoid medication, often dispensed in the form of asthma, arthritis, and anti-inflammatory steroid medications. (wikipedia.org)
  • These symptoms have been shown to improve within months to a year after discontinuing glucocorticoid medication, but residual impairments following prolonged steroid use can remain. (wikipedia.org)
  • Aside from discontinuation of glucocorticoid medication, potential treatments discussed in the research literature include:[citation needed] anti-glucocorticoids psychoactive drugs that up-regulate the GRII glucocorticoid receptor:tricyclic antidepressants: Desipramine, Imipramine, and Amitriptyline (SSRIs do not ) serotonin antagonists: Ketanserin mood stabilizers: Lithium corticotropin-releasing hormone (CRH) antagonists glutamate antagonists dehydroepiandrosterone (DHEA) small molecule brain-derived neurotrophic factor (BDNF) analogs stress reduction therapies and exercise. (wikipedia.org)
  • elicit
  • A team of researchers, led by Carolyn Cummins, at the University of Toronto, Ontario, has now shown that the protein LXR-beta is required in mice for glucocorticoid drugs to elicit many of their negative side effects. (redorbit.com)
  • In vivo evidence on whether particular SEGRAMs can elicit similar effects than classic glucocorticoid in cancer pathologies is currently lacking. (wikipedia.org)
  • Current preclinical tests show that the SEGRAMs available so far would elicit fewer side effect or at least less grave side effects than classic glucocorticoids would. (wikipedia.org)
  • hippocampus
  • Despite having a high level of receptor expression, the physiological role of glucocorticoid signaling in the developing hippocampus is not well defined. (wikipedia.org)
  • Scientific studies have mainly focused on the impact of glucocorticoids on the hippocampus because of its role in memory processes and on the prefrontal cortex for its role in attention and executive function. (wikipedia.org)
  • injections
  • An early report in the 1950s described 6700 glucocorticoid injections given to 2256 patients [ 1 ]. (uptodate.com)
  • Studies of glucocorticoid injections in other conditions that lead to joint pain suggest that this therapy may be well tolerated, relatively safe and effective in relieving pain. (cochrane.org)
  • modulator
  • It acts as both a transcription factor for responses to glucocorticoids and modulator for other transcription factors while also regulating phospholipase A2 activity. (wikipedia.org)
  • pathway
  • The activated GR can then regulate gene expression via one of two pathways: Transactivation The first (direct) pathway is called transactivation whereby the activated GR dimerizes, is translocated into the nucleus and binds to specific sequences of DNA called glucocorticoid response elements (GREs). (wikipedia.org)
  • glucose
  • The name "glucocorticoid" derives from early observations that these hormones were involved in glucose metabolism. (wikipedia.org)
  • Importantly, although mice lacking LXR-beta did not develop high levels of blood glucose or fatty liver when administered a glucocorticoid drug, they did show all the signs of immunosuppression. (redorbit.com)
  • Indeed, the designation glucocorticoid arose from observations that the hormones played a role in the utilization of glucose. (encyclopedia.com)
  • In an absence of food, which can be broken down to supply glucose, glucocorticoids act to increase and maintain the normal levels of glucose in the blood. (encyclopedia.com)
  • As well, glucocorticoids curb the storage of glucose in cells of the body, which leaves the sugar ready for use. (encyclopedia.com)
  • hippocampal
  • The following will provide an introduction to hippocampal development with particular focus on the role of glucocorticoid signaling. (wikipedia.org)
  • More research is needed to understand the role of glucocorticoids in the context of human hippocampal development. (wikipedia.org)
  • Steroid dementia syndrome describes the signs and symptoms of hippocampal and prefrontal cortical dysfunction, such as deficits in memory, attention, and executive function, induced by glucocorticoids. (wikipedia.org)
  • novel
  • In central nervous system structures, the glucocorticoid receptor is gaining interest as a novel representative of neuroendocrine integration, functioning as a major component of endocrine influence - specifically the stress response - upon the brain. (wikipedia.org)
  • Important discoveries are presented, as well as milestones in drug development, a survey of current clinical practice, and prospects for novel glucocorticoid-based therapeutics. (springer.com)