Genetic association studies. Medical search. Frequent questions

To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy (GenDIP) Consortium assembled genome-wide association studies (GWAS) of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. (lu.se)
METHODS: In this meta-analysis and prospective cohort study, we first did a fixed-effects meta-analysis of the association between genetic variants and gastric cancer in six independent genome-wide association studies (GWAS) with a case-control study design. (fry-it.com)
23andMe, a California-based personal genetics company, has participated in the first-ever genome-wide association study (GWAS) of the combined asthma-with-hay fever phenotype. (bioquicknews.com)
We performed a genome-wide association study (GWAS) and exome-sequencing analysis to identify common and rare genetic variants associated with plasma myeloperoxidase (MPO)-DNA complex levels, a biomarker for NETs, in the population-based Rotterdam Study cohort. (frontiersin.org)
GWAS was performed using haplotype reference consortium(HRC)-imputed genotypes of common variants in 3,514 individuals from the first and 2,076 individuals from the second cohort of the Rotterdam Study. (frontiersin.org)
Genome-wide association studies (GWAS) and exome-sequencing analysis have been successfully implemented as approaches to identify genetic variants associated with disease susceptibility. (frontiersin.org)
METHODS: We did a pooled analysis of data from newly recruited patients with an MRI-confirmed diagnosis of lacunar stroke and existing genome-wide association studies (GWAS). (ox.ac.uk)
We also did a multi-trait analysis of GWAS, in a joint analysis with a study of cerebral white matter hyperintensities (an aetiologically related radiological trait), to find additional genetic associations. (ox.ac.uk)
Genome -wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease . (bvsalud.org)
As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine25, we anticipate that increased diversity of participants will lead to more accurate and equitable26 application of polygenic scores in clinical practice. (bvsalud.org)
At the same time, large genome-wide association studies (GWAS), which analyzed gene sequences from thousands of people, have found evidence suggesting that schizophrenia arises from the combined effects of many genes and not from a defect in any single gene. (sciencedaily.com)
Johnson T., International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS) None. (ox.ac.uk)
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. (uni-luebeck.de)
Association to PD at SNCA was replicated in the Japanese GWAS, confirming this as a major risk locus across populations. (uni-luebeck.de)
Application to a GWAS meta-analysis of coronary disease with 48 contributing studies uncovered substantial systematic between-study heterogeneity, which could be partly explained by age-of-disease onset, family-history of disease and ancestry. (ox.ac.uk)
The aim of this study is to identify susceptibility gene variants that could contribute to the pathogenesis of diisocyanate asthma (DA) using a Genome-Wide Association Study (GWAS) approach. (cdc.gov)
Genome-wide association studies (or GWAS) are large-scale genetic investigations of human disease that measure simultaneously hundreds of thousands of genetic variants scattered throughout the human genome. (cdc.gov)
Propelled by technological advances and falling prices, GWAS have revolutionized the search for genetic influences on common diseases of major public health significance. (cdc.gov)
The GWAS approach also demonstrated associations of common variants in HNF1A with levels of C-reactive protein, which is a potential biomarker of the condition. (cdc.gov)

Eleven markers located on chromosomes 1A, 2B, 5A, 5D, 7B, and 7D by the genome-wide association studies analysis showed significant associations with at least two resistance-associated traits in two of the environments. (unboundmedicine.com)
Preparative yield, amylose/amylopectin content, and phosphorylation of potato tuber starch are starch-related traits studied at the genetic level. (peerj.com)
Our lab develops, applies, and distributes new statistical methods and user-friendly software to help unravel the complex genetic basis of common human diseases and traits. (mayo.edu)
The complex genetic basis of common human diseases and traits necessitates the development of new statistical methods to address new questions and new data emerging from ongoing and cutting-edge research. (mayo.edu)
These include aggregation of diseases in families, analysis of quantitative traits and genetic linkage studies. (mayo.edu)
30% Hispanic/Latino) into 6 contiguous, physiologically distinct (P wave, PR segment, QRS interval, ST segment, T wave, and TP segment) and 2 composite, conventional (PR interval and QT interval) interval scale traits and conducted multivariable-adjusted, trait-specific univariate genome-wide association studies using 1000-G imputed single-nucleotide polymorphisms. (elsevierpure.com)
Evidence of shared genetic effects was evaluated by aggregating meta-analyzed univariate results across the 6 continuous electrocardiographic traits using the combined phenotype adaptive sum of powered scores test. (elsevierpure.com)
Infection with the tuberculosis (TB) agent Mycobacterium tuberculosis ( M. tuberculosis ) and its subsequent outcomes (active TB, latent infection or clearance of the bacterium by the pulmonary immune system) are complex traits due to interactions between numerous host genetic susceptibility factors and the environment. (biomedcentral.com)
By considering mixed genetic lineages, researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, demonstrated that previously inferred links between a genomic variant that helps digest lactose and traits such as a person's height and cholesterol level may not be valid. (sourcearu.com)
What is clear based on our analysis, is when data from genetic association studies of people of European ancestry are evaluated, researchers should adjust for admixture in the population to uncover true links between genomic variants and traits. (sourcearu.com)
While the lactase gene is one example of a gene that may be incorrectly linked to some traits based on previous analyses, the researchers say it's likely that there are other false associations in the literature and that some true associations are yet to be found. (sourcearu.com)
Progress in mapping loci associated with common complex diseases or quantitative inherited traits has been expedited by large-scale meta-analyses combining information across multiple studies, assembled through collaborative networks of researchers. (ox.ac.uk)
Future meta-analyses of diseases and traits with multiple known genetic associations can use this approach to identify outlier studies and thereby optimize power to detect novel genetic associations. (ox.ac.uk)
This first set of ABs and ILs of eggplant will be extremely useful for the genetic dissection of traits of interest for eggplant, and represents an elite material for introduction into the breeding pipelines for developing new eggplant cultivars adapted to the challenges posed by the climate-change scenario. (frontiersin.org)
The present study was conducted to evaluate the green gram accessions to assess the magnitude of genetic variability and to understand the heritable component of variation for seed yield and its component traits. (ijcmas.com)
High heritability was observed for all the traits under study. (ijcmas.com)

LD describes a situation in which some combinations of alleles or genetic markers occur more or less frequently in a population than would be expected from a random formation of haplotypes from alleles based on their frequencies. (wikipedia.org)
Haplotypes can also show association with a disease or trait. (wikipedia.org)
Haplotype analysis has been increasingly used to study the genetic basis of human diseases, but models for characterizing genetic interactions between haplotypes from different chromosomal regions have not been well developed in the current literature. (uitm.edu.my)
Single polymorphisms as well as haplotypes of the variants were tested for association with TB using statistical analyses. (biomedcentral.com)

The precise mechanism of how these genes may contribute to neutrophil function or the formation of NETs remains unclear and should be further investigated in experimental studies. (frontiersin.org)
As orthologous genes are commonly mutated in canine models of human blinding disorders, canine ABCA4 appears to be an ideal candidate gene to identify and study sequence changes in dogs affected by various forms of inherited retinal degeneration. (edu.au)
As principal investigator of the Statistical Genetics and Genetic Epidemiology Lab, Dr. Schaid focuses on methods to track down genes that increase risk of disease and improve how patients respond to therapies for a variety of conditions. (mayo.edu)
Fifty-four polymorphisms in eight candidate genes were genotyped in over 800 tuberculosis cases and healthy controls in a population-based case-control association study in a South African population. (biomedcentral.com)
However, more recent studies suggest that multiple genes, perhaps up to 40, contribute to this trait. (medlineplus.gov)
Studies suggest that at least some of these genes help determine the overall right-left asymmetry of the body starting in the earliest stages of development. (medlineplus.gov)
Strong associations were also found for SNPs near the ODZ3 and CDH17 genes on chromosomes 4 and 8 (rs908084, p = 8.59 × 10(-9) and rs2514805, p = 1.22 × 10(-8), respectively). (cdc.gov)
This study identified SNPs mapping to the HERC2, CDH17, and ODZ3 genes as potential susceptibility loci for DA. (cdc.gov)
A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
Certain common changes (polymorphisms) in the CYP2C9 and VKORC1 genes account for most of the variation in warfarin metabolism due to genetic factors. (medlineplus.gov)
A genome-wide study in a northern European population replicated the association of SLE with susceptibility genes related to B-cell receptor pathway signaling, as well as confirmed the association of SLE with genes at the interferon regulatory factor 5 (IRF5)-TNPO3 locus. (medscape.com)
Genetic variants (specific mutations or allelles of genes) and their corresponding phenotypic variations in the trait or the disease which the genes controls. (bvsalud.org)
The association of idiopathic recurrent pregnancy loss with polymorphisms in hemostasis-related genes. (cdc.gov)

and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. (lu.se)
In this paper, we perform a genome-wide association study using a 22K SNP potato array to identify for the first time genomic regions associated with starch granule morphology and to increase number of known genome loci associated with potato starch yield. (peerj.com)
As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. (upf.edu)
We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. (upf.edu)
We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. (upf.edu)
To look at European genetic ancestry, the researchers collated data in published genetic association studies and generated a reference panel of genomic data that included 19,000 individuals of European ancestry across 79 populations in Europe and European Americans in the U.S., capturing ancestral diversity not seen in other large catalogs of human genomic variation. (sourcearu.com)
When the researchers considered the genetic admixture of the European population in their analysis, they found that the genomic variant that gives people the ability to digest lactose is not linked to height or level of low-density lipoprotein cholesterol. (sourcearu.com)
The findings of this study highlight the importance of appreciating that the majority of individuals in populations around the world have mixed ancestral backgrounds and that accounting for these complex ancestral backgrounds is critically important in genetic studies and the practice of genomic medicine," says Charles Rotimi, Ph.D., NIH Distinguished Investigator, director of the Center for Research on Genomics and Global Health and senior author of the study. (sourcearu.com)
The NHGRI Division of Intramural Research develops and implements technology to understand, diagnose and treat genomic and genetic diseases. (sourcearu.com)
while other major crops in the genus Solanum and in the family Solanaceae, like tomato, potato, pepper, tobacco, and petunia, have been widely studied from the genetic and genomic points of view, developments in eggplant genomics have lagged behind. (frontiersin.org)
Information on developing genomic resources and methods for studying long-lived species. (senescence.info)

Genetic association can be between phenotypes, such as visible characteristics such as flower color or height, between a phenotype and a genetic polymorphism, such as a single nucleotide polymorphism (SNP), or between two genetic polymorphisms. (wikipedia.org)
citation needed] Genetic association studies are performed to determine whether a genetic variant is associated with a disease or trait: if association is present, a particular allele, genotype or haplotype of a polymorphism or polymorphisms will be seen more often than expected by chance in an individual carrying the trait. (wikipedia.org)
Among these single-nucleotide polymorphisms (SNPs), the TCF7L2 rs7903146 (intron 4) shows the strongest association with T2DM. (medscape.com)
Recently, genome-wide association studies have identified seven germline single-nucleotide polymorphisms (SNP) that are associated with risk of Barrett's esophagus and esophageal adenocarcinoma. (who.int)
In these studies, upwards of a million single-nucleotide polymorphisms are typed in each individual. (medscape.com)
Genetic polymorphisms and plasma levels of tissue factor and tissue factor pathway inhibitor in venous thromboembolism. (cdc.gov)
Association of single nucleotide polymorphisms of tissue factor and tissue factor pathway inhibitor with venous thromboembolism in patients with lung cancer]. (cdc.gov)

Genetic variants may help explain variation in responses to trauma by identifying alleles that associate with changes in mental health measures. (nih.gov)
However, most previous GWAS4-23 have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid -level variation in other ancestry groups. (bvsalud.org)
This project will use a phenome-wide approach to assess the biological pathways and clinical outcomes associated with genetic variation in potential therapeutic targets, and will identify novel targets through screening and data mining approaches. (ox.ac.uk)
Design and analysis methods for DNA and RNA sequence variation studies. (mayo.edu)
In conclusion, our study identified that common genetic variation indeed influences the common substrate, but that these variants do not directly translate to increased disease risk. (nature.com)
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. (ox.ac.uk)
The phenotypic coefficient of variation (PCV) was greater than that of genotypic coefficient of variation (GCV) for all the characters studied thereby indicating the influence of environmental effect on the characters. (ijcmas.com)
Background: The variation in serum uric acid concentrations is under significant genetic influence. (edu.au)

While previous analyses provided evidence of a stronger genetic association of this combined phenotype, there has not been a genome-wide association study exploring the connection in further detail," said David Hinds, Ph.D., study author and 23andMe principal scientist in statistical genetics. (bioquicknews.com)
Here, we investigated the hypothesis that the common substrate serves as an intermediate phenotype to detect genetic risk variants relevant for psychiatric disease. (nature.com)
Conclusions: Despite including one-third as many participants as published electrocardiographic trait genome-wide association studies, our study identified 6 novel loci, emphasizing the importance of ancestral diversity and phenotype resolution in this era of ever-growing genome-wide association studies. (elsevierpure.com)
Participating studies will usually have been independently designed and implemented in unique settings that are potential sources of phenotype, ancestry or other variability that could introduce between-study heterogeneity into a meta-analysis. (ox.ac.uk)

Fig. 5: Nonlinear association between sleep variability, mental health, cognitive function and brain structures. (nature.com)
Genetic variability for grain yield, its attributes and temperature tolerance were estimated in 39 genotypes of bread wheat under normal and water stress environmental conditions. (arccjournals.com)
Drug addiction and stress-response genetic variability: Association study in African Americans. (bvsalud.org)

Our sequence analysis of the complete canine ABCA4 coding region will clearly provide a baseline and tools for future association studies and comparative genomics to further delineate the role of ABCA4 in canine blinding disorders. (edu.au)
By reading population genetics papers, we realized that the pattern of genetic makeup in Europe is too detailed to be viewed on a continental level," said Daniel Shriner, Ph.D., staff scientist in the NIH Center for Research on Genomics and Global Health and senior author of the study. (sourcearu.com)
Finding true genetic associations will help researchers be more efficient and careful with how further research is conducted," said Mateus Gouveia, Ph.D., research fellow in the Center for Research on Genomics and Global Health and first author of the study. (sourcearu.com)
Advanced backcrosses (ABs) and introgression lines (ILs) of eggplant ( Solanum melongena ) can speed up genetics and genomics studies and breeding in this crop. (frontiersin.org)
Studies focused on cancer, in particular using genomics and bioinformatics approaches. (senescence.info)

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. (hjarta.is)
Genome-wide association study identifies novel loci associated with diisocyanate -induced occupational asthma. (cdc.gov)
Recent genome-wide association studies have identified several novel loci associated with CAD. (le.ac.uk)

By the end of the DPhil, the student will be able to plan, undertake and interpret analyses of large-scale genetic and epidemiological data, and report research findings, including 3-5 publications in peer-reviewed journals. (ox.ac.uk)
The study, published in Nature Communications , shows that people with European ancestry, who were previously treated as a genetically homogenous group in large-scale genetic studies, have clear evidence of mixed genetic lineages, known as admixture. (sourcearu.com)

NIH study finds that failing to account for mixed genetic lineages could lead to inaccuracies. (mlo-online.com)

Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy. (lu.se)
Studies of genetic association aim to test whether single-locus alleles or genotype frequencies or more generally, multilocus haplotype frequencies differ between two groups of individuals usually diseased subjects and healthy controls). (wikipedia.org)
BACKGROUND: The genetic basis of lacunar stroke is poorly understood, with a single locus on 16q24 identified to date. (ox.ac.uk)
this genetic locus. (dokumen.tips)
Multilocus genetic models of handedness closely resemble single-locus models in explaining family data and are compatible with genome-wide association studies. (medlineplus.gov)
However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. (elsevierpure.com)
In conclusion, the work on locus 1p13.3 shows that it is possible to identify a causal SNP from a GWA study signal, and elucidate its mechanism, but the studies on locus 13q34, indicates that this is a challenging process. (le.ac.uk)

Increasingly, logistic regression methods for genetic association studies of binary phenotypes must be able to accommodate data sparsity, which arises from unbalanced case-control ratios and/or rare genetic variants. (karger.com)
Here, we are the first to apply these approaches to ascertain common and rare genetic variants associated with NETs using data from a population-based cohort study. (frontiersin.org)

The Statistical Genetics and Genetic Epidemiology Laboratory of Daniel J. Schaid, Ph.D., at Mayo Clinic designs studies, analyzes data, and develops computational and evaluation methods for genetic data generated by researchers. (mayo.edu)
Family-based genetic epidemiology studies. (mayo.edu)
Contact us about our methodology and software for use in studies on family-based genetic epidemiology, genetic association of common diseases, and DNA and RNA sequencing. (mayo.edu)
We've created an array of innovative software for the analysis of complex genetic mechanisms and genetic epidemiology and have made it available for use in biomedical research. (mayo.edu)
The ultimate ambition of GENESTAT is to guide on statistical methodology related to the broad spectrum of research in genetic epidemiology. (ox.ac.uk)
Ms. Sherri Berger and Dr. Lucy Peipins, of ATSDR's Division of Health Studies, provided an overview of the science of epidemiology. (cdc.gov)
They defined epidemiology as the study of the distribution (who, what, when, where) and determinants (why, then) of disease in populations. (cdc.gov)
Epidemiology can draw some information on exposures and outcomes from evidence already compiled in animal studies, case reports, or toxicological models. (cdc.gov)

The phenotypic datasets were used for 55K single-nucleotide polymorphism (SNP) array-based genome-wide association studies to identify effective resistance loci. (unboundmedicine.com)
Is the Subject Area "Genome-wide association studies" applicable to this article? (plos.org)
Genetic risk, incident gastric cancer, and healthy lifestyle: a meta-analysis of genome-wide association studies and prospective cohort study. (fry-it.com)
Evidence of the association is based on MNAs that are usually based on studies that include large sample sizes like genome-wide association studies. (wikipedia.org)
Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies. (ox.ac.uk)
PLINK 1.90 and PRSice ( http://www.prsice.info ) were used to perform genome-wide association analysis and calculate the PRS, respectively. (nature.com)
The power of genetic diversity in genome-wide association studies of lipids. (bvsalud.org)
Here we conduct a multi-ancestry, genome -wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. (bvsalud.org)
Genome-wide data, including 80,000 functional genetic variants, are available for 100,000 participants (with the remaining 400,000 expected in the next few years). (ox.ac.uk)
To this end, after a data reduction step, we conducted genome-wide association studies of a combined common substrate measure in four population-based cohorts ( n = 2271), followed by meta-analysis and replication in a fifth cohort ( n = 865). (nature.com)
yet, few have performed genome-wide association studies (GWASs) in AA. (ox.ac.uk)
Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. (ox.ac.uk)
Background: We examined how expanding electrocardiographic trait genome-wide association studies to include ancestrally diverse populations, prioritize more precise phenotypic measures, and evaluate evidence for shared genetic effects enabled the detection and characterization of loci. (elsevierpure.com)
Genome-wide association study of handedness excludes simple genetic models. (medlineplus.gov)
As such, the results from previous genome-wide association studies that do not account for admixture in their examinations of people with European ancestry should be re-evaluated. (sourcearu.com)
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. (wakehealth.edu)
Public Health Impact of Genome-Wide Association Studies: Glass Half Full or Half Empty? (cdc.gov)
Collection of large (several thousand strong) cohorts of SLE patients and their family members has allowed genome-wide association studies to proceed in this disease. (medscape.com)
Genome-wide association studies have identified more than 100 genetic loci for SLE susceptibility across populations, with most of the genetic risk shared across borders and ethnicities. (medscape.com)
Genome-wide association study identifies variants screening. (who.int)

However, the size of the gene and lack of haplotype assignment significantly limit targeted association and/or linkage approaches. (edu.au)

In this workshop, we will focus firstly on the website tools and criteria of selection of SNPs polymorphism that will be used on the study. (edu.sa)
ABSTRACT This study aimed to estimate the frequency of the SNPs (+45T>G and +276G>T) genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of T2DM in the Bahraini population. (who.int)
There was no association between both SNPs and metabolic parameters. (who.int)

If the case and control populations are not well matched for ethnicity or geographic origin then false positive association can occur because of the confounding effects of population stratification. (wikipedia.org)
[ 11 ] Subsequent studies have shown that several noncoding genetic variants of TCF7L2 are associated with T2DM risk in populations of diverse ancestries in the United Kingdom, the Netherlands, Finland, Sweden, France, India, and Japan. (medscape.com)

Whether these genetic susceptibility loci modify previously identified exposure-disease associations is unclear. (who.int)

Mendelian randomisation analyses demonstrated significant causal association (5% false discovery rate) of higher body mass index on increased GDM risk. (lu.se)
Mendelian randomisation analyses identified positive associations of elevated blood pressure, history of smoking, and type 2 diabetes with lacunar stroke. (ox.ac.uk)
In follow-up analyses, rs17076061 was not robustly associated with psychiatric disease, and no overlap was found between the broader genetic architecture of the common substrate and genetic risk for major depressive disorder, bipolar disorder, or schizophrenia. (nature.com)
Analyses using the AnAge database to study the evolution of longevity and ageing in vertebrate lineages. (senescence.info)

Our results highlight the value of studies that integrate genetic and psychosocial factors to better understand complex phenotypes, such as responses to trauma in contexts of high trauma exposure. (nih.gov)
However, this proof-of-concept study defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders," Sullivan said. (sciencedaily.com)

The high estimates of GCV, heritability and genetic advance were exhibited by plant height, number of primary branches per plant, number of clusters per plant, number of pods per clusters, number of pods per plant and seed yield per plant. (ijcmas.com)

Led by researchers at the QIMR Berghofer Medical Research Institute in Australia, the study identified 11 independent genetic markers associated with the development of asthma-with-hay fever, including two associations reaching a level of significance with allergic disease for the first time. (bioquicknews.com)
Case-control studies use subjects who already have a disease, trait or other condition and determine if there are characteristics of these patients that differ from those who do not have the disease or trait. (wikipedia.org)
A difference in the frequency of an allele or genotype of the polymorphism under test between the two groups indicates that the genetic marker may increase risk of the disease or likelihood of the trait, or be in linkage disequilibrium with a polymorphism which does. (wikipedia.org)
We sought to identify novel associations and provide mechanistic insights into the disease. (ox.ac.uk)
Molecular, or genetic, pathology is a cutting-edge discipline focused on the study and diagnosis of disease through the examination of molecules within organs, tissues, or bodily. (mlo-online.com)
These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease. (uni-luebeck.de)
Determining the genetic basis of rare diseases is important for counselling and for developing our understanding of disease pathogenesis. (frontlinegenomics.com)
Atypical scrapie could be a spontaneous disease influenced by genetic and metabolic factors. (cdc.gov)
Genetic factors should be considered when investigating risk factors for atypical scrapie because some mutations of the prnp gene, which codes for prion protein (PrP), modify the risk for this disease ( 2 , 18 , 19 ). (cdc.gov)
[ 29 ] These data suggest that genetic susceptibility to T2DM as determined by TCF7L2 variants might prove an actionable indicator for early intervention and disease prevention. (medscape.com)
Pediatric patients have been underrepresented in Ebola virus disease studies because total numbers of affected children in any given Ebola virus disease outbreak, whether associated with Ebola virus or Sudan virus or Bundibugyo virus are usually low because of outbreak dynamics and societal structure. (cdc.gov)
Association measures how much greater the frequency of disease may be in one group than another. (cdc.gov)
If the result of the calculation comes out to 1.0, there is no association between exposure and disease and the risk is even whether one is exposed or not. (cdc.gov)

Patients were recruited from hospitals in the UK as part of the UK DNA Lacunar Stroke studies 1 and 2 and from collaborators within the International Stroke Genetics Consortium. (ox.ac.uk)

Familial hemiplegic migraine in pediatric patients: A genetic, clinical, and follow-up study. (iasp-pain.org)
After working in cancer clinical trials and genetic studies from 1986 to 1992 at Mayo Clinic, he was sponsored by Mayo Clinic as a Mayo Scholar from 1992 to 1993 to work on statistical genetics problems with distinguished statistical geneticist Robert C. Elston, Ph.D., then at Louisiana State University Medical Center. (mayo.edu)
Even so, convincing evidence for its importance in the control of mycobacterial infections has been found in both experimental and clinical studies. (biomedcentral.com)
In a clinical study, there was no difference between the 13q34 genotype groups in restenosis rates in patients undergoing percutaneous coronary angioplasty. (le.ac.uk)
The use of genetic testing in clinical practice needs to be further evaluated. (cdc.gov)

Both measure association of genetic markers in nuclear families by transmission from parent to offspring. (wikipedia.org)
We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures, either at the level of common variant genetic architecture or for single genetic markers. (sciencedaily.com)
The research team examined maternally-inherited DNA (mitochondrial DNA) and microsatellite markers to study hybridization rates. (sciencedaily.com)
Recently, we analyzed serum biomarkers by using samples from the Gulu outbreak and identified associations between cytokines/chemokines, acute-phase reactants, markers of coagulopathy, and markers of endothelial function and patient death, hemorrhage, and viremia. (cdc.gov)

These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. (ox.ac.uk)

Using data from the UK Biobank for participants primarily of European ancestry aged 38-73 years, including 94% white people, we identified a nonlinear association between sleep, with approximately 7 h as the optimal sleep duration, and genetic and cognitive factors, brain structure, and mental health as key measures. (nature.com)
We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). (bvsalud.org)
Researchers have found that previous studies analyzing the genomes of people with European ancestry may have reported inaccurate results by not fully accounting for population structure. (sourcearu.com)
Information about who a person is biologically descended from, known as genetic ancestry, can give important clues about genetic risks for common diseases. (sourcearu.com)
We expected to identify some individuals with hybrid ancestry, but it was quite surprising that recent hybrid ancestry was found in every tenth wolf and every tenth shepherd dog," said study co-author Tarkhnishvili. (sciencedaily.com)
The study also found that about a third of the dogs sampled shared relatively recent maternal ancestry with local wolves, not with wolves domesticated in the Far East, where most experts believe dogs were first domesticated. (sciencedaily.com)

Genetic association is when one or more genotypes within a population co-occur with a phenotypic trait more often than would be expected by chance occurrence. (wikipedia.org)
In addition to the case control design, quantitative trait association can also be performed using an unrelated population sample or family trios in which the quantitative trait is measured in the offspring. (wikipedia.org)
More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity. (ox.ac.uk)

Through these findings, 23andMe aims to substantially improve the ability to detect genetic risk factors shared between both diseases. (bioquicknews.com)
In 2006, a case-control study of atypical scrapie in Norway did not detect such factors, but it showed that the removal of the placenta at lambing could have a protective effect ( 15 ). (cdc.gov)

We evaluated the statistical properties of our proposed two-step method and compared its performance to other shrinkage methods by a simulation study. (karger.com)
RESEARCH DESIGN AND METHODS- We performed a meta-analysis of 53 studies comprising 17,791 subjects investigating the angiotensin-I converting enzyme insertion/deletion polymorphism, taking into account the requirement for diabetic retinopathy in the case definition and assuming a random-effects model. (diabetesjournals.org)
Dr. Schaid has been actively researching statistical methods for genetic studies since 1993 and has collaborated on a broad range of human genetic studies. (mayo.edu)
Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)

Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). (upf.edu)
Genetic association studies of common diseases. (mayo.edu)

Database of human genetic variants associated with longevity. (senescence.info)

The efficacy of such interventions may be dependent on patient genotypes, and epidemiological evidence firmly supports a role for genetic susceptibility in the development of diabetic nephropathy in both type 1 and type 2 diabetes ( 2 ). (diabetesjournals.org)
We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes . (bvsalud.org)
A new study evaluated the relationship between common genetic variants implicated in schizophrenia and those associated with subcortical brain volumes, and found no evidence of genetic overlap between schizophrenia risk and subcortical volume measures. (sciencedaily.com)

BACKGROUND: Genetic variants and lifestyle factors have been associated with gastric cancer risk, but the extent to which an increased genetic risk can be offset by a healthy lifestyle remains unknown. (fry-it.com)
We aimed to establish a genetic risk model for gastric cancer and assess the benefits of adhering to a healthy lifestyle in individuals with a high genetic risk. (fry-it.com)
5 × 10-5) showed the strongest association with gastric cancer risk (p=7·56 × 10-10). (fry-it.com)
Participants with a high genetic risk and a favourable lifestyle had a lower risk of gastric cancer than those with a high genetic risk and an unfavourable lifestyle (0·53 [0·29-0·99], p=0·048), with an absolute risk reduction of 1·12% (95% CI 0·62-1·56). (fry-it.com)
Compared with individuals at a high genetic risk who adopt an unhealthy lifestyle, those who adopt a healthy lifestyle could substantially reduce their risk of incident gastric cancer. (fry-it.com)
Future studies should investigate gene-by-environment interactions and employ functional imaging to understand how salience network structure translates to psychiatric disorder risk. (nature.com)
A matched case-control study (95 cases and 220 controls) was designed to study risk factors for atypical scrapie in sheep in France. (cdc.gov)
15 ) and to explore further hypotheses on risk factors for atypical scrapie, we conducted a case-control study of sheep in France. (cdc.gov)
This makes TCF7L2 variants the strongest known genetic risk factors for T2DM. (medscape.com)
The risk of developing SLE is at least in part genetic, but it is a complex genetic illness with no clear mendelian pattern of inheritance. (medscape.com)
Am J outcomes associated with treatment of cervical the risk of cancer: a multisite case-control study in Clin Nutr 2008;88:1567-75. (who.int)
the accuracy of five cervical cancer screening tests and cancer risk: a multisite case-control study in Br J Cancer 2008;98:1574-81. (who.int)

Using multilevel models, we identified an association of MAOA variant, in males only, with symptom scores of psychosocial stress on the Perceived Stress Scale (PSS) over time (p = 8.1 x 10-4). (nih.gov)
In our study, we integrated results from common variant studies of schizophrenia and volumes of several brain structures," Sullivan said. (sciencedaily.com)
Eating dinner close to bedtime, when melatonin levels are high, disturbs blood sugar control, especially in individuals with a genetic variant in the melatonin receptor MTNR1B. (mlo-online.com)
We have developed and evaluated an aggregate heterogeneity M statistic that combines between-study heterogeneity information across multiple genetic variants, to reveal systematic patterns of heterogeneity that elude conventional single variant analysis. (ox.ac.uk)

Genetic association studies are based on the principle that genotypes can be compared "directly", i.e. with the sequences of the actual genomes or exomes via whole genome sequencing or whole exome sequencing. (wikipedia.org)
In genetic case-control studies, the frequency of alleles or genotypes is compared between the cases and controls. (wikipedia.org)
Because all described genotypes of the prnp gene confer susceptibility to sheep, a purely genetic origin is unlikely but a confounding effect could occur. (cdc.gov)

The project will be based in the Big Data Institute Building (BDI), Nuffield Department of Population Health, which has excellent facilities and a world-class community of population health, genetic and data scientists. (ox.ac.uk)

To determine primarily the association of TLR4 gene with myocardial infarction through family clustering analysis as well as a case control association study. (org.pk)

Workshop : Genetic Association Studies: From SNP design to analysis and interpretation. (edu.sa)
FINDINGS: Our meta-analysis comprised studies from Europe, the USA, and Australia, including 7338 cases and 254 798 controls, of which 2987 cases (matched with 29 540 controls) were confirmed using MRI. (ox.ac.uk)
MATLAB 2018b was used to perform nonlinear association analysis. (nature.com)
A retrospective meta-analysis of magnetic resonance imaging voxel-based morphometry studies proposed that reduced gray matter volumes in the dorsal anterior cingulate and the left and right anterior insular cortex-areas that constitute hub nodes of the salience network-represent a common substrate for major psychiatric disorders. (nature.com)
One of these reports was the large retrospective meta-analysis of 193 studies by Goodkind et al. (nature.com)
Identifying systematic heterogeneity patterns in genetic association meta-analysis studies. (ox.ac.uk)
GENESTAT: an information portal for design and analysis of genetic association studies. (ox.ac.uk)

Data was also collected from three additional studies conducted in Australia and the United Kingdom, with cases defined as persons who reported a physician diagnosis of asthma and also hay fever (total N=6,685). (bioquicknews.com)
With only little empirical data associating study results and study design, bias in genetic association studies are not well understood. (wikipedia.org)

citation needed] Linkage disequilibrium (LD) is a term used in the study of population genetics for the non-random association of alleles at two or more loci, not necessarily on the same chromosome. (wikipedia.org)

Heterogeneity tests based on individual genetic variants (e.g. (ox.ac.uk)

Neuroimaging studies have found that certain parts of the brain, such as the hippocampus and amygdala, are smaller in people with schizophrenia -- a devastating psychiatric illness with high heritability. (sciencedaily.com)
High GCV, high heritability and high genetic gain was recorded for GSI, flag leaf blade area, chlorophyll content and relative injury percentage. (arccjournals.com)

citation needed] Case control studies are a classical epidemiological tool. (wikipedia.org)

In this study, we used a series of multiplex assays to measure the concentrations of 55 serum analytes in specimens from patients from the Gulu outbreak to identify biomarkers that had age-specific associations with survival, hemorrhagic manifestations, or both. (cdc.gov)

Anatomy15

Diseases26

Chemicals and Drugs31

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Psychiatry and Psychology10

Phenomena and Processes73

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture1

Information Science15

Named Groups11

Health Care40

Geographicals11

GWAS19

Traits16

Haplotypes4

Genes13

Genomic11

Polymorphisms7

Variation8

Phenotype4

Variability3

Genomics5

Loci associated3

Large-scale genetic2

Mixed genetic lineages1

Locus7

Rare genetic2

Epidemiology8

Genome-wide20

Haplotype1

SNPs3

Populations2

Susceptibility Loci1

Analyses4

Phenotypes2

Heritability and genetic1

Disease13

Consortium1

Clinical5

Markers4

Influences1

Ancestry6

Trait3

Detect2

Methods4

Diseases2

Human genetic1

Evidence3

Risk12

Variant4

Genotypes3

Nuffield Department1

Myocardial infarction1

Analysis7

Data2

Population genetics1

Heterogeneity1

High heritability2

Epidemiological1

Identify1