• protein-codin
  • A recent study found only one-fifth of transcription across the human genome is associated with protein-coding genes, indicating at least four times more long non-coding than coding RNA sequences. (wikipedia.org)
  • Quantitatively, lncRNAs demonstrate ~10-fold lower abundance than mRNAs in a population of cells, which is explained by higher cell-to-cell variation of expression levels of lncRNA genes in the individual cells, when compared to protein-coding genes. (wikipedia.org)
  • While long ncRNAs are located and transcribed within the intergenic stretches, the majority are transcribed as complex, interlaced networks of overlapping sense and antisense transcripts that often includes protein-coding genes. (wikipedia.org)
  • It is estimated that 1 to 5% of all mammalian genes encode for miRNA, which regulate the expression of approximately 30% of all of the protein-coding genes [ 4 , 5 ], and that each miRNA on average regulates 200 target genes through an interaction between the seed sequence and the complementary target sites [ 6 ]. (ijbs.com)
  • miRNAs
  • Up-regulation of 20 miRNAs was observed in obese liver tissue. (uwindsor.ca)
  • MicroRNAs (miRNAs) are a class of small (18-24 nucleotides), endogenous and non-coding RNAs which bind to target mRNAs so as to regulate protein expression by repressing translation or by promoting degradation of the target mRNA [ 1 , 2 ], or by enhancing translation at the posttranscriptional level in RNA-induced silencing complex (RISC) [ 3 ]. (ijbs.com)
  • diverse
  • Instead, their preservation across diverse amniotes, their apparent conservation in exon structure, and similarities in their pattern of brain expression during embryonic and early postnatal stages together indicate that these are functional RNA molecules, of which some have roles in vertebrate brain development. (biomedcentral.com)
  • brain
  • We identify some of the first lncRNA orthologs present in birds (chicken), marsupial (opossum), and eutherian mammals (mouse), and investigate whether they exhibit conservation of brain expression. (biomedcentral.com)
  • strong
  • One example was a strong correlation between high proliferation rates in metastatic cancers and overexpression of genes that participate in cell cycle regulation, DNA replication, and DNA repair. (aacrjournals.org)