• structural
  • This, together with ongoing structural changes in chromosomes, could accelerate accumulation of alleles carrying pro-oncogenic mutations and loss of alleles containing wild-type tumor suppressor genes and thus accelerate the genomic changes characteristic of carcinoma, the most prevalent human cancer. (umassmed.edu)
  • Cells
  • Cells defective in BLM also exhibit genomic instability, the hallmark being an increased level of sister chromatid exchanges ( German, 1993 ). (embopress.org)
  • These cells preferentially exhibited pericentromeric instability, characterized by persistent occurrence of de novo pericentromeric or centromeric rearrangements, breaks, deletions or iso-chromosomes. (nrtisinhibitor.com)
  • human
  • This is because all intact/ normal human chrom.To cause genomic instability particularly at chromosome loci that are intrinsically difficult to replicate because of the complexity of secondary structures or difficulty in unwinding during DNA replication [3,18, (nrtisinhibitor.com)