Galectin 3. Medical search. Frequent questions

Interaction with Galectin-3 (GAL3) was identified, and confirmed by binding assay. (nih.gov)
Galectin-3 (GAL3) is known to have a detrimental function in neurodegenerative diseases. (lu.se)
Galectin-3 (Gal3), an endogenous lectin, has anti-microbial and pro-inflammatory functions. (duke.edu)
Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. (elsevierpure.com)

Given galectin-3's broad biological functionality, it has been demonstrated to be involved in cancer, inflammation and fibrosis, heart disease, and stroke. (wikipedia.org)
A correlation between galectin-3 expression levels and various types of fibrosis has been found. (wikipedia.org)
Galectin-3 is upregulated in cases of liver fibrosis, renal fibrosis, and idiopathic pulmonary fibrosis (IPF). (wikipedia.org)
In several studies with mice deficient in or lacking galectin-3, conditions that caused control mice to develop IPF, renal, or liver fibrosis either induced limited fibrosis or failed to induce fibrosis entirely. (wikipedia.org)
The galectin-3 inhibitor, TD139 and GR-MD-02 have the potential to treat fibrosis. (wikipedia.org)
Plasma galectin-3 (Gal-3) is associated with organ fibrosis, but whether urinary Gal-3 is a potential biomarker of kidney disease progression has never been explored. (mdpi.com)
Gal-3 promotes cell adhesion and proliferation, which are the mechanisms behind fibrosis. (dermcast.tv)
Levels of galectin-3 in blood may be increased in People with certain forms of advanced cancer and other conditions associated with organ fibrosis. (healthmatters.io)
This galectin-3 mediated form of heart failure is associated with progressive fibrosis, or stiffening, in the heart muscle, which impairs the heart's ability to pump. (gildehealthcare.com)
Galectin-3 is a circulating protein produced by the body when fibrosis is occurring and has been found in humans to correlate to the degree of fibrosis of the heart in HCM, as well as proving useful for identifying high-risk patients. (everycat.org)
In kidney from SHR, Gal-3 was upregulated, as well as the fibrotic markers (collagen type I, TGF-β and connective tissue growth factor) and tubulointerstitial fibrosis. (elsevierpure.com)
MCP treatment reduced Gal-3 levels and fibrosis. (elsevierpure.com)
Conclusion: Gal-3 inhibition attenuated early renal damage in SHR as indicated by reduced albuminuria, improved renal function and decreased renal fibrosis, EMT and inflammation, independently of blood pressure levels. (elsevierpure.com)
Mesenchymal stem cell ameliorate renal fibrosis by galectin -3 Akt/ GSK3? (imedpub.com)
Gal-3 KD notably inhibited the expression of p-Akt, p-GSK3β and snail in TGF-β1-induced HK-2 cells fibrosis. (imedpub.com)
Conclusion: The mechanism of MSCs anti-renal fibrosis was probably mediated by galectin-3/Akt/GSK3β/Snail signaling pathway. (imedpub.com)
Galectin-3 may be a valuable target for treating renal fibrosis. (imedpub.com)

Galectin-3 also may be used as a biomarker to identify at risk individuals, and predict patient response to different drugs and therapies. (wikipedia.org)
Galectin-3 is a biomarker that appears to be actively involved in both the inflammatory and some fibrotic pathways. (healthmatters.io)
This study aimed to elucidate the importance of Gal-3 in endometriosis, to reveal its potential power as a non-invasive diagnostic biomarker in disease etiopathogenesis. (istanbul.edu.tr)
Serum galectin-9 as a noninvasive biomarker for the detection of endometriosis and pelvic pain or infertility-related gynecologic disorders. (istanbul.edu.tr)
Galectin-3 has recently been proposed as a novel biomarker for cardiovascular disease in adults. (scilifelab.se)
Galectin-3 has been linked to obesity and been proposed to be a novel biomarker for cardiovascular disease in adults. (scilifelab.se)
The present study aims to analyze the role of galectin-3 (GAL-3) in the lung tumor microenvironment (TME) using tumorspheres as a model and explore its potential role as a predictive and prognostic biomarker in non-small cell lung cancer (NSCLC) patients. (qxmd.com)
Next, we evaluated levels of sGAL-3 before surgery in LUAD and LUSC patients, hypothesizing that sGAL-3 could be used as an independent prognostic biomarker for overall survival and relapse-free survival in early-stage LUAD patients. (qxmd.com)
Moreover, high levels might predict decreased progression-free survival and overall survival to anti-PD-1 therapy, with sGAL-3 being a prognosis-independent biomarker for advanced LUAD. (qxmd.com)
A novel cardiovascular stress biomarker known as galectin-3 might be useful for anticipating adverse cardiovascular outcomes. (bvsalud.org)

The study sought to assess the serum concentration of Gal-3 and investigate the relationship of Gal-3 with inflammatory activation and LV systolic and diastolic function in patients with psoriasis. (dermcast.tv)
The authors conclude that subclinical left ventricular systolic dysfunction in psoriasis is linked with the inflammatory upregulation, and enhanced profibrotic activity may be reflected by elevated serum Gal-3. (dermcast.tv)
Heterophile antibodies, in particular human-antimouse antibodies in human serum, may cause falsely elevated galectin-3 results. (healthmatters.io)
Materials and Methods: The serum concentration of Gal-3 and cancer antigen 125 (CA-125) from whole blood were measured using enzyme-linked immuno sorbent assay (ELISA) and an auto-analyzer, respectively. (istanbul.edu.tr)
Gal-3 levels in the serum of women with endometriosis are also remarkably increased compared with the control group. (istanbul.edu.tr)
In additon, advanced stage CRC patients had higher serum galectin-3 and CEA levels than early stage CRC patients. (oncotarget.com)
High serum CEA and galectin-3 levels correlated with advanced N stage and poor survival in CRC patients. (oncotarget.com)
In 57 patients admitted to the intensive care unit (ICU) with sepsis, serum Gal-3 was examined as a predictor of ICU mortality and development of AKI. (biomedcentral.com)
In a rat model of S-AKI induced by cecal ligation and puncture (CLP), 7-day mortality and serum Gal-3, Interleukin-6 (IL-6), and creatinine were examined at 2, 8, and 24 hours (h) post-CLP. (biomedcentral.com)
Serum Gal-3 was an independent predictor of AKI (OR = 1.2 [95% CI 1.1-1.4], p = 0.01) and ICU mortality (OR = 1.4 [95% CI 1.1-2.2], p = 0.04) before and after controlling for age, AKI, and acute physiology and chronic health evaluation (APACHE II) score. (biomedcentral.com)
In the CLP rat experiment, serum Gal-3 peaked earlier than IL-6. (biomedcentral.com)
However, no previous study has examined the relationship between serum Gal-3 at the time of admission and the subsequent development of AKI in patients with sepsis. (biomedcentral.com)
Frozen serum samples were analyzed for galectin-3 by the Proximity Extension Assay technique. (scilifelab.se)
Gal-3 and Lp(a) was measured in serum samples from patients and 17 healthy controls by immunometric assays. (unina.it)
Results: Gal-3 and Lp(a)/LDL serum levels showed increased levels in patients compared with the control group (p¼0.0001 and p¼0.001 respectively). (unina.it)
No correlations have been observed between Gal-3 serum levels and Gal-3 levels in atherosclerotic plaques. (unina.it)
No differences were found between Gal-3 serum levels among the different plaques types, nor between complicated and uncomplicated plaques. (unina.it)
Positive Association of Serum Galectin-3 with the Development of Aortic Stiffness of Patients on Peritoneal Dialysis. (bvsalud.org)
The objective of the current investigation was to assess the association between serum galectin-3 levels and aortic stiffness (AS) in 196 patients on peritoneal dialysis . (bvsalud.org)
An enzyme -linked immunosorbent examination and a cuff-based volumetric displacement were employed to determine the levels of serum galectin-3 and the carotid-femoral pulse wave velocity (cfPWV), respectively. (bvsalud.org)
The AS group, when compared with the group without AS, had a significantly higher prevalence of diabetes mellitus and hypertension in addition to greater fasting glucose levels, waist circumference , systolic blood pressure , and serum galectin-3 levels. (bvsalud.org)
Multivariate logistic and linear regression analysis demonstrated that serum glactin-3 levels, in addition to gender and age, were significantly and independently associated with cfPWV and AS. (bvsalud.org)
In summary, there was a significant correlation between serum galectin-3 levels and cfPWV in patients undergoing peritoneal dialysis therapy for end-stage kidney disease . (bvsalud.org)
The late blood response (7 and 28d) was characterized by increased serum osteopontin levels in conjunction with increased lung expression of genes coding for a macrophage related response (e.g. arginase I, galectin-3, osteopontin). (cdc.gov)

The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion. (rndsystems.com)
This gene encodes a member of the galectin family of carbohydrate binding proteins. (origene.com)
Galectin-3 belongs to the lectin family of carbohydrate binding proteins. (enquirebio.com)
Galectins, a family of carbohydrate binding proteins (lectins) have been implicated in inflammation and cancer. (angioproteomie.com)

Galectin-3 is a protein that in humans is encoded by the LGALS3 gene. (wikipedia.org)
Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21-q22. (wikipedia.org)
Homo sapiens galectin 3 (LGALS3), transcript variant 1, mRNA. (origene.com)
2019). Indeed, a unique phenotype has been identified as disease-associated microglia (DAM) or neurodegenerative microglia (MGnD), which in AD is enriched with Apoe, Trem2, Lpl, Itgax, Clec7a and Lgals3 (encoding Gal-3) (Keren-Shaul et al. (lu.se)

The amino acid sequences of human and mouse Galectin-3 proteins share 80% homology. (enquirebio.com)
SARS-CoV-2 is made up of four primary structural proteins: homotrimer spike (S) glycoprotein, small envelope (E) glycoprotein, membrane (M) glycoprotein and nucleocapsid (N) protein as well as a few ancillary proteins [ 3 ] . (encyclopedia.pub)
T2CA inhibited the expression of phosphorylated galectin-3 expression in human glioblastoma cell line which in turn inhibits the activity of MMP2 and MMP9 proteins in zymography investigations and inhibits migration of cancer cells in in vitro scratch assay. (arjournals.org)
Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. (arjournals.org)

Studies have also shown that the expression of galectin-3 is implicated in a variety of processes associated with heart failure, including myofibroblast proliferation, fibrogenesis, tissue repair, inflammation, and ventricular remodeling. (wikipedia.org)
3:15 Dr. Eliaz explains that inflammation is the driving force for nearly every chronic disease. (drweitz.com)
Inflammation is like an orchestra playing together and the conductor of the orchestra is Gallectin-3. (drweitz.com)
It is only extracellularly that Galectin-3 becomes this dangerous compound that stimulates inflammation and this wide variety of diseases. (drweitz.com)
If we change our lifestyle, we eat better, sleep better, exercise more, and relax, our inflammation will decrease and our Galectin-3 will decline. (drweitz.com)
Here we review the interactions of metabolism, galectins and glycoprotein ligands as well as the utility of this model to predict and treat inflammation and autoimmunity. (gr.jp)

Galectin-3 (Gal-3) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis. (wikipedia.org)
Of note, galectin-3 has been suggested to play important roles in cancer metastasis. (wikipedia.org)
Galectin-3 has specific binding affinity for beta-galactoside sugar moieties and has functional roles during development, innate immunity, cell apoptosis, and tumor metastasis. (enquirebio.com)
In this study, we investigated the role of galectin-3 and carcinoembryonic antigen (CEA) in metastasis and survival of colorectal cancer (CRC) patients. (oncotarget.com)
These findings suggest interaction between galectin-3 and CEA promotes CRC migration and metastasis, and correlates with poor survival of CRC patients. (oncotarget.com)
Deletion of galectin-3 in the host attenuates metastasis of murine melanoma by modulating tumor adhesion and NK cell activity. (arjournals.org)
In this context, include the galectins, protein family of animal lectins, which are involved in various biological processes in organisms such as cell cycle control, immune response, cell adhesion, apoptosis and metastasis. (bvsalud.org)

What starts all of this is the secretion of Galectin-3, which results from a trauma or even from emotional stress. (drweitz.com)
RESULTS: Galectin 3 induced secretion of interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor, CXCL8, and MMP-3 in both synovial and skin fibroblasts. (ox.ac.uk)
By contrast, galectin 3-induced secretion of TNFalpha, CCL2, CCL3, and CCL5 was significantly greater in synovial fibroblasts than in skin fibroblasts. (ox.ac.uk)
CONCLUSION: Our findings indicate that galectin 3 promotes proinflammatory cytokine secretion by tissue fibroblasts. (ox.ac.uk)
We analyzed the pattern of secretion and expression of GAL-3 using reverse transcription-quantitative real-time PCR (RTqPCR), immunoblot, immunofluorescence, flow cytometry and immunoassay analysis. (qxmd.com)
Additional reported applications (for relevant formats of this clone) include: costimulation 1 (clone 2E2 has been shown to enhance T-cell receptor mediated activation and cytokine secretion) and blocking 2,3 . (biolegend.com)

A recent study looked at the role of galectin-3 (Gal-3), a protein produced and released by macrophages, and epithelial cells of skin, among others, and its relation to the severity of disease and the level of LV longitudinal systolic deformation (GLS). (dermcast.tv)
Previous studies have demonstrated the effects of galectins on immune cells, such as lymphocytes and macrophages. (ox.ac.uk)
Galectin-3 is a carbohydrate-binding lectin whose expression is associated with inflammatory cells including macrophages, neutrophils, and mast cells. (healthmatters.io)
Galectin-3 is expressed by a wide range of cell types including activated T cells, tumor cells, macrophages, osteoclasts, fibroblasts, and epithelial cells. (enquirebio.com)
We will also evaluate the hypothesis that microglia-release Gal-3 impacts the integrity of BBB through perivascular macrophages and the glymphatic system, ultimately leading to aberrant T-cell response in AD. (lu.se)
instead exogenous galectin-3 increases adhesion to monocytes and macrophages but not epithelial cells. (ox.ac.uk)
Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). (biolegend.com)

Hemolysis has been shown to interfere with the galectin-3 assay due to intracellular release of galectin-3. (healthmatters.io)
Presence of human antimouse antibodies (HAMA) or rheumatoid factor (RF) may interfere with the galectin-3 assay, which could cause falsely elevated results. (healthmatters.io)
The galectin-3 assay should not be used in people with known HAMA or RF. (healthmatters.io)

Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. (wikipedia.org)

Intracellularly Galectin-3 contributes to embryogenesis, to differentiation of tissues, and to normalization of tissues. (drweitz.com)
It is widely expressed in all extracellular fluids and in pericellular areas of cell-rich tissues (1-3). (novusbio.com)
A positive correlation between PKM2 and galectin-9 expression is observed in HNSCC tissues. (researchsquare.com)
Immunohistochemical analysis indicated that galectin-3 is expressed during meningococcal disease and colocalizes with bacterial colonies in infected tissues from patients. (ox.ac.uk)
Immunohistochemical analysis showed that CEA co-localized with galectin-3 in CRC patient tissues. (oncotarget.com)
Galectin-3 was downregulated significantly in renal tissues and TGF-β1-induced rat tubular epithelial cells and interstitial fibroblasts, consistent with the iTRAQ results. (imedpub.com)

The wide variety of effects of galectin-3 on cancerous cells are due to the unique structure and various interaction properties of the molecule. (wikipedia.org)
The many interaction and binding properties of galectin-3 influence various cell activities based on its location. (wikipedia.org)
The galectin lattice is a multi-valent interaction of galectins with glycoproteins at the cell surface that displays rapid exchange of binding partners with properties of liquid-liquid phase transitions, thereby acting as an intermediary between freely diffusing glycoproteins and stable complexes in the membrane. (gr.jp)
Galectin-3 binds Neisseria meningitidis and increases interaction with phagocytic cells. (ox.ac.uk)
In this study we investigated the interaction between galectin-3 and Neisseria meningitidis, an important extracellular human pathogen, which is a leading cause of septicaemia and meningitis. (ox.ac.uk)
We show that galectin-3 binds to N. meningitidis and we demonstrate that this interaction requiresfull-length, intact lipopolysaccharide molecules. (ox.ac.uk)
Galectin-3 knockdown blocked induction of CRC cell migration by CEA, suggesting interaction between galectin-3 and CEA was necessary for CRC cell migration. (oncotarget.com)

Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain (CRD) of about 130 amino acids that enable the specific binding of β-galactosides. (wikipedia.org)

Galectin 3 induces a distinctive pattern of cytokine and chemokine production in rheumatoid synovial fibroblasts via selective signaling pathways. (ox.ac.uk)
This study was undertaken to investigate the hypothesis that galectin 3 induces proinflammatory effects in RA by modulating the pattern of cytokine and chemokine production in synovial fibroblasts. (ox.ac.uk)
METHODS: Matched samples of RA synovial and skin fibroblasts were pretreated with galectin 3 or tumor necrosis factor alpha (TNFalpha), and the levels of a panel of cytokines, chemokines, and matrix metalloproteinases (MMPs) were determined using enzyme-linked immunosorbent assays and multiplex assays. (ox.ac.uk)
However, galectin 3 induces the production of mononuclear cell-recruiting chemokines uniquely from synovial fibroblasts, but not matched skin fibroblasts, via a PI 3-kinase signaling pathway. (ox.ac.uk)
These data provide further evidence of the role of synovial fibroblasts in regulating the pattern and persistence of the inflammatory infiltrate in RA and suggest a new and important functional consequence of the observed high expression of galectin 3 in the rheumatoid synovium. (ox.ac.uk)

INTENDED USE AND DESCRIPTION: For use a quantitative control for the determination of human Galectin-3 concentrations in biological fluids. (rndsystems.com)
Concentrations of galectin-3 have been used to predict adverse remodeling after a variety of cardiac insults. (healthmatters.io)
At concentrations greater than 1 ug/ml, Galectin-3 significantly enhanced migration of PBMCs compared to control. (enquirebio.com)
Concentrations of galectin-3 in the sera of normal controls and cancer patients. (arjournals.org)

Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. (biolegend.com)

Our results using three-dimensional (3D) models of lung tumor cells revealed that soluble GAL-3 (sGAL-3) is highly expressed and secreted. (qxmd.com)
In this investigation, we describe the galectin-3 inhibitory and immune stimulating properties of a novel water-soluble nutraceutical made from Tinospora cordifolia stem. (arjournals.org)
Tim-3 has also been shown to exist as a soluble protein. (biolegend.com)

Galectin-3 will stimulate the macrophage to turn into an inflammatory macrophage, which is where IL6, IL8, and TNF alpha come from. (drweitz.com)
Galectin-3 interacts with carbohydrates, such as N-acetyllactosamine, certain cell surface receptors (such as macrophage CD11b/CD18) and extracellular receptors (such as collagen). (healthmatters.io)

The epithelial-mesenchymal transition (EMT) molecules (fibronectin, α-smooth muscle actin and β-catenin) were modified in SHR and normalized by Gal-3 inhibition. (elsevierpure.com)
In renal epithelial normal rat kidney-52E cells, Gal-3 treatment induced EMT markers, whereas Gal-3 silencing attenuated EMT. (elsevierpure.com)

Galectin-3BP binds Galectin-3 (formerly MAC-2) with high affinity, but also binds Galectins -1 and -7, several collagen types, fibronectin, beta 1 integrins and nidogen (3, 6, 7). (novusbio.com)

The galectin lattice (i) regulates flow of receptors and solute transporters to coated-pit endocytosis and/or caveolin domains, and (ii) promotes turnover of cell-cell contacts such as immune synapses and focal adhesion complexes. (gr.jp)
Metabolic regulation of UDP-GlcNAc supply to Golgi N-glycan remodeling regulates glycoprotein affinities for galectins -and in turn, trafficking and presentation at the cell surface. (gr.jp)

In the Current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an alpha(v)beta(3) integrin-specific and a galectin-1-specific peptide. (maastrichtuniversity.nl)
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. (bvsalud.org)

5. Caserta D, Di Benedetto L, Bordi G, D'Ambrosio A, Moscarini M. Levels of Galectin-3 and stimulation expressed gene 2 in the peritoneal fluid of women with endometriosis: A pilot study. (istanbul.edu.tr)
Further possible mechanism was explored by transfected galectin-3 gene for knockdown (Gal-3 KD) and overexpression (Gal-3 OE) in HK-2 cells with lentiviral vector. (imedpub.com)
[ 4 ] Nonfunctioning adenomas are associated with hypermethylation of p16 prolactinomas, and corticotropin-secreting tumors express galectin-3 (Gal-3), a gene involved in cell growth and apoptosis. (medscape.com)

Galectin-3 overexpression promotes neoplastic transformation and the maintenance of transformed phenotypes as well as enhances the tumour cell's adhesion to the extracellular matrix and increase metastatic spreading. (wikipedia.org)
When we regulate Galectin-3, we regulate all of the inflammatory cascade , the extracellular matrix damage cascade, and the fibrotic cascade, which all lead to dysfunction. (drweitz.com)

This article is a literature review that presents information of the expression of galectins 1 and 3 in oral squamous cell carcinoma, considering its multifunctional role in biological processes. (bvsalud.org)

Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)
We were the first to report that Gal-3 promotes Αβ toxicity and worsens cognition in an AD mouse model, later confirmed by Tao et al. (lu.se)

Galectin-3 is expressed and secreted by immune cells and has been implicated in multiple aspects of the inflammatory response. (ox.ac.uk)

Two experimental groups received the Gal-3 inhibitor modified citrus pectin (P-MCP) at 400 mg/kg/day and 1200 mg/kg/day, while the control group received water only ( n = 18 in each group). (biomedcentral.com)
We herein investigated the effects of pharmacological Gal-3 inhibition by modified citrus pectin (MCP) in renal damage in spontaneously hypertensive rats (SHRs). (elsevierpure.com)

It has been suggested in published literature that the beta-galactoside binding protein, galectin-9, acts on T cells to induce apoptosis, but whether this induced cell death is dependent on TIM3 remains an area of active debate and conflicting results. (emerging-researchers.org)
We hypothesized that Galectin-9 induced apoptosis of exhausted Jurkat T lymphocytes is dependent on T Cell Immunoglobulin and Mucin Protein 3 (TIM3). (emerging-researchers.org)
Galectin-9 protein ability to induce apoptosis was investigated using Jurkat T lymphocytes placed under an untreated negative control, a positive control of staurosporine, and 50, 100, or 200Nm of galectin-9 for 4, 12, and 18 hours. (emerging-researchers.org)

Companies have developed galectin modulators that block the binding of galectins to carbohydrate structures. (wikipedia.org)
Liu FT, Rabinovich GA. Galectins as modulators of tumor progression. (arjournals.org)

Overexpression and changes in the localization of galectin-3 molecules affects the prognosis of the patient and targeting the actions of galectin-3 poses a promising therapeutic strategy for the development of effective therapeutic agents for cancer treatment. (wikipedia.org)
Different expression pattern of TIM-3 and Galectin-9 molecules by peripheral and peritoneal lymphocytes in women with and without endometriosis. (istanbul.edu.tr)

There was also a correlation between galectin-3 and increase in total body fat over 2 years, while no such correlations were found for the other fat measurements. (scilifelab.se)

Galectin-3 (Gal-3) is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis. (istanbul.edu.tr)

Galectin-3 induces endothelial cell morphogenesis and angiogenesis. (arjournals.org)

Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. (prospecbio.com)
Inohara H, Raz A. Functional Evidence That Cell-Surface Galectin-3 mediates homotypic cell-adhesion. (arjournals.org)

We are now in the latest stages of studying patients with hypertension, a double blind study at Harvard, who have been given MCP for four years to patients who have Galectin-3 above 17.8 and it is finishing in February. (drweitz.com)

However, as heart disease progresses, significant upregulation of galectin-3 occurs in the myocardium. (wikipedia.org)
Transcriptional upregulation of galectin-3 in multiple sclerosis. (nih.gov)

Dr. Ben Weitz interviews Dr. Isaac Eliaz , who discusses Galectin-3 , an inflammatory protein measured in the blood, that increases risk of nearly every chronic disease, including heart disease, diabetes, arthritis, cancer, chronic kidney disease, and heart failure. (drweitz.com)
An inflammatory protein inside the brain Transcriptomic studies strongly support the role of galectin-3 as an important molecule in neuroinflammation. (lu.se)

Galectin-3 binding protein (Galectin-3BP), also known as MAC-2 binding protein (MAC-2BP or M2BP), and the 90 kDa tumor associated antigen (TAA90K or 90K), is a secreted glycoprotein of the scavenger receptor cysteine-rich (SRCR) superfamily (1, 2). (novusbio.com)

In direct ELISAs, less than 20% cross-reactivity with recombinant mouse Galectin‑3BP/MAC‑2BP is observed. (novusbio.com)

Galectin-3 is member of the protein family known as galectins. (healthmatters.io)

Exogenous CEA and galectin-3 synergistically promoted migration of galectin-3 knockdown DLD1 cells. (oncotarget.com)

But it's important to know that inside the cell, Galectin-3 has a very different role. (drweitz.com)
What is the Role of Galectin-3 in Cardiovascular Problems for Patients with Psoriasis? (dermcast.tv)
OBJECTIVE: High expression of galectin 3 at sites of joint destruction in rheumatoid arthritis (RA) suggests that galectin 3 plays a role in RA pathogenesis. (ox.ac.uk)
Galectins play an important and complex role in intracellular pathways and disease mechanisms. (healthmatters.io)
Building upon our preliminary results, we will investigate the role of microglia, prominent innate mediators in the brain, as targets for the orchestration of leukocytes via Gal-3 signalling. (lu.se)
Galectin-3 is a protein that has been shown to play an important role in the development and progression of heart failure in approximately 30% of the patients diagnosed with heart failure. (gildehealthcare.com)
The role of galectin-3 in heart failure was first established in 2004, and the clearance of the company's Galectin-3 blood test now for the first time allows physicians to use this product in the evaluation of patients diagnosed with heart failure. (gildehealthcare.com)
The goal of this project was to investigate the effects of galectin-9 and resolve the role of TIM3. (emerging-researchers.org)
We aim to better understand the role of Galectin-3 (Gal-3) and Lipoprotein(a) (Lp(a)) in atherosclerotic process and to define their potential role as peripheral marker of plaque instability. (unina.it)
Fukumori T, Kanayama HO, Raz A: The role of galectin-3 in cancer drug resistance. (arjournals.org)
Kamhawi S , Ramalho-Ortigao M , Pham VM , Kumar S , Lawyer PG , Turco SJ , A role for insect galectins in parasite survival. (cdc.gov)
detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration. (lu.se)

Galectin-3 has also been associated as a factor promoting ventricular remodeling following mitral valve repair, and may identify patients requiring additional therapies to obtain beneficial reverse remodeling. (wikipedia.org)
9:08 I told Dr. Eliaz that conditions affected by Galectin-3, like chronic kidney disease and aortic stenosis, are chronic diseases that are incurable and while these patients are often managed with drugs, they tend to go downhill fairly rapidly. (drweitz.com)
Increased amounts of Gal-3 have been found in patients with a number of conditions including heart failure. (dermcast.tv)
The results showed that the more Gal-3 present in patients with psoriasis, the greater the severity of the disease (as indicated by higher PASI). (dermcast.tv)
Galectin-3 results should be interpreted with caution in such patients. (healthmatters.io)
Galectin-3 results should be interpreted with caution in patients with a history of therapeutic use of murine monoclonal antibodies (IgG) or their fragments or in those who have known autoimmune disorders. (healthmatters.io)
Galectin-3 results from patients with diseases associated with hyperglobulinemia, such as multiple myeloma, should be interpreted with caution. (healthmatters.io)
Although the five-year survival rate has improved with great achievements [ 3 ], cachexia still seriously impacts the quality of life in most patients with advanced disease. (researchsquare.com)
2020). These findings have been followed up clinically in a phase 1b/2a clinical trial conducted by TrueBinding, Inc., in which a monoclonal antibody targeting gal-3 has shown remarkable positive preliminary data in 170 AD patients (NCT05476783). (lu.se)
Thus combinatorial therapy targeting galectin-3 and CEA may improve outcomes for advanced stage CRC patients. (oncotarget.com)
WALTHAM, MA (BUSINESS WIRE)- BG Medicine, Inc., a U.S.-based life sciences company, announced today that the U.S. Food and Drug Administration has cleared the company's Galectin-3 test for use in conjunction with clinical evaluation as an aid to assess the prognosis of patients diagnosed with chronic heart failure. (gildehealthcare.com)
With the introduction of our Galectin-3 test, we are offering physicians the first opportunity to identify those patients with higher levels of galectin-3. (gildehealthcare.com)
In the translational phase, we confirmed that patients with high expression levels of GAL-3 had more TREGS , which suggests that tumors may be recruiting this population through GAL-3. (qxmd.com)
Additionally, levels of sGAL-3 at pretreatment and first response assessment from plasma to predict clinical outcomes in advanced LUAD and LUSC patients treated with first-line pembrolizumab were evaluated, further supporting that sGAL-3 has a high efficiency in predicting durable clinical response to pembrolizumab with an area under curve (AUC) of 0.801 (p=0.011). (qxmd.com)
MMP-1 and MMP-3 polymorphism and arrhythmia recurrence after electrical cardioversion in patients with persistent atrial fibrillation. (cdc.gov)
sST2 and Galectin-3 genotyping in patients with persistent atrial fibrillation. (cdc.gov)
3. Patients not pregnant, breastfeeding, or planning pregnancy during the study period. (who.int)

Elevated levels of galectin-3 have been found to be significantly associated with higher risk of death in both acute decompensated heart failure and chronic heart failure populations. (wikipedia.org)
We found that Gal-3(-/-) mice had significantly lower levels of bacteraemia compared with wild-type mice after challenge with live bacteria, indicating that galectin-3 confers an advantage to N. meningitidis during systemic infection. (ox.ac.uk)

Galectin-3 has an affinity for beta-galactosides and exhibits antimicrobial activity against bacteria and fungi. (wikipedia.org)
All galectins bind lactose and other beta-galactosides but differ in their affinity for more complex saccharides. (angioproteomie.com)

Lactate production and the expression of galectin-9, a critical immunosuppression molecule, were detected after PKM2 knockdown and overexpression in HNSCC cells. (researchsquare.com)

Finally, the induction of galectin-9 expression by PKM2 can be affected by a lactate transporter inhibitor. (researchsquare.com)
The use of MP as a GAL-3 inhibitor could serve as an antiviral agent blocking against the SARS-CoV-2-binding spike protein. (encyclopedia.pub)
This involves the use of the GAL-3 inhibitor as an antiviral agent blocking against the SARS-CoV-2-binding spike protein. (encyclopedia.pub)

The purpose of this investigation was to assess relationships between galectin-3 levels and total body fat, abdominal fat, body fat distribution, aerobic fitness, blood pressure, left ventricular mass, left atrial size, and increase in body fat over a 2-year period in a population-based sample of children. (scilifelab.se)
Moreover, left atrial size, left ventricular mass, and relative wall thickness and pulse pressure were also correlated with galectin-3. (scilifelab.se)
More body fat and abdominal fat, more abdominal body fat distribution, more left ventricular mass, and increased left atrial size were all associated with higher levels of galectin-3. (scilifelab.se)

MP is safe and non-toxic with promising therapeutic properties with regard to targeting galectin-3 (GAL-3) toward the prevention and inhibition of viral infections through the modulation of the immune response and anti-inflammatory cytokine effects. (encyclopedia.pub)
Methods and results: Gal-3 inhibition did not modify blood pressure levels in 30-week-old SHR. (elsevierpure.com)
Inhibition of Gal-3 may serve as a molecular therapeutic target. (medscape.com)

Dr. Eliaz said that he has developed the only commercially available Galectin-3 blocker and it is a natural product that is a modification of pectin, which is a long chain of carbohydrates from citrus. (drweitz.com)
Odun-Ayo, F. Modified Pectin Binding Galectin-3 in SARS-CoV-2. (encyclopedia.pub)
Modified Pectin Binding Galectin-3 in SARS-CoV-2" Encyclopedia , https://encyclopedia.pub/entry/17071 (accessed November 29, 2023). (encyclopedia.pub)
The effects of MP are the subject of new and interesting research with evidence indicating that galactan-rich tiny molecular weight pectin fragments can bind to the carbohydrate recognition domain (CRD) on the pro-metastatic protein, GAL-3. (encyclopedia.pub)

Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. (prospecbio.com)
Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area. (istanbul.edu.tr)

Galectin-3 also helps promote angiogenesis. (wikipedia.org)
Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis. (istanbul.edu.tr)

Scholars@Duke publication: Galectin-3 as a Therapeutic Target for NSAID-Induced Intestinal Ulcers. (duke.edu)
This translational study demonstrates the importance of Gal-3 in the pathogenesis of S-AKI, and its potential utility as a therapeutic target. (biomedcentral.com)

One study concluded that individuals with systolic heart failure of ischaemic origin and elevated galectin-3 levels may benefit from statin treatment. (wikipedia.org)
Neither systolic blood pressure nor maximal oxygen uptake was correlated with galectin-3. (scilifelab.se)

Overexpression and changes in sub- and inter-cellular localization of galectin-3 are commonly seen in cancerous conditions. (wikipedia.org)

Anatomy7

Organisms10

Diseases2

Chemicals and Drugs33

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes17

Disciplines and Occupations1

Information Science4

GAL34

Fibrosis17

Biomarker10

Serum24

Family of carbohydrate binding4

LGALS34

Proteins4

Inflammation6

Metastasis7

Secretion6

Macrophages7

Assay3

Lectin family1

Tissues6

Interaction7

Carbohydrate-recognition-bindin1

Fibroblasts5

Concentrations4

Cytokines1

Soluble3

Macrophage2

Epithelial2

Collagen1

Regulates2

Ligands2

Gene3

Extracellular2

Squamous cell carc1

Promotes2

Immune cells1

Citrus Pectin2

Apoptosis3

Modulators2

Molecules2

Correlation1

Biological1

Induces1

Mediates2

17.81

Upregulation2

Inflammatory protein2

Antigen1

Recombinant1

Protein family1

Exogenous1

Role12

Patients17

Significantly2

Beta-galactosides2

Knockdown1

Inhibitor3

Atrial3

Inhibition3

Pectin4

Progression2

Angiogenesis2

Therapeutic Target2

Systolic2

Overexpression1