• chromosomes
  • To gain the functional flexibility necessary to respond to different triggering signals, at least three isoforms of RyRs are expressed in mammals, each one encoded by a distinct gene ( ryr1 , ryr2 and ryr3 ), residing on separate chromosomes. (biomedcentral.com)
  • leukemic
  • The identification of leukemic clones with unrelated DJ rearrangements and the presence of cytogenetic abnormalities on lineage negative cells strongly suggest the participation of primitive cells. (hindawi.com)
  • An medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause hypereosinophilia and leukemic diseases in humans. (wikipedia.org)
  • RARA, (17q12) at various points yields a (15;17)(q22;q21) fusion gene, FIP1L1-RARA that also has been implicated in the development of human leukemic diseases in three case reports. (wikipedia.org)
  • markers
  • This is because the Reed-Sternberg cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma. (wikipedia.org)
  • cell
  • The paradigm is based on the regulation of APC maturation and migration via ligation of pattern recognition receptors, but other examples include the ability of complement fragments to enhance B cell activation via CD21 ( 1 ) or direct effects of TLR ligation on lymphocyte activation ( 2 ). (jimmunol.org)
  • Gene-deficient mice revealed that Gpr97 is crucial for maintaining B-cell population via constitutive CREB and NF-κB activities. (wikipedia.org)
  • The purpose of thymocyte development is to produce mature T cells with a diverse array of functional T cell receptors, through the process of TCR gene rearrangement. (wikipedia.org)
  • Allelic exclusion has been observed most often in genes for cell surface receptors and has been extensively studied in immune cells such as B lymphocytes. (wikipedia.org)
  • process
  • In childhood ALL, this process begins at conception with the inheritance of some of these genes. (wikipedia.org)
  • Allelic exclusion is a process by which only one allele of a gene is expressed while the other allele is silenced. (wikipedia.org)
  • cells
  • In all of these cells, RyRs play a central role in the regulation of the intracellular free Ca 2+ concentration ([Ca 2+ ] i ), whose elevation triggers a cascade of events that culminates in, for example, neurotransmitter release, hormone secretion, lymphocyte activation and egg fertilization. (biomedcentral.com)
  • FIP1L1-PDGFRA fusion genes have been detected in the eosinophils, neutrophils, mast cells, monocytes, T lymphocytes, and B lymphocytes involved in hemtalogical malignancies. (wikipedia.org)
  • Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. (wikipedia.org)
  • Lymphocyte predominant (LP) ("popcorn") cells are present embedded in nodules consisting of B cells and other reactive cells (mainly reactive T cells). (wikipedia.org)
  • An example is the Saccharomyces pombe gene rad9 which arrests the cells in late S/G2 phase in the presence of DNA damage caused by radiation. (wikipedia.org)
  • MAIT cells are most common in the liver, where they usually comprise 20-40% of the T lymphocyte population. (wikipedia.org)
  • clinical
  • This was discovered using array comparative genomic hybridization, a DNA-based alternative for clinical evaluation of HER2 gene copy number. (wikipedia.org)
  • different
  • Since they have the same genes, different environmental exposures explain why one twin gets ALL and the other does not. (wikipedia.org)
  • The regions where the genes are randomly recombined together is the hyper variable region used to recognise different antigens on a clonal basis. (wikipedia.org)
  • variable
  • The FIP1L1-PDGFRA fusion gene consists of the 5'-end of FIP1L1 united to the 3'-end of PGDFRA at variable breakpoints in both genes extending over a 40 kilobase region in FIP1L1 and a small region of exon 12 in PDGFRA. (wikipedia.org)
  • forms
  • A-T is caused by a defect in the ATM gene, which is responsible for managing the cell's response to multiple forms of stress including double-strand breaks in DNA. (wikipedia.org)
  • found
  • The FIP1L1 gene is found in a wide range of species, being designated as FIP1 in Saccharomyces cerevisiae (yeast) and fip1l1 in coho salmon as well as mice and numerous other mammalian species. (wikipedia.org)
  • thus
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)