• protein
  • The inflammatory markers C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) were recently shown to predict the efficacy of nivolumab for NSCLC patients. (readbyqxmd.com)
  • If a cell retains DNA damage, transcription of a gene can be prevented and thus translation into a protein will also be blocked. (wikipedia.org)
  • also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). (wikipedia.org)
  • The fusion gene may produce a protein consisting of the first 233 amino acids of FIP1L1 joined to the last 523 amino acids of PDGFRA or fused proteins consisting of other FIP1L1 and PDGFRA amino acid lengths. (wikipedia.org)
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. (wikipedia.org)
  • In simple terms, the protein produced by the ATM gene recognizes that there is a break in DNA, recruits other proteins to fix the break, and stops the cell from making new DNA until the repair is complete. (wikipedia.org)
  • Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. (wikipedia.org)
  • This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. (wikipedia.org)
  • It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. (wikipedia.org)
  • Although researchers do not know how a reduction in the amount of p300 protein leads to the specific features of Rubinstein-Taybi syndrome, it is clear that the loss of one copy of the EP300 gene disrupts normal development. (wikipedia.org)
  • antibody
  • The anti-CD20 monoclonal antibody Rituximab has been used in lymphocyte predominant Hodgkin's lymphoma with encouraging results. (wikipedia.org)
  • Basically, the antibody paratope is polygenic, made up of three genes, V, D, and J. Each paratope locus is also polymorphic, such that during antibody production, one allele of V, one of D, and one of J is chosen. (wikipedia.org)
  • leukemic
  • The identification of leukemic clones with unrelated DJ rearrangements and the presence of cytogenetic abnormalities on lineage negative cells strongly suggest the participation of primitive cells. (hindawi.com)
  • An medically important aspect of the FIP1L1 gene is its fusion with other genes to form fusion genes which cause hypereosinophilia and leukemic diseases in humans. (wikipedia.org)
  • RARA, (17q12) at various points yields a (15;17)(q22;q21) fusion gene, FIP1L1-RARA that also has been implicated in the development of human leukemic diseases in three case reports. (wikipedia.org)
  • markers
  • This is because the Reed-Sternberg cell (RSC) variants (popcorn cells) that characterize this form of the disease invariably express B lymphocyte markers such as CD20 (thus making NLPHL an unusual form of B cell lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma. (wikipedia.org)
  • cell
  • The paradigm is based on the regulation of APC maturation and migration via ligation of pattern recognition receptors, but other examples include the ability of complement fragments to enhance B cell activation via CD21 ( 1 ) or direct effects of TLR ligation on lymphocyte activation ( 2 ). (jimmunol.org)
  • Gene-deficient mice revealed that Gpr97 is crucial for maintaining B-cell population via constitutive CREB and NF-κB activities. (wikipedia.org)
  • The purpose of thymocyte development is to produce mature T cells with a diverse array of functional T cell receptors, through the process of TCR gene rearrangement. (wikipedia.org)
  • Allelic exclusion has been observed most often in genes for cell surface receptors and has been extensively studied in immune cells such as B lymphocytes. (wikipedia.org)
  • activation
  • In all of these cells, RyRs play a central role in the regulation of the intracellular free Ca 2+ concentration ([Ca 2+ ] i ), whose elevation triggers a cascade of events that culminates in, for example, neurotransmitter release, hormone secretion, lymphocyte activation and egg fertilization. (biomedcentral.com)
  • Specificity of T lymphocyte activation relies upon TCR recognition of MHC-peptide a relatively low affinity interaction compared to immunoglobulin. (powershow.com)
  • expression
  • Alternatively, the increased levels of this GRK could be part of the changed pattern of gene expression of the failing heart. (ahajournals.org)
  • We first conducted gene expression microarray analysis of 9 PMA and 13 PA from infra- and supratentorial sites. (stanford.edu)
  • On one hand, one allele of the gene can be transcriptionally silent, which would result in the expression of only the second allele. (wikipedia.org)
  • process
  • In childhood ALL, this process begins at conception with the inheritance of some of these genes. (wikipedia.org)
  • Allelic exclusion is a process by which only one allele of a gene is expressed while the other allele is silenced. (wikipedia.org)
  • cells
  • FIP1L1-PDGFRA fusion genes have been detected in the eosinophils, neutrophils, mast cells, monocytes, T lymphocytes, and B lymphocytes involved in hemtalogical malignancies. (wikipedia.org)
  • Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. (wikipedia.org)
  • Lymphocyte predominant (LP) ("popcorn") cells are present embedded in nodules consisting of B cells and other reactive cells (mainly reactive T cells). (wikipedia.org)
  • An example is the Saccharomyces pombe gene rad9 which arrests the cells in late S/G2 phase in the presence of DNA damage caused by radiation. (wikipedia.org)
  • MAIT cells are most common in the liver, where they usually comprise 20-40% of the T lymphocyte population. (wikipedia.org)
  • different
  • Since they have the same genes, different environmental exposures explain why one twin gets ALL and the other does not. (wikipedia.org)
  • The regions where the genes are randomly recombined together is the hyper variable region used to recognise different antigens on a clonal basis. (wikipedia.org)
  • clinical
  • This was discovered using array comparative genomic hybridization, a DNA-based alternative for clinical evaluation of HER2 gene copy number. (wikipedia.org)
  • variable
  • The FIP1L1-PDGFRA fusion gene consists of the 5'-end of FIP1L1 united to the 3'-end of PGDFRA at variable breakpoints in both genes extending over a 40 kilobase region in FIP1L1 and a small region of exon 12 in PDGFRA. (wikipedia.org)
  • forms
  • A-T is caused by a defect in the ATM gene, which is responsible for managing the cell's response to multiple forms of stress including double-strand breaks in DNA. (wikipedia.org)
  • lead
  • If theHER-2/neu gene does not amplify in the case of polysomy, proteins may be overexpressed and could lead to tumerogenesis. (wikipedia.org)
  • found
  • The FIP1L1 gene is found in a wide range of species, being designated as FIP1 in Saccharomyces cerevisiae (yeast) and fip1l1 in coho salmon as well as mice and numerous other mammalian species. (wikipedia.org)
  • thus
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)