• tumors
  • Dysgerminomas, like other seminomatous germ cell tumors, are very sensitive to both chemotherapy and radiotherapy . (wow.com)
  • I. To determine the response rates following treatment with PD 0332991 in the following malignancies: 1) Metastatic breast cancer, 2) Metastatic colorectal cancer, 3) Metastatic melanoma with CDK4 mutation or amplification, or 4) Cisplatin-refractory, unresectable germ cell tumors. (clinicaltrials.gov)
  • genes
  • Although many genes involved in germ cell migration and SGP specification have been characterized, only three downstream genes have been identified that specifically coordinate the morphogenetic movements of gonad formation. (biologists.org)
  • tissue
  • Once germ cells contact SGPs, these two distinct cell types sort away from neighboring mesodermal cells, forming a contiguous tissue along PS10-12. (biologists.org)
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • type
  • Chemokine (C-X-C motif) ligand 12 (CXCL12) signaling via its receptor C-X-C chemokine receptor type 4 (CXCR4) is also involved in regulation of SSC fate decisions.CXCL12 is found in Sertoli cells in the basement membrane of the seminiferous tubules in adult mouse testes, and its receptor is expressed in undifferentiated spermatogonial cells. (wikipedia.org)
  • provide
  • SSCs survive within microenvironments, termed niches, which provide extrinsic stimuli that drive stem cell differentiation or self-renewal. (wikipedia.org)