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  • sequences
  • In this study, we determined the whole mitochondrial DNA (mtDNA) sequences of seven sharks including representatives of the five Hexanchiformes, one squaliform, and one carcharhiniform and inferred the phylogenetic relationships among those species and 12 other Chondrichthyes (cartilaginous fishes) species for which the complete mitogenome is available. (hindawi.com)
  • mtDNA
  • Study director Professor Lisa Matisoo-Smith explains that mitochondrial DNA (mtDNA) is only inherited through the mother's side and can be used to trace maternal lineages and provide insights into ancient origins and migration routes. (eurekalert.org)
  • complete
  • In a landmark study, University of Otago researchers have achieved the feat of sequencing complete mitochondrial genomes for members of what was likely to be one of the first groups of Polynesians to settle New Zealand and have revealed a surprising degree of genetic variation among these pioneering voyagers. (eurekalert.org)
  • Results from the team's successful mapping of complete mitochondrial genomes of four of the Rangitane iwi (tribe) tupuna (ancestors) who were buried at a large village on Marlborough's Wairau Bar more than 700 years ago will be published online in the prestigious US journal Proceedings of the National Academy of Sciences ( PNAS ). (eurekalert.org)
  • Possibly, it may have been missed due to most previous work only focusing on a small portion of the mitochondrial genome rather than complete analyses like ours. (eurekalert.org)
  • Neanderthal
  • Professor Matisoo-Smith and colleagues including ancient DNA analysis expert Dr Michael Knapp used Otago's state-of-the-art ancient DNA research facilities to apply similar techniques that other scientists recently employed to sequence the Neanderthal genome. (eurekalert.org)
  • NEW YORK (GenomeWeb) - Analysis of a newly sequenced Neanderthal mitochondrial genome indicates that Neanderthals and ancestors of modern humans migrating from Africa might have met earlier than previously assumed. (genomeweb.com)
  • Evidence presented in 2017 raises the possibility that a yet earlier migration, dated to around 270,000 years ago, may have left traces of admixture in Neanderthal genome. (wikipedia.org)
  • variants
  • A genome-wide association study that linked common genetic variants to salivary gland carcinoma risk has been retracted, according to Retraction Watch. (genomeweb.com)
  • The microarray interrogates all 16,500 bases of the human mitochondrial genome with only three polymerase chain reactions (PCR), providing scientists with the efficient method for detecting variants associated with genetic disease, forensics, population studies or stem cells. (technologynetworks.com)
  • Variants of MT-ND3 are associated with Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), Leigh's syndrome (LS) and Leber's hereditary optic neuropathy (LHON). (wikipedia.org)
  • subunit
  • Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland," Breast Cancer Research and Treatment , vol. 121, no. 2, pp. 511-518, 2010. (hindawi.com)
  • The ND3 protein is a subunit of NADH dehydrogenase (ubiquinone), which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. (wikipedia.org)
  • human
  • Until the advent of next generation sequencing techniques, the highly degraded state of DNA in human remains of this age has not allowed such genomes to be sequenced," she says. (eurekalert.org)
  • The robust Affymetrix GeneChip Human Mitochondrial Resequencing Array 2.0 provides a complete picture of variation in the mitochondrial genome, while significantly reducing the time, labor and cost involved in sample preparation," said Greg Yap, vice president of DNA Products at Affymetrix. (technologynetworks.com)
  • MT-ND3 is located in human mitochondrial DNA from base pair 10,059 to 10,404. (wikipedia.org)
  • species
  • It has been postulated that substoichiometric shifting may have evolved to permit the species to create and retain mitochondrial genetic variation in a silenced but retrievable form ( 22 ). (pnas.org)
  • The mitochondrial genome of Branchiostoma lanceolatum has been sequenced, and the species serves as a model organism for studying the development of vertebrates. (wikipedia.org)
  • Biology
  • In Genome Biology this week: peopling of the Sahara, epigenetic reprogramming analysis of liverwort, and more. (genomeweb.com)
  • Julia Bailey-Serres is professor of genetics, director of the Center for Plant Cell Biology, and a member of the Institute for Integrative Genome Biology at the University of California, Riverside. (wikipedia.org)
  • PNAS
  • Results from the team's successful mapping of complete mitochondrial genomes of four of the Rangitane iwi (tribe) tupuna (ancestors) who were buried at a large village on Marlborough's Wairau Bar more than 700 years ago will be published online in the prestigious US journal Proceedings of the National Academy of Sciences ( PNAS ). (eurekalert.org)
  • stable
  • Endo T, Nakayama Y, Nakai M (1995) Avidin fusion protein as a tool to generate a stable translocation intermediate spanning the mitochondrial membranes. (springer.com)
  • protein
  • The flow of electrons changes the redox state of the protein, resulting in a conformational change and pK shift of the ionizable side chain, which pumps four hydrogen ions out of the mitochondrial matrix. (wikipedia.org)
  • researchers
  • In a landmark study, University of Otago researchers have achieved the feat of sequencing complete mitochondrial genomes for members of what was likely to be one of the first groups of Polynesians to settle New Zealand and have revealed a surprising degree of genetic variation among these pioneering voyagers. (eurekalert.org)
  • The researchers discovered that the four genomes shared two unique genetic markers found in modern Maori while also featuring several previously unidentified Polynesian genetic markers. (eurekalert.org)
  • found
  • However, increasingly correlations are being found between various mitochondrial haplogroups and susceptibility to cancer or diseases in some cases and successful aging in others. (hindawi.com)
  • Most DNA in an individual genome is found in chromosomes but DNA found outside the nucleus also serves important biological functions. (wikipedia.org)
  • In addition to DNA found outside the nucleus in cells, infection of viral genomes also provides an example of extrachromosomal DNA. (wikipedia.org)
  • A study of the mitochondrial control region of the specimen that Hodgson collected (labelled BM58.6.24.61) was found to fall within the proposed Himalayan wolf clade. (wikipedia.org)
  • Physical
  • Evidence for the overwhelming contribution of the "recent African origin" of modern populations outside of Africa, due to the wave of expansion beginning after 70,000 years ago, was established based on mitochondrial DNA, combined with evidence based on physical anthropology of archaic specimens, during the 1990s and 2000s. (wikipedia.org)
  • size
  • Three regions unique to race A are also presented bringing the size of this genome to 100,314 bp. (springer.com)
  • studies
  • Low "penetrance" of phylogenetic knowledge in mitochondrial disease studies," Biochemical and Biophysical Research Communications , vol. 333, no. 1, pp. 122-130, 2005. (hindawi.com)
  • This webinar will discuss an optimized protocol for methyl-CpG binding domain sequencing (MBD-seq), which enables comprehensive, adequately powered, and cost-effective large-scale methylome-wide association studies (MWAS) of almost all 28 million CpG sites in the genome. (genomeweb.com)
  • plants
  • In higher plants, mitochondrial functions and behavior have clearly been influenced by the unique context of the plant cell. (pnas.org)
  • years
  • Based on this, it appears that the genome has been more-or-less frozen in time for millions and millions of years. (redorbit.com)
  • However, mitochondrial DNA evidence had pointed to a more recent divergence some 400,000 years ago. (genomeweb.com)
  • Abnormalities in mitochondrial energy generation result in neurodegenerative disorders like Leigh syndrome, which is characterized by an onset of symptoms between 12 months and three years of age. (wikipedia.org)