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  • transmembrane
  • The TH-activating deiodinase ( DIO2 ) and transmembrane transporter of thyroxine ( SLCO1C1 ) genes were expressed in the last week of incubation, which coincided with a marked increase of circulating thyroxine and a reduction in the yolk sac weight. (go.jp)
  • 2001
  • Caprioli J, Bettinaglio P, Zipfel PF et al (2001) The molecular basis of familial hemolytic uremic syndrome: mutation analysis of factor H gene reveals a hot spot in short consensus repeat 20. (springer.com)
  • The Act, the Gene Technology Regulations 2001 (the Regulations) or instruments issued by the Regulator can require compliance with these guidelines in conducting dealings with GMOs or in obtaining and maintaining certification or accreditation. (wikipedia.org)
  • 2001). "Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • It was established as part of the Gene Technology Act 2003 and operates according to the Gene Technology Regulations 2001. (wikipedia.org)
  • regulatory
  • A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. (wikipedia.org)
  • In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site. (wikipedia.org)
  • Positive regulators are regulatory elements that permit RNA polymerase binding to the promoter region, thus allowing transcription to occur. (wikipedia.org)
  • Insulators, also called boundary elements, are DNA sequences that create cis-regulatory boundaries that prevent the regulatory elements of one gene from affecting neighboring genes. (wikipedia.org)
  • There are several different techniques to detect regulatory genes, but of the many there are a certain few that are used more frequently than others. (wikipedia.org)
  • The regulatory pathway is there for gene therapy," she said. (theusdaily.com)
  • This legislation sets forth a nationally consistent regulatory system for gene technology in Australia. (wikipedia.org)
  • She is responsible for administering the national regulatory system for gene technology as set out in the Act. (wikipedia.org)
  • In administering the gene technology regulatory system the Regulator has specific responsibility to protect the health and safety of people, and to protect the environment, by identifying risk posed by or as a result of gene technology, and by managing those risks through regulating certain dealings with GMOs. (wikipedia.org)
  • During development of the gene technology legislation, it was determined that the Regulator's activities should form part of an integrated legislative framework that also includes a number of other regulatory authorities with complementary responsibilities and expertise. (wikipedia.org)
  • The Gene Technology Act was accompanied by consequential amendments of the other relevant Acts relating to requirements for reciprocal request and provision of advice and exchange of information between the Regulator and other relevant regulatory agencies. (wikipedia.org)
  • These requirements include the following: the Regulator must consult Commonwealth regulatory agencies prescribed in the Regulations on all licence applications for dealings involving the intentional release of GMOs to the environment there are requirements for agencies regulating GM products to consult and/or notify the Regulator regarding applications for registration of products that are GM or contain GMOs. (wikipedia.org)
  • This technology will permit efficient knockdown and evaluation of the candidate regulatory genes in resting primary CD4 T cells. (grantome.com)
  • CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. (wikipedia.org)
  • repressor
  • In terms of the lac operon, the negative regulator would be the lac repressor which binds to the promoter in the same site that RNA polymerase normally binds. (wikipedia.org)
  • The binding of the lac repressor to RNA polymerase's binding site inhibits the transcription of the lac genes. (wikipedia.org)
  • Only when a corepressor is bound to the lac repressor will the binding site be free for RNA polymerase to carry out transcription of the lac genes. (wikipedia.org)
  • 1. The specific role of the lac repressor (i-gene product) in transient catabolite repression evoked by the introduction of glucose into the medium has been investigated in Escherichia coli by using mutants of the i-gene. (biochemj.org)
  • 5. It is concluded that the i-gene product interacts with the catabolite co-repressor in such a way that its affinity for the operator is increased. (biochemj.org)
  • species
  • White Rot Fungi's Size Explained by Breadth of Gene Families Involved "Armillaria species are some of the most devastating forest pathogens, responsible for forest decline in many temperate regions. (doe.gov)
  • Although not specific for humans, it is a partial explanation for the fact that human and other, much more simple species (such as nematodes) have a similar number of genes (in the range of 20 - 25 thousand). (wikipedia.org)
  • A total of 74 OPR genes in 11 species from six major plant lineages were found. (wikipedia.org)
  • These barriers maintain the integrity of a species by reducing gene flow between related species. (wikipedia.org)
  • novel
  • We propose testing the involvement of various gene candidates in primary CD4 T cells using a novel Vpx-based technology to introduce lentiviral encoded shRNAs into these cells. (grantome.com)
  • enzymes
  • Using genomics, we explore the diversity of fungi to develop catalogs of genes, enzymes, and pathways -- parts lists for bio-based economy and bioenergy applications," said Grigoriev. (eurekalert.org)
  • The structural genes, which encode enzymes for arabinose catabolism, are araB, araA, and araD (collectively known as araBAD). (wikipedia.org)
  • expression
  • asburiae isolates identified an upstream LysR-type regulator gene that explained inducibility of IMI-2 expression. (thefreedictionary.com)
  • Silencers are thought to turn off gene expression at specific time points and locations. (wikipedia.org)
  • To clarify the roles of the egg yolk as a source of THs, the TH content in the yolk and the expression of TH regulator genes in the yolk sac membrane were evaluated throughout the 21-day incubation period of chicken embryos. (go.jp)
  • Real-time PCR revealed gene expression of transthyretin, a principal TH distributor in the chicken, and of a TH-inactivating iodothyronine deiodinase ( DIO3 ), until the second week of incubation when the embryonic pituitary-thyroid axis is generally thought to start functioning. (go.jp)
  • For example, in animals it is involved in suppressing transposon activity, while in algae it is positively associated with gene expression. (eurekalert.org)
  • Our analysis has shown that 6mA modifications are associated with expressed genes and is preferentially deposited based on gene function and conservation, revealing 6mA as a marker of expression for important functionally-relevant genes. (eurekalert.org)
  • The Yale researchers analyzed gene expression datasets of human breast tumors, as well as those of cancer cells, and found that overexpression of the enzyme RBP2 is critical for breast cancer metastasis to the lung. (medicalxpress.com)
  • The lac operon is another operon in E. coli that has been a focus for research in gene expression. (wikipedia.org)
  • SATB1 has also been shown to induce breast cancer tumor growth and metastasis through the altered expression of large numbers of genes. (wikipedia.org)
  • mutation
  • To screen the mutation in the retinitis pigmentosa GTPase regulator ( RPGR) ORF15 in a large Chinese family with X-linked recessive retinitis pigmentosa and describe the phenotype in affected male and female carriers. (molvis.org)
  • 3. A strain carrying an amber suppressor-sensitive mutation in the i-gene is phenotypically constitutive and also fails to show transient catabolite repression. (biochemj.org)
  • locus
  • Next, we targeted a different genomic locus, the Drosophila melanogaster histone cluster, and identified several regulators of the essential histone locus and validated their functional association with genes within the locus. (pnas.org)
  • exons
  • In eukaryotes, as a gene is transcribed from DNA into a messenger RNA (mRNA) transcript, intervening introns are removed, leaving only exons in the mature mRNA, which can subsequently be translated to produce the protein product. (wikipedia.org)
  • There are three ways in which exon scrambling can occur: Tandem exon duplication in the genome, which often occurs in cancers Trans-splicing (in which two RNA transcripts fuse), which results in a linear transcript that contains exons that, for example, may be derived from genes encoded on two different chromosomes. (wikipedia.org)
  • 2014 Developed CIRCexplorer to identify thousands of circRNAs in human with p(A)- w/o RNase R RNA-seq data The vast majority of highly expressed exonic circular RNAs identified were processed from exons located in the middle of RefSeq genes, suggesting that the circular RNA formation is generally coupled to RNA splicing. (wikipedia.org)
  • The SPG7 gene contains 21 exons and encodes for a protein that is approximately 88 kDa in size. (wikipedia.org)
  • variants
  • Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined. (wikipedia.org)
  • Two transcript variants encoding distinct isoforms have been identified for this gene. (wikipedia.org)
  • binds
  • An activator binds to a site on the DNA molecule and causes an increase in transcription of a nearby gene. (wikipedia.org)
  • cellular
  • The evaluation of these cellular genes in primary CD4 T cell models of HIV latency formed in memory CD4 T cells, Th17 CD4 T cells and Treg CD4 T cells promises to provide key insights into the role of these genes in HIV latency. (grantome.com)
  • inhibits
  • Researchers from Virginia Tech and the University of Texas Southwestern Medical Center have discovered one gene regulator that maintains the fast muscle type and inhibits the development of a slow muscle type. (healthcanal.com)
  • promoters
  • Promoters reside at the beginning of the gene and serve as the site where the transcription machinery assembles and transcription of the gene begins. (wikipedia.org)
  • Specifically, while 5mC is found at repetitive regions of the genome, the methylated adenines were clustered into dense "methylated adenine clusters" (MACs) at gene promoters. (eurekalert.org)
  • antibodies
  • We believe that just like antibodies, gene therapy will one day be a mainstay in clinical practice," he said in a statement. (theusdaily.com)
  • human
  • We test the hypothesis that polymorphisms of the brain regulator genes MCPH1 and ASPM contribute to variations in human brain size and its correlates. (royalsocietypublishing.org)
  • While the Regulator must consider risks to human health and safety and the environment relating to dealings with GMOs, other agencies have responsibility for regulating GMOs or genetically modified (GM) products as part of a broader or different mandate. (wikipedia.org)
  • development
  • Washington, July 21 (AIN): Identifying a master regulator gene for early embryonic development of the pancreas and other organs, scientists at Cincinnati Children's Hospital Medical Center have moved a step closer to coaxing stem cells into pancreatic cells as a possible cure for type1 diabetes. (thefreedictionary.com)
  • If genetic testing showed an individual was a carrier of the risk-related variation of the MiRNA-137 gene, avoiding an unhealthy lifestyle or drugs in a critical phase of brain development might prevent disease onset," Siegert says. (mit.edu)
  • Genes & Development. (wikipedia.org)
  • OGTR
  • The OGTR reports directly to Parliament through a Ministerial Council on Gene Technology and has legislative powers. (wikipedia.org)
  • bioenergy
  • They comprise a little-explored realm of fungi, providing a repertoire of important and valuable gene products for DOE missions in bioenergy and environment. (eurekalert.org)
  • Gene Atlases of Grass-Microbe Interactions This proposal seeks to build comprehensive gene atlas maps for diverse bioenergy grass-microbe interactions, including pathogenic and beneficial interactions in two grass models, Brachypodium and Setaria. (doe.gov)
  • legislation
  • The legislation establishes the Regulator as an independent statutory office holder to administer the national scheme. (wikipedia.org)
  • Under the intergovernmental Gene Technology Agreement, the states and territories have committed to maintaining corresponding legislation with the Commonwealth. (wikipedia.org)
  • The Regulator is charged with performing functions and exercising powers under the Act and corresponding legislation. (wikipedia.org)
  • targets
  • In vitro microarray based assay (DAP-chip) can be used to determine gene targets and functions of two component signal transduction systems. (wikipedia.org)
  • transcription
  • In terms of the lac operon, the positive regulator would be the CRP-cAMP complex that must be bound close to the site of the start of transcription of the lac genes. (wikipedia.org)
  • ChIP-chip is an in vivo technique used to determine genomic binding sites for transcription factors in two component system response regulators. (wikipedia.org)
  • scientists
  • 5 January Scientists from the US and UK have mapped the genome of the bowhead whale and identified genes responsible for its 200-year lifespan, the longest of any mammal. (wikipedia.org)
  • function
  • This protein is associated with a heterotetrameric complex, specifically interacting with the regulator of G-protein signaling 9, and appears to function as the membrane anchor for the other largely soluble interacting partners. (wikipedia.org)
  • research
  • This enzyme is of interest in plant biology research because the disrupted OPR3 gene has been shown to cause male sterility in Arabidopsis thaliana. (wikipedia.org)
  • researchers
  • Researchers at MIT's Picower Institute for Learning and Memory have identified a master genetic regulator that could account for faulty brain functions that contribute to schizophrenia. (mit.edu)
  • By identifying the bacterial genes that can alter how well microbes can colonize a plant, researchers can develop targeted approaches to improve plant health and growth for a number of applications, including increased biomass yield for biofuel production. (doe.gov)
  • master
  • O'Malley, senior author of the study appearing in the journal Science, said that fasting for a day can cause the blood sugar levels of mice lacking steroid receptor-2 (SRC-2)-a master regulator gene called a coactivator-to plummet, and that the animals can die if they go another day without food. (thefreedictionary.com)
  • These pathways are controlled by RGS5 which makes it a kind of master regulator. (perkins.org.au)
  • differences
  • Although all measures were construct valid and the allele frequencies showed expected population differences, no relationship was found between the genes and any of the criteria. (royalsocietypublishing.org)
  • brain
  • Both genes were hypothesized to confer a selective advantage such as increased brain size and general mental ability (GMA). (royalsocietypublishing.org)
  • A magnetic resonance imaging study has demonstrated a link between common variation in the CDK5RAP2 gene and brain structure. (wikipedia.org)
  • responsible
  • The Regulator is an independent statutory office holder responsible for administering the Gene Technology Act 2000 (the Act) and corresponding state and territory laws. (wikipedia.org)
  • powers
  • The OTGR is a Commonwealth Government Authority within the Department of Health and Ageing and reports directly to Parliament through a Ministerial Council on Gene Technology and has legislative powers. (wikipedia.org)
  • tumor
  • While the pathway is very detailed and not completely understood, in general, when Wnt is not present, GSK-3B (a member of the pathway) is able to phosphorylate β-catenin as a result of a complex formation that includes β-catenin, AXIN1, AXIN2, APC (a tumor suppressor gene product), CSNK1A1, and GSK3B. (wikipedia.org)
  • bacteria
  • Among these: If cryptic communities of diverse fungi and bacteria reside in plants when new genes are inserted, what controls have been implemented to exclude the engineered genes from microbial genomes? (blogspot.com)
  • expression
  • This previously unidentified progenitor occurs as a temporally discrete population during ES cell differentiation, and differs from the preceding and succeeding populations in gene expression and differentiation potential, with the unique ability to form surface ectoderm in response to BMP4 signalling. (biologists.org)
  • A possible role in chemical carcinogenesis for epigenetic, heritable changes in gene expression. (springer.com)
  • The oncotecture of a cancer derives from the gene-expression profiles (gene activity) of that cancer. (wikipedia.org)
  • One candidate master regulator is an oestrogen-receptor that is involved in breast cancer that controls the expression of many genes. (wikipedia.org)
  • humans
  • 26S proteasome non-ATPase regulatory subunit 7, also known as 26S proteasome non-ATPase subunit Rpn8, is an enzyme that in humans is encoded by the PSMD7 gene. (wikipedia.org)
  • M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene. (wikipedia.org)
  • response
  • Tumors induce the proliferative vascular response of host blood vessels by influencing the local balance of angiogenic regulators, a rate-limiting step termed the angiogenic switch [ 9 , 10 ]. (hindawi.com)
  • negative
  • B lymphocytes can also participate in light chain receptor editing, VH gene replacement, or be released and later undergo negative selection in the periphery. (wikipedia.org)
  • specific
  • A feature of this peer reviewed study that left a deep impression on me was the fact that each time we modified our PCR primers (think of these as the baited fish hooks used to pull specific genes out of an ocean of DNA), we found new species. (blogspot.com)
  • among
  • As ETC first warned in May last year and again in February this year, the pressure of two mergers among the Big Six Gene Giants would make a third merger inevitable. (mofga.org)
  • By Kevin Miller - House lawmakers voted Tuesday to move forward with a proposed constitutional amendment declaring Mainers have a "right to food freedom," a step that could increase tensions among local food producers, government regulators and the agribusiness industry. (mofga.org)
  • found
  • What is to keep this fungus (the genera is typically found in diverse habitats) from transferring to other host plants, propagating patented genes throughout the environment? (blogspot.com)
  • However
  • However, they named this gene odd Oz (Odz) after the oddless pair-rule phenotype displayed in Odz mutant embryos, where every odd-numbered body segment was deleted. (wikipedia.org)