• tumors
  • Dysgerminomas, like other seminomatous germ cell tumors, are very sensitive to both chemotherapy and radiotherapy . (wow.com)
  • I. To determine the response rates following treatment with PD 0332991 in the following malignancies: 1) Metastatic breast cancer, 2) Metastatic colorectal cancer, 3) Metastatic melanoma with CDK4 mutation or amplification, or 4) Cisplatin-refractory, unresectable germ cell tumors. (clinicaltrials.gov)
  • Drosophila
  • Previously, we have shown that gonad formation in Drosophila requires the homophilic cell-adhesion molecule Drosophila E-cadherin (DE-cadherin), and also Fear of Intimacy (FOI), which is required for stable accumulation of DE-cadherin protein in the gonad. (biologists.org)
  • Germ cells are initially formed at the posterior pole of Drosophila embryos during the syncytial blastoderm stage. (biologists.org)
  • genes
  • Although many genes involved in germ cell migration and SGP specification have been characterized, only three downstream genes have been identified that specifically coordinate the morphogenetic movements of gonad formation. (biologists.org)
  • PGCs
  • nos-1 is expressed in PGCs after gastrulation, and is required redundantly with nos-2 to prevent PGCs from dividing in starved animals and to maintain germ cell viability during larval development. (biologists.org)
  • tissue
  • Once germ cells contact SGPs, these two distinct cell types sort away from neighboring mesodermal cells, forming a contiguous tissue along PS10-12. (biologists.org)
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)