• transcriptomic
  • CLC bio's software allows the user to analyze, visualize, and compare genomic, transcriptomic, and epigenomic data from all major high-throughput sequencing platforms such as Illumina, Life Technologies, Roche 454, Pacific Biosciences, and Complete Genomics. (wikipedia.org)
  • chromosomes
  • The authors painted a series of individual human chromosomes from a DNA library with two different fluorophores in different proportions to test the technique, and also applied CGH to genomic DNA from patients affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line. (wikipedia.org)
  • Genetic variation is brought about, fundamentally, by mutation, which is a permanent change in the chemical structure of chromosomes. (wikipedia.org)
  • copy
  • In recent studies, copy-number variations are tested on people who do not have genetic diseases, using methods that are used for quantitative SNP genotyping. (wikipedia.org)
  • Results show that 28% of the suspected regions in the individuals actually do contain copy number variations. (wikipedia.org)
  • Copy number variation is a type of structural variation: specifically, it is a type of duplication or deletion event that affects a considerable number of base pairs. (wikipedia.org)
  • In mammals, copy number variations play an important role in generating necessary variation in the population as well as disease phenotype. (wikipedia.org)
  • Copy number variations can be generally categorized into two main groups: short repeats and long repeats. (wikipedia.org)
  • The short repeat size of these copy number variations lends itself to errors in the polymerase as these repeated regions are prone to misrecognition by the polymerase and replicated regions may be replicated again, leading to extra copies of the repeat. (wikipedia.org)
  • Although these are the general groups that copy number variations are grouped into, the exact number of base pairs copy number variations affect depends on the specific loci of interest. (wikipedia.org)
  • Currently, using data from all reported copy number variations, the mean size of copy number variant is around 118kb, and the median is around 18kb. (wikipedia.org)
  • Moreover, these copy number variation hotspots are consistent throughout many populations from different continents, implying that these hotspots were either independently acquired by all the populations and passed on through generations, or they were acquired in early human evolution before the populations split, the latter seems more likely. (wikipedia.org)
  • nucleotides
  • Technical variations of chain-termination sequencing include tagging with nucleotides containing radioactive phosphorus for radiolabelling, or using a primer labeled at the 5' end with a fluorescent dye. (wikipedia.org)
  • large
  • This technique can also be used in evolution studies by identifying large structural variation between different populations. (wikipedia.org)
  • Investments in computer infrastructure from the 2003 CFI/Ontario Innovation Trust competition resulted in the establishment of new phases of the high-performance computing cluster (HPF) that is currently used by TCAG and many other users, to allow analysis of large genomic datasets arising from new microarray and sequencing technologies. (wikipedia.org)
  • molecular
  • Modern descriptions of biological evolution will typically elaborate on major contributing factors to evolution such as the formation of local micro-environments, mutational robustness, molecular degeneracy, and cryptic genetic variation. (wikipedia.org)