• signaling pathway
  • From the original setting of mouse ESC culture, scientists identified the active components leukaemia inhibitory factor (LIF) and bone morphogenic proteins (BMP), which maintain the pluripotency in ESCs through activating the Jak/Stat3 signaling pathway and inducing the inhibitors of differentiation (Id) genes, respectively [ 4 , 5 , 6 ]. (mdpi.com)
  • profiles
  • We tested reproducibility by comparing the expression profiles provided by U133 Plus 2.0 GeneChipsĀ® for 3 independently amplified RNA samples: a high degree of correlation between the replicates was obtained. (unimi.it)
  • studies
  • ResultsThe Emerging Technologies for Translational Bioinformatics symposium on gene expression profiling for archival tissues featured presentations of two large-scale FFPE expression profiling studies each involving over 1,000 samples, overviews of several smaller studies, and representatives from three leading companies in the field Illumina, Affymetrix, and NuGEN. (duhnnae.com)
  • One of these studies derived the prognostic signature from genes correlating with histological grade [ 4 ], while in [ 5 ] it was derived directly from correlations with clinical outcome data and was validated in estrogen receptor positive lymph node negative (ER+LN-) breast cancer. (biomedcentral.com)
  • patients
  • A total of 142 genes were differentially expressed (115 genes were upregulated and 27 downregulated) between the patients with any stage of ROP compared to the no-ROP premature controls. (arvojournals.org)