• Specificity: MUC5AC is expressed in airway and gastric epithelial cells and highly expressed in colorectal carcinomas. (scytek.com)
  • Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization. (wikipedia.org)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • Mucin 1 ( MUC1 ) is a kind of cell surface mucins and is abundant in mucosal tissues, especially in normal gastric epithelial cells [ 9 ]. (biomedcentral.com)
  • Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for targeted endoscopic surveillance in regions with low-intermediate incidence of GC. (bmj.com)
  • Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)
  • We demonstrate that DBZ elicits a homogeneous goblet cell conversion all along the mouse intestinal tract, associated with an overexpression of the gene Muc2 without ectopic expression of the gastric genes Muc5ac and Muc6 , and with the emergence of lysozyme-positive 'intermediate cells' in the colon. (biologists.com)
  • 2 Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer (ie, mucinous NOS, intestinal type, signet ring cell type, invasive stratified mucin producing carcinoma and gastric type) based on 2020 WHO classification of cervical cancer. (who.int)
  • The cytoprotective action of the green tea- catechins against ethanol - or restraint plus water -immersion stress-induced acute gastric mucosal injury, and acetic acid-induced chronic gastric ulcers in rats has been reported. (rsc.org)
  • The prophylactic action of the tea seed-derived triterpene saponins against ethanol -induced gastric mucosal lesions, 6,7 and of BT extract against various ulcerogens 8,9 have been reported in rat models. (rsc.org)
  • The study participants comprised 2980 patients undergoing screening gastroscopy with standardised gastric mucosal sampling, from January 2004 and December 2010, with scheduled surveillance endoscopies at year 3 and 5. (bmj.com)
  • Evidence for coexpression of mucins and trefoil peptides has been suggested in numerous gastrointestinal mucosal pathologies. (embl.de)
  • bound to mucin and then transferred to a mucosal cell surface receptor. (dssurgery.com)
  • Established benign lesions, which are rare, include simple gastric metaplasia and lobular endocervical glandular hyperplasia (LEGH) (complex gastric metaplasia). (nih.gov)
  • BACKGROUND AND AIMS: Trefoil factor family (TFF) peptides and the chromosome 11p15.5 mucin glycoproteins are expressed and secreted in a site specific fashion along the length of the gastrointestinal tract. (embl.de)
  • Composite diagram of proposed structures for typical branched oligosaccharides in human 223 and pig 219 gastric mucin glycoproteins showing the immunodeterminant blood group A and H (- - -) and I (‐ ‐ ‐) saccharide structures. (comprehensivephysiology.com)
  • Mucins are high molecular-weight glycoproteins (120-1000 kDa) with sialylated oligosaccharides. (romj.org)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is a distinct subtype that accounts for nearly 10% of gastric carcinomas. (spandidos-publications.com)
  • In 1990, Burke et al ( 3 ), first reported the association between EBV and gastric carcinoma with characteristic lymphoepithelioma-like histology based on polymerase chain reaction (PCR) techniques. (spandidos-publications.com)
  • In gastric carcinoma cells, EBV is not integrated into the host genome but maintained as a type of plasmid called an episome. (spandidos-publications.com)
  • The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
  • In addition to accumulating more case series of EBV-associated gastric carcinoma (EBVaGC), the development of comprehensive molecular analyses has provided evidence that EBVaGC is a distinct subset both in terms of its clinicopathological and molecular features. (spandidos-publications.com)
  • The concept of gastric-type cervical glandular lesions has emerged over recent decades and our understanding of the full spectrum of benign, premalignant and malignant lesions is still evolving. (nih.gov)
  • Uncommonly, gastric-type cervical glandular lesions involve multiple sites in the female genital tract and it may be problematic to discern whether these represent independent synchronous or metastatic lesions. (nih.gov)
  • There is also an association between gastric-type cervical lesions and Peutz-Jeghers syndrome. (nih.gov)
  • Awareness of the spectrum of gastric-type lesions is important, as the diagnostic features of both gAIS and GAS, particularly well differentiated examples, may be subtle, and p16 immunohistochemistry is usually negative. (nih.gov)
  • Yet, no association could be established between the esogastric lesions and malabsorption, weight loss, or gastric bile acid concentrations. (nature.com)
  • Strong pS2 gene expression was also observed in the normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract . (xenbase.org)
  • The original progression of GC is gastric mucosa lesions. (biomedcentral.com)
  • In addition, the ability of KT4 to reduce gastric acid secretion might also contribute to its ulcer-healing activity. (rsc.org)
  • Pharmacology of a new porcine pancreatic polypeptide with spasmolytic and gastric acid secretion inhibitory effects. (xenbase.org)
  • In order to define which glycans may be implicated in the binding of the bacteria to the gastric mucosa in humans, we have characterized the exact pattern of glycosylation of gastric mucins. (pasteur.fr)
  • We have also demonstrated that around 80% of O-glycans carried blood group A, B or H antigens, suggesting that the variation of gastric mucin glycosylation between individuals is partly due to the blood group status. (pasteur.fr)
  • 09:45 - Differentiation markers in gastric carcinogenesis with emphasis on mucin and mucin glycosylation. (seap.es)
  • Overall, the results reported here give us the necessary background information to begin studies to determine whether individuals who express certain carbohydrate epitopes on specific mucins are predisposed to certain gastric diseases. (pasteur.fr)
  • We tested the hypothesis that individual trefoil peptides are uniquely localised with specific mucins in the UACL and normal gastrointestinal epithelia. (embl.de)
  • The MUC5AC Antibody detects for mucin 5AC (MUC5AC), a secretory-type mucin found in columnar mucous cells of surface gastric epithelium, in goblet cells of the fetal, and in precancerous colon, but is not found in normal colon cells. (neuromics.com)
  • A gastric immunophenotype has been demonstrated using markers of pyloric gland mucin, MUC6 and HIK1083. (nih.gov)
  • Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
  • In general, mucins have the unique function of protecting and lubricating epithelial surfaces, but in recent years they have also been implicated in additional diverse roles, such as growth, fetal development, epithelial renewal and differentiation, epithelial integrity, carcinogenesis, and metastasis. (bmj.com)
  • In the present review we highlight the latest findings on EBVaGC from clinicopathological and molecular perspectives to provide a better understanding of EBV involvement in gastric carcinogenesis. (spandidos-publications.com)
  • In spite of these findings, the importance of EBV in gastric carcinogenesis has long been underestimated. (spandidos-publications.com)
  • Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
  • METHODS: Expression of mucin genes in the UACL from small bowel tissue of patients with Crohn's disease was detected by in situ hybridisation, and localisation of the products by immunohistochemistry. (embl.de)
  • We have examined surface-functionalized gold nanoparticles (Au NPs) within mucin/mucus matrices to gain a better understanding of the mechanical and chemical interactions, as these systems are model nanoparticle-based therapeutics. (confex.com)
  • In addition, we have examined the bulk rheological effects for synthetic mucus solutions-based on pig gastric mucin (PGM) and different stabilizers-in response to GC-Au nanoparticle addition at different concentrations. (confex.com)
  • adherent gastric mucus viewed under bright field on a transverse section 1.6 mm thick) of rat gastric mucosa. (comprehensivephysiology.com)
  • dependence of solution viscosity of pig gastric mucus on glycoprotein concentration. (comprehensivephysiology.com)
  • Concentration of glycoprotein in gastric mucus (pig and human) is ∼50 mg/ml. (comprehensivephysiology.com)
  • mechanical spectrum for pig gastric mucus showing a plot of elastic (storage modulus, --) and viscous (loss modulus, --) moduli against frequency of oscillatory deformations 20. (comprehensivephysiology.com)
  • Native gastric mucus and mucus reconstituted from isolated glycoprotein have the behavior characteristic of a weak viscoelastic gel with the elastic modulus dominant over the viscous modulus. (comprehensivephysiology.com)
  • Mucus depends on mucins, biopolymers with a protein backbone and an attached forest of sugar molecules. (mit.edu)
  • The healing capacities of the tea extracts could be attributed to their antioxidant activity as well as the ability to protect the mucin content of the gastric tissues. (rsc.org)
  • Early gastric cancer in the gastric body. (medscape.com)
  • however, some patients with incidental complaints are diagnosed with early gastric cancer. (medscape.com)
  • Participants were also matched against the National Registry of Diseases Office for missed diagnoses of early gastric neoplasia (EGN). (bmj.com)
  • Probiotic compounds, including those found in kombucha, have been shown to improve "a wide range of gastrointestinal diseases including gastric ulcers, IBS, ulcerative colitis, celiac disease, and other inflammatory bowel diseases. (organicfacts.net)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • namely, MUC3, MUC4, MUC12, MUC13, and the recently described mucin MUC17, which share a C-terminal structural domain that consists of two or three epithelial growth factor (EGF)-like regions, a transmembrane segment, and a short cytoplasmic tail. (bmj.com)
  • Mucin-17 is a protein that in humans is encoded by the MUC17 gene. (wikipedia.org)
  • 2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine" (PDF). (wikipedia.org)
  • 2006). "Characterization of human mucin MUC17. (wikipedia.org)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • The reason for this is that Helicobacter Pylori ( H. pylori ), discovered in 1983 by Marshall and Warren, and classified as a definite carcinogen by World Health Organization in 1994, has been regarded as the major factor in almost all gastric carcinomas worldwide ( 7 - 9 ). (spandidos-publications.com)
  • Thus, it is necessary to maintain the function of gastric mucosa, which prevents infection by the variety of microorganisms. (biomedcentral.com)
  • New measures being investigated involve reducing oropharyngeal and gastric colonization by pathogenic microorganisms. (cdc.gov)
  • Although most patients are asymptomatic, persistent infection may cause chronic gastritis and gastric cancer. (pasteur.fr)
  • Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality. (frontiersin.org)
  • Gastric cancer is the sixth most common cancer and the fourth most common cause of cancer-related death in the world. (medscape.com)
  • Most symptoms of gastric cancer reflect advanced disease. (medscape.com)
  • All physical signs in gastric cancer are late events. (medscape.com)
  • The surgical approach in gastric cancer depends on the location, size, and locally invasive characteristics of the tumor. (medscape.com)
  • Background: Immunotherapy has brought new hope to gastric cancer (GC) patients. (portlandpress.com)
  • Gastric cancer (GC) is the fifth most commonly diagnosed cancer, accounting for 8.2% of all cancer deaths, and is the third leading cause of cancer deaths worldwide [ 1 ]. (portlandpress.com)
  • 11:45 - Molecular pathology of gastric cancer. (seap.es)
  • Levels of expression of breast epithelial mucin detected by monoclonal antibody BrE-3 in breast-cancer prognosis. (xenbase.org)
  • Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori -infected pathogenesis of gastric cancer (GC). (biomedcentral.com)
  • Although the incidence and mortality rates of gastric cancer (GC) are decreased over the past few decades, GC is still a severe public health problem. (biomedcentral.com)
  • Cancer in the body and tail may cause splenic vein obstruction, resulting in splenomegaly, gastric and esophageal varices, and gastrointestinal hemorrhage. (msdmanuals.com)
  • Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. (embl.de)
  • Colocalisation of mucins and trefoil peptides was demonstrated by immunofluorescent colabelling in UACL and normal gastrointestinal epithelia. (embl.de)
  • Coordinated localisation of trefoil peptides and mucins in UACL and normal gastrointestinal epithelia suggests they may assist each others' functions in protection and repair of gastrointestinal mucosa. (embl.de)
  • Trefoil factor family 2 ( TFF2 ), a member of secreted peptides, is also expressed in gastric mucosa and triggers cell migration signaling to promote epithelial repair [ 14 , 15 ]. (biomedcentral.com)
  • CONCLUSIONS: The UACL has a unique profile of mucin gene expression. (embl.de)
  • Epithelial mucins can be classified into two distinct families: secretory (gel forming) and membrane bound. (bmj.com)
  • Chronic dry eye results from a lack of mucins, and current remedies are less than ideal. (mit.edu)
  • Adhesion of the bacteria to the gastric mucosa is a necessary prerequisite for the pathogenesis of H. pylori-related diseases and is mediated by mucin O-glycans. (pasteur.fr)
  • This study will help better understanding the role of O-glycans in the physiology and homeostasis of gastric mucosa. (pasteur.fr)
  • Katharina Ribbeck, the Eugene Bell Career Development Professor of Tissue Engineering at MIT, diagrams the molecular structure of mucin, which has a protein backbone and a brushlike array of attached sugars, or glycans. (mit.edu)
  • On the contrary, BA concentrations were the highest in the residual gastric pouch of OAGB-15 rats. (nature.com)
  • This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. (nature.com)
  • Malabsorption of iron is a rare cause of iron deficiency in the general public but is seen in patients who have had a partial gastrectomy, RNY Gastric Bypass, or who have a surgical malabsorption, such as Duodenal Switch. (dssurgery.com)
  • In case of cooked foods, gastric digestion is also directed toward the liquification of the stomach contents, but it is interfered with by the fact that the heat of cooking has precipitated the colloids. (price-pottenger.org)
  • The digestive action takes place between the food particles and the gastric mucosa, which to be sure does not digest itself. (price-pottenger.org)
  • The proinflammatory effect of mucin-coated particles is still unclear, and our aim was to study the role of mucin sorption in activation of neutrophil respiratory burst. (romj.org)
  • Mucin, a major component of mucosa, is not only absorbed by these particles but is also actively incorporated [2, 4]. (romj.org)
  • Earlier it was shown that crystals coated with plasma proteins can stimulate greater chemiluminescent response of polymorphonuclear leukocytes than untreated particles [7], but little is known about effects of adsorbed mucin. (romj.org)
  • The aim of the present work was to investigate the chemiluminescence (CL) of neutrophils activated with calcium phosphate particles coated with mucin. (romj.org)
  • 1995. A case of gastric cicatrization caused by ingestion of sulfuric acid, treated with Hunt-Lawrence jejunal pouch substitution for the stomach. (cdc.gov)
  • reepithelialized mucosa: rat gastric mucosa after exposure to 70% (vol/vol) ethanol for 45 s and rapid wash with 0.9% (wt/vol) sodium chloride followed by 0.9% (wt/vol) sodium chloride for 1 h. (comprehensivephysiology.com)
  • Morphological characteristics of these hybrid systems were examined using TEM, and net-surface charge effects of the nanoparticle interacting with mucin was characterized by z-potential measurements. (confex.com)
  • Bit by bit, with genetic perturbations of the microbes, and biochemical dissection of the mucins, we can begin to understand the mechanisms of interaction between the mucins and the microbes. (mit.edu)
  • We're dissecting the mechanisms now by which the mucins do that, to then build synthetic molecules that can do the same job. (mit.edu)
  • Yeast cells in mucins remain in the benign form, which the body presumably can tolerate," she says. (mit.edu)
  • We think mucin prevents their virulence. (mit.edu)
  • 5 It is believed that polyphenols or polyphenol derivatives from green tea may be useful either in prevention or treatment of H . pylori -associated gastric diseases. (rsc.org)
  • Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. (nih.gov)
  • Obviously, sorption of mucin but not that of HSA stimulated generation of reactive oxygen and halogen species with no increase in cytokine production. (romj.org)