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  • genes
  • The onset of disease is influenced not only by your genes, but also by other natural and environmental external factors. (easydna.ie)
  • There are certain factors (perhaps the types of foods you eat or your lifestyle habits) which are known to be possible triggers for certain diseases by activating the disease-causing genes. (easydna.ie)
  • Variations in other genes, such as BARD1 and BRIP1 , also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller. (nih.gov)
  • Although each of these variations only slightly increases a person's risk, having changes in several different genes may combine to increase disease risk significantly. (nih.gov)
  • A Hcs locus, with high phenotypic effects, and various epistatic gene-gene interactions were identified in rats, suggesting a genetic model of predisposition to hepatocarcinogenesis with different subset of low-penetrance genes, at play in different subsets of population, and a major locus. (uniss.it)
  • Identifying variants which control the activity of many genes is a greater challenge than we anticipated but we are developing appropriate tools to uncover them and understand their contribution to disease," comments Panos Deloukas. (medicalxpress.com)
  • A high-quality reference catalogue of the genetic changes that result in the deactivation of human genes has been developed by a team of researchers. (medicalxpress.com)
  • Maybe there are people who are interested in publishing their genetic information on the web to make it available, but those people don't have the opportunity," Though Greshake acknowledges that there are services that allow people to test their own genes and discover inherent predispositions, they are often expensive, or difficult to access. (wikipedia.org)
  • Human leukocyte antigen class II genes are more frequent in patients with Kikuchi disease, suggesting a genetic predisposition to the proposed autoimmune response. (wikipedia.org)
  • heritable
  • NAFLD is a heritable and complex trait, the genetic component of which has been explored by a myriad of studies that used different approaches illustrated in Figure 1 . (e-cmh.org)
  • coronary
  • The result is enhanced shear stress on vessel walls, and repeated nicotine exposure contributes to accelerated health problems that are a function of chronic vascular injury such as coronary artery disease, acute cardiac ischemic events, and hypertension Studies have shown that nicotine exposure contributes to stroke, peptic ulcer disease, and esophageal reflux. (wikipedia.org)
  • cholesterol
  • Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported. (le.ac.uk)
  • CONCLUSIONS: Genetic predisposition to increased blood cholesterol and triglyceride lipid levels is not associated with elevated LOAD risk. (ox.ac.uk)
  • subset
  • In addition to the genetic defects in dystrophin or other cytoskeletal proteins, a subset of dilated cardiomyopathy is linked to enteroviral infection in the heart, especially coxsackievirus B. Enterovirus infections are responsible for about 30% of the cases of acquired dilated cardiomyopathy in humans. (wikipedia.org)
  • Humans
  • This decellularized valve tissue provides a scaffold with the remaining extracellular matrix (ECM) that can then be used for tissue engineering and valve replacement in humans inflicted with valvular disease. (wikipedia.org)
  • makeup
  • Whilst you cannot alter your genetic makeup, you can alter conditions in your environment. (easydna.ie)
  • Although a person's genetic makeup cannot be altered, some lifestyle and environmental modifications (such as having more frequent disease screenings and maintaining a healthy weight) may be able to reduce disease risk in people with a genetic predisposition. (nih.gov)
  • The individual genetic makeup of each single person determines his or her radiation sensitivity or radiation resistance. (bfs.de)
  • After receiving his results, he posted them on Github, hoping to find other users willing to share their personal genetic makeup. (wikipedia.org)
  • variants
  • An international team of researchers from King's College, Oxford University, Wellcome Trust Sanger Institute and Faculty of Medicine of University of Geneva, has discovered several thousands new genetic variants impacting gene expression some of which are responsible for predisposition to common diseases, bringing closer to the biological interpretation of personal genomes. (medicalxpress.com)
  • With an international team co-led by Professor Tim Spector (Kings College), Professor Mark McCarthy (Oxford University) and Dr. Panos Deloukas (Wellcome Trust Sanger Institute), he publishes a study highlighting thousands of these genetic variants that seem to explain individual differences in gene expression . (medicalxpress.com)
  • The method researchers followed allowed them to uncover nearly 358 variants apparently involved in the predisposition to certain diseases including quantifying the contribution of rare regulatory variants that was previously not possible to identify by conventional analysis methods. (medicalxpress.com)
  • Our work adds to those who have previously demonstrated the contribution of common variants in the predisposition to these disorders", explains Emmanouil Dermitzakis. (medicalxpress.com)
  • Thanks to this new level of knowledge, and if we manage to adapt this methodology to search for these variants in each individual, this will be a powerful tool to help prognose the predisposition to certain diseases and more importantly understand the biological aetiology in order to develop and employ individualized treatments. (medicalxpress.com)
  • chronic
  • Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. (e-cmh.org)
  • Abstract: BACKGROUND: Depression and chronic pain are the two most important causes of disability (Global Burden of Disease Study 2013). (duhnnae.com)
  • familial
  • Although shared socio-demographic risk factors (e.g. gender, deprivation) might explain the co-morbidity of these three conditions, we hypothesised that these three long-term, highly prevalent conditions co-occur and may be due to shared familial risk, and/or genetic factors. (duhnnae.com)
  • Histologically, familial AD is practically indistinguishable from other forms of the disease. (wikipedia.org)
  • Variation
  • Some people with a predisposing genetic variation will never get the disease while others will, even within the same family. (nih.gov)
  • Pei L, Zhu H, Zhu J, Ren A, Finnell R, Li Z. Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China. (labome.ru)
  • Variation in radiation sensitivity may be partly caused by changes in gene products (proteins), which ensure that the genetic material ( DNA ) is maintained and damage is repaired. (bfs.de)
  • disorders
  • It is a widely explored treatment option for many central nervous system (CNS) disorders including neurodegenerative diseases, stroke, traumatic brain injury, spinal cord injury, and acute management of neurotoxin consumption (i.e. methamphetamine overdoses). (wikipedia.org)
  • abnormalities
  • Abnormalities in liver enzyme tests are usually present and elevated gamma-glutamyl transferase and alkaline phosphatase (ALP) are found in early disease. (wikipedia.org)
  • The accumulation is due to various genetic and biochemical abnormalities. (wikipedia.org)
  • diagnostic
  • Hence, knowledge of the disease pathogenesis and predisposing factors is crucial for understanding the disease biology and making decisions on diagnostic or therapeutic interventions, the latter being the main goal of Precision Medicine. (e-cmh.org)
  • Graves
  • Graves' disease will develop in about 0.5% of males and 3% of females. (wikipedia.org)
  • The signs and symptoms of Graves' disease virtually all result from the direct and indirect effects of hyperthyroidism, with main exceptions being Graves' ophthalmopathy, goiter, and pretibial myxedema (which are caused by the autoimmune processes of the disease). (wikipedia.org)
  • While a theoretical mechanism occurs by which stress could cause an aggravation of the autoimmune response that leads to Graves' disease, more robust clinical data are needed for a firm conclusion. (wikipedia.org)
  • A genetic predisposition for Graves' disease is seen, with some people more prone to develop TSH receptor activating antibodies due to a genetic cause. (wikipedia.org)
  • polymorphisms
  • Lu P, Chen M, Wu X, Gu J, Liu Y, Gu R. Genetic polymorphisms of UGT1A7 and cancer risk: evidence from 21 case-control studies. (labome.ru)
  • This research revealed parts of the IL12 signaling cascade, particularly IL12A and IL12RB2 polymorphisms, to be important in the aetiology of the disease in addition to the HLA region. (wikipedia.org)
  • autoimmunity
  • More recently it has become accepted that autoimmune responses are an integral part of vertebrate immune systems (sometimes termed "natural autoimmunity"), normally prevented from causing disease by the phenomenon of immunological tolerance to self-antigens. (wikipedia.org)
  • certain
  • Not an easy task, but invaluable since it allows us to understand all the genetic causes that can explain the predisposition to certain diseases. (medicalxpress.com)
  • Certain alterations to the genetic material can lead to a dramatic change in radiation sensitivity. (bfs.de)
  • Genetic predisposition towards certain human behaviors is scientifically investigated by attempts to identify patterns of human behavior that seem to be invariant over long periods of time and in very different cultures. (wikipedia.org)
  • E. O. Wilson's book on sociobiology and his book Consilience discuss the idea of genetic predisposition to behaviors The field of evolutionary psychology explores the idea that certain behaviors have been selected for during the course of evolution. (wikipedia.org)
  • various genetic
  • The degree of radiation sensitivity depends upon the combination of various genetic traits and how they interact with each other. (bfs.de)
  • pathogenesis
  • In this review, we focused on the genetic component of NAFLD, with special emphasis on the role of genetics in the disease pathogenesis and natural history. (e-cmh.org)
  • common
  • Current research is focused on identifying genetic changes that have a small effect on disease risk but are common in the general population. (nih.gov)
  • scleroderma
  • It has been noted that clinical diagnosis of BXO can be "almost unmistakable," though there are other dermatologic conditions such as lichen planus, localized scleroderma, leukoplakia, vitiligo, and the cutaneous rash of Lyme disease can have a similar appearance. (wikipedia.org)
  • In June 2004, Broadway's wife, Dianne, died after 14 years of battling scleroderma, a rheumatic disease of the connective tissues. (wikipedia.org)
  • etiology
  • Classically recognized white dot syndromes include: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) Birdshot chorioretinopathy Multiple evanescent white dot syndrome (MEWDS) Acute zonal occult outer retinopathy (AZOOR) Multifocal choroiditis and panuveitis (MCP) Punctate inner choroiditis (PIC) Serpiginous choroiditis Specific characteristics regarding the white dots and predicted etiology are presented of selected diseases. (wikipedia.org)
  • interpretation
  • Because of many difficulties and often wrong interpretation of genetic test results, it is recommended that each genetic test result should be consulted with specialist genetic advisory clinic. (cbdna.eu)
  • progresses
  • As the disease progresses the patient exhibits more serious problems, becoming subject to mood swings and unable to perform complex activities such as driving. (wikipedia.org)
  • people
  • Of the people who qualified for the study, 1,254 had at least 1 diagnosis of lumbar disc disease or lumbar disc herniation, along with the requisite genealogical data. (apta.org)
  • First-degree relatives of people with lumbar disc disease had a relative risk of 4.15 of having the disease themselves. (apta.org)
  • Due to the fact that genetic tests are specific type of tests, and their results may have huge influence on patients and their families' personal life, tests on genetic predisposition for neoplasm may only be performed for adult people, who express conscious consent for making such genetic tests. (cbdna.eu)
  • In theory, two people could thus share a gene that is perfectly identical and yet show differences in their predisposition to a disease due to genetic differences concerning the regulation (overexpression or underexpression) of this same gene. (medicalxpress.com)
  • PBC is a relatively rare disease, affecting up to 1 in 3-4,000 people. (wikipedia.org)
  • HWSD is often confused with white line disease (WLD) by those people who have no experience or knowledge of this genetic condition. (wikipedia.org)
  • specific
  • Imagine the value of being able to know which specific diseases you should be screened for during medical check-ups. (easydna.ie)
  • you could start making the right lifestyle changes, planning specific health screening and blood tests and work together with a genetic councellor towards a tailored program for disease prevention. (easydna.ie)
  • However, which determining factors are responsible in particular, remains largely unknown apart from a few specific individual diseases. (bfs.de)
  • presence
  • A single nucleotide polymorphism present in region 24 on the long arm of chromosome 10 (region 10q24) is analyzed and the risk of onset of a bone and joint disease and/or the presence or absence of onset of the same are diagnosed on the basis of a result of the analysis. (patentsencyclopedia.com)
  • The present invention relates to a diagnosis method for determining the risk of onset of a bone and joint disease such as scoliosis and/or the presence or absence of onset of the same and to a reagent used for the diagnosis method. (patentsencyclopedia.com)
  • prevalent
  • Stanford University School of Medicine investigators have found that for people harboring a genetic predisposition that is prevalent among Americans, beta carotene, which the body converts to a close cousin of vitamin A, may lower the risk for the most common form of diabetes, while gamma tocopherol, the major form of vitamin E in the American diet, may increase risk for the disease. (quantumday.com)
  • Additionally, new tests from Genetic Technologies LTD and Phenogen Sciences Inc. comparing non-coding DNA to a woman's lifetime exposure to estrogen can now determine a woman's probability of developing estrogen positive breast cancer also known as sporadic breast cancer (the most prevalent form of breast cancer). (wikipedia.org)
  • It is one of several genetic disorders known to be highly prevalent among the Afrikaner population. (wikipedia.org)
  • infection
  • In addition to yield, BPMV can reduce grain quality through protein and oil content, reduced seed quality and performance (discolored appearance, low germination and seedling vigor), delayed plant maturation, and the predisposition to other stresses and diseases (such as infection of Phomopsis fungus decreasing germination of seed and seedling vigor). (wikipedia.org)
  • Kaposi's Sarcoma caused by Human herpesvirus 8 (HHV8), also called Kaposi's sarcoma-associated herpesvirus (KSHV) Legionnaires' Disease (Legionella pneumophila) Microsporidium Mycobacterium avium complex (MAC) (Nontuberculosis Mycobacterium) Mycobacterium tuberculosis Pneumocystis jirovecii, previously known as Pneumocystis carinii f. hominis Pseudomonas aeruginosa Salmonella Staphylococcus aureus Streptococcus pneumoniae Streptococcus pyogenes Toxoplasma gondii Since opportunistic infections can cause severe disease, much emphasis is placed on measures to prevent infection. (wikipedia.org)
  • In epidemiology, a risk factor is a variable associated with an increased risk of disease or infection. (wikipedia.org)
  • Secondary lactose intolerance is due to injury to the small intestine such as from infection, celiac disease, inflammatory bowel disease, or other diseases. (wikipedia.org)
  • gene
  • Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. (abnova.com)
  • In people carrying a double dose of one such predisposing gene variant, the researchers pinpointed a highly statistically significant inverse association of beta carotene blood levels with type-2 diabetes risk, along with a suspiciously high positive association of gamma tocopherol with risk for the disease. (quantumday.com)
  • Moreover, the fact that both beta carotene and gamma tocopherol interact with the same gene variant to influence diabetes risk, albeit in opposite directions, suggests that the protein the gene called, SLC30A4, codes for may play a crucial role in the disease. (quantumday.com)
  • Genetic variants in the Factor V gene is associated with an increased tendency to form blood clots, such as deep vein thrombosis (DVTs). (wikipedia.org)
  • The PHACTR1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. (wikipedia.org)
  • In genetic knock-out and rescue experiments, restoration of a caretaker gene from the mutated form to the wildtype version does not limit tumorigenesis. (wikipedia.org)
  • The MHC HLA gene (IDDM1) and the insulin gene INS (IDDM2) are the major genetic candidates in the development of insulin-dependent (type I) diabetes mellitus(IDDM), which are located on the chromosome 6p21.3 and chromosome 11p15 respectively. (wikipedia.org)
  • Zollo, M., P. Dear, and F. Pociot, Insulin‐dependent Diabetes Mellitus (IDDM): Identifying the Disease‐causing Gene at the IDDM11 Locus. (wikipedia.org)
  • A candidate gene is a gene that is suspected to cause a disease or disorder. (wikipedia.org)
  • disorders
  • Available types of predictive medicine through health care professionals include: Newborn screening: Newborn screening is conducted just after birth to identify genetic disorders that can be treated early in life. (wikipedia.org)
  • This testing of infants for certain disorders is one of the most widespread uses of genetic screening - all US states currently test infants for phenylketonuria and congenital hypothyroidism. (wikipedia.org)
  • Upregulation of PHACTR1 by transforming growth factor (TGF)-β has been described in breast cancer cell lines, potentially pointing to a connection with the TGF-β signaling pathway, which is also implicated in genetic predisposition to migraine9 and has a key role in Marfan and Loeys-Dietz syndromes, two inherited connective tissue disorders causing aortic dissection. (wikipedia.org)
  • Lists of child and adult mental disorders can be found in the International Statistical Classification of Diseases and Related Health Problems, 10th Edition (ICD-10), published by the World Health Organization (WHO) and in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), published by the American Psychiatric Association (APA). (wikipedia.org)
  • Many psychopathological disorders in children involve genetic and physiological mechanisms, though there are still many with out any physical grounds. (wikipedia.org)
  • Humans
  • Chromosomal instability resulting from dysfunctional caretaker genes is the most common form of genetic instability that leads to cancer in humans. (wikipedia.org)
  • Newborn
  • Despite health improvements over the last thirty years, lives continue to be lost to early childhood diseases, inadequate newborn care and childbirth-related causes. (wikipedia.org)
  • significantly
  • Predictive medicine is a field of medicine that entails predicting the probability of disease and instituting preventive measures in order to either prevent the disease altogether or significantly decrease its impact upon the patient (such as by preventing mortality or limiting morbidity). (wikipedia.org)
  • cause
  • Known contraindications include: Hypersensitivities to doxepin, other TCAs, or any of the excipients inside the product used Glaucoma A predisposition to developing urinary retention such as in benign prostatic hyperplasia Use of monoamine oxidase inhibitors in last 14 days Its use in pregnant and lactating women is advised against, although the available preclinical (based on animal studies) evidence suggests it is unlikely to cause any deleterious effects on fetal development. (wikipedia.org)
  • Some diseases and conditions are caused by dysfunction in the intestinal epithelium, and some diseases and conditions cause problems with these cells, which then leads to further complications. (wikipedia.org)
  • Many of these pathogens do not cause disease in a healthy host that has a normal immune system. (wikipedia.org)
  • Keratolytic Winter erythema ( Oudtshoorn disease and Oudtshoorn skin, }is a rare autosomal dominant skin disease of unknown cause which causes redness and peeling of the skin on the palms and soles. (wikipedia.org)
  • citation needed] Children with a predisposition to psychopathology may cause higher stress in the relationship with their mother, and mothers who suffer from psychopathology may also cause higher stress in the relationship with their child. (wikipedia.org)
  • clinical
  • Genetic screening of newborns and children in the field of predictive medicine is deemed appropriate if there is a compelling clinical reason to do so, such as the availability of prevention or treatment as a child that would prevent future disease. (wikipedia.org)
  • detect
  • Although proteomics and cytomics allow for the early detection of disease, much of the time those detect biological markers that exist because a disease process has already started. (wikipedia.org)
  • risks
  • The Estonian government has launched an initiative to provide 100,000 residents with free genetic sequencing and personalized information about their health risks. (datainnovation.org)
  • Some prefer the term risk factor to mean causal determinants of increased rates of disease, and for unproven links to be called possible risks, associations, etc. (wikipedia.org)
  • advocacy
  • Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives. (diseaseinfosearch.org)
  • decades
  • Government health authorities estimate that one-third of all children born in the United States since the year 2000 will get this disease at some point in their lives, possibly knocking decades off their life expectancies. (quantumday.com)
  • However, comprehensive genetic testing (such as through the use of DNA arrays or full genome sequencing) allows for the estimation of disease risk years to decades before any disease even exists, or even whether a healthy fetus is at higher risk for developing a disease in adolescence or adulthood. (wikipedia.org)
  • symptoms
  • For most diseases, symptoms will vary from person to person. (nih.gov)
  • Do you have more information about symptoms of this disease? (nih.gov)
  • Bean pod mottle virus Table of Contents Description and Importance Symptoms Disease Cycle and Pathogenesis Agronomic Impact Management Strategies Genetic Resistance Cultural Tactics Chemical Tactics Description and Importance BPMV is the viral pathogen that causes the disease Bean Pod Mottle in soybeans and other legumes such as snap peas. (wikipedia.org)
  • common
  • Psoriasis is one of the most common dermatologic diseases, affecting about 2% of the world population. (blogspot.in)
  • Psoriasis is one of the most common dermatologic diseases and still stands as a challenge to different medical systems. (blogspot.in)
  • diagnosis
  • The average survival at 5 years is much higher if the diagnosis is made in the early stages of the disease (stage I). For this reason, to know the epidemiology and risk factors is an important weapon that we can use for 'prevention' and consequently the reduction of incidence and mortality. (imedpub.com)
  • healthcare
  • If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. (nih.gov)
  • higher
  • It is often used to determine if an individual is at higher than average or lower than average risk of developing a disease over a given period of time. (wikipedia.org)
  • primary
  • Regarding aetiology of maxillary displaced canines, different theories have been proposed, two primary theories are: the guidance theory and the genetic theory.6 The guidance theory7 suggests that the eruption of the canine is influenced by presence, size, shape and positioning of the maxillary lateral incisor while genetic theory8 suggests that the impaction is due to a genetic predisposition. (thefreelibrary.com)
  • Lactose intolerance is a consequence of lactase deficiency, which may be genetic (primary hypolactasia and primary congenital alactasia) or environmentally induced (secondary or acquired hypoalactasia). (wikipedia.org)
  • Diarrheal diseases are the primary causes of early childhood mortality. (wikipedia.org)
  • diet
  • Management is typically by decreasing the amount of lactose in the diet, taking lactase supplements, or treating the underlying disease. (wikipedia.org)
  • health
  • The cardiac extracellular matrix (ECM) not only provides mechanical support, but also transduces essential molecular signals in health and disease. (jci.org)
  • Current genetic testing guidelines supported by the health care professionals discourage purely predictive genetic testing of minors until they are competent to understand the relevancy of genetic screening so as to allow them to participate in the decision about whether or not it is appropriate for them. (wikipedia.org)
  • Aside from genetic testing, predictive medicine utilizes a wide variety of tools to predict health and disease, including assessments of exercise, nutrition, spirituality, quality of life, and so on. (wikipedia.org)
  • exist
  • While different prediction methodologies exist, such as genomics, proteomics, and cytomics, the most fundamental way to predict future disease is based on genetics. (wikipedia.org)
  • presence
  • Predictive Risk Testing: Testing that is conducted to determine the probability of developing a specific disease not the presence of the disease. (wikipedia.org)
  • There are genetic, cultural, and chemical options which should be used together in an integrated pest management plan, in addition to managing the vector presence as well. (wikipedia.org)
  • Available
  • Genetic Resistance Partial resistance to BPMV is available in some soybean varieties meaning there is less yield reductions, lower rates of green stem and seed mottling. (wikipedia.org)
  • major
  • Psychological stress is emphasized as one of the major triggering factor in the exacerbation of the disease. (blogspot.in)