• chromosome
  • In the 1970's came the discovery of a staining technique called G-banding, from the Giemsa dye, which made the identification of each chromosome much easier with characteristic darker and lighter bands providing the equivalent of latitudes and serving as rough landmarks on the chromosomes. (powerofthegene.com)
  • disease
  • This is important to allow further studies of the gene, its inheritance, and possible diagnostic techniques if the gene in question, when mutated, leads to a disease. (powerofthegene.com)
  • The potential for a safe, efficient method of addressing ailments ranging from Parkinson's disease to muscular dystrophy is certainly very compelling, but early successes while testing on mice don't necessarily mean that the technique will be viable for humans. (sciencealert.com)
  • The new map will help disease geneticists working to map genetic disea. (bio-medicine.org)
  • The new map will help disease geneticists working to map genetic diseases in African Americans because it provides a more accurate understanding of recombination rates among that population, said the senior author of the research, John Novembre, a UCLA assistant professor of ecology and evolutionary biology and of bioinformatics. (bio-medicine.org)
  • Disease gene identification techniques often follow the same overall procedure. (wikipedia.org)
  • DNA is first collected from several patients who are believed to have the same genetic disease. (wikipedia.org)
  • With the advent of modern laboratory techniques such as High-throughput sequencing and software capable of genome-wide analysis, sequence acquisition has become increasingly less expensive and time-consuming, thus providing significant benefits to science in the form of more efficient disease gene identification techniques. (wikipedia.org)
  • Given that an affected sibling and an unaffected sibling do not have the same disease phenotype, their DNA must by definition be different (barring the presence of a genetic or environmental modifier). (wikipedia.org)
  • mice
  • A trial of their technique was successfully used on mice to treat several diseases. (sciencealert.com)
  • For his PhD thesis, Crusio studied the inheritance of the effects of anosmia on exploratory behavior of mice, and more in general the genetic architecture of exploratory behavior, using quantitative-genetic methods such as the diallel cross. (wikipedia.org)
  • Genetic differences between humans and mice that may account for these different aging rates include differences in efficiency of DNA repair, antioxidant defenses, energy metabolism, proteostasis maintenance, and recycling mechanisms such as autophagy. (wikipedia.org)
  • Among them are her articles on "Morphological and physiological development of auditory synapses," "Gata3 is a critical regulator of cochlear wiring," and "Deaf and dizzy mice: A genetic dissection of inner ear development. (wikipedia.org)
  • strains
  • Algae-based product producer Aurora Algae has developed a new technique for genetic optimization to create advanced-trait algae strains for product development in the pharmaceutical, nutrition, renewable energy and animal feed markets. (wattagnet.com)
  • Genetic diversity plays an important role in plant breeding because hybrids between lines of diverse origin generally display a greater heterosis than those between closely related strains. (jacketflap.com)
  • genome
  • As well as manipulating the DNA, techniques had to be developed for its insertion (known as transformation) into an organism's genome. (wikipedia.org)
  • The life scientists used an innovative method involving population genetic models in which they scanned the individual genomes of 2,565 African Americans, as well as 299 African Caribbeans, to study where in the genome each had African ancestry, where they had European ancestry, and where the "switch points" were that mark the location where the ancestry of a DNA segment changes. (bio-medicine.org)
  • This name is the Italian term for "perfect murder", and it refers to the ability of the technique to create desired genetic changes without leaving any foreign DNA in the genome. (wikipedia.org)
  • The primary advantage of this technique is its ability to eliminate any foreign DNA from the genome after the mutagenesis process. (wikipedia.org)
  • humans
  • Humans of course make excellent animal models, but are horrible for molecular genetics because everything is un ethical , and for similar reasons, less useful than animals that you can drug, cut open, and cross with careful predetermined precision for classical genetics techniques. (everything2.com)
  • If the findings can be safely transferred into humans, it might eventually be possible for men with Klinefelter syndrome (XXY) or Double Y syndrome (XYY) that are infertile to have children through assisted reproduction using this technique. (eurekalert.org)
  • That said, there's still a long way to go before the technique could be tested in humans. (sciencealert.com)
  • analysis
  • Having a way of continuously monitoring and guiding the process can lead to faster and cheaper results from genetic analysis and reduce the size of the machines used. (medgadget.com)
  • This technique is rapid, because many side chains are analyzed simultaneously and the need for protein purification and biophysical analysis is circumvented. (wikipedia.org)
  • Genetic techniques capable of providing this sort of information include Restriction Fragment Length Polymorphism (RFLP) analysis and microsatellite analysis. (wikipedia.org)
  • human
  • Safety and ethical considerations will also have to be addressed before bringing this technique to human patients. (sciencealert.com)
  • The resulting embryo would carry DNA from three parents, and to prove the technique could work in the clinic, scientists would have to try the technique in healthy human embryos - a task that would be "impossible" due to the associated ethical issues [ The Scientist ] , argues researcher Jun-Ichi Hayashi, who wasn't part of the project. (discovermagazine.com)
  • Since not all nations have our "ethical issues", I fully expect this technique, using human zygotes, in the not-tto-distant future. (discovermagazine.com)
  • primarily
  • Evolutionary biologist Richard Dawkins made groundbreaking headway into the field of cultural transmission with his 1976 book entitled The Selfish Gene, which focused heavily on the move to evolution being understood primarily by genetic influence. (wikipedia.org)
  • uses
  • Another technique uses evolutionary pressures such as breeding from only older members or altering levels of extrinsic mortality. (wikipedia.org)
  • involves
  • Molecular genetics, however, generally involves gene knockout or gene replacement (the addition, change, or removal of a part of the genetic material the codes for a protein ). (everything2.com)
  • However
  • However, in most cases our understanding of these spatial patterns of natural variation at a genetic level is limited. (dtu.dk)
  • However, many previous genetic studies have observed weak genetic structure in marine fish and, combined with a pelagic larval stage, this has supported the hypothesis that gene flow is extensive and that there is little opportunity for differentiation and local adaptation any scale other than macrogeographic. (dtu.dk)
  • material
  • Polymerase chain reaction (PCR), developed by Kary Mullis in 1983, allowed small sections of DNA to be amplified and aided identification and isolation of genetic material. (wikipedia.org)
  • large
  • A team including Carnegies Martin Jonikas developed a highly sophisticated tool that will transform the work of plant geneticists by making large-scale genetic characterization of Chlamydomonas mutants possible for the first time. (bio-medicine.org)
  • role
  • This technique can also be used to determine whether the side chain of a specific residue plays a significant role in bioactivity. (wikipedia.org)
  • environmental
  • This technique was developed by a group at the National Institute of Environmental Health Sciences (NIEHS) composed of Michael A. Resnick, Francesca Storici (now at Georgia Institute of Technology), and L. Kevin Lewis (now at Southwest Texas State University). (wikipedia.org)
  • function
  • Our genetic code, or DNA, is like an orchestra - it contains all of the elements we need to function - but the epigenetic code is essentially the conductor, telling which instruments to play or stay silent, or how to respond at any given moment," Associate Professor Hughes says. (innovations-report.com)