Genome archaeal. Medical search. Frequent questions

This list of sequenced archaeal genomes contains all the archaea known to have publicly available complete genome sequences that have been assembled, annotated and deposited in public databases. (wikipedia.org)
Currently in this list there are 39 genomes belonging to Crenarchaeota species, 105 belonging to the Euryarchaeota, 1 genome belonging to Korarchaeota and to the Nanoarchaeota, 3 belonging to the Thaumarchaeota and 1 genome belonging to an unclassified Archaea, totalling 150 Archaeal genomes. (wikipedia.org)
The genome of Hyperthermus butylicus: a sulfur-reducing, peptide fermenting, neutrophilic Crenarchaeote growing up to 108 degrees C". Archaea. (wikipedia.org)
We applied genome-resolved metagenomics to 41 Arctic seawater samples, collected at various depths in different seasons during the Tara Oceans Polar Circle expedition, to evaluate the ecology, metabolic potential and activity of resident bacteria and archaea. (edu.sa)
However, genome-wide searches of archaea have failed to detect any orthologs to both GTPases. (rcsb.org)
The multiple binding capacity of archaeal EF1α explains the absence of GTPase orthologs for eRF3 and HBS1 in archaea species and suggests that universal molecular mechanisms underlie translational elongation and termination, and mRNA surveillance pathways. (rcsb.org)
Archaea, together with Bacteria, represent the two main divisions of life on Earth, with many of the defining characteristics of the more complex eukaryotes tracing their origin to evolutionary innovations first made in their archaeal ancestors. (biomedcentral.com)
One of the most notable such features is nucleosomal chromatin, although archaeal histones and chromatin differ significantly from those of eukaryotes, not all archaea possess histones and it is not clear if histones are a main packaging component for all that do. (biomedcentral.com)
Here, we adapt the ATAC-seq assay to archaea and use it to map the accessible landscape of the genome of the euryarchaeote Haloferax volcanii . (biomedcentral.com)
The team's finding hinted that genome packing may have originated in archaea, organisms that lack nuclei. (phys.org)
The AOM mechanism most relevant to this study is mediated by microbial consortia of archaea, related to the archaeal anaerobic methane oxidizer group ANME, and bacterial sulfate-reducers of the Desulfosarcinales/ Desulfococcus (DSS) group ( Knittel and Boetius, 2009 and references therein). (frontiersin.org)
Phylogeny and evolution of the Archaea: one hundred genomes later. (biostars.org)
In particular, the recent years have witnessed the discovery of various and previously unknown archaeal lineages of high taxonomic rank such as the enigmatic DPANN archaea. (nioz.nl)
DPANN archaea include several different and highly diverse phyla that are comprised by organisms with small cell sizes and genomes and encode a limited metabolic repertoire suggesting that they may be dependent on symbiotic interactions with other organisms. (nioz.nl)
Genome researchers from the US and Germany have published the initial "volume" of the Genomic Encyclopedia of Bacteria and Archaea (GEBA)-an analysis of the first 56 genomes sequenced from the two domains. (greencarcongress.com)
The genetic complement of an archaeal organism ( ARCHAEA ) as represented in its DNA . (nih.gov)
AbstractAsgard archaea have recently been identified as the closest archaeal relatives of eukaryotes. (uibk.ac.at)
We found related viruses in the genomes of diverse prokaryotes from geothermal environments, including other Asgard archaea. (uibk.ac.at)
Characterization of cellular functions consistently predicted from the sequenced microbial genomes in a phylogenetic context can shed light on their evolution in Bacteria and Archaea. (biomedcentral.com)

We assembled 530 metagenome-assembled genomes (MAGs) to form the Arctic MAGs catalogue comprising 526 species. (edu.sa)
The authors present a workflow from recovering metagenome-assembled genomes that utilizes Megahit, Minimus2, BinSanity, and CheckM. (peerj.com)
I do have some concerns and questions regarding the workflow, the reported quality of the metagenome-assembled genomes, and the presented phylogenetic assignments. (peerj.com)
We assembled 451 metagenome-assembled genomes from 18 bacterial and archaeal phyla, constituting the largest resource of Antarctic soil microbial genomes to date. (biorxiv.org)
In the current study, nine metagenome-assembled genomes of Bathyarchaeota from four subgroups were constructed from mangrove sediments, and metatranscriptomes were obtained for evaluating their in situ transcriptional activities. (biomedcentral.com)

Predicted highly expressed genes in archaeal genomes. (wikigenes.org)
instead, only one or a very small number of histone genes are found in archaeal genomes, and the structures they form are very different from those of eukaryotes. (biomedcentral.com)
Such bends in the springlike structures could potentially let archaeal proteins sidle up to the DNA and switch genes on and off, Luger suggests. (phys.org)
Bending the DNA slinky in this way might expose particular archaeal genes, which the cell could then turn off or on. (phys.org)
To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. (embl.de)
To go back in time, the researchers used information written in the genomes of modern organisms, organizing life forms according to the evolution of genes and proteins linked to chromatin. (analytica-world.com)
Its presence has never been a mystery: it is due to the presence of protein coding genes in genomes. (biomedcentral.com)
Comparative analyses with reference genomes and the transcripts of functional genes posit an expanded role for Bathyarchaeota in phototrophy, autotrophy, and nitrogen and sulfur cycles, respectively. (biomedcentral.com)
Notably, the presence of genes for rhodopsins, cobalamin biosynthesis, and the oxygen-dependent metabolic pathways in some Bathyarchaeota subgroup 6 genomes suggest a light-sensing and microoxic lifestyle within this subgroup. (biomedcentral.com)
First, genes are predicted from the genome sequence. (biomedcentral.com)
The genome has not yet been sequenced, but using relationships between various hyperthermophiles with respect to their size, their structural organization and their phylogenetic relationship based on the content of the respectetive 16rDNA genes it is determined the entire genome of pyrodictium abyssi is a single circular chromosome and approximately 1.6Mb. (kenyon.edu)
Contains prophage information for all the genes of the genome, one per line. (github.io)

Nearly all eukaryotic genomes are packaged by nucleosomes, consisting of two tetramers of the four core histones H2A, H2B, H3, and H4, wrapping around ∼ 147 bp of DNA. (biomedcentral.com)
Its association to protein coding proved to be useful to locate exons in higher eukaryotic genomes [ 18 ]. (biomedcentral.com)
The relationships and divergence times (Mya - million years ago) of 95 organisms (41 bacterial, 11 archaeal, and 43 eukaryotic genomes) are based on recent studies [95]. (biomedcentral.com)

The decreasing cost of sequencing technologies and the improving ability to sequence complete microbial genomes promises to enhance taxonomic classification and the phylogenetic placement of metagenomic data, produced from multiple gene families. (news-medical.net)

Additionally, the team performed phylogenetic analyses of the whole-genome sequences using the Genome-Blast Distance Phylogeny approach. (genomeweb.com)
We observed that genomes with increased phylogenetic distance encoded the highest number of novel protein families, supporting the rationale for continued phylogeny-driven sequencing efforts aimed at expanding the representation of cultivated microbes. (genomeweb.com)
As far as a phylogeny, the Tree of Life project has a good Archaeal component -- maybe use that for inspiration? (biostars.org)

This collection of 17,163 genomes was built by selecting exactly one genome assembly for each species among the 272,000+ prokaryotic genomes in RefSeq, except for E. coli for which two assemblies were selected as reference. (nih.gov)
RefSeq prokaryotic genomes and proteins are now annotated with Gene Ontology (GO) terms. (nih.gov)
We are embarking on this adventure and starting to place terms from the Biological Process, Molecular Function and Cellular Component ontologies to genomes and proteins we annotate with the Prokaryotic Genome Annotation Pipeline (PGAP). (nih.gov)
Average nucleotide identity analysis is a useful tool to verify taxonomic identities in prokaryotic genomes, for both complete and draft assemblies. (nih.gov)
Using optimum threshold ranges appropriate for different prokaryotic taxa, we have reviewed all prokaryotic genome assemblies in GenBank with regard to their taxonomic identity. (nih.gov)
Many clades in the prokaryotic tree of life have now been covered by sequenced genomes in GenBank. (biomedcentral.com)
A total of 14,727 GenBank prokaryotic genomes were re-annotated using a new protein family database, UniFam, to obtain consistent functional annotations for accurate comparison. (biomedcentral.com)
706 prokaryotic metabolic pathways were inferred from these genomes using Pathway Tools and MetaCyc. (biomedcentral.com)

We use established model organisms and genome-enabled species from many branches of the tree of life. (berkeley.edu)
OPPORTUNITY TO PROPOSE ORGANISMS FOR BAC LIBRARY CONSTRUCTION Release Date: December 19, 2001 NOTICE: NOT-HG-02-004 National Human Genome Research Institute Annual Submission Dates: February 10, June 10 and October 10 Over the past several years, the bacterial artificial chromosome (BAC) has emerged as the vector system of choice for the construction of the large- insert chromosomal DNA libraries that are needed in genomic studies. (nih.gov)
Because BAC clones are relatively large and appear to faithfully represent an organism"s genome, the BAC system will also be the vehicle of choice for the isolation of targeted regions of genomic DNA from additional organisms being used in specific biological studies, a variety of mouse strains, and even from individual humans. (nih.gov)
During the past decade, cultivation-independent approaches such as metagenomics, which allows to sequence DNA directly from environmental samples and to subsequently reconstruct individual genomes of organisms in these samples, has brought about significant new insights into the evolution and genomic potential of uncultivated microorganisms. (nioz.nl)
In this project, you will establish and maintain co-cultures of both organisms as well as pure cultures of I. hospitalis and follow those over various generations by among others using microscopy and genome sequencing techniques. (nioz.nl)
The GEBA pilot was launched in May 2007 in collaboration with the non-profit German Collection of Microorganisms and Cell Cultures, DSMZ to sequence 100 bacterial and archaeal genomes based on the phylogenetic positions of organisms. (greencarcongress.com)
The distribution of nucleotides in genomes is not random, various biases are affecting the genome sequences from organisms spanning the three domains of life. (biomedcentral.com)

Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure. (cam.ac.uk)
The GEBA initiative aims to "expand the reference genome catalog of broad phylogenetic and physiological diversity, to determine how this catalog facilitates the discovery of protein families and expands the diversity of known functions, and to ascertain whether these type-strain genomes improve the recruitment and phylogenetic assignment of existing metagenomic sequences," the researchers wrote. (genomeweb.com)
Once the researchers had obtained specimens, they sequenced them using Illumina instruments to generate whole-genome sequences. (genomeweb.com)
This bias is present throughout a given genome, both in coding and non-coding sequences. (biomedcentral.com)
A large proportion of protein sequences identified in MGI SAGs were absent in the marine cultures Cenarchaeum symbiosum and Nitrosopumilus maritimus, thus expanding the predicted protein space for this archaeal group. (uni-bielefeld.de)
Genome sequences identified as bacterial. (github.io)
Phage sequences extracted from the genome in FASTA format. (github.io)
Phage sequences extracted from the genome in GenBank format. (github.io)

Figure 1: Excerpt from the RefSeq record for NZ_CP091650.1 , a Klebsiella pneumoniae genome, showing the annotation of the the katG gene, with Molecular Function GO terms GO:0004096 and GO:0004601 and Biological Process GO term GO:0006979 . (nih.gov)
Annotation of the Drosophila genome. (wikigenes.org)
The functional profile of a genome was represented by the biological process Gene Ontology (GO) terms in its annotation. (biomedcentral.com)

Our results provide the first comprehensive maps of chromatin accessibility and active transcription in Haloferax across conditions and thus a foundation for future functional studies of archaeal chromatin. (biomedcentral.com)
Bowerman notes that the idea still needs to be confirmed in studies of archaeal cells, rather than DNA in solution. (phys.org)

The researchers found that prokaryotes lack the machinery necessary to modify histones, suggesting archaeal chromatin at the time could have played a basic structural role but did not regulate the genome. (analytica-world.com)
The genomes of prokaryotes and lower eukaryotes display a very strong 11 bp periodic bias in the distribution of their nucleotides. (biomedcentral.com)
When taken together, these patterns cover up to half of the genome in the majority of prokaryotes. (biomedcentral.com)
The first prevalent bias, the most intense one, is easily visualized in the genomes of all prokaryotes, as well as of lower eukaryotes. (biomedcentral.com)
Likewise, the second prevalent bias, also very intense, is visualized in the genomes of most prokaryotes and lower eukaryotes. (biomedcentral.com)

Studies of the human colonic microbiota have previously highlighted exclusive methane production to a small number of archaeal lineages. (news-medical.net)

Despite increased interest in archaeal chromatin in recent years, its properties have been little studied using genomic tools. (biomedcentral.com)
New cryo-electron microscopy images suggest archaeal microbes pack their chromatin into tight coils that can spring open, forming unexpected contortions. (phys.org)
Archaeal chromatin 'slinkies' are inherently dynamic complexes with deflected DNA wrapping pathways, eLife (2021). (phys.org)

Bacterial and archaeal genomes with GO terms in RefSeq! (nih.gov)
They will progressively appear on genomes that are already in RefSeq as these get reannotated (about once a year). (nih.gov)
We expect all RefSeq genomes to have some GO terms by the spring of 2023. (nih.gov)
15-) using a local database for identification of all viruses, bacteria and archaeal genomes extracted from the NCBI refseq database (downloaded 15/04/2017). (cdc.gov)

The extent of genomic change that distinguishes the acidophilic archaeon Ferroplasma acidarmanus fer1 from an environmental population of the same species from the same site, fer1(env), was determined by comparing the 1.94-megabase (Mb) genome sequence of the isolate with that reconstructed from 8 Mb of environmental sequence data. (illinois.edu)
Here, for the first time in a member of the archaeal domain, we report a genome-wide assay of spontaneous mutations in the halophilic species Haloferax volcanii using a direct and unbiased method: mutation accumulation experiments combined with deep whole-genome sequencing. (elsevierpure.com)
A total of 441 MAGs belonged to species that have not previously been reported and 299 genomes showed an exclusively polar distribution. (edu.sa)
We present the methods used to make such comparisons, the current status of GenBank verifications, and recent developments in confirming species assignments in new genome submissions. (nih.gov)
For a microbial species, some essential cellular functions are maintained via vertical gene transfer, some beneficial ones are gained via horizontal gene transfer or evolutionary innovation, and some dispensable ones are lost in order to maintain a compact genome. (biomedcentral.com)

Detecting anomalous gene clusters and pathogenicity islands in diverse bacterial genomes. (wikigenes.org)
A dozen completely sequenced bacterial genomes all had an ftsZ gene, as did the several sequenced archaeal genomes. (duke.edu)

What distinguishes GEBA is that it is less about the individual genomes and more about building a more balanced catalog of the diversity of genomes present on the planet which in turn should facilitate searches for novel functions and our understanding of the complex processes of the biosphere. (greencarcongress.com)

An updated bacterial and archaeal reference genome collection is available! (nih.gov)

As of November 15, 2001, the following procedure will apply to all requests from investigators who wish to access the NIH-supported capacity for constructing BAC libraries from the genome of any organism for which there is currently no BAC library or for which a new library is needed. (nih.gov)
2001 ) The sequence of the human genome. (academictree.org)

This pipeline is applied to metagenomic samples from around the Mediterranean Sea and the 290 genomes recovered from these metagenomes presented as a genomic resource for use by the larger research community. (peerj.com)
All microbial members (bacterial, archaeal, bacteriophage, viral, and fungal) have been included in this baseline dataset and both phylogenetic marker gene sequence [e.g. 16S rRNA, 18S rRNA, and internal transcribed spacer region (ITS)] and metagenomic whole genome shotgun sequence data were generated. (nih.gov)
Phylogenetic and metagenomic recruitment analysis revealed that MGI single amplified genomes (SAGs) are genetically and biogeographically distinct from existing thaumarchaea cultures obtained from surface waters. (uni-bielefeld.de)
The development of reference databases will also aid the phylogenetic assignment of metagenomic data as more genomes are sequenced. (news-medical.net)

Using newly sequenced and existing plague genomes, researchers saw signs that the Second Plague Pandemic may have involved multiple introductions to Europe. (genomeweb.com)
Researchers sequenced 61 Zika virus genomes isolated from patients in the region to reconstruct viral movements. (genomeweb.com)
Researchers also used citrus genomes to untangle their relationships and suggest new taxonomic classifications. (genomeweb.com)
State-of-the-art cryo-EM, a type of electron microscopy, let the researchers examine archaeal DNA in different solutions. (phys.org)
Genome Insider: Methane Makers in Yosemite's Lakes Meet researchers who sampled the microbial communities living in the mountaintop lakes of the Sierra Nevada mountains to see how climate change affects freshwater ecosystems, and how those ecosystems work. (doe.gov)
But with two projects, communities are forming to generate high quality genomes to benefit researchers. (doe.gov)
This resource data set is the single largest effort (to our knowledge) to increase the phylogenetic coverage of cultivated bacterial and archaeal isolates," the researchers wrote. (genomeweb.com)

We integrate the resulting datasets with genome-wide maps of active transcription and single-stranded DNA (ssDNA) and find that while H. volcanii promoters exist in a preferentially accessible state, unlike most eukaryotes, modulation of transcriptional activity is not associated with changes in promoter accessibility. (biomedcentral.com)
Thus, we now know that many of the complex cellular features that characterize eukaryotes trace their origins to their archaeal ancestry [ 6 , 7 ]. (biomedcentral.com)
Archaeal histones differ substantially from those in eukaryotes - while they share the core histone fold domain, they usually do not have the unstructured tails of H2A/H2B/H3/H4 that are the main sites of key PTMs. (biomedcentral.com)
It has also been proposed that archaeal histones exhibit an inherently dynamic association with DNA [ 19 ], in contrast to the much more stable association of nucleosomes with DNA in eukaryotes. (biomedcentral.com)
It also appears, though very dimly, in the genomes of higher eukaryotes. (biomedcentral.com)

We also recovered genomes of microorganisms capable of oxidizing other inorganic compounds, including nitrogen, sulfur, and iron compounds, as well as harvesting solar energy via photosystems and novel microbial rhodopsins. (biorxiv.org)
Bacterial and archaeal microorganisms are capable of very diverse cellular functions. (biomedcentral.com)

Like DNA in the nucleus of human cells, archaeal DNA coils around proteins like string wrapped around a yo-yo. (phys.org)
Computer simulations of archaeal DNA (gray and blue) wound around proteins (pink and purple) suggest that the coiled structure is flexible. (phys.org)
In this work, we explore the metabolic adaptation of four syntrophic SRB clades (HotSeep-1, Seep-SRB2, Seep-SRB1a and Seep-SRB1g) from a phylogenomics perspective, tracing the evolution of conserved proteins in the syntrophic SRB clades, and comparing the genomes of syntrophic SRB to their nearest evolutionary neighbors in the phylum Desulfobacterota. (darkenergybiosphere.org)

Genome Biology. (wikipedia.org)
H. volcanii is a key model organism not only for the study of halophilicity, but also for archaeal biology in general. (elsevierpure.com)

This article has been updated to clarify that the number of bacterial type strains were doubled as a result of this project, not the number of bacterial reference genomes as previously stated. (genomeweb.com)

A phylogenetic reconstruction is formed from homology with sequenced genomes of isolated strains. (news-medical.net)

The resulting contigs were scanned against several BLAST ( 12 ) pre-generated databases downloaded from NCBI ( nt , tsa_nt , ref_prok_rep_genomes , ref_viruses_rep_genomes , and vector - downloaded 15/04/2017). (cdc.gov)
If I were you, I would just choose (NCBI list is a good place to start) or make a list of the Archaeal genomes you want to include in your study and work from there -- don't add or allow for changes in the future. (biostars.org)

To complete the overall dataset, the human genome sequence has also been analyzed for these subjects. (nih.gov)

The sequencing of eubacterial, archaeal, and plant genomes are more appropriate to the missions of other components of the NIH and/or other agencies. (nih.gov)

An online browser, called 'Theta-Base' ( www.helmholtz-hiri.de/en/datasets/bacteroides ), is launched to interrogate the obtained gene expression data and annotations of ~4500 transcription start sites, untranslated regions, operon structures, and 269 noncoding RNA elements. (nature.com)

Silver Age of GOLD Introduces New Features The Genomes OnLine Database makes curated microbiome metadata that follows community standards freely available and enables large-scale comparative genomics analysis initiatives. (doe.gov)

A compendium of bacterial and archaeal single-cell amplified genomes from oxygen deficient marine waters. (io-warnemuende.de)

The methyl-coenzyme M reductase (MCR) complex is a key enzyme in archaeal methane generation and has recently been proposed to also be involved in the oxidation of short-chain hydrocarbons including methane, butane, and potentially propane. (darkenergybiosphere.org)

2003 ) The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism. (academictree.org)
Tracing the Evolution of Shiitake Mushrooms Understanding Lentinula genomes and their evolution could provide strategies for converting plant waste into sugars for biofuel production. (doe.gov)
This will allow us to determine rates of genome evolution and horizontal gene transfer as well as unveil potential adaptations towards a symbiotic lifestyle and thereby shed first insights into how a DPANN archaeon influences the evolution of its hosts. (nioz.nl)

2000 ) The genome sequence of Drosophila melanogaster. (academictree.org)

The GO term enrichment analysis differentiated the functional profiles between selected archaeal taxa. (biomedcentral.com)

Genomic and proteomic comparisons between bacterial and archaeal genomes and related comparisons with the yeast and fly genomes. (wikigenes.org)
They were subsequently grown in the lab for proteomic and genome sequencing. (analytica-world.com)

1. To propose an organism as a candidate for having a BAC library constructed from its genome, a written request must be submitted to NHGRI. (nih.gov)

The main driver behind the GEBA project is that while the currently available sequenced genomes cover a wide range of biological and functional diversity, they have not covered a wide enough range of phylogenetic diversity. (greencarcongress.com)
The full set of cellular functions, or the functional profile, of a microorganism is encoded in its genome. (biomedcentral.com)

We also evaluate the degree of coordination of transcription within archaeal operons and make the unexpected observation that some CRISPR arrays are associated with highly prevalent ssDNA structures. (biomedcentral.com)

Here, we describe the closed genome of Ca. Odinarchaeum yellowstonii LCB_4, and, from this, obtain novel CRISPR arrays with spacer targets to several viral contigs. (uibk.ac.at)

Microbes mediate almost every conceivable biological process on the planet and genome sequencing has revolutionized our understanding of the diverse roles that they play. (greencarcongress.com)

Most Arctic MAGs have large genomes and the potential for fast generation times, both of which may enable adaptation to a copiotrophic lifestyle in nutrient-rich waters. (edu.sa)
Among them, bathyarchaeotal MAGs were picked out and combined with reference bathyarchaeotal genomes to form a database, then short DNA reads of Bathyarchaeota were recovered by remapping DNA reads of all samples to the genome database. (biomedcentral.com)

Predicting gene expression levels from codon biases in alpha-proteobacterial genomes. (wikigenes.org)
Among the different biases observed in the nucleotides distribution in genomes, two stood out prominently. (biomedcentral.com)
Both are short-range biases, i.e. correlating nucleotides over a short distance only, inferior to one thousand base pairs (bp), and both are affecting the genome as a whole. (biomedcentral.com)
This prevalent intensity and ubiquity is a hint that these biases are very likely to be the result of some strong physical constraints and/or biological functions acting on the affected genomes. (biomedcentral.com)

In one instance of metabolic adaptation to different partnerships, we show that Seep-SRB1a partners of ANME-2c appear to lack nutritional auxotrophies, while the related Seep-SRB1a partners of a different methanotrophic archaeal lineage, ANME-2a, are missing the cobalamin synthesis pathway, suggesting that the Seep-SRB1a partners of ANME-2a may have a nutritional dependence on its partner. (darkenergybiosphere.org)
A synthesis of bacterial and archaeal phenotypic trait data. (cns.fr)

The extensive metabolic potential encoded in the B . thetaiotaomicron genome, including 88 defined polysaccharide utilization loci (PULs) 2 , 3 , forms the prerequisite for gut colonization. (nature.com)
However, due to the great diversity of them, there is limited genomic information that accurately encompasses the metabolic potential of the entire archaeal phylum. (biomedcentral.com)

Anatomy10

Organisms50

Diseases2

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes117

Disciplines and Occupations6

Technology, Industry, Agriculture1

Information Science12

Health Care13

Geographicals2

Archaea19

Metagenome-assembled5

Genes12

Eukaryotic genomes3

Microbial genomes1

Phylogeny3

Prokaryotic8

Organisms7

Sequences8

Annotation3

Studies of archaeal2

Prokaryotes5

Lineages1

Chromatin3

RefSeq4

Species5

Bacterial genomes2

Individual genomes1

Reference genome1

20012

Metagenomic4

Researchers7

Eukaryotes5

Microorganisms2

Proteins3

Biology2

Type strains1

Strains1

NCBI2

Human genome1

Eubacterial1

Datasets1

Microbiome1

Compendium1

Methane1

Evolution3

Drosophila1

Taxa1

Proteomic2

Organism1

Functional2

Structures1

Viral1

Biological Process1

MAGs2

Biases4

Synthesis2

Metabolic potential2