• allow
  • Although rickettsiae are maintained in nature through arthropod vectors, they frequently infect vertebrates, which in turn allow new lines of vectors to acquire infection from the rickettsemic hosts. (cdc.gov)
  • human
  • This vector has been shown to restore vision in animal models that resemble human MERTK-associated Retinitis Pigmentosa (RP), an incurable retinal degeneration that causes severe vision loss. (clinicaltrials.gov)
  • Although rickettsiae have a symbiotic relationship with their arthropod hosts, in some instances, they act as true parasites-for example, members of the Wolbachia and Orientia tsutsugamushi alter reproduction and manipulate cellular processes in their arthropod hosts (4) , and the agent of epidemic typhus, Rickettsia prowazekii , kills its vector, the human body louse (5) . (cdc.gov)
  • efficient
  • Their intimate relationships with vector hosts ( Table 1 ) are characterized by efficient multiplication, long-term maintenance, transstadial and transovarial transmission, and extensive geographic and ecologic distribution. (cdc.gov)